{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:03:53Z","timestamp":1784610233211,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570350"],"award-info":[{"award-number":["31570350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.phytochem.2026.114986","type":"journal-article","created":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:35:18Z","timestamp":1779582918000},"page":"114986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Caged xanthones with cytotoxic activity from the leaves and twigs of Garcinia oligantha"],"prefix":"10.1016","volume":"250","author":[{"given":"Xiao-Hui","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-3647","authenticated-orcid":false,"given":"Hui-Ming","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2026.114986_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3109\/13880209.2011.636176","article-title":"Prenylated caged xanthones: chemistry and biology","volume":"50","author":"Anantachoke","year":"2012","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.phytochem.2026.114986_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.canlet.2017.12.014","article-title":"Therapeutic potential of gambogic acid, a caged xanthone, to target cancer","volume":"416","author":"Banik","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.phytochem.2026.114986_bib3","series-title":"Specdis Version 1.70","author":"Bruhn","year":"2017"},{"key":"10.1016\/j.phytochem.2026.114986_bib4","doi-asserted-by":"crossref","first-page":"10915","DOI":"10.1016\/S0040-4020(98)00644-9","article-title":"Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae)","volume":"54","author":"Cao","year":"1998","journal-title":"Tetrahedron"},{"key":"10.1016\/j.phytochem.2026.114986_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ejmech.2019.02.047","article-title":"Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer","volume":"168","author":"Chantarasriwong","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib6","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1039\/C9QO00586B","article-title":"Four intricately caged polycyclic polyprenylated acylphloroglucinols from Garcinia multiflora fruits","volume":"6","author":"Chen","year":"2019","journal-title":"Chem. Front."},{"key":"10.1016\/j.phytochem.2026.114986_bib7","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1021\/acs.joc.0c00637","article-title":"Acylphloroglucinol derivatives with a tricyclo-[4.4.1.11,4] dodecane skeleton from Garcinia bracteata fruits","volume":"85","author":"Chen","year":"2020","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib8","series-title":"Gaussian 16, Rev. B.01","author":"Frisch","year":"2016"},{"key":"10.1016\/j.phytochem.2026.114986_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1021\/acs.jnatprod.8b00379","article-title":"Phloroglucinols from the roots of Garcinia dauphinensis and their antiproliferative and antiplasmodial activities","volume":"82","author":"Fuentes","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114986_bib10","first-page":"188381","article-title":"Gambogic acid: a shining natural compound to nanomedicine for cancer therapeutics","volume":"1874","author":"Hatami","year":"2020","journal-title":"BBA - Reviews on Cancer"},{"key":"10.1016\/j.phytochem.2026.114986_bib11","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1021\/acs.jnatprod.9b01045","article-title":"Garcinoic acids and a benzophenone derivative from the seeds of Garcinia kola and their antibacterial activities against oral bacterial pathogenic organisms","volume":"83","author":"Hioki","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114986_bib12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.chembiol.2020.03.008","article-title":"Combined omics approach identifies gambogic acid and related xanthones as covalent inhibitors of the serine palmitoyltransferase complex","volume":"27","author":"Hoch","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.phytochem.2026.114986_bib13","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/s11418-017-1092-7","article-title":"A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities","volume":"71","author":"Jia","year":"2017","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.phytochem.2026.114986_bib14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fitote.2018.02.023","article-title":"Chiral resolution and anticancer effect of xanthones from Garcinia paucinervis","volume":"127","author":"Jia","year":"2018","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.114986_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3389\/fphar.2019.01561","article-title":"Gaudichaudione H inhibits inflammatory responses in macrophages and dextran sodium sulfate-induced colitis in mice","volume":"10","author":"Jiang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.phytochem.2026.114986_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11418-018-1240-8","article-title":"Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana","volume":"73","author":"Kaennakam","year":"2019","journal-title":"J. Nat. Med."},{"key":"10.1016\/j.phytochem.2026.114986_bib17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jep.2005.11.034","article-title":"Medicinal plants: an important asset to health care in a region of Central Laos","volume":"106","author":"Libman","year":"2006","journal-title":"Ethnopharmacol"},{"key":"10.1016\/j.phytochem.2026.114986_bib18","doi-asserted-by":"crossref","first-page":"105092","DOI":"10.1016\/j.fitote.2021.105092","article-title":"Cytotoxic new caged-polyprenylated xanthonoids from Garcinia oligantha","volume":"156","author":"Liu","year":"2022","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.114986_bib19","first-page":"1497","article-title":"Chemical composition and cytotoxicity of Garcinia rubro-echinata, a western ghats endemic species","volume":"13","author":"Menon","year":"2018","journal-title":"Nat. Prod. Commun."},{"key":"10.1016\/j.phytochem.2026.114986_bib20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/acs.jnatprod.7b00454","article-title":"Bioassay- and chemistry-guided isolation of scalemic caged prenylxanthones from the leaves of Garcinia bracteata","volume":"81","author":"Niu","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114986_bib21","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1039\/C7OB01007A","article-title":"Neobraclactones A-C, three unprecedented chaise longue-shaped xanthones from Garcinia bracteata","volume":"15","author":"Niu","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2006-951748","article-title":"Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi","volume":"73","author":"Reutrakul","year":"2007","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.114986_bib23","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.phytochem.2007.05.024","article-title":"Cytotoxic caged-polyprenylated xanthonoids and a xanthone from Garcinia cantleyana","volume":"68","author":"Shadid","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114986_bib24","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1021\/acs.jnatprod.9b01106","article-title":"Picrorhizones A-H, polyprenylated benzoylphloroglucinols from the stem bark of Garcinia picrorhiza","volume":"83","author":"Sukandar","year":"2020","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114986_bib25","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/acs.jnatprod.6b00137","article-title":"Bioassay-guided isolation of prenylated xanthone derivatives from the leaves of Garcinia oligantha","volume":"79","author":"Tang","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.114986_bib26","doi-asserted-by":"crossref","first-page":"111536","DOI":"10.1016\/j.ejmech.2019.07.039","article-title":"Xanthone derivatives from the leaves of Garcina oligantha","volume":"181","author":"Tang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib27","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.2147\/DDDT.S258811","article-title":"Anti-tumor xanthones from Garcinia nujiangensis suppress proliferation, and induce apoptosis via PARP, PI3K\/AKT\/mTOR, and MAPK\/ERK signaling pathways in human ovarian cancers cells","volume":"14","author":"Tang","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.phytochem.2026.114986_bib28","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cclet.2008.06.013","article-title":"A new cytotoxic caged polyprenylated xanthone from the resin of Garcinia hanburyi","volume":"19","author":"Wang","year":"2008","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.phytochem.2026.114986_bib29","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/acs.orglett.9b00388","article-title":"Garsubelone A, the first dimeric polycyclic polyprenylated acylphloroglucinols with complicated heptacyclic architecture from Garcinia subelliptica","volume":"21","author":"Wang","year":"2019","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2026.114986_bib30","doi-asserted-by":"crossref","first-page":"104339","DOI":"10.1016\/j.bioorg.2020.104339","article-title":"Prenylated xanthones and benzophenones from the fruits of Garcinia bracteata and their potential antiproliferative and anti-inflammatory activities","volume":"104","author":"Xue","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib31","doi-asserted-by":"crossref","first-page":"112329","DOI":"10.1016\/j.phytochem.2020.112329","article-title":"Cytotoxic xanthone derivatives from the twigs of Garcinia oligantha","volume":"174","author":"Yang","year":"2020","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.114986_bib32","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1002\/cjoc.202100362","article-title":"Cytotoxic 7-methoxylated caged xanthones from the twigs of Garcinia oligantha","volume":"39","author":"Yang","year":"2021","journal-title":"Chin. J. Chem."},{"key":"10.1016\/j.phytochem.2026.114986_bib33","doi-asserted-by":"crossref","first-page":"10005","DOI":"10.1021\/acs.jmedchem.4c00140","article-title":"Thermal proteome profiling strategy identifies CNPY3 as a cellular target of gambogic acid for inducing prostate cancer pyroptosis","volume":"67","author":"Zhang","year":"2024","journal-title":"J. Med. Chem."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:18:54Z","timestamp":1784607534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226002190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"alternative-id":["S0031942226002190"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114986","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caged xanthones with cytotoxic activity from the leaves and twigs of Garcinia oligantha","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.114986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114986"}}