{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:44:07Z","timestamp":1789253047060,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.phytochem.2020.112259","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T17:28:03Z","timestamp":1579109283000},"page":"112259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Salicornolides A-C from Gracilaria salicornia attenuate pro-inflammatory 5-lipoxygense: Prospective natural anti-inflammatory leads"],"prefix":"10.1016","volume":"172","author":[{"given":"Kajal","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tima","family":"Antony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.phytochem.2020.112259_bib1","doi-asserted-by":"crossref","first-page":"740","DOI":"10.2174\/138955708784912148","article-title":"Natural marine anti-inflammatory products","volume":"8","author":"Abad","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"issue":"5","key":"10.1016\/j.phytochem.2020.112259_bib2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.phytochem.2005.11.020","article-title":"Rings B, D-seco limonoids from the leaves of Swietenia mahogani","volume":"67","author":"Abdelgaleil","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2020.112259_bib3","article-title":"First report of antioxidant abeo-labdane type diterpenoid from intertidal red seaweed Gracilaria salicornia with 5-lipoxygenase inhibitory potential","author":"Antony","year":"2018","journal-title":"Nat. Prod. Res. Epub. Ahead Print"},{"issue":"10","key":"10.1016\/j.phytochem.2020.112259_bib4","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1080\/10498850.2019.1684407","article-title":"Pharmacological properties of seaweeds against progressive lifestyle diseases","volume":"28","author":"Antony","year":"2019","journal-title":"J. Aquat. Food Prod. Technol."},{"issue":"2\u20133","key":"10.1016\/j.phytochem.2020.112259_bib5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0962-4562(03)00083-3","article-title":"Inhibition of 5-lipoxygenase by essential oils and other natural fragment extracts","volume":"13","author":"Baylac","year":"2003","journal-title":"Int. J. Aromather."},{"issue":"2","key":"10.1016\/j.phytochem.2020.112259_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1039\/C2NP20112G","article-title":"Marine natural products","volume":"30","author":"Blunt","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2020.112259_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biopha.2018.11.034","article-title":"Macrocyclic lactones from seafood Amphioctopus neglectus: newly described natural leads to attenuate angiotensin-II induced cardiac hypertrophy","volume":"110","author":"Chakraborty","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phytochem.2020.112259_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00253-016-7810-3","article-title":"O-heterocyclic derivatives with antibacterial properties from marine bacterium Bacillus subtilis associated with seaweed, Sargassum myriocystum","volume":"101","author":"Chakraborty","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"50","key":"10.1016\/j.phytochem.2020.112259_bib9","doi-asserted-by":"crossref","first-page":"12194","DOI":"10.1021\/jf504845m","article-title":"Polyketide family of novel antibacterial 7-O-methyl-5\u2032-hydroxy-3\u2019-heptenoate-macrolactin from seaweed-associated Bacillus subtilis MTCC 10403","volume":"62","author":"Chakraborty","year":"2014","journal-title":"J. Agric. Food Chem."},{"issue":"7","key":"10.1016\/j.phytochem.2020.112259_bib10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nrd2590","article-title":"The exploration of macrocycles for drug discovery an underexploited structural class","volume":"7","author":"Driggers","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phytochem.2020.112259_bib11","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1126\/science.294.5548.1871","article-title":"Prostaglandins and leukotrienes: advances in eicosanoid biology","volume":"294","author":"Funk","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.phytochem.2020.112259_bib12","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1096\/fj.12-205286","article-title":"Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at serine-663","volume":"26","author":"Gilbert","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.phytochem.2020.112259_bib13","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ci9904261","article-title":"Neural network modeling for estimation of partition coefficient based on atom-type electrotopological state indices","volume":"40","author":"Huuskonen","year":"2000","journal-title":"J. Chem. Inf. Comput. Sci."},{"issue":"8","key":"10.1016\/j.phytochem.2020.112259_bib14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1007\/s00044-017-1886-x","article-title":"Previously undescribed antioxidative and anti-inflammatory chromenyls bearing 3H-isochromenone and furanyl-2H-chromenyl skeletons from the venerid clam, Paphia malabarica","volume":"26","author":"Joy","year":"2017","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.phytochem.2020.112259_bib15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1071\/CH9820113","article-title":"Macrocyclic enolethers containing an acetylenic group from the red alga Phacelocarpus labillardieri","volume":"35","author":"Kazlauskas","year":"1982","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.phytochem.2020.112259_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/ol702598q","article-title":"New cytotoxic 14-membered macrolides from marine-derived fungus Aspergillus ostianus","volume":"10","author":"Kito","year":"2008","journal-title":"Org. Lett."},{"issue":"1","key":"10.1016\/j.phytochem.2020.112259_bib17","first-page":"47","article-title":"Peroxidative oxidation of leuco-dichloroluorescein by prostaglandin-H synthase in prostaglandin biosynthesis from polyunsaturated fatty acids","volume":"1299","author":"Larsen","year":"1996","journal-title":"BBA: Lipid Lipid Met."},{"key":"10.1016\/j.phytochem.2020.112259_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1475-2867-13-55","article-title":"Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties","volume":"13","author":"Lee","year":"2013","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.phytochem.2020.112259_bib19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.phytochem.2020.112259_bib20","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.foodres.2017.07.006","article-title":"Unprecedented antioxidative and anti-inflammatory aryl polyketides from the brown seaweed Sargassum wightii","volume":"100","author":"Maneesh","year":"2017","journal-title":"Food Res. Int."},{"issue":"7","key":"10.1016\/j.phytochem.2020.112259_bib21","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1021\/jm1012374","article-title":"Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery","volume":"54","author":"Marsault","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phytochem.2020.112259_bib22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/ard.62.6.501","article-title":"Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs","volume":"62","author":"Martel-Pelletier","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.phytochem.2020.112259_bib23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/bcpt.12134","article-title":"Inhibitors of the arachidonic acid cascade: interfering with multiple pathways","volume":"114","author":"Meirer","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"10","key":"10.1016\/j.phytochem.2020.112259_bib24","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1016\/j.ejmech.2011.07.057","article-title":"Natural products: an evolving role in future drug discovery","volume":"46","author":"Mishra","year":"2011","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.phytochem.2020.112259_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrd2487","article-title":"Drug development from marine natural products","volume":"8","author":"Molinski","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.phytochem.2020.112259_bib26","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1021\/np200487k","article-title":"Cyclic ether-containing macrolactins, antimicrobial 24-membered isomeric macrolactones from a marine Bacillus sp","volume":"74","author":"Mondol","year":"2011","journal-title":"J. Nat. Prod."},{"issue":"5","key":"10.1016\/j.phytochem.2020.112259_bib27","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.3390\/md12052913","article-title":"Anti-bacterial and anti-yeast compounds from marine-derived bacteria.","volume":"12","author":"Mondol","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2020.112259_bib28","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/S0040-4039(00)79931-X","article-title":"Oscillariolide, a novel macrolide from a blue-green alga Oscillatoria sp","volume":"32","author":"Murakami","year":"1991","journal-title":"Tetrahedron Lett."},{"issue":"9","key":"10.1016\/j.phytochem.2020.112259_bib29","first-page":"287","article-title":"A New neo-clerodane diterpenoid from Teucrium polium Linn","volume":"4","author":"Sadaka","year":"2017","journal-title":"Int. J. Pharmacogn."},{"issue":"11\u201312","key":"10.1016\/j.phytochem.2020.112259_bib30","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1007\/s00044-018-2248-z","article-title":"An unreported polyether macrocyclic lactone with antioxidative and anti-lipoxygenase activities from the Babylonidae gastropod mollusc Babylonia spirata","volume":"27","author":"Salas","year":"2018","journal-title":"Med. Chem. Res."},{"issue":"1","key":"10.1016\/j.phytochem.2020.112259_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/ol8024814","article-title":"Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia","volume":"11","author":"Stout","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2020.112259_bib32","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1021\/ja00302a042","article-title":"Norhalichondrin A: an antitumor polyether macrolide from a marine sponge","volume":"107","author":"Uemura","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phytochem.2020.112259_bib33","doi-asserted-by":"crossref","first-page":"4443","DOI":"10.1021\/jp068423w","article-title":"Fast approaches for molecular polarizability calculations","volume":"111","author":"Wang","year":"2007","journal-title":"J. Phys. Chem. A"},{"key":"10.1016\/j.phytochem.2020.112259_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11030-005-1314-x","article-title":"What can a chemist learn from nature's macrocycles?-A brief, conceptual view","volume":"9","author":"Wessjohann","year":"2005","journal-title":"Mol. Divers."},{"issue":"3","key":"10.1016\/j.phytochem.2020.112259_bib35","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.foodchem.2007.04.038","article-title":"Antioxidant activity and phenolic compounds in 32 selected herbs","volume":"105","author":"Wojdylo","year":"2007","journal-title":"Food Chem."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942219308891?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942219308891?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:39:38Z","timestamp":1758479978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942219308891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":35,"alternative-id":["S0031942219308891"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2020.112259","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salicornolides A-C from Gracilaria salicornia attenuate pro-inflammatory 5-lipoxygense: Prospective natural anti-inflammatory leads","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2020.112259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112259"}}