{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:25:01Z","timestamp":1777659901307,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.phytochem.2024.114311","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T01:32:45Z","timestamp":1729733565000},"page":"114311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Iridoids and lignans from Valeriana officinalis and their bioactivities"],"prefix":"10.1016","volume":"229","author":[{"given":"Zhengyang","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingzi","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8130-1961","authenticated-orcid":false,"given":"Xianju","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangzhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2024.114311_bib1","first-page":"342","article-title":"Lignans and other constituents from Helianthemum sessiliflorum Pers","volume":"9","author":"Benabdelaziz","year":"2015","journal-title":"Rec. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114311_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0021-9673(02)00036-5","article-title":"Determination of valepotriates","volume":"967","author":"Bos","year":"2002","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phytochem.2024.114311_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107923","article-title":"Licochalcone E improves insulin sensitivity in palmitic acid-treated HepG2 cells through inhibition of the NLRP3 signaling pathway","volume":"99","author":"Cao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phytochem.2024.114311_bib4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fitote.2018.10.013","article-title":"Chemical constituents from Valeriana polystachya Smith and evaluation of their effects on the acetylcholinesterase and prolyl oligopeptidase activities","volume":"131","author":"de \u00c1vila","year":"2018","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/j.phytochem.2024.114311_bib5","first-page":"793","article-title":"Overview of comprehensive research on plants of the genus Valeriana","volume":"11","author":"Duan","year":"2008","journal-title":"China Pharmacist"},{"key":"10.1016\/j.phytochem.2024.114311_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113590","article-title":"Secondary metabolites from the underground parts of Valeriana sisymbriifolia Vahl. and their in vitro cytotoxic activities","volume":"208","author":"Erdo\u011fan","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2020.104143","article-title":"Chemical constituents isolated from Valeriana officinalis L","volume":"93","author":"Fan","year":"2020","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.phytochem.2024.114311_bib8","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.3390\/molecules20045740","article-title":"Antileishmanial and cytotoxic compounds from Valeriana wallichii and identification of a novel nepetolactone derivative","volume":"20","author":"Glaser","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2024.114311_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11130-019-00790-2","article-title":"The effect of methanolic Valeriana officinalis root extract on adipocyte differentiation and adiponectin production in 3T3-L1 Adipocytes","volume":"75","author":"Harada","year":"2020","journal-title":"Plant Food Hum. Nutr."},{"issue":"3","key":"10.1016\/j.phytochem.2024.114311_bib10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/0031-9422(82)83196-8","article-title":"Prinsepiol, a lignan from stems of Prinsepia utilis","volume":"21","author":"Kilidhar","year":"1982","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib11","article-title":"Chemical constituents from the seeds of Nigella glandulifera and their hypoglycemic activities","volume":"12","author":"Li","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.phytochem.2024.114311_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113474","article-title":"Sesquiterpenoids and monoterpenoids from the water decoction of Valeriana officinalis L","volume":"205","author":"Li","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106651","article-title":"Isolation and antihyperglycemic effects of garcibractinols A\u2013H, intricate polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia bracteata","volume":"138","author":"Li","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2024.114311_bib14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1021\/np800716f","article-title":"Acylated iridoids with cytotoxicity from Valeriana jatamansi","volume":"72","author":"Lin","year":"2009","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114311_bib15","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1021\/np100426j","article-title":"Revision of the Structures of 1,5-dihydroxy-3,8-epoxyvalechlorine, volvaltrate B, and valeriotetrate C from Valeriana jatamansi and V. officinalis","volume":"73","author":"Lin","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114311_bib16","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/jms.3697","article-title":"Mass spectrometric profiling of valepotriates possessing various acyloxy groups from Valeriana jatamansi","volume":"50","author":"Lin","year":"2015","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.phytochem.2024.114311_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.phytochem.2012.08.015","article-title":"Characterization of chlorinated valepotriates from Valeriana jatamansi","volume":"85","author":"Lin","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113934","article-title":"Iridoids and other constituents from the leaves and stems of Valeriana officinalis var. latifolia","volume":"218","author":"Liu","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201800524","article-title":"Iridoid derivatives with cytotoxic activity from Pedicularis uliginosa BUNGE","volume":"16","author":"Liu","year":"2019","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phytochem.2024.114311_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114168","article-title":"8-hydroxypinoresinol-4-O-\u03b2-D-glucoside from Valeriana officinalis L. Is a novel Kv1.5 channel blocker","volume":"276","author":"Liu","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2024.114311_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2022.105423","article-title":"New iridoids from Patrinia scabiosaefolia and their hypoglycemic effects by activating PI3K\/Akt signaling pathway","volume":"165","author":"Liu","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2024.114311_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114049","article-title":"Antihyperglycemic effects of triterpenoid saponins from the seeds of Aesculus chinensis Bge","volume":"221","author":"Mei","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104693","article-title":"Anti-inflammatory and antiproliferative prenylated sulphur-containing amides from the leaves of Glycosmis pentaphylla","volume":"146","author":"Nian","year":"2020","journal-title":"Fitoterapia"},{"issue":"11","key":"10.1016\/j.phytochem.2024.114311_bib24","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1248\/cpb.32.4653","article-title":"Effects of O-methylation and O-glucosylation on Carbon-13 nuclear magnetic resonance chemical shifts of matairesinol, (+)-pinoresinol and (+)-epipinoresinol","volume":"32","author":"Nishibe","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114311_bib25","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/0031-9422(74)80247-5","article-title":"A new valepotriate: 7-epi-deacetylisovaltrate from Valeriana officinalis","volume":"13","author":"Popov","year":"1974","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200609","article-title":"Valeridoids G \u2013 Q, eleven seco-Iridoids from Valeriana jatamansi and their bioactivites","volume":"19","author":"Quan","year":"2022","journal-title":"Chem. Biodivers."},{"issue":"10","key":"10.1016\/j.phytochem.2024.114311_bib27","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/np010464q","article-title":"Lignans isolated from Valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A1 adenosine receptors","volume":"65","author":"Schumacher","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114311_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113478","article-title":"Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities","volume":"205","author":"Shi","year":"2023","journal-title":"Phytochemistry"},{"issue":"8","key":"10.1016\/j.phytochem.2024.114311_bib29","first-page":"1181","article-title":"A new diterpenoid and a lignan from pinus thunbergii","volume":"12","author":"Sono","year":"2017","journal-title":"Nat. Prod. Commun."},{"issue":"4","key":"10.1016\/j.phytochem.2024.114311_bib30","first-page":"286","article-title":"Isolation and identification of chemical constituents of Forsythia suspensa Thunb","volume":"31","author":"Sun","year":"2021","journal-title":"Vahl. Chin. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2024.114311_bib31","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.3390\/molecules20022165","article-title":"New lignans and iridoid glycosides from Dipsacus asper Wall","volume":"20","author":"Sun","year":"2015","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.phytochem.2024.114311_bib32","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1080\/10286020.2022.2145958","article-title":"Lignans from the root of Valeriana jatamansi and their biological evaluation","volume":"25","author":"Tan","year":"2023","journal-title":"J. Asian Nat. Prod. Res."},{"issue":"3","key":"10.1016\/j.phytochem.2024.114311_bib33","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1248\/cpb.33.1232","article-title":"Lignans from bark of the Olea plants. II","volume":"33","author":"Tsukamoto","year":"1985","journal-title":"Chem. Pharm. Bull."},{"issue":"7","key":"10.1016\/j.phytochem.2024.114311_bib34","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1248\/cpb.32.2730","article-title":"Lignans from bark of the Olea plants. I","volume":"32","author":"Tsukamoto","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114311_bib35","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/cbdv.201000247","article-title":"Sesquiterpenoids and lignans from the roots of Valeriana officinalis","volume":"8","author":"Wang","year":"2011","journal-title":"L. Chem. Biodivers."},{"key":"10.1016\/j.phytochem.2024.114311_bib36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.phytochem.2017.05.010","article-title":"Iridoids from the roots of Valeriana jatamansi jones","volume":"141","author":"Wang","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114311_bib37","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/hlca.201300287","article-title":"Two new iridoids from the root and rhizome of Valeriana jatamansi Jones","volume":"97","author":"Wang","year":"2014","journal-title":"Helve. Chim. Acta"},{"key":"10.1016\/j.phytochem.2024.114311_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104331","article-title":"Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo","volume":"104","author":"Wu","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2024.114311_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.phytol.2022.08.016","article-title":"The chemical constituents from Valeriana jatamansi and their anti-influenza virus and anti-inflammatory effects","volume":"52","author":"Wang","year":"2022","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2024.114311_bib40","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.fitote.2011.07.013","article-title":"Iridoids from the roots of Valeriana jatamansi and their neuroprotective effects","volume":"82","author":"Xu","year":"2011","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2024.114311_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113297","article-title":"Germacranolide-and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway","volume":"202","author":"Xue","year":"2022","journal-title":"Phytochemistry"},{"issue":"16","key":"10.1016\/j.phytochem.2024.114311_bib42","first-page":"2806","article-title":"Chemical constituents from Spiraea salicifolia","volume":"47","author":"Yan","year":"2016","journal-title":"Chin. Tradit. Herbal Drugs"},{"key":"10.1016\/j.phytochem.2024.114311_bib43","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/hlca.201400389","article-title":"Two new iridoid esters from the root and rhizome of Valeriana jatamansi jones","volume":"98","author":"Yang","year":"2015","journal-title":"Helve. Chim. Acta"},{"key":"10.1016\/j.phytochem.2024.114311_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214206","article-title":"Anti-proliferative effects of iridoids from Valeriana fauriei on cancer stem cells","volume":"23","author":"Yoshikawa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phytochem.2024.114311_bib45","article-title":"Design, synthesis and biological evaluation of valepotriate derivatives as novel antitumor agents","volume":"7","author":"Zhang","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.phytochem.2024.114311_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phytol.2022.03.018","article-title":"Iridoids and lignans from Valeriana officinalis L. and their cytotoxic activities","volume":"49","author":"Zhang","year":"2022","journal-title":"Phytochem. Lett."},{"issue":"7","key":"10.1016\/j.phytochem.2024.114311_bib47","first-page":"551","article-title":"Isolation and identification of the non-alkaloid constituents from whole plant af Gelsemium elegans Benth. (III)","volume":"27","author":"Zhao","year":"2010","journal-title":"J. Shenyang Pharm. Univ."},{"issue":"4","key":"10.1016\/j.phytochem.2024.114311_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3724\/SP.J.1009.2008.00270","article-title":"Two new terpenoids from Valeriana officinalis","volume":"7","author":"Zhou","year":"2009","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phytochem.2024.114311_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113962","article-title":"Eighteen iridoids from the roots and rhizomes of Valeriana jatamansi and their protective effects against \u03b1-hemolysin","volume":"219","author":"Zhu","year":"2024","journal-title":"Phytochemistry"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224003480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224003480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T17:44:05Z","timestamp":1731433445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942224003480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":49,"alternative-id":["S0031942224003480"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114311","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Iridoids and lignans from Valeriana officinalis and their bioactivities","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114311"}}