{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T01:06:55Z","timestamp":1779239215027,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key Areas of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111110003"],"award-info":[{"award-number":["2020B1111110003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key Areas of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1111050003"],"award-info":[{"award-number":["2022B1111050003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.phytochem.2026.114912","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:42:34Z","timestamp":1775306554000},"page":"114912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Toddacoumalins A-J, ten undescribed coumarins from the roots of Toddalia asiatica"],"prefix":"10.1016","volume":"248","author":[{"given":"Feng","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Rui","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert S.C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-6128","authenticated-orcid":false,"given":"Hou-Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2759-8394","authenticated-orcid":false,"given":"Wen-Jian","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2026.114912_bib1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/0031-9422(88)80298-X","article-title":"Furanocoumarin glucosides from the seeds of Apium graveolens","volume":"27","author":"Ahluwalia","year":"1988","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114912_bib2","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.3390\/molecules17032675","article-title":"Bioactive phenolic amides from Celtis africana","volume":"17","author":"Al-Taweel","year":"2012","journal-title":"Molecules"},{"key":"10.1016\/j.phytochem.2026.114912_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/14786419.2021.1961138","article-title":"New coumarin glycosides from endemic Prangos heyniae H. Duman & MF Watson","volume":"37","author":"Albayrak","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2026.114912_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117177","article-title":"The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds","volume":"178","author":"Bhol","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phytochem.2026.114912_bib5","first-page":"382","article-title":"Todasinoid A, a new eremophilane-type sesquiterpene from the plant Toddalia asiatica","volume":"17","author":"Cai","year":"2023","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114912_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bse.2021.104244","article-title":"Alkaloids of Toddalia asiatica (Rutaceae)","volume":"95","author":"Chen","year":"2021","journal-title":"Biochem. Systemat. Ecol."},{"key":"10.1016\/j.phytochem.2026.114912_bib7","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/jo010136v","article-title":"Determination of absolute configuration of acyclic 1,2-diols with Mo2(OAc)4. 1. Snatzke's method revisited","volume":"66","author":"Di Bari","year":"2001","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2026.114912_bib8","article-title":"Rapid identification of natural acetylcholinesterase inhibitors from Glycosmis parviflora stem utilizing dereplication, in vitro and in silico approach","volume":"17","author":"Duong","year":"2024","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.phytochem.2026.114912_bib10","first-page":"852","article-title":"Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities","volume":"21","author":"He","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phytochem.2026.114912_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phytol.2016.08.008","article-title":"Cytotoxic and antimalarial constituents from the roots of Toddalia asiatica","volume":"17","author":"Hirunwong","year":"2016","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2026.114912_bib12","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1021\/jf990155u","article-title":"Isolation of furocoumarins from bergamot fruits as HL-60 differentiation-inducing compounds","volume":"47","author":"Kawaii","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.phytochem.2026.114912_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4314\/ejhs.v26i1.10","article-title":"Safety and analgesic properties of ethanolic extracts of Toddalia Asiatica (L) Lam. (Rutaceae) used for central and peripheral pain management among the east African ethnic communities","volume":"26","author":"Kimang'a","year":"2016","journal-title":"Ethiop. J. Health Sci."},{"key":"10.1016\/j.phytochem.2026.114912_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0031-9422(00)81445-4","article-title":"Gleinene and gleinadiene, 5,7-dimethoxycoumarins from Murraya gleinei root","volume":"26","author":"Kumar","year":"1987","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114912_bib15","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1021\/np401040d","article-title":"Prenylated coumarins: natural phosphodiesterase-4 inhibitors from Toddalia asiatica","volume":"77","author":"Lin","year":"2014","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114912_bib16","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.3389\/fphar.2020.00109","article-title":"Toddalolactone protects lipopolysaccharide-induced sepsis and attenuates lipopolysaccharide-induced inflammatory response by modulating HMGB1-NF-\u03baB translocation","volume":"11","author":"Ni","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phytochem.2026.114912_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-023-03939-4","article-title":"Evaluation of the antibacterial activity of selected Kenyan medicinal plant extract combinations against clinically important bacteria","volume":"23","author":"Odongo","year":"2023","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.phytochem.2026.114912_bib19","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1055\/s-0034-1368568","article-title":"Cytotoxic coumarins from Toddalia asiatica","volume":"80","author":"Phatchana","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114912_bib20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jlac.199019900137","article-title":"Natural product chemistry, 134. Syntheses of the natural coumarins gleinene and gleinadiene","author":"Reisch","year":"1990","journal-title":"Liebigs Ann. Chem."},{"key":"10.1016\/j.phytochem.2026.114912_bib21","first-page":"169","article-title":"Antioxidant and antibacterial activity of Toddalia Asiatica (Linn) Lam root extracts","volume":"12","author":"Shi","year":"2015","journal-title":"Afr. J. Tradit., Complementary Altern. Med."},{"key":"10.1016\/j.phytochem.2026.114912_bib22","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1248\/cpb.55.899","article-title":"Facile discrimination of aldose enantiomers by Reversed-Phase HPLC","volume":"55","author":"Tanaka","year":"2007","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.phytochem.2026.114912_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.phymed.2012.03.008","article-title":"Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells","volume":"19","author":"V\u00e1zquez","year":"2012","journal-title":"Phytomedicine"},{"key":"10.1016\/j.phytochem.2026.114912_bib24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0031-9422(00)89547-3","article-title":"Sinapyl alcohol derivatives and other constituents from Ligularia nelumbifolia","volume":"37","author":"Yu","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114912_bib25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jsps.2021.05.003","article-title":"A systematic review on traditional medicine Toddalia asiatica (L.) Lam.: chemistry and medicinal potential","volume":"29","author":"Zeng","year":"2021","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.phytochem.2026.114912_bib26","first-page":"296","article-title":"A new prenylated coumarin from the roots of Toddalia asiatica","volume":"18","author":"Zeng","year":"2024","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114912_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13065-017-0283-3","article-title":"Hemostatic chemical constituents from natural medicine Toddalia asiatica root bark by LC-ESI Q-TOF MSE","volume":"11","author":"Zhang","year":"2017","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.phytochem.2026.114912_bib28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/s10600-025-04745-9","article-title":"Compounds isolated from the pericarp of Zanthoxylum bungeanum and their Antibacterial Activity","volume":"61","author":"Zhao","year":"2025","journal-title":"Chem. Nat. Compd."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226001457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226001457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:23:21Z","timestamp":1779236601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226001457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":26,"alternative-id":["S0031942226001457"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114912","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toddacoumalins A-J, ten undescribed coumarins from the roots of Toddalia asiatica","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114912","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114912"}}