{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:20:14Z","timestamp":1785511214406,"version":"3.56.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Laboratory Medicine"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.plabm.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,11,26]],"date-time":"2017-11-26T20:17:34Z","timestamp":1511727454000},"page":"15-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Simple and rapid validated HPLC-fluorescence determination of perampanel in the plasma of patients with epilepsy"],"prefix":"10.1016","volume":"10","author":[{"given":"Susan","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmina","family":"Candela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Contin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plabm.2017.11.003_bib1","series-title":"Fycompa: Summary of Product Characteristics","author":"European Medicines Agency","year":"2012"},{"key":"10.1016\/j.plabm.2017.11.003_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/epi.12865","article-title":"The clinical pharmacology profile of the new antiepileptic drug, Perampanel","volume":"56","author":"Patsalos","year":"2015","journal-title":"Epilepsia"},{"key":"10.1016\/j.plabm.2017.11.003_bib3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/FTD.0000000000000274","article-title":"Perampanel serum concentrations in adults with epilepsy: effect of dose, age, sex, and concomitant anti-epileptic drugs","volume":"38","author":"Patsalos","year":"2016","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.plabm.2017.11.003_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eplepsyres.2016.08.021","article-title":"Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies \u2013 an Italian observational multicenter study","volume":"27","author":"De Liso","year":"2016","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.plabm.2017.11.003_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/ane.12529","article-title":"Perampanel for focal epilepsy: insights from early clinical experience","volume":"133","author":"Trinka","year":"2016","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.plabm.2017.11.003_bib6","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/epi.12240","article-title":"Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures","volume":"54","author":"Gidal","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.plabm.2017.11.003_bib7","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/bmc.3463","article-title":"HPLC with fluorescence detection assay of perampanel, a novel AMPA receptor antagonist, in human plasma for clinical pharmacokinetic studies","volume":"29","author":"Mano","year":"2015","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.plabm.2017.11.003_bib8","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/bmc.3764","article-title":"An inter-laboratory cross-validation study for determination of perampanel in human plasma by liquid chromatography assays","volume":"30","author":"Mano","year":"2016","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.plabm.2017.11.003_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpba.2014.12.018","article-title":"High-performance liquid chromatography-tandem mass spectrometry method for the determination of perampanel, a novel \u03b1- amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma","volume":"107","author":"Mano","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.plabm.2017.11.003_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/FTD.0000000000000350","article-title":"Development and validation of an HPLC-UV assay for the therapeutic monitoring of the new antiepileptic drug perampanel in human plasma","volume":"38","author":"Franco","year":"2016","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.plabm.2017.11.003_bib11","unstructured":"EMEA\/CHMP\/EWP\/192217\/2009, Committee for Medicinal Products for Human Use (CHMP), Guideline on Bioanalytical Method Validation, 2011, pp. 1\u201322."},{"key":"10.1016\/j.plabm.2017.11.003_bib12","unstructured":"International Conference on Harmonisation, ICH Harmonised Tripartite Guideline prepared within the Third International Conference on Harmonisation of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH), Validation of Analytical Procedures: Methodology, 1996, pp. 1\u201313."},{"key":"10.1016\/j.plabm.2017.11.003_bib13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0731-7085(00)00529-X","article-title":"Guidance for robustness\/ruggedness tests in method validation","volume":"24","author":"Vander Heyden","year":"2001","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.plabm.2017.11.003_bib14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/157015910792246254","article-title":"Landmark, antiepileptic drug interactions - principles and clinical implications","volume":"8","author":"Johannessen","year":"2010","journal-title":"Curr. Neuropharmacol."}],"container-title":["Practical Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352551717300768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352551717300768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:16:01Z","timestamp":1542845761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352551717300768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":14,"alternative-id":["S2352551717300768"],"URL":"https:\/\/doi.org\/10.1016\/j.plabm.2017.11.003","relation":{},"ISSN":["2352-5517"],"issn-type":[{"value":"2352-5517","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simple and rapid validated HPLC-fluorescence determination of perampanel in the plasma of patients with epilepsy","name":"articletitle","label":"Article Title"},{"value":"Practical Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plabm.2017.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}