{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:42:39Z","timestamp":1791830559666,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003606"],"award-info":[{"award-number":["82003606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204853"],"award-info":[{"award-number":["82204853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304822"],"award-info":[{"award-number":["82304822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["25JCLMJC00040"],"award-info":[{"award-number":["25JCLMJC00040"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014717","name":"Youth Science Fund Project","doi-asserted-by":"publisher","award":["252300421137"],"award-info":[{"award-number":["252300421137"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["25A360024"],"award-info":[{"award-number":["25A360024"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","award":["24IRTSTHN039"],"award-info":[{"award-number":["24IRTSTHN039"]}],"id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.phytochem.2026.114768","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T15:45:49Z","timestamp":1767455149000},"page":"114768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Guaianolide sesquiterpenoids from Chrysanthemum indicum\u2002L. alleviate rheumatoid arthritis by targeting of NLRP3 inflammasome pathway"],"prefix":"10.1016","volume":"245","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5919-524X","authenticated-orcid":false,"given":"Gui-Min","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Rong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding-Qiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Jun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Le","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Wu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Feng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.phytochem.2026.114768_bib1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1021\/np049954j","article-title":"Polyol monoterpenes and sesquiterpene lactones from the Pacific Northwest plant Artemisia suksdorfii","volume":"67","author":"Ahmed","year":"2004","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.phytochem.2026.114768_bib2","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1038\/ncomms5243","article-title":"Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis","volume":"11","author":"Chang","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.phytochem.2026.114768_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.phytochem.2026.114768_bib31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13075-015-0775-2","article-title":"Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis","volume":"17","author":"Choulaki","year":"2015","journal-title":"Arthritis. Res. Ther."},{"key":"10.1016\/j.phytochem.2026.114768_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.591393","article-title":"Natural products that target the NLRP3 inflammasome to treat fibrosis","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phytochem.2026.114768_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10600-010-9574-9","article-title":"Synthesis and molecular structure of halohydrins of the guaianolide ludartin","volume":"46","author":"Dzhalmakhanbetova","year":"2010","journal-title":"Chem. Nat. Compd."},{"issue":"4","key":"10.1016\/j.phytochem.2026.114768_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10600-009-9399-6","article-title":"Epoxidation of sesquiterpene lactones tourneforin and ludartin","volume":"45","author":"Dzhalmakhanbetova","year":"2009","journal-title":"Chem. Nat. Compd."},{"issue":"2","key":"10.1016\/j.phytochem.2026.114768_bib7","first-page":"126","article-title":"Montanone, a new sesquiterpene from jasonia montana","volume":"14","author":"El-Bassuony","year":"2006","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.phytochem.2026.114768_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.104980","article-title":"Quassinoids from Brucea javanica and attenuates lipopolysaccharide-induced acute lung injury by inhibiting PI3K\/Akt\/NF-\u03baB pathways","volume":"153","author":"He","year":"2021","journal-title":"Fitoterapia"},{"issue":"4","key":"10.1016\/j.phytochem.2026.114768_bib9","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0031-9422(86)80021-8","article-title":"Seco-guaianolides and other constituents from Artemisia Species","volume":"25","author":"Huneck","year":"1986","journal-title":"Phytochemistry"},{"issue":"5","key":"10.1016\/j.phytochem.2026.114768_bib10","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/0031-9422(91)84243-L","article-title":"Sesquiterpene lactones from Artemisia Rutifolia","volume":"30","author":"Jakupovic","year":"1991","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.phytochem.2026.114768_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1749-8546-8-7","article-title":"Hepatoprotective effect of water extract from Chrysanthemum indicum L. flower","volume":"8","author":"Jeong","year":"2013","journal-title":"Chin. Med."},{"issue":"2","key":"10.1016\/j.phytochem.2026.114768_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/cmi.2015.95","article-title":"Molecular mechanisms regulating NLRP3 inflammasome activation","volume":"13","author":"Jo","year":"2016","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.phytochem.2026.114768_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1021\/np020593m","article-title":"Sesquiterpenoids from Artemisia gilvescens and an anti-MRSA compound","volume":"66","author":"Kawazoe","year":"2003","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.phytochem.2026.114768_bib14","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1021\/acs.jnatprod.6b00694","article-title":"Sesquiterpenoids with various carbocyclic skeletons from the flowers of Chrysanthemum indicum","volume":"80","author":"Liu","year":"2017","journal-title":"J. Nat. Prod."},{"issue":"16","key":"10.1016\/j.phytochem.2026.114768_bib15","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1055\/s-0030-1271138","article-title":"Chrysindins A-D, polyacetylenes from the flowers of Chrysanthemum indicum","volume":"77","author":"Liu","year":"2011","journal-title":"Planta Med."},{"issue":"2","key":"10.1016\/j.phytochem.2026.114768_bib16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/acs.jnatprod.8b00863","article-title":"Monomeric and dimeric cytotoxic guaianolide-type sesquiterpenoids from the aerial parts of Chrysanthemum indicum","volume":"82","author":"Luo","year":"2019","journal-title":"J. Nat. Prod."},{"issue":"9","key":"10.1016\/j.phytochem.2026.114768_bib17","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1021\/jf048703d","article-title":"Application of Hansch's model to guaianolide ester derivatives: a quantitative structure-activity relationship study","volume":"53","author":"Mac\u00edas","year":"2005","journal-title":"J. Agric. Food Chem."},{"issue":"14","key":"10.1016\/j.phytochem.2026.114768_bib18","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1016\/S0040-4020(01)93807-4","article-title":"Synthesis of dihydro arbiglovin and stereochemistry of arbiglovin","volume":"28","author":"Marx","year":"1972","journal-title":"Tetrahedron"},{"issue":"3","key":"10.1016\/j.phytochem.2026.114768_bib19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1055\/s-2007-969486","article-title":"Sesquiterpene lactones from Chrysanthemum Indicum","volume":"51","author":"Mladenova","year":"1985","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114768_bib20","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3389\/fmicb.2020.01159","article-title":"Interleukin-8 release inhibitors generated by fermentation of Artemisia princeps Pampanini herb extract with Lactobacillus plantarum SN13T","volume":"11","author":"Okamoto","year":"2020","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.phytochem.2026.114768_bib21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1142\/S0192415X20500421","article-title":"Chrysanthemum indicum L.: a comprehensive review of its botany, phytochemistry and pharmacology","volume":"48","author":"Shao","year":"2020","journal-title":"Am. J. Chin. Med."},{"issue":"87","key":"10.1016\/j.phytochem.2026.114768_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1021\/acs.jnatprod.3c00786","article-title":"Maydistacins A-G, terpestacin-type sesterterpenoids with anti-inflammatory activity from the phytopathogenic fungus Bipolaris maydis","volume":"26","author":"Shi","year":"2024","journal-title":"J. Nat. Prod."},{"issue":"2","key":"10.1016\/j.phytochem.2026.114768_bib23","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acs.jnatprod.7b00867","article-title":"Highly oxidized guaianolide sesquiterpenoids with potential anti-inflammatory activity from Chrysanthemum indicum","volume":"81","author":"Xue","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114768_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2025.114608","article-title":"Sesquiterpenoids from Achillea setacea Waldst. & Kit. with anti-inflammatory activity by inhibiting the glycolytic pathway","volume":"239","author":"Xue","year":"2025","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114768_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2022.113297","article-title":"Germacranolide- and guaianolide-type sesquiterpenoids from Achillea alpina L. reduce insulin resistance in palmitic acid-treated HepG2 cells via inhibition of the NLRP3 inflammasome pathway","volume":"202","author":"Xue","year":"2022","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114768_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111917","article-title":"Chrysanthemum indicum extract inhibits NLRP3 and AIM2 inflammasome activation via regulating ASC phosphorylation","volume":"239","author":"Yu","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.phytochem.2026.114768_bib28","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1021\/acs.jafc.9b00185","article-title":"Liquiritin from Glycyrrhiza uralensis attenuating rheumatoid arthritis via reducing inflammation, suppressing angiogenesis, and inhibiting MAPK signaling pathway","volume":"67","author":"Zhai","year":"2019","journal-title":"J. Agric. Food Chem."},{"issue":"9","key":"10.1016\/j.phytochem.2026.114768_bib29","doi-asserted-by":"crossref","first-page":"7516","DOI":"10.1021\/acs.jmedchem.4c00357","article-title":"Novel isoalantolactone-based derivatives as potent NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization","volume":"67","author":"Zhao","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phytochem.2026.114768_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.freeradbiomed.2021.12.259","article-title":"Iso-seco-tanapartholide activates Nrf2 signaling pathway through Keap1 modification and oligomerization to exert anti-inflammatory effects","volume":"178","author":"Zhu","year":"2022","journal-title":"Free Radic. Biol. Med."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226000014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226000014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:07:50Z","timestamp":1774987670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226000014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"alternative-id":["S0031942226000014"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114768","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guaianolide sesquiterpenoids from Chrysanthemum indicum\u2002L. alleviate rheumatoid arthritis by targeting of NLRP3 inflammasome pathway","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"114768"}}