{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:04:30Z","timestamp":1784610270815,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E001TS03"],"award-info":[{"award-number":["CI2023E001TS03"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3504000"],"award-info":[{"award-number":["2023YFC3504000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phytochem.2026.114975","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:02:28Z","timestamp":1779282148000},"page":"114975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Seven undescribed steroidal glycosides with CYP3A4 inhibitory activity from the stems of Marsdenia tenacissima"],"prefix":"10.1016","volume":"250","author":[{"given":"Bian-Xia","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-Min","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Hua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.phytochem.2026.114975_bib1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.phytochem.2005.03.018","article-title":"Marsdenosides A\u2013H, polyoxypregnane glycosides from Marsdenia tenacissima","volume":"66","author":"Deng","year":"2005","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114975_bib2","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1002\/hlca.200590208","article-title":"Three new polyoxypregnane glycosides from Marsdenia tenacissima","volume":"88","author":"Deng","year":"2005","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.phytochem.2026.114975_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.chroma.2006.03.021","article-title":"Quantitation of seven polyoxypregnane glycosides in Marsdenia tenacissima using reversed-phase high-performance liquid chromatography-evaporative light-scattering detection","volume":"1116","author":"Deng","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phytochem.2026.114975_bib4","series-title":"In Vitro Drug Interaction Studies\u2014Cytochrome P450 enzyme- and transporter-mediated Drug Interaction Guidance for Industry","year":"2020"},{"key":"10.1016\/j.phytochem.2026.114975_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2021.103342","article-title":"Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments","volume":"166","author":"Gougis","year":"2021","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"165","key":"10.1016\/j.phytochem.2026.114975_bib6","first-page":"1","article-title":"Enhancement of gefitinib-induced growth inhibition by Marsdenia tenacissima extract in non-small cell lung cancer cells expressing wild or mutant EGFR","volume":"14","author":"Han","year":"2014","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.phytochem.2026.114975_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jep.2013.10.021","article-title":"Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes","volume":"151","author":"Han","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"34","key":"10.1016\/j.phytochem.2026.114975_bib8","doi-asserted-by":"crossref","first-page":"56893","DOI":"10.18632\/oncotarget.18137","article-title":"Marsdenia tenacissima extract overcomes Axl- and Met- mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cells","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.phytochem.2026.114975_bib10","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4238\/2014.January.21.3","article-title":"Marsdenia tenacissima extract sensitizes MG63 cells to doxorubicin-induced apoptosis","volume":"13","author":"Huang","year":"2014","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.phytochem.2026.114975_bib9","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1002\/hlca.200900116","article-title":"Two new polyoxypregnane glycosides from Marsdenia tenacissima","volume":"92","author":"Huang","year":"2009","journal-title":"Helv. Chim. Acta"},{"issue":"5","key":"10.1016\/j.phytochem.2026.114975_bib11","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2133\/dmpk.DMPK-12-RG-014","article-title":"Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standards","volume":"27","author":"Kozakai","year":"2012","journal-title":"Drug Metabol. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.phytochem.2026.114975_bib13","first-page":"32","article-title":"Authentication on the dai medicinal herb \"dai-bai-jie\" using molecular and morphological data","volume":"43","author":"Li","year":"2023","journal-title":"Guihaia"},{"issue":"3","key":"10.1016\/j.phytochem.2026.114975_bib12","first-page":"384","article-title":"Meta-analysis of effect of Marsdenia tenacissima extract (MTE) on immune function in patients with intermediated and advanced cancer treated by chemotherapy","volume":"16","author":"Li","year":"2021","journal-title":"World Chin. Med."},{"key":"10.1016\/j.phytochem.2026.114975_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105940","article-title":"Twelve novel sesquiterpenes with anti-inflammatory and cholesterol-lowering activities from burdock leaves","volume":"127","author":"Liang","year":"2022","journal-title":"Bioorg. Chem."},{"issue":"5","key":"10.1016\/j.phytochem.2026.114975_bib15","first-page":"108","article-title":"Marsdenia tenacissima extract in the treatment of cancer: a re-evaluation of systematic reviews","volume":"33","author":"Liu","year":"2024","journal-title":"China Pharmaceuticals"},{"key":"10.1016\/j.phytochem.2026.114975_bib16","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2174\/1389200043335397","article-title":"CYP3A4 induction by xenobiotics: biochemistry, experimental methods and impact on drug discovery and development","volume":"5","author":"Luo","year":"2004","journal-title":"Curr. Drug Metabol."},{"issue":"12","key":"10.1016\/j.phytochem.2026.114975_bib17","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1016\/S0031-9422(00)83756-5","article-title":"Five glycosides from the chinese drug 'tong-guang-san': the stems of Marsdenia tenacissima","volume":"25","author":"Miyakawa","year":"1986","journal-title":"Phytochemistry"},{"issue":"4","key":"10.1016\/j.phytochem.2026.114975_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2174\/0113892002312369240703102215","article-title":"Role of cytochrome P450 3A4 in cancer drug resistance: challenges and opportunities","volume":"25","author":"Pandey","year":"2024","journal-title":"Curr. Drug Metabol."},{"issue":"3","key":"10.1016\/j.phytochem.2026.114975_bib19","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s11418-016-0982-4","article-title":"The cytotoxic and tyrosine kinase inhibitory properties of C21 steroids and iridoids from the tubers of Alocasia cucullata","volume":"70","author":"Peng","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.phytochem.2026.114975_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jpba.2012.10.016","article-title":"A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC\u2013MS\/MS","volume":"74","author":"Pillai","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.phytochem.2026.114975_bib21","first-page":"585","article-title":"Study on the chemical constituents of total glycoside H of Marsdenia tenacissima","volume":"46","author":"Shen","year":"2011","journal-title":"Chin. Pharmaceut. J."},{"key":"10.1016\/j.phytochem.2026.114975_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105551","article-title":"Pregnane steroids and steroid glycosides with multidrug resistance reversal activity from Marsdenia tenacissima","volume":"168","author":"Song","year":"2023","journal-title":"Fitoterapia"},{"issue":"3","key":"10.1016\/j.phytochem.2026.114975_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrd1984","article-title":"Targeting multidrug resistance in cancer","volume":"5","author":"Szak\u00e1cs","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.phytochem.2026.114975_bib24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jep.2017.03.051","article-title":"Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes","volume":"203","author":"To","year":"2017","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.phytochem.2026.114975_bib25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00280-019-03905-3","article-title":"Cytochrome P450 3A4, 3A5, and 2C8 expression in breast, prostate, lung, endometrial, and ovarian tumors: relevance for resistance to taxanes","volume":"84","author":"Van Eijk","year":"2019","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"7","key":"10.1016\/j.phytochem.2026.114975_bib26","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1142\/S0192415X18500751","article-title":"Marsdenia tenacissima: a review of traditional uses, phytochemistry and pharmacology","volume":"46","author":"Wang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.phytochem.2026.114975_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fonc.2018.00473","article-title":"The antitumor activities of Marsdenia tenacissima","volume":"8","author":"Wang","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.phytochem.2026.114975_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmgm.2019.107527","article-title":"Identification of potential platelet-derived growth factor receptor \u03b1 inhibitors by computational screening and binding simulations","volume":"96","author":"Wu","year":"2020","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.phytochem.2026.114975_bib29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jep.2019.02.028","article-title":"Tenacigenin B ester derivatives from Marsdenia tenacissima actively inhibited CYP3A4 and enhanced in vivo antitumor activity of paclitaxel","volume":"235","author":"Xie","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.phytochem.2026.114975_bib30","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1021\/np500385b","article-title":"Polyoxypregnane steroids from the stems of Marsdenia tenacissima","volume":"77","author":"Yao","year":"2014","journal-title":"J. Nat. Prod."},{"issue":"1","key":"10.1016\/j.phytochem.2026.114975_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol. Ther."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:21:49Z","timestamp":1784607709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226002086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"alternative-id":["S0031942226002086"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114975","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Seven undescribed steroidal glycosides with CYP3A4 inhibitory activity from the stems of Marsdenia tenacissima","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114975"}}