{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:43:35Z","timestamp":1786995815281,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-028"],"award-info":[{"award-number":["2021-I2M-1-028"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.phytochem.2026.114870","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:00:21Z","timestamp":1773126021000},"page":"114870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Clerodane diterpenes lactones, alkaloids, and furan derivatives with hepatoprotective activity isolated from the tuberous root of Paratinospora sagittata (Oliv.) Wei Wang"],"prefix":"10.1016","volume":"247","author":[{"given":"Junhua","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanrong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoxuan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8991-2844","authenticated-orcid":false,"given":"Jie","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2026.114870_bib1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.indcrop.2014.10.005","article-title":"NaOH catalyzed condensation reactions between levulinic acid and biomass derived furan-aldehydes in water","volume":"65","author":"Amarasekara","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.phytochem.2026.114870_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1055\/s-2007-969629","article-title":"Quaternary alkaloids of Tinospora capillipes","volume":"50","author":"Chang","year":"1984","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114870_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1021\/np900551u","article-title":"Cis-clerodane-type furanoditerpenoids from Tinospora crispa","volume":"73","author":"Choudhary","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114870_bib4","series-title":"Pharmacopoeia of People'S Republic of China (Chinese)","first-page":"368","year":"2020"},{"key":"10.1016\/j.phytochem.2026.114870_bib5","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1080\/14786419.2011.619190","article-title":"A novel lignan glycoside with antioxidant activity from Tinospora sagittata var. yunnanensis","volume":"26","author":"Huang","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2026.114870_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-0034-1368252","article-title":"New clerodane diterpenes from Tinospora sagittata var. yunnanensis","volume":"80","author":"Jiang","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114870_bib7","article-title":"Clerodane diterpenoids with anti-inflammatory activity from the tuberous root of Paratinospora sagittata (Oliv.) Wei Wang","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phytochem.2026.114870_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molcatb.2014.09.015","article-title":"Biotransformation of licochalcone A by transgenic crown galls of Panax quinquefolium","volume":"110","author":"Li","year":"2014","journal-title":"J. Mol. Catal. B Enzym."},{"key":"10.1016\/j.phytochem.2026.114870_bib9","first-page":"1","article-title":"Two new clerodane diterpenoids with analgesic activity from the roots of Paratinospora sagittata (Oliv.) Wei Wang","volume":"26","author":"Li","year":"2025","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2026.114870_bib10","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.tetlet.2008.01.065","article-title":"Synthesis of deacetyl-1,10-didehydrosalvinorin G","volume":"49","author":"Ma","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2026.114870_bib11","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1055\/s-0030-1270743","article-title":"Cytotoxic and antimicrobial activities of aporphine alkaloids isolated from Stephania venosa (Blume) Spreng","volume":"77","author":"Makarasen","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114870_bib12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-2006-961425","article-title":"Zur NMR-spektroskopie von N-acylaporphin-alkaloiden aus Tinospora crispa","volume":"58","author":"Pachaly","year":"1992","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114870_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.phytol.2015.03.014","article-title":"Cytotoxic clerodane furanoditerpenoids from the root of Tinospora sagittata","volume":"12","author":"Qin","year":"2015","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2026.114870_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bioorg.2017.10.006","article-title":"New iridoid glycosides from the fruits of Forsythia suspensa and their hepatoprotective activities","volume":"75","author":"Shao","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.114870_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.phytochem.2023.113932","article-title":"Clerodane diterpenoids with in-vitro anti-neuroinflammatory activity from the tuberous root of Tinospora sagittata (Menispermaceae)","volume":"218","author":"Song","year":"2024","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114870_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22404","article-title":"Hepatoprotective effect of boldine against diethylnitrosamine\u2010induced hepatocarcinogenesis in wistar rats","volume":"33","author":"Subramaniam","year":"2019","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.phytochem.2026.114870_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ympev.2016.12.038","article-title":"New insights into the phylogeny of Burasaieae (Menispermaceae) with the recognition of a new genus and emphasis on the southern Taiwanese and mainland Chinese disjunction","volume":"109","author":"Wang","year":"2017","journal-title":"Mol. Phylogenet. Evol."},{"key":"10.1016\/j.phytochem.2026.114870_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104551","article-title":"Aporphine and phenanthrene alkaloids with antioxidant activity from the roots of Stephania tetrandra","volume":"143","author":"Wang","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.114870_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.104963","article-title":"Chemical constituents from Tinospora sagittata and their biological activities","volume":"153","author":"Xu","year":"2021","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.114870_bib20","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1021\/np50022a020","article-title":"A spectral method for the determination of the position of a phenolic group on ring A of an aporphine. Four new aporphines from Polyalthia acuminata","volume":"45","author":"Zarga","year":"1982","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114870_bib21","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1248\/cpb.50.1195","article-title":"Sesquiterpenes and alkaloids from Lindera chunii and their inhibitory activities against HIV-1 integrase","volume":"50","author":"Zhang","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2026.114870_bib22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.fitote.2016.02.012","article-title":"Clerodane-type diterpenoids from tuberous roots of Tinospora sagittata (Oliv.) Gagnep","volume":"110","author":"Zhang","year":"2016","journal-title":"Fitoterapia"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226001032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226001032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:33:17Z","timestamp":1776144797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226001032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"alternative-id":["S0031942226001032"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114870","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clerodane diterpenes lactones, alkaloids, and furan derivatives with hepatoprotective activity isolated from the tuberous root of Paratinospora sagittata (Oliv.) Wei Wang","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114870"}}