{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T02:16:04Z","timestamp":1773195364828,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"am","delay-in-days":671,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004387","name":"Ningbo University","doi-asserted-by":"publisher","award":["D16013"],"award-info":[{"award-number":["D16013"]}],"id":[{"id":"10.13039\/501100004387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008865","name":"Xiamen University","doi-asserted-by":"publisher","award":["FJ-YW-2022KF01"],"award-info":[{"award-number":["FJ-YW-2022KF01"]}],"id":[{"id":"10.13039\/501100008865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["2021Z046"],"award-info":[{"award-number":["2021Z046"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.phytochem.2024.114097","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T22:00:39Z","timestamp":1713391239000},"page":"114097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Cyclic peroxides and analogs: Antibacterial, antimalarial, and cytotoxic marine products from Xisha sponge Diacarnus sp."],"prefix":"10.1016","volume":"223","author":[{"given":"Xue","family":"Leng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0250-3723","authenticated-orcid":false,"given":"J. Enrico H.","family":"Lazaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Te","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-8008","authenticated-orcid":false,"given":"Xia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2024.114097_bib1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/bscb.19820910907","article-title":"Cavernosine, a novel ichthyotoxic terpenoid lactone from the sponge Fasciospongia cavernosa","volume":"91","author":"Braekman","year":"1982","journal-title":"Bull. Soc. Chim. Belg."},{"key":"10.1016\/j.phytochem.2024.114097_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/0929867323666151127200949","article-title":"Natural endoperoxides as drug lead compounds","volume":"23","author":"Bu","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.phytochem.2024.114097_bib3","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1016\/S0040-4020(01)96691-8","article-title":"Structural and stereochemical studies on marine norterpene cyclic peroxides","volume":"41","author":"Capon","year":"1985","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2024.114097_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1021\/np50050a018","article-title":"Structural and stereochemical studies on marine norterpene cyclic peroxides. Part 2","volume":"50","author":"Capon","year":"1987","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1071\/CH04234","article-title":"Spongosoritin A: a new polyketide from a Fijian marine sponge, Spongosorites sp","volume":"58","author":"Capon","year":"2005","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.phytochem.2024.114097_bib6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1021\/np0604883","article-title":"Hypoxia-selective antitumor agents: norsesterterpene peroxides from the marine sponge Diacarnus levii preferentially suppress the growth of tumor cells under hypoxic conditions","volume":"70","author":"Dai","year":"2007","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib7","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/jo010136v","article-title":"Determination of absolute configuration of acyclic 1, 2-diols with Mo2 (OAc)4 Snatzke's method revisited","volume":"66","author":"Di Bari","year":"2001","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2024.114097_bib32","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/np000529+","article-title":"Antimalarial, antiviral, and antitoxoplasmosis norsesterterpene peroxide acids from the Red Sea sponge Diacarnus erythraeanus","volume":"64","author":"El Sayed","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib8","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0957-4166(99)00115-9","article-title":"[Rh2 (OCOCF3) 4] as an auxiliary chromophore in chiroptical studies on steroidal alcohols","volume":"10","author":"Frelek","year":"1999","journal-title":"Tetrahedron: Asymmetry"},{"key":"10.1016\/j.phytochem.2024.114097_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0957-4166(00)86328-4","article-title":"Circular dichroism, XCIII determination of the absolute configuration of alcohols, olefins, epoxides, and ethers from the CD of their \u201cin situ\u201d complexes with [Rh2(O2CCF3)4]","volume":"1","author":"Gerards","year":"1990","journal-title":"Tetrahedron: Asymmetry"},{"key":"10.1016\/j.phytochem.2024.114097_bib10","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1021\/jo062445x","article-title":"Practical method for the absolute configuration assignment of tert\/tert 1, 2-diols using their complexes with Mo2(OAc)4","volume":"72","author":"G\u00f3recki","year":"2007","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2024.114097_bib34","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/S0040-4039(01)93630-5","article-title":"Muqubilin, a new C24-isoprenoid from a marine sponge","volume":"20","author":"Kashman","year":"1979","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.phytochem.2024.114097_bib11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0040-4039(01)80065-4","article-title":"Bioactive marine sponge norditerpene and norsesterterpene peroxides","volume":"25","author":"Lawrence","year":"1984","journal-title":"Tetrahedron Lette"},{"key":"10.1016\/j.phytochem.2024.114097_bib12","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1021\/np400107t","article-title":"In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells","volume":"76","author":"Lefranc","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.steroids.2018.05.009","article-title":"Two new cytotoxic steroids from the Chinese soft coral Sinularia sp","volume":"136","author":"Li","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.phytochem.2024.114097_bib14","doi-asserted-by":"crossref","first-page":"9806","DOI":"10.1021\/acs.joc.2c00784","article-title":"Sinuscalide A: an antiviral norcembranoid with an 8\/8-fused carbon scaffold from the South China sea soft coral Sinularia scabra","volume":"87","author":"Liu","year":"2022","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2024.114097_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113088","article-title":"Nardosinane-related antimicrobial terpenoids from Lemnalia sp. soft coral","volume":"196","author":"Liu","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114097_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.tet.2020.131062","article-title":"New polyketides and norterpenoids from the marine sponge Diacarnus megaspinorhabdosa","volume":"76","author":"Miao","year":"2020","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2024.114097_bib17","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/0040-4020(76)80139-1","article-title":"The stereoisomers of 3, 7, 11-trimethyldodeca-2, 6, 10-triene","volume":"32","author":"Nishino","year":"1976","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2024.114097_bib18","first-page":"861","article-title":"Structural diversity and chemical synthesis of peroxide and peroxide-derived polyketide metabolites from marine sponges","volume":"33","author":"Norris","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2024.114097_bib19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1021\/np980223r","article-title":"Nuapapuin A and sigmosceptrellins D and E: new norterpene ccyclic peroxides from a Southern Australian marine sponge, Sigmosceptrella sp","volume":"62","author":"Ovenden","year":"1999","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1021\/np800711a","article-title":"The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness","volume":"72","author":"Rubio","year":"2009","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib21","first-page":"5192","article-title":"Meroterpenoid constituents from marine sponge Dysidea fragilis","volume":"52","author":"Shang","year":"2021","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.phytochem.2024.114097_bib23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.phytochem.2024.114097_bib24","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1248\/cpb.c15-00022","article-title":"New metabolites from the South China sea sponge Diacarnus megaspinorhabdosa","volume":"63","author":"Wang","year":"2015","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114097_bib25","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1016\/j.bmcl.2016.02.070","article-title":"New antimalarial norterpene cyclic peroxides from Xisha Islands sponge Diacarnus megaspinorhabdosa","volume":"26","author":"Yang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phytochem.2024.114097_bib26","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.3390\/md12084399","article-title":"Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine sponge Diacarnus megaspinorhabdosa","volume":"12","author":"Yang","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2024.114097_bib27","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.3390\/md12084399","article-title":"Relative and absolute stereochemistry of diacarperoxides: antimalarial norditerpene endoperoxides from marine songe Diacarnus megaspinorhabdosa","volume":"12","author":"Yang","year":"2014","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2024.114097_bib28","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/np0340192","article-title":"Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus","volume":"67","author":"Youssef","year":"2004","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114097_bib29","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4161\/auto.7.6.15103","article-title":"PARP and RIP 1 are required for autophagy induced by 11'-deoxyverticillin A, which precedes caspase-dependent apoptosis","volume":"7","author":"Zhang","year":"2011","journal-title":"Autophagy"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224001341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224001341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:47:30Z","timestamp":1762217250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942224001341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":30,"alternative-id":["S0031942224001341"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114097","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclic peroxides and analogs: Antibacterial, antimalarial, and cytotoxic marine products from Xisha sponge Diacarnus sp.","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114097","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114097"}}