{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:40:05Z","timestamp":1792471205189,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014136","name":"Central Asian Center of Drug Discovery and Development, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0205600"],"award-info":[{"award-number":["2020YFE0205600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.phytochem.2026.115063","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:40:53Z","timestamp":1787409653000},"page":"115063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Discovery of myrsinane diterpenoids from Euphorbia monostyla with cytotoxic potential"],"prefix":"10.1016","volume":"253","author":[{"given":"Atabay","family":"Kokanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hequn","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artyk","family":"Kokanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-3925","authenticated-orcid":false,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2026.115063_bib1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/01616412.2017.1376789","article-title":"TAMEC: a new analogue of cyclomyrsinol diterpenes decreases anxiety- and depression-like behaviors in a mouse model of multiple sclerosis","volume":"39","author":"Ayatollahi","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.phytochem.2026.115063_bib2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.biopha.2017.03.072","article-title":"Antioxidant and selective anticancer activities of two Euphorbia species in human acute myeloid leukemia","volume":"90","author":"Ben Jannet","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.phytochem.2026.115063_bib3","series-title":"Medicinal Plants of Turkmenistan. IV, T\u00fcrkmenistany\u0148 Dermanlyk \u00d6s\u00fcmlikleri","author":"Berdimuhamedow","year":"2012"},{"key":"10.1016\/j.phytochem.2026.115063_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: a complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.phytochem.2026.115063_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/metabo11010015","article-title":"Cytotoxic activity and metabolic profiling of fifteen Euphorbia species","volume":"11","author":"El-Hawary","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.phytochem.2026.115063_bib6","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1021\/acs.jnatprod.7b00233","article-title":"Isolation of premyrsinane, myrsinane, and tigliane diterpenoids from Euphorbia pithyusa using a Chikungunya virus cell-based assay and analogue annotation by molecular networking","volume":"80","author":"Esposito","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib7","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1021\/acs.jnatprod.9b00343","article-title":"Lathyrane, premyrsinane, and related diterpenes from Euphorbia boetica : effect on in vitro neural progenitor cell proliferation","volume":"82","author":"Flores-Giubi","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib8","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jnatprod.5c01408","article-title":"Discovery of myrsinane diterpenoids from Euphorbia prolifera as a new type of antiliver fibrosis agents that inhibit the PI3K-AKT signaling pathway","author":"Gan","year":"2026","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2025.106525","article-title":"Tigliane and premyrsinane diterpenoids from Euphorbia monostyla and their cytotoxic activity","volume":"183","author":"Kokanov","year":"2025","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.115063_bib10","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s10600-025-04865-2","article-title":"Chemical composition of Euphorbia monostyla and their biological activity","volume":"61","author":"Kokanov","year":"2025","journal-title":"Chem. Nat. Compd."},{"key":"10.1016\/j.phytochem.2026.115063_bib11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1107\/S1600576715005580","article-title":"DSR: enhanced modelling and refinement of disordered structures with SHELXL","volume":"48","author":"Kratzert","year":"2015","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.phytochem.2026.115063_bib12","first-page":"147","article-title":"Myrsinane-type diterpenes: a comprehensive review on structural diversity, chemistry and biological activities","volume":"25","author":"Mendes","year":"2023","journal-title":"Int. J. Math. Stat."},{"key":"10.1016\/j.phytochem.2026.115063_bib13","series-title":"\u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0438\u0442\u0435\u043b\u044c \u0420\u0430\u0441\u0442\u0435\u043d\u0438\u0439 \u0422\u0443\u0440\u043a\u043c\u0435\u043d\u0438\u0441\u0442\u0430\u043d\u0430","author":"Nikitin","year":"1988"},{"key":"10.1016\/j.phytochem.2026.115063_bib14","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1021\/acs.jnatprod.8b00916","article-title":"Investigation of premyrsinane and myrsinane esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and combinatorial molecular network annotation propagation","volume":"82","author":"Nothias-Esposito","year":"2019","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib15","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/0031-9422(94)00806-5","article-title":"Four diterpene esters from Euphorbia myrsinites","volume":"38","author":"\u00d6ks\u00fcz","year":"1995","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2026.115063_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104636","article-title":"Kopetdaghinanes, pro-apoptotic hemiacetialic cyclomyrsinanes from Euphorbia kopetdaghi","volume":"146","author":"Riahi","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.115063_bib17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/14786419.2014.979418","article-title":"New macrocyclic diterpenes from Euphorbia connata Boiss. with cytotoxic activities on human breast cancer cell lines","volume":"29","author":"Shadi","year":"2015","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2026.115063_bib18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1107\/S2053273314026370","article-title":"Crystal structure solution with ShelXT","volume":"71","author":"Sheldrick","year":"2015","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.phytochem.2026.115063_bib19","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.fitote.2010.05.015","article-title":"Diterpenoid (poly)esters and a ring A-seco-phorboid from the aerial parts of Euphorbia macroclada Boiss","volume":"81","author":"Shokoohinia","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.phytochem.2026.115063_bib20","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1021\/acs.jmedchem.8b01693","article-title":"Tigliane diterpenoids as a new type of antiadipogenic agents inhibit GR\u03b1-Dexras1 axis in adipocytes","volume":"62","author":"Song","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phytochem.2026.115063_bib21","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jnatprod.5c01467","article-title":"Bistaxascendins A\u2013G, abietane diterpenoid dimers from Taxodium ascendens , inducing mitophagy in colorectal cancer cells","author":"Tu","year":"2026","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib22","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/acs.jnatprod.6b00260","article-title":"Myrsinane, premyrsinane, and cyclomyrsinane diterpenes from Euphorbia falcata as potassium ion channel inhibitors with selective G protein-activated inwardly rectifying ion channel (GIRK) blocking effects","volume":"79","author":"Vasas","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib23","doi-asserted-by":"crossref","first-page":"8579","DOI":"10.1021\/cr400541j","article-title":"Euphorbia diterpenes: isolation, structure, biological activity, and synthesis (2008\u20132012)","volume":"114","author":"Vasas","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.phytochem.2026.115063_bib24","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1007\/s11101-025-10100-1","article-title":"Diterpenoids from Euphorbia lathyris L.: a comprehensive review update","volume":"24","author":"Wang","year":"2025","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phytochem.2026.115063_bib25","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1021\/acs.jnatprod.3c00822","article-title":"Discovery of ingenane diterpenoids from Euphorbia hylonoma as antiadipogenic agents","volume":"86","author":"Wu","year":"2023","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106595","article-title":"Discovery of myrsinane-type Euphorbia diterpene derivatives through a skeleton conversion strategy from lathyrane diterpene for the treatment of Alzheimer's disease","volume":"138","author":"Xiao","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.phytochem.2026.115063_bib27","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1021\/np200591h","article-title":"Bioactive myrsinol diterpenoids from the roots of Euphorbia prolifera","volume":"74","author":"Xu","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2026.115063_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104788","article-title":"Novel PROTACs for degradation of SHP2 protein","volume":"110","author":"Zheng","year":"2021","journal-title":"Bioorg. Chem."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942226002967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:19:34Z","timestamp":1792469974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942226002967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":28,"alternative-id":["S0031942226002967"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115063","relation":{"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/www.ccdc.cam.ac.uk\/structures\/search?access=referee&ccdc=2429267&author=atabay+kokanov","asserted-by":"subject"}]},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of myrsinane diterpenoids from Euphorbia monostyla with cytotoxic potential","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2026.115063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115063"}}