{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:45:13Z","timestamp":1791002713462,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.placenta.2004.01.005","type":"journal-article","created":{"date-parts":[[2004,2,27]],"date-time":"2004-02-27T05:22:03Z","timestamp":1077859323000},"page":"S93-S101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":170,"special_numbering":"S","title":["Circulating Fetal DNA: Its Origin and Diagnostic Potential\u2014A Review"],"prefix":"10.1016","volume":"25","author":[{"given":"D.W.","family":"Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2004.01.005_BIB1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1046\/j.1365-2141.1999.01383.x","article-title":"Fetal cells in the maternal circulation: feasibility for prenatal diagnosis","volume":"105","author":"Bianchi","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/514885","article-title":"PCR quantitation of fetal cells in maternal blood in normal and aneuploid pregnancies","volume":"61","author":"Bianchi","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB3","first-page":"972","article-title":"Microsatellite alterations in plasma DNA of small lung cancer patients","volume":"2","author":"Chen","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.placenta.2004.01.005_BIB4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nm0996-1035","article-title":"Microsatellite alterations in serum DNA of head and neck cancer patients","volume":"2","author":"Nawroz","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.placenta.2004.01.005_BIB5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB6","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1086\/301800","article-title":"Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis","volume":"62","author":"Lo","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB7","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/clinchem\/46.12.1903","article-title":"Fetal DNA in maternal plasma: biology and diagnostic applications","volume":"46","author":"Lo","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/302205","article-title":"Rapid clearance of fetal DNA from maternal plasma","volume":"64","author":"Lo","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB9","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/excr.2000.5027","article-title":"Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis","volume":"260","author":"Halicka","year":"2000","journal-title":"Exp Cell Res"},{"issue":"Suppl","key":"10.1016\/j.placenta.2004.01.005_BIB10","first-page":"189","article-title":"Fetal DNA in maternal plasma circulates as apoptotic bodies: elucidation of the structural nature of fetal DNA for non-invasive prenatal genetic diagnosis","volume":"73","author":"Bischoff","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000213536","article-title":"PlasmaDNA as cell death marker in elderly patients","volume":"39","author":"Fournie","year":"1993","journal-title":"Gerontology"},{"key":"10.1016\/j.placenta.2004.01.005_BIB12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/1097-0223(200011)20:11<886::AID-PD942>3.0.CO;2-4","article-title":"Apoptosis in fetal nucleated erythrocytes circulating in maternal blood","volume":"20","author":"Sekizawa","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2004.01.005_BIB13","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/clinchem\/47.10.1870","article-title":"More than one-half of the erythroblasts in the fetal circulation and cord blood are TUNEL positive","volume":"47","author":"Hristoskova","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB14","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/clinchem\/46.5.729","article-title":"Detection of apoptotic fetal cells in plasma of pregnant women","volume":"46","author":"Van Wijk","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1749-6632.2001.tb03872.x","article-title":"Fetomaternal cellular and plasma DNA trafficking: the Yin and the Yang","volume":"945","author":"Bianchi","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.placenta.2004.01.005_BIB16","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/molehr\/8.9.864","article-title":"Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts","volume":"8","author":"Zhong","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2004.01.005_BIB17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1373\/49.1.195","article-title":"Fetal cell-free plasma DNA concentrations in maternal blood are stable 24 hours after collection: analysis of first- and third-trimester samples","volume":"49","author":"Angert","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00439-001-0649-3","article-title":"Fetal gender determination in early pregnancy through qualitative and quantitative analysis of fetal DNA in maternal serum","volume":"110","author":"Honda","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB19","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1373\/49.4.678","article-title":"Serial analysis of fetal DNA concentrations in maternal plasma in late pregnancy","volume":"49","author":"Chan","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB20","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/humrep\/deg320","article-title":"Kinetics of SRY gene appearance in maternal serum: detection by real time PCR in early pregnancy after assisted reproductive technique","volume":"18","author":"Guibert","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2004.01.005_BIB21","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1093\/clinchem\/47.12.2164","article-title":"Cell-free fetal DNA is increased in plasma of women with hyperemesis gravidarum","volume":"47","author":"Sekizawa","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB22","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/clinchem\/48.2.386","article-title":"Correlation of fetal DNA and human chorionic gonadotropin concentrations in second-trimester maternal serum","volume":"48","author":"Ohashi","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB23","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.1073\/pnas.0637450100","article-title":"mRNA of placental origin is readily detectable in maternal plasma","volume":"100","author":"Ng","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2004.01.005_BIB24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00439-002-0725-3","article-title":"Presence of fetal DNA in maternal plasma decades after pregnancy","volume":"110","author":"Invernizzi","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00439-003-0931-7","article-title":"Fetal DNA in maternal serum: does it persist after pregnancy?","volume":"113","author":"Benachi","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00439-002-0796-1","article-title":"Evidence against the long-term persistence of fetal DNA in maternal plasma after pregnancy","volume":"111","author":"Johnson-Hopson","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB27","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00439-003-0919-3","article-title":"No evidence of fetal DNA persistence in maternal plasma after pregnancy","volume":"112","author":"Smid","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00439-002-0797-0","article-title":"Presence of fetal DNA in maternal plasma decades after pregnancy: further comments","volume":"111","author":"Invernizzi","year":"2002","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB29","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/clinchem\/47.9.1607","article-title":"Effects of blood-processing protocols on fetal and total DNA quantification in maternal plasma","volume":"47","author":"Chiu","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1073\/pnas.93.2.705","article-title":"Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum","volume":"93","author":"Bianchi","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2004.01.005_BIB31","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.V93.6.2033.406k18_2033_2037","article-title":"Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma","volume":"93","author":"Evans","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.placenta.2004.01.005_BIB32","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2003.07.028","article-title":"Cell-free fetal DNA levels in maternal plasma after elective first trimester termination of pregnancy","author":"Wataganara","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.placenta.2004.01.005_BIB33","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1373\/49.9.1526","article-title":"Fetal DNA in maternal plasma in twin pregnancies","volume":"49","author":"Smid","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB34","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00439-003-0987-4","article-title":"Evaluation of bidirectional transfer of plasma DNA through placenta","volume":"113","author":"Sekizawa","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB35","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1093\/clinchem\/47.10.1867","article-title":"Large amounts of cell-free fetal DNA are present in amniotic fluid","volume":"47","author":"Bianchi","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB36","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/clinchem\/46.8.1078","article-title":"Genetic analysis of DNA extracted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism","volume":"46","author":"Botezatu","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/pd.69","article-title":"Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction","volume":"21","author":"Al-Yatama","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2004.01.005_BIB38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2003.10.562","article-title":"Cell-free fetal DNA in the cerebrospinal fluid of peripartum women","author":"Angert","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0301-2115(02)00262-2","article-title":"Detection of fetal DNA in the peritoneal cavity during pregnancy","volume":"107","author":"Cioni","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB40","first-page":"483","article-title":"Fetal DNA in maternal plasma: emerging clinical applications","volume":"98","author":"Pertl","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s004399900166","article-title":"Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amplification of short tandem repeats","volume":"106","author":"Pertl","year":"2000","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/clinchem\/48.1.35","article-title":"Differential DNA methylation between fetus and mother as a strategy for detecting fetal DNA in maternal plasma","volume":"48","author":"Poon","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB43","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1373\/49.5.727","article-title":"The concentration of circulating corticotrophin-releasing hormone mRNA in maternal plasma is increased in preeclampsia","volume":"49","author":"Ng","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB44","first-page":"374","article-title":"Fetal sex determination from maternal plasma in pregnancies at risk for congenital adrenal hyperplasia","volume":"98","author":"Rijnders","year":"2001","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB45","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1093\/clinchem\/48.5.689","article-title":"Prenatal exclusion of recessively inherited disorders: should maternal plasma analysis precede invasive techniques?","volume":"48","author":"Bianchi","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB46","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1093\/clinchem\/45.10.1747","article-title":"Increased fetal DNA concentrations in the plasma of pregnant women carrying fetuses with trisomy 21","volume":"45","author":"Lo","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB47","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/1097-0223(200010)20:10<795::AID-PD897>3.0.CO;2-P","article-title":"Fetal DNA in maternal plasma is elevated in pregnancies with aneuploid fetuses","volume":"20","author":"Zhong","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2004.01.005_BIB48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s004390100457","article-title":"Quantitation of fetal DNA in maternal serum in normal and aneuploid pregnancies","volume":"108","author":"Ohashi","year":"2001","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB49","doi-asserted-by":"crossref","unstructured":"Spencer K, de Kok JB, Swinkels DW. Increased total cell-free DNA in the serum of pregnant women carrying a fetus affected by trisomy 21. Prenat Diagn 2003;23:580\u2013583.","DOI":"10.1002\/pd.647"},{"key":"10.1016\/j.placenta.2004.01.005_BIB50","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1067\/mob.2002.127462","article-title":"Down syndrome and cell-free fetal DNA in archived maternal serum","volume":"187","author":"Lee","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB51","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s00439-002-0853-9","article-title":"Maternal serum cell-free fetal DNA levels are increased in cases of trisomy 13 but not trisomy 18","volume":"112","author":"Wataganara","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1373\/49.2.239","article-title":"Evaluation of cell-free fetal DNA as a second-trimester maternal serum marker of Down syndrome pregnancy","volume":"49","author":"Farina","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/pd.262","article-title":"Testing normality of fetal DNA concentration in maternal plasma at 10\u201312 completed weeks' gestation: a preliminary approach to a new marker for genetic screening","volume":"22","author":"Farina","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2004.01.005_BIB54","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1093\/clinchem\/47.5.937","article-title":"Fetal DNA analyzed in plasma from a mother's three consecutive pregnancies to detect paternally inherited aneuploidy","volume":"47","author":"Chen","year":"2001","journal-title":"Clin Chem"},{"issue":"Suppl","key":"10.1016\/j.placenta.2004.01.005_BIB55","first-page":"599","article-title":"The prenatal molecular karyotype: DNA microarray analysis of cell-free fetal DNA (cffDNA) in amniotic fluid","volume":"73","author":"Larrabee","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB56","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/clinchem\/45.2.184","article-title":"Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia","volume":"45","author":"Lo","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB57","first-page":"669","article-title":"Disturbed feto-maternal cell traffic in preeclampsia","volume":"91","author":"Holzgreve","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB58","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1067\/mob.2001.109594","article-title":"Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia","volume":"184","author":"Zhong","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB59","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/clinchem\/48.4.650","article-title":"Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum","volume":"48","author":"Swinkels","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/8.6.501","article-title":"Fetal cells and cell-free fetal DNA in maternal blood: new insight into pre-eclampsia","volume":"8","author":"Hahn","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.placenta.2004.01.005_BIB61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/clinchem\/47.1.137","article-title":"Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia","volume":"47","author":"Leung","year":"2001","journal-title":"Clin Chem"},{"issue":"Suppl","key":"10.1016\/j.placenta.2004.01.005_BIB62","first-page":"S55","article-title":"Two stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia","volume":"187","author":"Levine","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB63","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1086\/301809","article-title":"Fetal DNA in maternal plasma: the plot thickens and the placental barrier thins","volume":"62","author":"Bianchi","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB64","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1016\/S0140-6736(05)60395-9","article-title":"Maternal plasma fetal DNA as a marker for preterm labour","volume":"352","author":"Leung","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB65","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/clinchem\/48.2.353","article-title":"Increased cell-free fetal DNA in plasma of two women with invasive placenta","volume":"48","author":"Sekizawa","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB66","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1067\/mob.2003.27","article-title":"Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restriction","volume":"188","author":"Sekizawa","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB67","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1056\/NEJM199812103392402","article-title":"Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma","volume":"339","author":"Lo","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.placenta.2004.01.005_BIB68","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(05)60534-X","article-title":"Detection of fetal RHD-specific sequences in maternal plasma","volume":"352","author":"Faas","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB69","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107155769900600203","article-title":"Noninvasive determination of fetal RhD status using fetal DNA in maternal serum and PCR","volume":"6","author":"Bischoff","year":"1999","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.placenta.2004.01.005_BIB70","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1471-0528.2000.tb13338.x","article-title":"Detection of fetal Rhesus D and sex using fetal DNA from maternal plasma by multiplex polymerase chain reaction","volume":"107","author":"Zhong","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.placenta.2004.01.005_BIB71","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2141.2002.03780.x","article-title":"Fetal RhD genotyping in maternal serum during the first trimester of pregnancy","volume":"119","author":"Costa","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB72","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0301-2115(02)00356-1","article-title":"Detection of fetal Rhesus D gene in whole blood of women booking for routine antenatal care","volume":"108","author":"Turner","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.placenta.2004.01.005_BIB73","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1046\/j.1537-2995.2002.00165.x","article-title":"Prediction of fetal D status from maternal plasma: introduction of a new noninvasive fetal RHD genotyping service","volume":"42","author":"Finning","year":"2002","journal-title":"Transfusion"},{"key":"10.1016\/j.placenta.2004.01.005_BIB74","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/clinchem\/46.2.301","article-title":"Prenatal diagnosis of myotonic dystrophy using fetal DNA obtained from maternal plasma","volume":"46","author":"Amicucci","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB75","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/S0140-6736(00)02767-7","article-title":"Prenatal DNA diagnosis of a single-gene disorder from maternal plasma","volume":"356","author":"Saito","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB76","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/pd.439","article-title":"Prenatal detection of a cystic fibrosis mutation in fetal DNA from maternal plasma","volume":"22","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2004.01.005_BIB77","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/clinchem\/48.5.778","article-title":"Noninvasive prenatal exclusion of congenital adrenal hyperplasia by maternal plasma analysis: a feasibility study","volume":"48","author":"Chiu","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB78","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0140-6736(02)11086-5","article-title":"Prenatal exclusion of beta thalassaemia major by examination of maternal plasma","volume":"360","author":"Chiu","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2004.01.005_BIB79","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/clinchem\/46.11.1832","article-title":"Presence of fetal RNA in maternal plasma","volume":"46","author":"Poon","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2004.01.005_BIB80","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/clinchem\/48.10.1647","article-title":"Stability of endogenous and added RNA in blood specimens, serum, and plasma","volume":"48","author":"Tsui","year":"2002","journal-title":"Clin Chem"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400404000190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400404000190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:31:26Z","timestamp":1758907886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400404000190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":80,"alternative-id":["S0143400404000190"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2004.01.005","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating Fetal DNA: Its Origin and Diagnostic Potential\u2014A Review","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2004.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}