{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:11:51Z","timestamp":1792005111931,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.phytochem.2026.115026","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:21:03Z","timestamp":1784071263000},"page":"115026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Metabolomics-guided discovery of previously undescribed lupane-type triterpenoids with anti-inflammatory activity from Mallotus repandus (Willd.) M\u00fcll. Arg."],"prefix":"10.1016","volume":"251","author":[{"given":"Wenyi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinglong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-8891","authenticated-orcid":false,"given":"Fenfei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiubiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2894-4153","authenticated-orcid":false,"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.phytochem.2026.115026_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/plants10010119","article-title":"Sterols and triterpenes from Dobera glabra growing in Saudi Arabia and their cytotoxic activity","volume":"10","author":"Abdel-Mageed","year":"2021","journal-title":"Plants"},{"issue":"3","key":"10.1016\/j.phytochem.2026.115026_bib2","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/np50045a028","article-title":"Nepetidone and nepedinol, two new triterpenoids from Nepeta hindostana","volume":"49","author":"Ahmad","year":"1986","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115026_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117177","article-title":"The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds","volume":"178","author":"Bhol","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phytochem.2026.115026_bib4","series-title":"SpecDis Version 1.71","author":"Bruhn","year":"2017"},{"issue":"7","key":"10.1016\/j.phytochem.2026.115026_bib5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/1097-458X(200007)38:7<488::AID-MRC704>3.0.CO;2-G","article-title":"Assignment of 1H and 13C spectra and investigation of hindered side-chain rotation in lupeol derivatives","volume":"38","author":"Burns","year":"2000","journal-title":"Magn. Reson. Chem."},{"issue":"7","key":"10.1016\/j.phytochem.2026.115026_bib6","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/S0031-9422(82)85077-2","article-title":"Isolation of dihydroxylupene and dihydroxylupane from the bark of Lawsonia inermis","volume":"21","author":"Chakrabartty","year":"1982","journal-title":"Phytochemistry (Elsevier)"},{"issue":"38","key":"10.1016\/j.phytochem.2026.115026_bib7","article-title":"Quercetin inhibits TNF-\u03b1 induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.phytochem.2026.115026_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107918","article-title":"Structurally diverse phenylpropanoyl phloroglucinol derivatives from Mallotus philippensis and their anti-bacterial activities","volume":"153","author":"Chen","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"4","key":"10.1016\/j.phytochem.2026.115026_bib9","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/np0004808","article-title":"New peroxy triterpenes from the aerial roots of Ficus microcarpa","volume":"64","author":"Chiang","year":"2001","journal-title":"J. Nat. Prod."},{"issue":"24","key":"10.1016\/j.phytochem.2026.115026_bib11","first-page":"3302","article-title":"Chemical constituents from flowers of Chrysanthemum indicum","volume":"35","author":"Feng","year":"2010","journal-title":"China J. Chin. Mater. Med"},{"key":"10.1016\/j.phytochem.2026.115026_bib12","series-title":"Gaussian 16, Revision A.03","author":"Frisch","year":"2016"},{"issue":"12","key":"10.1016\/j.phytochem.2026.115026_bib13","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.phytochem.2026.115026_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.phytol.2017.10.014","article-title":"Unusual 28,29-nor-9,19 cycloartane triterpenoids from Chinese medical plant Streptocaulon griffithii Hook","volume":"22","author":"Ge","year":"2017","journal-title":"Phytochem. Lett."},{"key":"10.1016\/j.phytochem.2026.115026_bib15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s40610-025-00167-2","article-title":"Unravelling immunity: understanding inflammatory pathways as key players in immune response and disease progression","volume":"11","author":"Ghara","year":"2025","journal-title":"Curr. Mol. Bio. Rep."},{"key":"10.1016\/j.phytochem.2026.115026_bib16","article-title":"Analgesic and anti-inflammatory activities of leaf extract of Mallotus repandus (Willd.) Muell. Arg","author":"Hasan","year":"2014","journal-title":"BioMed Res. Int. 2014"},{"key":"10.1016\/j.phytochem.2026.115026_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s13596-018-0312-3","article-title":"Analgesic and anti-inflammatory activities of methanolic extract of Mallotus repandus stem in animal models","volume":"18","author":"Hasan","year":"2018","journal-title":"Orient. Pharm. Exp. Med."},{"issue":"4","key":"10.1016\/j.phytochem.2026.115026_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1055\/s-0028-1097397","article-title":"Mallorepine, cyano-gamma-pyridone from Mallotus repandus","volume":"33","author":"Hikino","year":"1978","journal-title":"Planta Med."},{"issue":"23","key":"10.1016\/j.phytochem.2026.115026_bib19","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.3390\/ijms20236008","article-title":"Cytokines in inflammatory disease","volume":"20","author":"Kany","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phytochem.2026.115026_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105373","article-title":"Lupeol and its derivatives as anticancer and anti-inflammatory agents: molecular mechanisms and therapeutic efficacy","volume":"164","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"7","key":"10.1016\/j.phytochem.2026.115026_bib21","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1021\/acs.jnatprod.3c00293","article-title":"Ursane-type triterpenes with a phenylpropanoid unit from Camellia ptilosperma and evaluation of their cytotoxic activities","volume":"86","author":"Ma","year":"2023","journal-title":"J. Nat. Prod."},{"issue":"3","key":"10.1016\/j.phytochem.2026.115026_bib22","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0031-9422(98)00167-8","article-title":"Bioactive polar triterpenoids from Melilotus messanensis","volume":"49","author":"Macias","year":"1998","journal-title":"Phytochemistry (Elsevier)"},{"issue":"8","key":"10.1016\/j.phytochem.2026.115026_bib23","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1080\/14786410903262865","article-title":"Rearrangement and oxidation of beta-amyrin promoted by growing cells of Lecanicillium muscarinium","volume":"24","author":"Martins","year":"2010","journal-title":"Nat. Prod. Res."},{"issue":"6","key":"10.1016\/j.phytochem.2026.115026_bib24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.cell.2010.03.006","article-title":"Inflammation 2010: new adventures of an old flame","volume":"140","author":"Medzhitov","year":"2010","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.phytochem.2026.115026_bib25","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1021\/acsomega.9b04189","volume":"5","author":"Mondal","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.phytochem.2026.115026_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.29090\/psa.2024.04.24.AP0726","article-title":"Quality control of Mallotus repandus stem samples collected in Thailand; pharmacognostic, physical and chemical characteristics","volume":"51","author":"Petchprayoon","year":"2024","journal-title":"Pharm. Sci. Asia."},{"issue":"8","key":"10.1016\/j.phytochem.2026.115026_bib27","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1135\/cccc19782190","article-title":"Preparation of 29-acetoxy-30-norlupan-20-one derivatives with the substituted ring C","volume":"43","author":"Pouzar","year":"1978","journal-title":"Collect. Czech Chem. Commun."},{"key":"10.1016\/j.phytochem.2026.115026_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117763","article-title":"Aqueous distillate of mature leaves of Vernonia zeylanica (L.) less. and Mallotus repandus (Rottler) M\u00fcll. Arg. cued from traditional medicine exhibits rapid wound healing properties","volume":"324","author":"Ratnayake","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.phytochem.2026.115026_bib29","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.3390\/ijerph18052262","article-title":"Indol-3-carbinol and quercetin ameliorate chronic DSS-induced colitis in C57BL\/6 mice by AhR-mediated anti-inflammatory mechanisms","volume":"18","author":"Riemschneider","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.phytochem.2026.115026_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11101-009-9152-6","article-title":"Mallotus species from Vietnamese mountainous areas: phytochemistry and pharmacological activities","volume":"9","author":"Rivi\u00e8re","year":"2010","journal-title":"Phytochem. Rev."},{"issue":"11","key":"10.1016\/j.phytochem.2026.115026_bib31","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"5","key":"10.1016\/j.phytochem.2026.115026_bib32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1021\/np0005560","article-title":"D:A Friedo-oleanane lactones from the stems of Mallotus repandus","volume":"64","author":"Sutthivaiyakit","year":"2001","journal-title":"J. Nat. Prod."},{"issue":"11","key":"10.1016\/j.phytochem.2026.115026_bib33","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.4049\/jimmunol.2100829","article-title":"Metabolic regulation of inflammation and its resolution: current status, clinical needs, challenges, and opportunities","volume":"207","author":"Tandon","year":"2021","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.phytochem.2026.115026_bib34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3897\/pharmacia.69.e86904","article-title":"Combination of selected Thai traditional pain relief medicinal plants with anti-inflammatory abilities in a protein denaturation assay","volume":"69","author":"Theanphong","year":"2022","journal-title":"Pharmacia"},{"issue":"8","key":"10.1016\/j.phytochem.2026.115026_bib35","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nbt.3597","article-title":"Sharing and community curation of mass spectrometry data with global natural products social molecular networking","volume":"34","author":"Wang","year":"2016","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/j.phytochem.2026.115026_bib36","article-title":"Chronic inflammation: a multidisciplinary analysis of shared pathways in autoimmune, infectious, and degenerative diseases","volume":"17","author":"Yacine","year":"2025","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.phytochem.2026.115026_bib37","first-page":"375","article-title":"Chemical constituents from Hypericum beanii","volume":"7","author":"Yang","year":"2015","journal-title":"Chin. Herb. Med."},{"issue":"8","key":"10.1016\/j.phytochem.2026.115026_bib38","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/cbdv.201400269","article-title":"Lupane- and friedelane-type triterpenoids from Celastrus stylosus","volume":"12","author":"Ying","year":"2015","journal-title":"Chem. Biodivers."},{"issue":"4","key":"10.1016\/j.phytochem.2026.115026_bib40","doi-asserted-by":"crossref","first-page":"324","DOI":"10.25135\/rnp.217.20.10.1854","article-title":"Chemical composition, and evaluation of antibacterial, antibiofilm and synergistic effects with conventional antibiotics of essential oil from Mallotus repandus","volume":"15","author":"Zhang","year":"2021","journal-title":"Record Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115026_bib39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.bse.2012.04.015","article-title":"A new triterpenoid and other constituents from the stem bark of Juglans mandshurica","volume":"44","author":"Zhang","year":"2012","journal-title":"Biochem. Systemat. Ecol."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T08:15:50Z","timestamp":1786695350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226002591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"alternative-id":["S0031942226002591"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115026","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics-guided discovery of previously undescribed lupane-type triterpenoids with anti-inflammatory activity from Mallotus repandus (Willd.) M\u00fcll. Arg.","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115026"}}