{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:11:25Z","timestamp":1788613885088,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22494693"],"award-info":[{"award-number":["22494693"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277074"],"award-info":[{"award-number":["22277074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22494694"],"award-info":[{"award-number":["22494694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22507073"],"award-info":[{"award-number":["22507073"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82425058"],"award-info":[{"award-number":["82425058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2024ZD0523103"],"award-info":[{"award-number":["2024ZD0523103"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011238","name":"Chinese Academy of Sciences Kunming Institute of Botany State Key Laboratory of Phytochemistry and Plant Resources in West China","doi-asserted-by":"publisher","award":["P2025-KF0X"],"award-info":[{"award-number":["P2025-KF0X"]}],"id":[{"id":"10.13039\/501100011238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.phytochem.2026.115040","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:36:19Z","timestamp":1785252979000},"page":"115040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Guaiane sesquiterpenes from Lindera glauca: isolation, structural elucidation, and hepatoprotective effect"],"prefix":"10.1016","volume":"252","author":[{"given":"Lan-Lan","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Nan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Jun","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2026.115040_bib1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s11101-015-9432-2","article-title":"The genus Lindera: a source of structurally diverse molecules having pharmacological significance","volume":"15","author":"Cao","year":"2016","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phytochem.2026.115040_bib2","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1021\/np900504a","article-title":"Chemical constituents of the bark of Machilus wangchiana and their biological activities","volume":"72","author":"Cheng","year":"2009","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115040_bib3","first-page":"6816","article-title":"Research progress on medicinal plants of genus Lindera and their sesquiterpenoids","volume":"50","author":"Guo","year":"2025","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.phytochem.2026.115040_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1021\/np500819f","article-title":"Mechanistic studies on the autoxidation of \u03b1-Guaiene: structural diversity of the sesquiterpenoid downstream products","volume":"78","author":"Huang","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115040_bib5","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1016\/j.apsb.2023.05.001","article-title":"A new class of potent liver injury protective compounds: structural elucidation, total synthesis and bioactivity study","volume":"13","author":"Ji","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.phytochem.2026.115040_bib6","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202300428RR","article-title":"HIF\u20101\u03b1 inhibition in macrophages preserves acute liver failure by reducing IL\u20101\u03b2 production","volume":"37","author":"Kong","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.phytochem.2026.115040_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105821","article-title":"Dimeric sesquiterpenoids and anti-inflammatory constituents of Sarcandra glabra","volume":"124","author":"Li","year":"2022","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1055\/s-2004-815540","article-title":"New lignans and cytotoxic constituents from Wikstroemia lanceolata","volume":"70","author":"Lin","year":"2004","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2026.115040_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105604","article-title":"Sesquiterpenoids from the roots of Aucklandia costus and their anti-inflammatory activities","volume":"169","author":"Lyu","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.115040_bib10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00044-019-02385-7","article-title":"Advance in biological activities of natural guaiane-type sesquiterpenes","volume":"28","author":"Ma","year":"2019","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.phytochem.2026.115040_bib11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.2174\/1568026621666210305102500","article-title":"Antidiabetic potential of naturally occurring sesquiterpenes: a review","volume":"21","author":"Maurya","year":"2021","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cmet.2018.01.007","article-title":"Digoxin suppresses pyruvate kinase M2-promoted HIF-1\u03b1 transactivation in steatohepatitis","volume":"27","author":"Ouyang","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.phytochem.2026.115040_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107135","article-title":"Glaucatotones A\u2212I: Guaiane-type sesquiterpenoids from the roots of Lindera glauca with anti-inflammatory activity","volume":"144","author":"Pan","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib14","doi-asserted-by":"crossref","first-page":"7249","DOI":"10.3390\/ijms22147249","article-title":"Liver injury and the macrophage issue: molecular and mechanistic facts and their clinical relevance","volume":"22","author":"Roohani","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.phytochem.2026.115040_bib15","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1039\/C9CC09159A","article-title":"Pseudoguaianelactones A\u2013C: three unusual sesquiterpenoids from Lindera glauca with anti-inflammatory activities by inhibiting the LPS-induced expression of iNOS and COX-2","volume":"56","author":"Ruan","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.phytochem.2026.115040_bib16","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.14309\/ajg.0000000000002340","article-title":"Acute liver failure guidelines","volume":"118","author":"Shingina","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.phytochem.2026.115040_bib17","doi-asserted-by":"crossref","first-page":"13466","DOI":"10.1021\/acs.joc.0c01491","article-title":"Artatrovirenols A and B: two cagelike sesquiterpenoids from Artemisia atrovirens","volume":"85","author":"Su","year":"2020","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.phytochem.2026.115040_bib19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/hlca.201200408","article-title":"Unusual guaiane sesquiterpenoids from Artemisia rupestris","volume":"96","author":"Xie","year":"2013","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.phytochem.2026.115040_bib20","first-page":"122","article-title":"Rupestonic acid, a new sesquiterpene from Artemisia rupestris L","volume":"23","author":"Xu","year":"1988","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.phytochem.2026.115040_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108376","article-title":"Acronynoids A\u2013G, novel prenylated acetophenone-based meroterpenoids with angiogenesis inhibitory activities from Acronychia pedunculata","volume":"159","author":"Yang","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib22","article-title":"Artificial cells delivering itaconic acid induce anti-inflammatory memory-like macrophages to reverse acute liver failure and prevent reinjury","volume":"4","author":"Yin","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.phytochem.2026.115040_bib23","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1007\/s12272-016-0838-1","article-title":"A new rearranged eudesmane sesquiterpene and bioactive sesquiterpenes from the twigs of Lindera glauca (Sieb. et Zucc.) Blume","volume":"39","author":"Yu","year":"2016","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.phytochem.2026.115040_bib24","first-page":"408","article-title":"Studies on chemical constituents of Artemisia rupestris L","volume":"39","author":"Zhang","year":"2016","journal-title":"J. Xinjiang Med. Univ."},{"key":"10.1016\/j.phytochem.2026.115040_bib25","doi-asserted-by":"crossref","first-page":"15298","DOI":"10.1021\/acs.joc.1c01880","article-title":"Three unusual sesquiterpenes with distinctive ring skeletons from Daphne penicillata uncovered by molecular networking strategies","volume":"86","author":"Zhao","year":"2021","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.phytochem.2026.115040_bib26","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1039\/C9CC02681A","article-title":"Triangeliphthalides A\u2013D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism","volume":"55","author":"Zou","year":"2019","journal-title":"Chem. Commun."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T12:11:53Z","timestamp":1788610313000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226002736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":26,"alternative-id":["S0031942226002736"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115040","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Guaiane sesquiterpenes from Lindera glauca: isolation, structural elucidation, and hepatoprotective effect","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115040"}}