{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:52:44Z","timestamp":1779346364796,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.phytochem.2024.114339","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T06:31:41Z","timestamp":1732602701000},"page":"114339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Characterization and anti-inflammatory investigation of sesquiterpene lactones from Ixeris chinensis"],"prefix":"10.1016","volume":"231","author":[{"given":"Shaoqiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohua","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongsong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1894-9500","authenticated-orcid":false,"given":"Liya","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2024.114339_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.9734\/jpri\/2021\/v33i731201","article-title":"A comprehensive review on natural products and anti-inflammatory activity","volume":"33","author":"Alam","year":"2021","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.phytochem.2024.114339_bib2","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1016\/S0040-4039(00)75507-9","article-title":"Optical activity and lactone ring configurations","volume":"32","author":"Beecham","year":"1968","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2024.114339_bib3","doi-asserted-by":"crossref","first-page":"D488","DOI":"10.1093\/nar\/gkac1077","article-title":"RCSB Protein Data Bank (RCSB.org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from artificial intelligence\/machine learning","volume":"51","author":"Burley","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib4","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1055\/s-0030-1250369","article-title":"New guaiane sesquiterpene lactones from Ixeris dentata","volume":"77","author":"Cha","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2024.114339_bib5","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.phytochem.2024.114339_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2005-916182","article-title":"New guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica","volume":"72","author":"Chen","year":"2006","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2024.114339_bib7","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3390\/life11070616","article-title":"Alantolactone suppresses proliferation and the inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced skin lesions in a psoriasis-like mouse model","volume":"11","author":"Chuo","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.phytochem.2024.114339_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108913","article-title":"Parthenolide ameliorates neurological deficits and neuroinflammation in mice with traumatic brain injury by suppressing STAT3\/NF-\u03baB and inflammasome activation","volume":"108","author":"Ding","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.phytochem.2024.114339_bib9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/acs.jafc.2c06312","article-title":"Pharmacokinetics and oral bioavailability of Panax notoginseng saponins administered to rats using a validated UPLC-MS\/MS method","volume":"71","author":"Fu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib10","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1039\/D0FO03433A","article-title":"Traditional plants from Asteraceae family as potential candidates for functional food industry","volume":"12","author":"Garcia-Oliveira","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.phytochem.2024.114339_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133081","article-title":"(\u2212)-5-O-(3-O-\u03b2-D-glucopyranosylcaffeoyl)-quinic acid from the fruits of Lycium barbarum L. var. auranticarpum K. F. Ching: purification, identification and in vitro bioactivities","volume":"389","author":"Hu","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.phytochem.2024.114339_bib13","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1039\/jr9650007211","article-title":"Optical rotatory dispersion. Part XXIV. Lactones","author":"Jennings","year":"1965","journal-title":"J. Chem. Soc."},{"key":"10.1016\/j.phytochem.2024.114339_bib14","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.3390\/molecules27103148","article-title":"Hepatoprotective effects of Ixeris chinensis on nonalcoholic fatty liver disease induced by high-fat diet in mice: an integrated gut microbiota and metabolomic analysis","volume":"27","author":"Jin","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2024.114339_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1248\/cpb.53.15","article-title":"Two new sesquiterpene lactones from Ixeris chinensis","volume":"53","author":"Khalil","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114339_bib16","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3892\/ijmm.2015.2120","article-title":"Protective effect of ixerisoside A against UVB-induced pro-inflammatory cytokine production in human keratinocytes","volume":"35","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.phytochem.2024.114339_bib17","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3987\/COM-94-6776","article-title":"A new sesquiterpene lactone glucoside of Ixeris chinensis","volume":"38","author":"Lee","year":"1994","journal-title":"Heterocycles"},{"key":"10.1016\/j.phytochem.2024.114339_bib18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.ijbiomac.2019.09.158","article-title":"Structural characterization of arabinogalactan extracted from Ixeris chinensis (Thunb.) Nakai and its immunomodulatory effect on RAW264.7 macrophages","volume":"143","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.phytochem.2024.114339_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduction Targeted Ther."},{"key":"10.1016\/j.phytochem.2024.114339_bib20","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1021\/acs.jafc.2c00828","article-title":"New monoterpene acid and gallic acid glucose esters with anti-inflammatory activity from blue gum (Eucalyptus globulus) leaves","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib21","doi-asserted-by":"crossref","first-page":"W609","DOI":"10.1093\/nar\/gkq300","article-title":"PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach","volume":"38","author":"Liu","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib22","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.hermed.2017.08.002","article-title":"Anti-helicobacter pylori effect of various extracts of Ixeris chinensis on inflammatory markers in human gastric epithelial AGS cells","volume":"11","author":"Lu","year":"2018","journal-title":"J. Herb. Med."},{"key":"10.1016\/j.phytochem.2024.114339_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130610","article-title":"Ingredients with anti-inflammatory effect from medicine food homology plants","volume":"368","author":"Lu","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/pharmaceutics13070991","article-title":"Sesquiterpene lactones: promising natural compounds to fight inflammation","volume":"13","author":"Matos","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.phytochem.2024.114339_bib25","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1248\/cpb.33.4451","article-title":"Studies on sesquiterpene glycosides from Crepis japonica BENTH","volume":"33","author":"Miyase","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114339_bib26","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1248\/cpb.35.1969","article-title":"Studies on sesquiterpene glycosides from Prenanthes acerifolia BENTH","volume":"35","author":"Miyase","year":"1987","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114339_bib27","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1248\/cpb.33.3361","article-title":"Sesquiterpene lactones from Ixeris stolonifera A. Gray","volume":"8","author":"Nishimura","year":"1985","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114339_bib28","author":"Oliveros"},{"key":"10.1016\/j.phytochem.2024.114339_bib29","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/molecules27031142","article-title":"Anti-inflammatory and immunoregulatory action of sesquiterpene lactones","volume":"27","author":"Paco","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2024.114339_bib30","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.14233\/ajchem.2013.14746","article-title":"Analysis of macroelements, beneficial trace elements, rare earth elements in the wild Ixeris chinensis (Thunb.) Nakai by ICP-MS","volume":"25","author":"Rui","year":"2013","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib31","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1248\/cpb.34.4170","article-title":"Sesquiterpene lactones from Ixeris dentata NAKAI","volume":"34","author":"Seto","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2024.114339_bib32","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib33","first-page":"187","article-title":"Effects of Ixeris chinensis (Thunb.) Nakai boiling water extract on hepatitis B viral activity and hepatocellular carcinoma","volume":"11","author":"Shih","year":"2014","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.phytochem.2024.114339_bib34","doi-asserted-by":"crossref","first-page":"1.30.31","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinf."},{"key":"10.1016\/j.phytochem.2024.114339_bib35","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib36","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","article-title":"UniProt: the universal protein knowledgebase in 2023","volume":"51","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib37","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0040-4039(01)87872-2","article-title":"Circular dichroism of sesquiterpene lactones","volume":"17","author":"Waddell","year":"1969","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2024.114339_bib38","first-page":"1706","article-title":"Study on chemical constituents of the Ixeris chinensis","volume":"34","author":"Wang","year":"2011","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.phytochem.2024.114339_bib39","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/acs.jcim.5b00690","article-title":"Enhancing the enrichment of pharmacophore-based target prediction for the polypharmacological profiles of drugs","volume":"56","author":"Wang","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.phytochem.2024.114339_bib40","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.phytochem.2024.114339_bib41","first-page":"1945","article-title":"Study on chemical constituents of Ixeris chinensis","volume":"35","author":"Wu","year":"2012","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.phytochem.2024.114339_bib42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/acs.jafc.7b03285","article-title":"Urolithins attenuate LPS-induced neuroinflammation in BV2 microglia via MAPK, Akt, and NF-kappaB signaling pathways","volume":"66","author":"Xu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.105061","article-title":"Chemical characterization, antiproliferative and antifungal activities of Clinacanthus nutans","volume":"155","author":"Xu","year":"2021","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2024.114339_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133668","article-title":"Discovery, preparation and characterization of lipid-lowering alkylphenol derivatives from Syzygium jambos fruit","volume":"396","author":"Xu","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.phytochem.2024.114339_bib45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1021\/np800005r","article-title":"Guaiane sesquiterpene lactones and amino acid-sesquiterpene lactone conjugates from the aerial parts of Saussurea pulchella","volume":"71","author":"Yang","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114339_bib46","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phytochem.2016.01.015","article-title":"Sesquiterpenoids and tirucallane triterpenoids from the roots of Scorzonera divaricata","volume":"124","author":"Yang","year":"2016","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114339_bib47","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/0031-9422(95)00763-6","article-title":"Circular dichroism of C-7, C-6 trans-fused guaianolides of Centaurea scoparia","volume":"41","author":"Youssef","year":"1996","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2024.114339_bib48","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/np068015j","article-title":"Bioactive guaianolides from siyekucai (Ixeris chinensis)","volume":"69","author":"Zhang","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2024.114339_bib49","first-page":"3089","article-title":"Chemical constituents from roots of Ixeris chinensis","volume":"39","author":"Zhang","year":"2014","journal-title":"Zhongguo Zhongyao Zazhi"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224003765?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942224003765?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T20:59:45Z","timestamp":1736283585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942224003765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":49,"alternative-id":["S0031942224003765"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114339","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization and anti-inflammatory investigation of sesquiterpene lactones from Ixeris chinensis","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2024.114339","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114339"}}