{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:17:03Z","timestamp":1773872223889,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200307"],"award-info":[{"award-number":["32200307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.phytochem.2025.114719","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:33:09Z","timestamp":1763692389000},"page":"114719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Structurally diverse sesquiterpenes from the roots of Isotrema yunnanense and their analgesic and anti-inflammatory activity"],"prefix":"10.1016","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9118-3057","authenticated-orcid":false,"given":"Xishan","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiarebati","family":"Tuerkesitan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-7482","authenticated-orcid":false,"given":"Ziliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-3067","authenticated-orcid":false,"given":"Xiangzhong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2025.114719_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s11010-016-2830-y","article-title":"Anti-arthritogenic and cardioprotective action of hesperidin and daidzein in collagen-induced rheumatoid arthritis","volume":"423","author":"Ahmad","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.phytochem.2025.114719_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118104","article-title":"Triterpenes G-A and G-E from Galphimia glauca with anti-inflammatory and anti-arthritic activity in mice","volume":"328","author":"Alejandra","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.phytochem.2025.114719_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/13880209.2022.2163407","article-title":"Antinociceptive activity of doliroside B","volume":"61","author":"Bai","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phytochem.2025.114719_bib4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1248\/cpb.58.1093","article-title":"Two new aristolochic acid derivatives from the roots of Aristolochia fangchi and their cytotoxicities","volume":"58","author":"Cai","year":"2010","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2025.114719_bib5","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1016\/S0040-4039(98)01833-4","article-title":"Three sesquiterpenes from the roots and stems of Aristolochia heterophylla hemsl with novel skeletons","volume":"39","author":"Chan","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2025.114719_bib6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12272-016-0843-4","article-title":"Aristoyunnolin H attenuates extracellular matrix secretion in cardiac fibroblasts by inhibiting calcium influx","volume":"40","author":"Chen","year":"2017","journal-title":"Arch Pharm. Res."},{"key":"10.1016\/j.phytochem.2025.114719_bib7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/np300887d","article-title":"Extracellular signal-regulated kinases (ERK) inhibitors from Aristolochia yunnanensis","volume":"76","author":"Cheng","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114719_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/rheumatology\/kep329","article-title":"Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor","volume":"49","author":"Dayer","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.phytochem.2025.114719_bib9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fitote.2014.12.015","article-title":"Anti-complement sesquiterpenes from Viola yedoensis","volume":"101","author":"Du","year":"2015","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2025.114719_bib10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.5560\/znb.2014-4059","article-title":"Two rare hydroazulene-type sesquiterpenes from the roots of Aristolochia yunnanensis","volume":"69","author":"Du","year":"2014","journal-title":"Z. Naturforsch. B Chem. Sci."},{"key":"10.1016\/j.phytochem.2025.114719_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154905","article-title":"Network pharmacology analysis of the pharmacological mechanism of Artemisia lavandulaefolia DC. in rheumatoid arthritis","volume":"118","author":"Huang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phytochem.2025.114719_bib12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/molecules26010044","article-title":"Two new aristolochic acid analogues from the roots of Aristolochia contorta with significant cytotoxic activity","volume":"26","author":"Ji","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2025.114719_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154907","article-title":"Diversity-oriented synthesis of diterpenoid alkaloids yields a potent anti-inflammatory agent","volume":"117","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phytochem.2025.114719_bib14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ptr.6219","article-title":"(+)-Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor \u03b2\/small mother against decapentaplegic signaling pathway","volume":"33","author":"Lou","year":"2019","journal-title":"Phytother Res."},{"key":"10.1016\/j.phytochem.2025.114719_bib15","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1021\/acs.jmedchem.9b00708","article-title":"Germacrane sesquiterpenoids as a new type of anticardiac fibrosis agent targeting transforming growth factor \u03b2 type I receptor","volume":"62","author":"Lou","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phytochem.2025.114719_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0031-6997(25)06663-3","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.phytochem.2025.114719_bib17","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.3390\/md13074197","article-title":"Red algae (Rhodophyta) from the coast of Madagascar: preliminary bioactivity studies and isolation of natural products","volume":"13","author":"Rahelivao","year":"2015","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2025.114719_bib18","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s10787-023-01370-2","article-title":"Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund's adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers","volume":"31","author":"Saleem","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.phytochem.2025.114719_bib19","first-page":"723","article-title":"Chemical constituents from rhizome of Menispermum dauricum and their anti-hypoxic activities. China","volume":"44","author":"Shao","year":"2019","journal-title":"J. Chin. Mater. Med."},{"key":"10.1016\/j.phytochem.2025.114719_bib20","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.trsl.2013.09.013","article-title":"Inhibitory effect of ethyl acetate extract of Aristolochia yunnanensis on cardiac fibrosis through extracellular signal-regulated kinases 1\/2 and transforming growth factor \u03b2\/small mother against decapentaplegic signaling pathways","volume":"163","author":"Shao","year":"2014","journal-title":"Transl. Res."},{"key":"10.1016\/j.phytochem.2025.114719_bib21","series-title":"Chinese Materia Medica (Zhonghua BenCao)","author":"Song","year":"1999"},{"key":"10.1016\/j.phytochem.2025.114719_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105496","article-title":"KP-10\/Gpr54 attenuates rheumatic arthritis through inactivating NF-\u03baB and MAPK signaling in macrophages","volume":"171","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.phytochem.2025.114719_bib23","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.12659\/MSM.895116","article-title":"Serum levels of IL-6 and TNF-\u03b1 may correlate with activity and severity of rheumatoid arthritis","volume":"21","author":"Wei","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.phytochem.2025.114719_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1021\/np0002886","article-title":"Constituents of the roots and stems of Aristolochia mollissima","volume":"64","author":"Wu","year":"2001","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2025.114719_bib25","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/jccs.200000132","article-title":"The constituents of the leaves of Aristolochia Mollissima Hance","volume":"47","author":"Wu","year":"2000","journal-title":"J. Chin. Chem. Soc."},{"key":"10.1016\/j.phytochem.2025.114719_bib26","first-page":"917","article-title":"The structure of versicolactone D","volume":"24","author":"Xue","year":"1989","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phytochem.2025.114719_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/acs.jnatprod.4c01209","article-title":"Macrocyclic compounds with diverse skeletons from the roots of Myrica nana and their spasmolytic activity","volume":"88","author":"Zhang","year":"2025","journal-title":"J. Nat. Prod."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225003425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942225003425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:51:04Z","timestamp":1773845464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942225003425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":27,"alternative-id":["S0031942225003425"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114719","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structurally diverse sesquiterpenes from the roots of Isotrema yunnanense and their analgesic and anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2025.114719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"114719"}}