{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:32:12Z","timestamp":1793291532383,"version":"4.5.0"},"reference-count":15,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Practical Laboratory Medicine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.plabm.2026.e00561","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:55:19Z","timestamp":1791215719000},"page":"e00561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A new indicator of cobalamin deficiency"],"prefix":"10.1016","volume":"52","author":[{"given":"Arne","family":"\u00c5sberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8yvind","family":"Skadberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.plabm.2026.e00561_bib1","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plabm.2026.e00561_bib2","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1515\/cclm-2025-1722","article-title":"Optimizing diagnostic thresholds of total vitamin B12 (B12) for identifying cobalamin deficiency in adults with macrocytic anemia","volume":"64","author":"Pelloso","year":"2026","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1056\/NEJMcp1113996","article-title":"Clinical practice. Vitamin B12 deficiency","volume":"368","author":"Stabler","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.mayocpiqo.2019.03.002","article-title":"The many faces of cobalamin (vitamin B12) deficiency","volume":"3","author":"Wolffenbuttel","year":"2019","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"10.1016\/j.plabm.2026.e00561_bib5","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1515\/cclm-2025-0939","article-title":"Assessing the harmonization of current total vitamin B12 measurement methods: relevance and implications","volume":"63","author":"Cesana","year":"2025","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fmolb.2016.00027","article-title":"Biomarkers and algorithms for the diagnosis of vitamin B12 deficiency","volume":"3","author":"Hannibal","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.plabm.2026.e00561_bib7","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1515\/cclm-2014-0818","article-title":"Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points","volume":"53","author":"Fedosov","year":"2015","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib8","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/ajcn\/nqab122","article-title":"Fewer US adults had low or transitional vitamin B12 status based on the novel combined indicator of vitamin B12 status compared with individual, conventional markers, NHANES 1999\u20132004","volume":"114","author":"Mineva","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.plabm.2026.e00561_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00365513.2025.2463084","article-title":"Three new tools to diagnose B12 deficiency: e-adjusted methylmalonic acid (MMA100), a bivariate reference area for MMA100 and cobalamin, and a cobalamin deficiency index","volume":"85","author":"\u00c5sberg","year":"2025","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.plabm.2026.e00561_bib10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/00365513.2025.2585469","article-title":"Testing MMA100 \u2013 the eGFR-adjusted concentration of methylmalonic acid in plasma","volume":"85","author":"\u00c5sberg","year":"2025","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.plabm.2026.e00561_bib11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.7326\/M20-4366","article-title":"Development and validation of a modified full age spectrum creatinine-based equation to estimate glomerular filtration rate: a cross-sectional analysis of pooled data","volume":"174","author":"Pottel","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1055\/s-0038-1634008","article-title":"Building multivariable regression models with continuous covariates in clinical epidemiology\u2014with an emphasis on fractional polynomials","volume":"44","author":"Royston","year":"2005","journal-title":"Methods Inf. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/jalm\/jfac101","article-title":"Estimation of reference intervals from routine data using the refineR algorithm\u2014a practical guide","volume":"8","author":"Ammer","year":"2023","journal-title":"J. Appl. Lab. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM197507312930505","article-title":"Therapeutic decision making: a cost-benefit analysis","volume":"293","author":"Pauker","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.plabm.2026.e00561_bib15","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1056\/NEJM198005153022003","article-title":"The threshold approach to clinical decision making","volume":"302","author":"Pauker","year":"1980","journal-title":"N. Engl. J. Med."}],"container-title":["Practical Laboratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352551726000430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352551726000430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:41:22Z","timestamp":1793288482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352551726000430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":15,"alternative-id":["S2352551726000430"],"URL":"https:\/\/doi.org\/10.1016\/j.plabm.2026.e00561","relation":{},"ISSN":["2352-5517"],"issn-type":[{"value":"2352-5517","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new indicator of cobalamin deficiency","name":"articletitle","label":"Article Title"},{"value":"Practical Laboratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.plabm.2026.e00561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"e00561"}}