{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T19:08:29Z","timestamp":1788721709378,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2023xktdzy2"],"award-info":[{"award-number":["2023xktdzy2"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phytochem.2025.114523","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T11:46:27Z","timestamp":1745927187000},"page":"114523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Anti-inflammatory abietane-type diterpenoids from the roots of Salvia przewalskii"],"prefix":"10.1016","volume":"237","author":[{"given":"Yan-Fang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Yun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Cai","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Pu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2025.114523_bib1","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1246\/cl.1990.1885","article-title":"Cryptoacetalide and epicryptoacetalide, novel spirolactone diterpenoids from Salvia miltiorrhiza","volume":"19","author":"Asari","year":"1990","journal-title":"Chem. Lett."},{"key":"10.1016\/j.phytochem.2025.114523_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s13659-022-00358-9","article-title":"Development and structure\u2013activity relationships of tanshinones as selective 11\u03b2-hydroxysteroid dehydrogenase 1 inhibitors","volume":"12","author":"Deng","year":"2022","journal-title":"Natural Products and Bioprospecting"},{"key":"10.1016\/j.phytochem.2025.114523_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.phytochem.2025.114523_bib4","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/ja511813g","article-title":"Phainanoids A\u2013F, A new class of potent immunosuppressive triterpenoids with an unprecedented carbon skeleton from Phyllanthus hainanensis","volume":"137","author":"Fan","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.phytochem.2025.114523_bib5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0031-9422(00)94548-5","article-title":"Diterpenes from the roots of Salvia canariensis","volume":"25","author":"Fraga","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114523_bib6","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/0031-9422(92)83130-Q","article-title":"Diterpenes and diterpene quinones from the roots of Salvia apiana","volume":"31","author":"Gonz\u00e1lez","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114523_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13980","article-title":"Cinnamaldehyde and eugenol protect against LPS\u2010stimulated oxidative stress and inflammation in Raw 264.7 cells","volume":"45","author":"Gulec Peker","year":"2021","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.phytochem.2025.114523_bib8","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.2147\/DDDT.S266911","article-title":"Pharmacological activity and mechanism of tanshinone IIA in related diseases","volume":"14","author":"Guo","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phytochem.2025.114523_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0031-9422(88)80638-1","article-title":"Epi-danshenspiroketallactone from Salvia miltiorrhiza","volume":"27","author":"Hou","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114523_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232415753","article-title":"Anti-inflammatory mechanisms of dietary flavones: tapping into nature to control chronic inflammation in obesity and cancer","volume":"23","author":"Kariagina","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phytochem.2025.114523_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/np50050a004","article-title":"Isolation and bioactivity of new tanshinones","volume":"50","author":"Lee","year":"1987","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114523_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0031-9422(01)00415-0","article-title":"Polyphenolics of salvia\u2014a review","volume":"59","author":"Lu","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114523_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1126\/science.abi5200","article-title":"The spectrum of inflammatory responses","volume":"374","author":"Medzhitov","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.phytochem.2025.114523_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12967-017-1141-8","article-title":"Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity","volume":"15","author":"Navegantes","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.phytochem.2025.114523_bib15","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1142\/S0192415X14500621","article-title":"Chinese prescription kangen-karyu and Salviae miltiorrhizae Radix improve age-related oxidative stress and inflammatory response through the PI3K\/akt or MAPK pathways","volume":"42","author":"Park","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phytochem.2025.114523_bib16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1080\/14786419.2021.1906666","article-title":"Salprzesides A and B: two novel icetexane diterpenes with antiangiogenic activity from Salvia przewalskii Maxim","volume":"36","author":"Qiu","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2025.114523_bib17","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1021\/np010032f","article-title":"Leishmanicidal, antiplasmodial, and cytotoxic activity of novel diterpenoid 1,2-quinones from Perovskia abrotanoides: new source of tanshinones","volume":"64","author":"Sairafianpour","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114523_bib18","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.phytochem.2025.114523_bib19","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3390\/biom14080948","article-title":"Inflammation: is it a healer, confounder, or a promoter of cardiometabolic risks?","volume":"14","author":"Tate","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.phytochem.2025.114523_bib20","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0049-3848(03)00379-7","article-title":"The mechanism of action of aspirin","volume":"110","author":"Vane","year":"2003","journal-title":"Thromb. Res."},{"key":"10.1016\/j.phytochem.2025.114523_bib21","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0031-9422(88)80642-3","article-title":"Triterpenoids from Salvia przewalskii","volume":"27","author":"Wang","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114523_bib22","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1248\/bpb.b19-00775","article-title":"Extract of Salvia przewalskii repair tissue damage in chronic hypoxia maybe through the RhoA\u2013ROCK signalling pathway","volume":"43","author":"Wang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114523_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116697","article-title":"Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis","volume":"317","author":"Wei","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2025.114523_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106834","article-title":"11,12-seco-Abietane-type diterpene lactones with potential antiplatelet activity from Salvia prattii","volume":"140","author":"Xia","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2025.114523_bib25","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1021\/ol061609t","article-title":"Przewalskin A: a new C23 terpenoid with a 6\/6\/7 carbon ring skeleton from Salvia przewalskii Maxim","volume":"8","author":"Xu","year":"2006","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2025.114523_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1021\/ol062748d","article-title":"Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim","volume":"9","author":"Xu","year":"2007","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2025.114523_bib27","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1248\/cpb.53.1575","article-title":"Two new icetexane diterpenoids from Salvia przewalskii","volume":"53","author":"Xu","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114523_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.fitote.2014.09.022","article-title":"Salviprzols A and B, C21- and C22-terpenoids from the roots of Salvia przewalskii Maxim","volume":"99","author":"Xue","year":"2014","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2025.114523_bib29","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1021\/acs.joc.2c03091","article-title":"Stereodivergent construction of [5,5]-Oxaspirolactones of Phainanoids","volume":"88","author":"Xun","year":"2023","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2025.114523_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107686","article-title":"The strategies and techniques of drug discovery from natural products","volume":"216","author":"Zhang","year":"2020","journal-title":"Pharmacol. Therapeut."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225001463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225001463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:48:03Z","timestamp":1762217283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942225001463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"alternative-id":["S0031942225001463"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114523","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory abietane-type diterpenoids from the roots of Salvia przewalskii","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114523","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114523"}}