{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:33:44Z","timestamp":1772022824125,"version":"3.50.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY23H300001"],"award-info":[{"award-number":["LY23H300001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21937002"],"award-info":[{"award-number":["21937002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773599"],"award-info":[{"award-number":["81773599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.phytochem.2025.114533","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T06:26:23Z","timestamp":1746253583000},"page":"114533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Diterpene-phenylpropanoid hybrids and structurally diverse diterpenoid monomers from the endangered conifer Podocarpus annamiensis and their bioactivities"],"prefix":"10.1016","volume":"237","author":[{"given":"Chi","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-5898","authenticated-orcid":false,"given":"Yeun-Mun","family":"Choo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyao","family":"Mei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-1454","authenticated-orcid":false,"given":"Jin-Feng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2025.114533_bib1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jep.2010.07.019","article-title":"Anti-inflammatory, antioxidant, anti-tyrosinase and phenolic contents of four Podocarpus species used in traditional medicine in South Africa","volume":"136","author":"Abdillahi","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2025.114533_bib2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3390\/ph15070902","article-title":"Naturally occurring 8\u03b2,13\u03b2-kaur-15-en-17-al and anti-malarial activity from Podocarpus polystachyus leaves","volume":"15","author":"Amir Rawa","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.phytochem.2025.114533_bib3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0031-9422(90)80044-H","article-title":"Tricyclic diterpenoids from root bark of Azadirachta indica","volume":"29","author":"Ara","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s13659-020-00268-8","article-title":"Anticancer activities and mechanism of action of nagilactones, a group of terpenoid lactones isolated from Podocarpus species","volume":"10","author":"Bailly","year":"2020","journal-title":"Nat. Prod. Bioprospect."},{"key":"10.1016\/j.phytochem.2025.114533_bib5","article-title":"Extraction, characterization of bioactive compounds and biological activities of the leaves of Podocarpus lambertii Klotzch ex Endl","volume":"31","author":"Bandeira","year":"2022","journal-title":"J. Appl. Res. Med. Aroma."},{"key":"10.1016\/j.phytochem.2025.114533_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41573-021-00367-2","article-title":"Lipogenesis inhibitors: therapeutic opportunities and challenges","volume":"21","author":"Batchuluun","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phytochem.2025.114533_bib7","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0040-4020(01)99366-4","article-title":"Chemistry of the Podocarpaceae\u2014VIII: macrophyllic acid, a bisditerpenoid from podocarpus macrophyllus D. Don","volume":"19","author":"Bocks","year":"1963","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2025.114533_bib8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0040-4020(01)92694-8","article-title":"Chemistry of the Podocarpaceae\u2014VI: constituents of the heartwood of Podocorpus totara g. benn","volume":"18","author":"Cambie","year":"1962","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2025.114533_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112319","article-title":"Malonylation of acetyl-CoA carboxylase 1 promotes hepatic steatosis and is attenuated by ketogenic diet in NAFLD","volume":"42","author":"Cao","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.phytochem.2025.114533_bib10","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1016\/j.jas.2012.12.026","article-title":"First molecular identification of a hafting adhesive in the late howiesons poort at diepkloof rock shelter (Western Cape, South Africa)","volume":"40","author":"Charri\u00e9-Duhaut","year":"2013","journal-title":"J. Archaeol. Sci."},{"key":"10.1016\/j.phytochem.2025.114533_bib11","first-page":"517","article-title":"Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells","volume":"18","author":"Chen","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phytochem.2025.114533_bib12","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1016\/S0040-4020(01)88015-7","article-title":"Further acidic constituents and neutral components of pinus massoniana Resin","volume":"49","author":"Cheung","year":"1993","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2025.114533_bib13","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3891\/acta.chem.scand.16-1296","article-title":"The chemistry of the natural order cupressales. 43. The structure and configuration of hinokiol and hinokione","volume":"16","author":"Chow","year":"1962","journal-title":"Acta Chem. Scand."},{"key":"10.1016\/j.phytochem.2025.114533_bib14","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0031-9422(75)85047-3","article-title":"Terpenes of Podocarpus lambertius","volume":"14","author":"de Paiva Campello","year":"1975","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116401","article-title":"A comprehensive review on the medicinal usage of Podocarpus species: phytochemistry and pharmacology","volume":"310","author":"Deng","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2025.114533_bib16","author":"Deresa"},{"key":"10.1016\/j.phytochem.2025.114533_bib17","article-title":"Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice","volume":"4","author":"Desjardins","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phytochem.2025.114533_bib18","series-title":"China Plant Red Data Book","first-page":"198","author":"Fu","year":"1992"},{"key":"10.1016\/j.phytochem.2025.114533_bib19","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/acs.jnatprod.2c00464","article-title":"Antiviral profiling of C-18- or C-19-functionalized semisynthetic abietane diterpenoids","volume":"85","author":"Gonzalez-Cardenete","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib20","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/acs.jnatprod.8b00884","article-title":"Synthesis and biological studies of (+)-liquiditerpenoic acid A (abietopinoic acid) and representative analogues: SAR studies","volume":"82","author":"Hamuli\u0107","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/10286020.2017.1319821","article-title":"Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus","volume":"20","author":"Hu","year":"2018","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2025.114533_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112184","article-title":"Phytochemical and biological studies on rare and endangered plants endemic to China. Part XV. Structurally diverse diterpenoids and sesquiterpenoids from the vulnerable conifer Pseudotsuga sinensis","volume":"169","author":"Huang","year":"2020","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib23","doi-asserted-by":"crossref","first-page":"16832","DOI":"10.1073\/pnas.1311528110","article-title":"Significance of endangered and threatened plant natural products in the control of human disease","volume":"110","author":"Ibrahim","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phytochem.2025.114533_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105825","article-title":"Structurally diverse mono-\/dimeric triterpenoids from the vulnerable conifer Pseudotsuga gaussenii and their PTP1B inhibitory effects. The role of protecting species diversity in support of chemical diversity","volume":"124","author":"Jiang","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2025.114533_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2019.112161","article-title":"Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla","volume":"169","author":"Jiang","year":"2020","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113366","article-title":"Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXV. Structurally diverse triterpenoids and diterpenoids from two endangered Pinaceae plants endemic to the Chinese Qinling Mountains and their bioactivities","volume":"203","author":"Jiang","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib27","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/plants12051171","article-title":"Diversity, distribution, systematics and conservation status of Podocarpaceae","volume":"12","author":"Khan","year":"2023","journal-title":"Plants"},{"key":"10.1016\/j.phytochem.2025.114533_bib28","article-title":"Diterpenoids isolated from Podocarpus macrophyllus inhibited the inflammatory mediators in LPS-induced HT-29 and RAW 264.7 cells","volume":"26","author":"Kim","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2025.114533_bib29","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.ejmech.2016.12.018","article-title":"Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase","volume":"126","author":"Koerner","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2025.114533_bib30","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.orggeochem.2008.02.020","article-title":"An unprecedented condensation pathway leading to the formation of phenolic C40 bis-diterpenoids in sediments from the Lower Oligocene of the Rhine Rift Valley","volume":"39","author":"Le M\u00e9tayer","year":"2008","journal-title":"Org. Geochem."},{"key":"10.1016\/j.phytochem.2025.114533_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.114882","article-title":"Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-\u03b2\/Smad signaling pathway","volume":"389","author":"Li","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.phytochem.2025.114533_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113567","article-title":"Chlorine-containing guaianolide sesquiterpenoids from Achillea millefolium L. with inhibitory effects against LPS-induced NO release in BV-2 microglial cells","volume":"207","author":"Li","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113161","article-title":"Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXII. Structurally diverse diterpenoids from the leaves and twigs of the endangered conifer Torreya jackii and their bioactivities","volume":"198","author":"Li","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0031-9422(97)00360-9","article-title":"Reassignment of relative stereochemistry at C-7 and C-8 in arylcoumaran neolignans","volume":"46","author":"Li","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113663","article-title":"Squamabietenols A-F, undescribed abietane-O-abietane dimeric diterpenoids from the ornamental conifer Juniperus squamata and their ATP-citrate lyase inhibitory activities","volume":"210","author":"Liang","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113550","article-title":"Coumaronochromones, flavanones, and isoflavones from the twigs and leaves of Erythrina subumbrans inhibit PTP1B and nitric oxide production","volume":"206","author":"Liu","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e20034","article-title":"Phytochemical and metabolic profiling of the different Podocarpus species in Egypt: potential antimicrobial and antiproliferative activities","volume":"9","author":"Mohamed","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.phytochem.2025.114533_bib38","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.phytochem.2025.114533_bib40","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1021\/acs.orglett.1c01358","article-title":"Synthesis of sterically hindered \u03b1-hydroxycarbonyls through radical\u2212radical coupling","volume":"23","author":"Ota","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib41","article-title":"New cytotoxic norditerpene dilactones from leaves of Podocarpus macrophyllus var. maki","volume":"35","author":"Park","year":"2004","journal-title":"ChemInform"},{"key":"10.1016\/j.phytochem.2025.114533_bib42","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1080\/14786419.2021.1893317","article-title":"The first synthesis of podocarflavone A and its analogs and evaluation of their antimycobacterial potential against Mycobacterium tuberculosis with the support of virtual screening","volume":"36","author":"Puranik","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2025.114533_bib43","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1016\/j.bmc.2010.09.035","article-title":"Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition","volume":"18","author":"Ryu","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.phytochem.2025.114533_bib44","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1248\/cpb.56.1691","article-title":"Antibacterial novel phenolic diterpenes from Podocarpus macrophyllus D. DON","volume":"56","author":"Sato","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114533_bib45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.phytol.2024.04.010","article-title":"Annamiacids A and B: two dissymmetric bis-diterpenes containing a rare ketal-\u03b3-lactone motif from Podocarpus annamiensis and their inhibitory effects on ATP-citrate lyase","volume":"61","author":"Song","year":"2024","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib46","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jhep.2023.03.038","article-title":"An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH","volume":"79","author":"Tacke","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.phytochem.2025.114533_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2022.08.014","article-title":"Pillar[6]arenes: from preparation, host-guest property to self-assembly and applications","volume":"34","author":"Tang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib48","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1039\/D3CC04196D","article-title":"Polydopamine modified by pillar[5]arene in situ for targeted chemo-photothermal cancer therapy","volume":"60","author":"Tang","year":"2024","journal-title":"Chem. Commun."},{"key":"10.1016\/j.phytochem.2025.114533_bib49","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1016\/S0031-9422(00)97560-5","article-title":"Abietane diterpenoids from Salvia pomifera","volume":"31","author":"Ulubelen","year":"1992","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s42003-022-03170-w","article-title":"Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion","volume":"5","author":"Veprik","year":"2022","journal-title":"Commun. Bio."},{"key":"10.1016\/j.phytochem.2025.114533_bib51","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41586-019-1095-5","article-title":"Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle","volume":"568","author":"Verschueren","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.phytochem.2025.114533_bib52","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.3390\/molecules29245980","article-title":"Bis-iridoid glycosides and triterpenoids from Kolkwitzia amabilis and their potential as inhibitors of ACC1 and ACL","volume":"29","author":"Wan","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2025.114533_bib53","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1002\/chem.201901349","article-title":"Trifluoromethylation and monofluoroalkenylation of alkenes through radical\u2013radical cross-coupling","volume":"25","author":"Wang","year":"2019","journal-title":"Chem. Eur J."},{"key":"10.1016\/j.phytochem.2025.114533_bib54","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/S0031-9422(00)86934-4","article-title":"Diterpenes of Podocarpus ferrugineus bark","volume":"13","author":"Wenkert","year":"1974","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib55","doi-asserted-by":"crossref","first-page":"533","DOI":"10.4155\/fmc-2019-0312","article-title":"Recent development in acetyl-CoA carboxylase inhibitors and their potential as novel drugs","volume":"12","author":"Wu","year":"2020","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.phytochem.2025.114533_bib56","series-title":"Flora of China","first-page":"99","author":"Wu","year":"2003"},{"key":"10.1016\/j.phytochem.2025.114533_bib57","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.phytol.2024.10.001","article-title":"High-value flavonoids with potential anti-inflammatory benefits from Platanus \u00d7 acerifolia Willd leaves: turning waste into treasure","volume":"64","author":"Wu","year":"2024","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib58","doi-asserted-by":"crossref","first-page":"22270","DOI":"10.1002\/anie.202109082","article-title":"Forrestiacids A and B, pentaterpene inhibitors of ACL and lipogenesis: extending the limits of computational NMR methods in the structure assignment of complex natural products","volume":"60","author":"Xiong","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.phytochem.2025.114533_bib59","doi-asserted-by":"crossref","first-page":"12859","DOI":"10.1002\/anie.202100288","article-title":"(\u2013)-Isoscopariusin A, a naturally occurring immunosuppressive meroditerpenoid: structure elucidation and scalable chemical synthesis","volume":"60","author":"Yan","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.phytochem.2025.114533_bib60","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/0031-9422(91)85046-3","article-title":"Complete 1H and 13C NMR assignments of totarol and its derivatives","volume":"30","author":"Ying","year":"1991","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib61","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.phytol.2013.04.003","article-title":"Three new abietane diterpenoids from Podocarpus fleuryi","volume":"6","author":"Zhang","year":"2013","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib62","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.phymed.2018.09.222","article-title":"Nagilactone E suppresses TGF-\u03b21-induced epithelial\u2013mesenchymal transition, migration and invasion in non-small cell lung cancer cells","volume":"52","author":"Zhang","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phytochem.2025.114533_bib63","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/np900814s","article-title":"Diterpenoids from the feces of Trogopterus xanthipes","volume":"73","author":"Zhao","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib64","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1021\/acs.jnatprod.3c00181","article-title":"Structurally Diverse triterpene-26-oic acids as potential dual ACL and ACC1 inhibitors from the vulnerable conifer Keteleeria fortunei","volume":"86","author":"Zhao","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114259","article-title":"Major specialized natural products from the endangered plant Heptacodium miconioides for potential medicinal uses and insights into its longstanding unresolved systematic classification","volume":"228","author":"Zhao","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202401520","article-title":"Fortunefuroic acid J from Keteleeria hainanensis and its dual inhibitory effects on ATP-citrate lyase and acetyl-CoA carboxylase","volume":"21","author":"Zhao","year":"2024","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.phytochem.2025.114533_bib67","volume":"235","author":"Zhao","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib68","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1021\/acs.jnatprod.0c00291","article-title":"Diverse types of diterpenoids with an aromatized C ring from the twigs of Podocarpus imbricatus","volume":"83","author":"Zhou","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.137754","article-title":"Structurally diverse terpenoids and their DRAK2 inhibitory activities: a follow-up study on the vulnerable conifer Pseudotsuga forrestii","volume":"1305","author":"Zhou","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.phytochem.2025.114533_bib70","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1016\/j.cclet.2021.12.009","article-title":"Forrestiacids C and D, unprecedented triterpene-diterpene adducts from Pseudotsuga forrestii","volume":"33","author":"Zhou","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.phytochem.2025.114533_bib71","first-page":"1","article-title":"Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes","volume":"22","author":"Zhou","year":"2024","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phytochem.2025.114533_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2024.114221","volume":"226","author":"Zhou","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114533_bib73","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1039\/D4QO02210F","article-title":"Spiroamentotaxols A\u2212D: unprecedented 6\/6\/6\/5\/6\/6\/6\/6 spiro-octacyclic bis-diterpene heterodimers from the endangered conifer Amentotaxus yunnanensis and their bioactivities","volume":"12","author":"Zhou","year":"2025","journal-title":"Org. Chem. Front."},{"key":"10.1016\/j.phytochem.2025.114533_bib74","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/acs.jnatprod.3c00040","article-title":"Forrestiacids E-K: further [4 + 2]-type triterpene-diterpene hybrids as potential ACL inhibitors from the vulnerable conifer Pseudotsuga forrestii","volume":"86","author":"Zhou","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114533_bib75","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.1073\/pnas.1107336108","article-title":"Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting","volume":"108","author":"Zhu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225001566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225001566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T23:59:31Z","timestamp":1749513571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942225001566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":74,"alternative-id":["S0031942225001566"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114533","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diterpene-phenylpropanoid hybrids and structurally diverse diterpenoid monomers from the endangered conifer Podocarpus annamiensis and their bioactivities","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114533"}}