{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:37:29Z","timestamp":1784072249345,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.phytochem.2025.114622","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T23:48:00Z","timestamp":1752623280000},"page":"114622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Phytochemical investigation and evaluation of the antioxidant activity of Cornus sanguinea"],"prefix":"10.1016","volume":"240","author":[{"given":"Annunziata","family":"Paolillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Cerulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Cuozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Sottile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ciaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4998-2311","authenticated-orcid":false,"given":"Sonia","family":"Piacente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Masullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2025.114622_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202301888","article-title":"Therapeutic potential of cornus genus: navigating phytochemistry, pharmacology, clinical studies, and advanced delivery approaches","volume":"21","author":"Badoni","year":"2024","journal-title":"Chem. Biodiversity"},{"key":"10.1016\/j.phytochem.2025.114622_bib2","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1007\/s10886-021-01319-1","article-title":"Aggregation pheromones of weevils (Coleoptera: Curculionidae): advances in the identification and potential uses in semiochemical-based Pest management strategies","volume":"47","author":"Bandeira","year":"2021","journal-title":"J. Chem. Ecol."},{"key":"10.1016\/j.phytochem.2025.114622_bib3","first-page":"623","article-title":"Total phenolic content, cyclooxygenases, \u03b1-glucosidase, acetylcholinesterase, tyrosinase inhibitory and DPPH radical scavenging effects of Cornus sanguinea leaves and fruits","volume":"24","author":"Barut","year":"2020","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.phytochem.2025.114622_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/pca.2824","article-title":"HR-LC-ESI-Orbitrap-MS based metabolite profiling of Prunus dulcis Mill. (Italian cultivars Toritto and Avola) husks and evaluation of antioxidant activity","volume":"30","author":"Bottone","year":"2019","journal-title":"Phytochem. Anal."},{"key":"10.1016\/j.phytochem.2025.114622_bib5","first-page":"675","article-title":"Caffeic acid in dermatological formulations: in vitro release profile and skin absorption","volume":"20","author":"Caroline","year":"2017","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.phytochem.2025.114622_bib6","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jpba.2018.07.046","article-title":"Metabolite profiling of \"green\" extracts of Corylus avellana leaves by 1H NMR spectroscopy and multivariate statistical analysis","volume":"160","author":"Cerulli","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.phytochem.2025.114622_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081643","article-title":"Immuno-modulatory and anti-inflammatory effects of dihydrogracilin A, a terpene derived from the marine sponge Dendrilla membranosa","volume":"18","author":"Ciaglia","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phytochem.2025.114622_bib8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jep.2012.10.065","article-title":"Traditional plant use in the National Park of Cilento and Vallo di Diano, Campania, Southern, Italy","volume":"145","author":"Di Novella","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2025.114622_bib9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1021\/np200604k","article-title":"HPLC-ESIMSn profiling, isolation, structural elucidation, and evaluation of the antioxidant potential of phenolics from Paepalanthus geniculatus","volume":"75","author":"do Amaral","year":"2012","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114622_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23806","article-title":"The inhibitory effect of chlorogenic acid on oxidative stress and apoptosis induced by PM(2.5) in HaCaT keratinocytes","volume":"38","author":"Herath","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.phytochem.2025.114622_bib11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1055\/a-1471-6666","article-title":"Cornus sanguinea fruits: a source of antioxidant and antisenescence compounds acting on aged human dermal and gingival fibroblasts","volume":"87","author":"Iannuzzi","year":"2021","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2025.114622_bib12","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3390\/gels10120794","article-title":"Potential unlocking of biological activity of caffeic acid by incorporation into hydrophilic gels","volume":"10","author":"Jokubaite","year":"2024","journal-title":"Gels"},{"key":"10.1016\/j.phytochem.2025.114622_bib13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12906-017-1618-2","article-title":"Chemical composition and anti-herpes simplex virus type 1 (HSV-1) activity of extracts from Cornus canadensis","volume":"17","author":"Lavoie","year":"2017","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.phytochem.2025.114622_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0031-9422(99)00502-6","article-title":"Phenolic compounds from the leaves of Cornus controversa","volume":"53","author":"Lee","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114622_bib15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3390\/f14020319","article-title":"Nutshell physicochemical characteristics of different hazel cultivars and their defensive activity toward Curculio nucum (Coleoptera: Curculionidae)","volume":"14","author":"Li","year":"2023","journal-title":"Forests"},{"key":"10.1016\/j.phytochem.2025.114622_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030519","article-title":"From hamamelitannin synthesis to the study of enzymatic acylations of D-Hamamelose","volume":"13","author":"Mastihubov\u00e1","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.phytochem.2025.114622_bib17","doi-asserted-by":"crossref","DOI":"10.1248\/cpb.58.438","article-title":"Structural revisions of blumenol C glucoside and byzantionoside B","author":"Matsunami","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114622_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06297","article-title":"Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: a review of antioxidant potential and antiproliferative capacity","volume":"7","author":"Maya-Cano","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.phytochem.2025.114622_bib19","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1248\/cpb.49.845","article-title":"Medicinal foodstuffs. XXIV. Chemical constituents of the processed leaves of Apocynum venetum L.: absolute stereostructures of apocynosides I and II","volume":"49","author":"Murakami","year":"2001","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114622_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.foodchem.2018.06.121","article-title":"Multi-class polar lipid profiling in fresh and roasted hazelnut (Corylus avellana cultivar \u201cTonda di Giffoni\u201d) by LC-ESI\/LTQOrbitrap\/MS\/MSn","volume":"269","author":"Napolitano","year":"2018","journal-title":"Food Chem."},{"key":"10.1016\/j.phytochem.2025.114622_bib21","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1248\/cpb.32.483","article-title":"Tannins and related compounds. XVII. Galloylhamameloses from Castanea crenata L. and Sanguisorba officinalis L","volume":"32","author":"Nonaka","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114622_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/foods13101429","article-title":"Development of a new extraction method for pomegranate and metabolite profiling by a LC-MS and 1H NMR Combiced Approach","volume":"13","author":"Polcaro","year":"2024","journal-title":"Foods"},{"key":"10.1016\/j.phytochem.2025.114622_bib23","doi-asserted-by":"crossref","DOI":"10.1515\/tjb-2016-0175","article-title":"First evidence and quantification of quercetin derivatives in dogberries (Cornus sanguinea L.)","author":"Popovi\u0107","year":"2017","journal-title":"Turk. J. Biochem."},{"key":"10.1016\/j.phytochem.2025.114622_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.phytochem.2017.04.008","article-title":"Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling","volume":"140","author":"Santos","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114622_bib25","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.phytochem.2008.02.015","article-title":"Accumulation of apocarotenoids in mycorrhizal roots of leek (Allium porrum)","volume":"69","author":"Schliemann","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114622_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112660","article-title":"Dietary phytochemicals alleviate the premature skin aging: a comprehensive review","volume":"199","author":"Singh","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.phytochem.2025.114622_bib27","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0305-1978(98)00050-7","article-title":"Iridoid glycosides of Cornus canadensis: a comparison with some other Cornus species","volume":"26","author":"Stermitz","year":"1998","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.phytochem.2025.114622_bib28","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1016\/j.phytochem.2006.09.007","article-title":"Bridelionosides A\u2013F: megastigmane glucosides from Bridelia glauca f. balansae","volume":"67","author":"Sueyoshi","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114622_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/foods11091240","article-title":"An overview of traditional uses, phytochemical compositions and biological activities of edible fruits of European and Asian cornus species","volume":"11","author":"Tenuta","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.phytochem.2025.114622_bib30","doi-asserted-by":"crossref","first-page":"8838","DOI":"10.1039\/D3FO02987E","article-title":"Iridoid- and flavonoid-enriched fractions of Cornus sanguinea and Cornus mas exert antioxidant and anti-inflammatory effects and inhibit key enzymes in the treatment of metabolic disorders","volume":"14","author":"Tenuta","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.phytochem.2025.114622_bib31","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1080\/14786419.2020.1839458","article-title":"Three new C(21) steroidal glycosides isolated from Metaplexis japonica and their potential inhibitory effects on tyrosine protein kinases","volume":"36","author":"Wang","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2025.114622_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113361","article-title":"Megastigmane sesquiterpenoids from whole plants of Viola kunawurensis","volume":"203","author":"Yaermaimaiti","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2025.114622_bib33","author":"Yamamoto"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225002456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225002456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:38:48Z","timestamp":1757450328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942225002456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":33,"alternative-id":["S0031942225002456"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114622","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phytochemical investigation and evaluation of the antioxidant activity of Cornus sanguinea","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"114622"}}