{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:59:58Z","timestamp":1779260398576,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015047","name":"Polit National Laboratory for Marine Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41876161"],"award-info":[{"award-number":["41876161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42276088"],"award-info":[{"award-number":["42276088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991522"],"award-info":[{"award-number":["81991522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U2006204"],"award-info":[{"award-number":["U2006204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.phytochem.2022.113578","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T19:29:52Z","timestamp":1672428592000},"page":"113578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Sarcoelegans A\u2013H, eight undescribed cembranes with anti-inflammatory and anti-thrombotic activities from the South China Sea soft coral Sarcophyton elegans"],"prefix":"10.1016","volume":"207","author":[{"given":"Cili","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiarui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kechun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinglin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2022.113578_bib1","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1021\/acs.orglett.1c00847","article-title":"Dumulmycin, an antitubercular bicyclic macrolide from a riverine sediment-derived streptomyces sp","volume":"23","author":"An","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0300-483X(98)00124-3","article-title":"Sarcophytolide: a new neuroprotective compound from the soft coral Sarcophyton glaucum","volume":"131","author":"Badria","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.phytochem.2022.113578_bib3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1039\/b701534h","article-title":"Marine natural products","volume":"25","author":"Blunt","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2022.113578_bib4","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.ijbiomac.2022.09.210","article-title":"New flexible cembrane-type macrocyclic diterpenes as TNF-\u03b1 inhibitors from the South China Sea soft coral Sarcophyton mililatensis","volume":"222","author":"Bu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phytochem.2022.113578_bib5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/md20050297","article-title":"Computationally assisted structural elucidation of cembranoids from the soft coral Sarcophyton tortuosum","volume":"20","author":"Chao","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib6","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1021\/acs.orglett.1c01601","article-title":"Sinusiaetone A, an anti-inflammatory norditerpenoid with a bicyclo[11.3.0]hexadecane nucleus from the hainan soft coral Sinularia siaesensis","volume":"23","author":"Chen","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib7","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1039\/D1QO00034A","article-title":"Structural characterisation of natural products by means of quantum chemical calculations of NMR parameters: new insights","volume":"8","author":"Costa","year":"2021","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.phytochem.2022.113578_bib8","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1248\/cpb.56.988","article-title":"New cembranoid diterpenes from the Vietnamese soft coral Sarcophyton mililatensis stimulate osteoblastic differentiation in MC3T3-E1 cells","volume":"56","author":"Cuong","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2022.113578_bib9","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1021\/jo01017a001","article-title":"Cembrene, a fourteen-membered ring diterpene Hydrocarbon*,1,2","volume":"30","author":"Dauben","year":"1965","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/acs.orglett.8b04019","article-title":"Septosones A-C, in vivo anti-inflammatory meroterpenoids with rearranged carbon skeletons from the marine sponge Dysidea septosa","volume":"21","author":"Gui","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0002-8703(84)90132-7","article-title":"Thromboxane B2, 6-keto-PGF1 alpha, PGE2, PGF2 alpha, and PGA1 plasma levels in arteriosclerosis obliterans: relationship to clinical manifestations, risk factors, and arterial pathoanatomy","volume":"107","author":"Jouve","year":"1984","journal-title":"Am. Heart J."},{"key":"10.1016\/j.phytochem.2022.113578_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/cjoc.202100564","article-title":"Xishaglaucumins A-J, new cembranoids with anti-inflammatory activities from the South China Sea Soft coral Sarcophyton glaucum","volume":"40","author":"Li","year":"2022","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib13","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1021\/acs.orglett.0c01155","article-title":"Quantum mechanical-NMR-aided configuration and conformation of two unreported macrocycles isolated from the soft coral Lobophytum sp.: energy calculations versus coupling constants","volume":"22","author":"Li","year":"2020","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib14","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/ol403723b","article-title":"Tortuosenes A and B, new diterpenoid metabolites from the Formosan soft coral Sarcophyton tortuosum","volume":"16","author":"Lin","year":"2014","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cjoc.202100597","article-title":"New cembrane-type diterpenoids from the South China Sea Soft coral Sinularia nanolobata","volume":"40","author":"Lin","year":"2022","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib16","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/ol901070e","article-title":"Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum","volume":"11","author":"Lin","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib17","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1021\/ol901070e","article-title":"Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum","volume":"11","author":"Lin","year":"2009","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2022.113578_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/md19090519","article-title":"Oxygenated cembrene diterpenes from Sarcophyton convolutum: Cytotoxic Sarcoconvolutum A-E","volume":"19","author":"Mohamed","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib19","article-title":"Cherbonolides M and N from a formosan soft coral","volume":"19","author":"Peng","year":"2021","journal-title":"Sarcophyton cherbonnieri. Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib20","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/jat.3303","article-title":"Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model","volume":"36","author":"Pereira","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.phytochem.2022.113578_bib21","article-title":"Four new cembranoids from the South China Sea soft coral Sarcophyton trocheliophorum","volume":"1\u20138","author":"Ren","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2022.113578_bib22","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/acs.jctc.8b01026","article-title":"OPLS3e: extending Force Field Coverage for Drug-Like Small Molecules","volume":"15","author":"Roos","year":"2019","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.phytochem.2022.113578_bib23","doi-asserted-by":"crossref","first-page":"12946","DOI":"10.1021\/ja105035r","article-title":"Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probability","volume":"132","author":"Smith","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phytochem.2022.113578_bib24","doi-asserted-by":"crossref","first-page":"13466","DOI":"10.1021\/acs.joc.0c01491","article-title":"Artatrovirenols A and B: two cagelike sesquiterpenoids from artemisia atrovirens","volume":"85","author":"Su","year":"2020","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00214-012-1209-8","article-title":"Theoretical study on the structures and electronic properties of oligo(p-phenylenevinylene) carboxylic acid and its derivatives: effects of spacer and anchor groups","volume":"131","author":"Suramitr","year":"2012","journal-title":"Theor. Chem. Acc."},{"key":"10.1016\/j.phytochem.2022.113578_bib26","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1074\/jbc.M510798200","article-title":"The substrate-induced conformational change of Mycobacterium tuberculosis mycothiol synthase","volume":"281","author":"Vetting","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib27","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3390\/md20090574","article-title":"Sarcoeleganolides C-G, five new cembranes from the South China Sea Soft coral Sarcophyton elegans","volume":"20","author":"Wang","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib28","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.3390\/md11114318","article-title":"New diterpenoids from soft coral Sarcophyton ehrenbergi","volume":"11","author":"Wang","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib29","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.3390\/md11093186","article-title":"Sarcophyolides B\u2013E, new cembranoids from the soft coral Sarcophyton elegans","volume":"11","author":"Xi","year":"2013","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2022.113578_bib30","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.2174\/138527212800672583","article-title":"Cembrane diterpenes chemistry and biological properties","volume":"16","author":"Yang","year":"2012","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib31","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1021\/acs.joc.8b03020","article-title":"Sarcomililate A, an unusual diterpenoid with tricyclo[11.3.0.0(2,16)]hexadecane carbon skeleton, and its potential biogenetic precursors from the hainan soft coral Sarcophyton mililatensis","volume":"84","author":"Yang","year":"2019","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2022.113578_bib32","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1021\/acs.orglett.1c02772","article-title":"Sinunanolobatone A, an anti-inflammatory diterpenoid with bicyclo[13.1.0]pentadecane carbon scaffold, and related casbanes from the sanya soft coral Sinularia nanolobata","volume":"23","author":"Zeng","year":"2021","journal-title":"Org. Lett."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942222004940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942222004940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:49:25Z","timestamp":1758480565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942222004940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":32,"alternative-id":["S0031942222004940"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2022.113578","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcoelegans A\u2013H, eight undescribed cembranes with anti-inflammatory and anti-thrombotic activities from the South China Sea soft coral Sarcophyton elegans","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2022.113578","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113578"}}