{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:23Z","timestamp":1791919103190,"version":"4.3.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173698"],"award-info":[{"award-number":["82173698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.phytochem.2025.114579","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T12:09:04Z","timestamp":1749557344000},"page":"114579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Coumarins isolated from Paederia scandens (Lour.) Merr. and their anti-neuroinflammatory activity"],"prefix":"10.1016","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5260-3389","authenticated-orcid":false,"given":"Huadong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-7657","authenticated-orcid":false,"given":"Xiangjiu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.phytochem.2025.114579_bib1","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1248\/cpb.30.2025","article-title":"Studies on coumarins from the root of Angelica pubescens MAXIM. IV. Structures of angelol-type Prenylcoumarins","volume":"30","author":"Baba","year":"1982","journal-title":"Chem. Pharmaceut. Bull."},{"issue":"10","key":"10.1016\/j.phytochem.2025.114579_bib2","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1021\/np100354c","article-title":"Prenyl coumarins from Fatoua pilosa","volume":"73","author":"Chiang","year":"2010","journal-title":"J. Nat. Prod."},{"issue":"10","key":"10.1016\/j.phytochem.2025.114579_bib3","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/ptr.1424","article-title":"In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica","volume":"19","author":"Choi","year":"2005","journal-title":"Phytother Res."},{"issue":"6","key":"10.1016\/j.phytochem.2025.114579_bib4","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/s10600-010-9477-9","article-title":"Chemical constituents from the aerial parts of Sophora mollis","volume":"45","author":"Fei","year":"2009","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.phytochem.2025.114579_bib5","author":"Frisch"},{"issue":"9","key":"10.1016\/j.phytochem.2025.114579_bib6","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1248\/cpb.56.1338","article-title":"Coumarins from Campylotropis hirtella (FRANCH.) SCHINDL. and their inhibitory activity on prostate specificantigen secreted from LNCaP Cells","volume":"56","author":"Han","year":"2008","journal-title":"Chem. Pharm. Bull."},{"issue":"2","key":"10.1016\/j.phytochem.2025.114579_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.14573\/altex.2009.2.83","article-title":"The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation","volume":"26","author":"Henn","year":"2009","journal-title":"ALTEX"},{"key":"10.1016\/j.phytochem.2025.114579_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.fct.2013.11.022","article-title":"Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate","volume":"64","author":"Hou","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.phytochem.2025.114579_bib9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0040-4039(00)75612-7","article-title":"Die iridoidglucoside aus paederia scandens (lour.) merrill var. Mairei (l\u00e9veill\u00e9) hara","volume":"9","author":"Inouye","year":"1968","journal-title":"Tetrahedron Lett."},{"issue":"9","key":"10.1016\/j.phytochem.2025.114579_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1248\/cpb.56.1349","article-title":"Studies of coumarins from the Chinese drug Qianhu, XXVII: structure of a new Simple coumarin glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum","volume":"56","author":"Ishii","year":"2008","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114579_bib11","first-page":"150","article-title":"1,1-Diphenyl-2-picrylhydrazyl radical scavenging compounds of Fraxini Cortex","volume":"11","author":"Kim","year":"2005","journal-title":"Nat. Prod. Sci."},{"issue":"9","key":"10.1016\/j.phytochem.2025.114579_bib12","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1248\/cpb.46.1404","article-title":"Coumarin glycosides of Glehnia littoralis root and rhizoma","volume":"46","author":"Kitajima","year":"1998","journal-title":"Chem. Pharmaceut. Bull."},{"issue":"3","key":"10.1016\/j.phytochem.2025.114579_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12272-009-1303-1","article-title":"Lignan constituents from Chloranthus japonicus Sieb","volume":"32","author":"Kuang","year":"2009","journal-title":"Arch Pharm. Res. (Seoul)"},{"issue":"6","key":"10.1016\/j.phytochem.2025.114579_bib14","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF02976860","article-title":"Antibacterial coumarins from Angelica gigas roots","volume":"26","author":"Lee","year":"2003","journal-title":"Arch Pharm. Res"},{"issue":"5","key":"10.1016\/j.phytochem.2025.114579_bib15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1055\/s-2006-958145","article-title":"Two new 6-alkylcoumarins from Angelica pubescens f. Biserrata","volume":"61","author":"Liu","year":"2007","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.phytochem.2025.114579_bib16","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/0031-9422(95)00045-9","article-title":"Angelol-type coumarins from Angelica pubescence f. Biserrata and their inhibitory effect on platelet aggregation","volume":"39","author":"Liu","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114579_bib17","article-title":"Anti-neuroinflammatory triterpenoids from the seeds of Quercus serrata Thunb","volume":"142","author":"Mai","year":"2020","journal-title":"Fitoterapia (Milano, 1934)"},{"issue":"8","key":"10.1016\/j.phytochem.2025.114579_bib18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-2007-971386","article-title":"Carbon-13 spectral data of prenylated coumarins","volume":"45","author":"Nicoletti","year":"2007","journal-title":"Planta Med."},{"issue":"5","key":"10.1016\/j.phytochem.2025.114579_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0031-9422(02)00096-1","article-title":"Iridoid glucosides from roots of Vietnamese Paederia scandens","volume":"60","author":"Quang","year":"2002","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.phytochem.2025.114579_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0040-4020(01)83488-8","article-title":"Structures of cleomiscosins, coumarinolignoids of cleome viscosa seeds","volume":"41","author":"Ray","year":"1985","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2025.114579_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174867","article-title":"Coumarins derivatives and inflammation: review of their effects on the inflammatory signaling pathways","volume":"922","author":"Rostom","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.phytochem.2025.114579_bib22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/10286020701273759","article-title":"Irritant and cytotoxic coumarins from Angelica glauca Edgew roots","volume":"10","author":"Saeed","year":"2008","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2025.114579_bib23","first-page":"19","article-title":"Isolation and identification of osthol from the fruits and essential oil composition of the leaves of Prangos asperula Boiss","volume":"4","author":"Sajjadi","year":"2009","journal-title":"Res. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.phytochem.2025.114579_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1055\/s-2006-962446","article-title":"Studies on coumarins of a Chinese drug, \u201cQian-Hu\u201d; VIII1. Structures of new coumarin-glycosides of \u201cBai-Hua Qian-Hu\u201d","volume":"54","author":"Takata","year":"2007","journal-title":"Planta Med."},{"issue":"7","key":"10.1016\/j.phytochem.2025.114579_bib25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1021\/acs.jafc.8b06489","article-title":"Coumarin analogues from the Citrus grandis (L.) Osbeck and their hepatoprotective activity","volume":"67","author":"Tian","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.phytochem.2025.114579_bib26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1021\/np50055a021","article-title":"Native American food and medicinal plants, 8. Water-soluble constituents of Lomatium dissectum","volume":"51","author":"VanWagenen","year":"1988","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114579_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.phytochem.2018.01.019","article-title":"Anti-inflammatory steroidal glycosides from the berries of Solanum nigrum L. (European black nightshade)","volume":"148","author":"Xiang","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114579_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113705","article-title":"Anti-inflammatory iridoid glycosides from Paederia scandens (lour.) merrill","volume":"212","author":"Xu","year":"2023","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114579_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.indcrop.2019.01.004","article-title":"Bioactive sterols and triterpenoids from the fruits of giant crepe-myrtle","volume":"130","author":"Yan","year":"2019","journal-title":"Ind. Crop. Prod."},{"issue":"7","key":"10.1016\/j.phytochem.2025.114579_bib30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/15287394.2019.1615019","article-title":"Melatonin attenuates expression of cyclooxygenase-2 (COX-2) in activated microglia induced by lipopolysaccharide (LPS)","volume":"82","author":"Yao","year":"2019","journal-title":"J. Toxicol. Environ. Health, Part A"},{"key":"10.1016\/j.phytochem.2025.114579_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113313","article-title":"Anti-neuroinflammatory 3-hydroxycoumaronochromones and isoflavanones enantiomers from the fruits of Ficus altissima Blume","volume":"202","author":"Yao","year":"2022","journal-title":"Phytochemistry"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003194222500202X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003194222500202X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T16:02:40Z","timestamp":1753718560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003194222500202X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"alternative-id":["S003194222500202X"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114579","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coumarins isolated from Paederia scandens (Lour.) Merr. and their anti-neuroinflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114579","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114579"}}