{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T01:08:08Z","timestamp":1787620088881,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"4-5","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2006,4]]},"DOI":"10.1016\/j.placenta.2005.04.008","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T17:24:29Z","timestamp":1122571469000},"page":"432-437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Umbilical Cord Serum Activin A Levels are Increased in Pre-eclampsia with Impaired Blood Flow in the Uteroplacental and Fetal Circulation"],"prefix":"10.1016","volume":"27","author":[{"given":"P.","family":"Florio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.M.","family":"Severi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Luisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Imperatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Gioffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Petraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2005.04.008_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/eje.0.1450225","article-title":"Expression and secretion of activin A: possible physiological and clinical implications","volume":"145","author":"Luisi","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/321776a0","article-title":"Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid","volume":"321","author":"Vale","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2005.04.008_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mce.2004.02.018","article-title":"Inhibins and activins in pregnancy","volume":"225","author":"Florio","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1210\/edrv.23.2.0459","article-title":"Predictive value of hormone measurements in maternal and fetal complications of pregnancy","volume":"23","author":"Reis","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.placenta.2005.04.008_bib5","first-page":"558","article-title":"Abnormal concentration of maternal serum activin A in gestational diseases","volume":"80","author":"Petraglia","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2005.04.008_bib6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1071-5576(03)00047-9","article-title":"Concentrations of serum total activin A and inhibin A in preterm and term labor patients: a cross-sectional study","volume":"10","author":"Plevyak","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.placenta.2005.04.008_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of pre-eclampsia","volume":"357","author":"Roberts","year":"2001","journal-title":"Lancet"},{"issue":"Suppl A","key":"10.1016\/j.placenta.2005.04.008_bib8","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1053\/plac.2002.0930","article-title":"Pre-eclampsia, the placenta and the maternal systemic inflammatory response \u2013 a review","volume":"24","author":"Redman","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2005.04.008_bib9","doi-asserted-by":"crossref","first-page":"F170","DOI":"10.1136\/fn.85.3.F170","article-title":"The relation between pre-eclampsia at term and neonatal encephalopathy","volume":"85","author":"Impey","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.placenta.2005.04.008_bib10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1210\/endo.142.2.8110","article-title":"Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E2","volume":"142","author":"Jenkin","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2005.04.008_bib11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1203\/01.PDR.0000086905.71963.1D","article-title":"Activin a plasma levels at birth: an index of fetal hypoxia in preterm newborn","volume":"54","author":"Florio","year":"2003","journal-title":"Pediatr Res"},{"key":"10.1016\/j.placenta.2005.04.008_bib12","first-page":"181","article-title":"Inhibin A, inhibin B and activin A concentrations in umbilical cord artery and vein","volume":"17","author":"Florio","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib13","first-page":"1039","article-title":"National diabetes data group classification and diagnosis of diabetes mellitus and other categories of glucose intolerance","volume":"28","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.placenta.2005.04.008_bib14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the National high blood pressure education program working group on high blood pressure in pregnancy","volume":"183","author":"National High Blood Pressure Education Program","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.04.008_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1469-0705.2002.00652.x","article-title":"Uterine and fetal cerebral Doppler predict the outcome of third-trimester small-for-gestational age fetuses with normal umbilical artery Doppler","volume":"19","author":"Severi","year":"2002","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.04.008_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/joe.0.1650157","article-title":"Increased maternal serum activin A but not follistatin levels in pregnant women with hypertensive disorders","volume":"165","author":"D'Antona","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1530\/eje.0.1350340","article-title":"Episodic secretion of activin A in pregnant women","volume":"135","author":"Gallinelli","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1111\/j.1471-0528.1999.tb08114.x","article-title":"Activin A, inhibin A, inhibin B and parturition: changes of maternal serum and cord levels according to the mode of delivery","volume":"106","author":"Florio","year":"1996","journal-title":"Br J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.04.008_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1210\/jcem.85.1.6249","article-title":"Gonadotropins, prolactin, inhibin A, inhibin B, and activin A in human fetal serum from midpregnancy and term pregnancy","volume":"85","author":"Debieve","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2005.04.008_bib20","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/plac.2002.0840","article-title":"Maternal and foetal activin A levels: associations with normal and abnormal labour","volume":"23","author":"Schneider-Kolsky","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2005.04.008_bib21","first-page":"1521","article-title":"The tissue distribution of activin \u03b2A- and \u03b2B subunit and follistatin messenger ribonucleic acids suggests multiple sites of action for the activin-follistatin system during human development","volume":"6","author":"Tuuri","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2005.04.008_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/107155760200900509","article-title":"Mechanism of increased maternal serum total activin A and inhibin A in preeclampsia","volume":"9","author":"Silver","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.placenta.2005.04.008_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1677\/joe.0.1710057","article-title":"Activin A and activin receptors in gestational tissue from preeclamptic pregnancies","volume":"171","author":"Manuelpillai","year":"2001","journal-title":"J Endocrinol"},{"key":"10.1016\/j.placenta.2005.04.008_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1469-0705.1995.06010019.x","article-title":"Changes observed in Doppler studies of the fetal circulation in pregnancies complicated by pre-eclampsia or the delivery of a small-for-gestational-age baby. I. Cross-sectional analysis","volume":"6","author":"Harrington","year":"1995","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.04.008_bib25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1471-0528.2004.00098.x","article-title":"Fetal activin A: associations with labour, umbilical artery pH and neonatal outcome","volume":"111","author":"Tong","year":"2004","journal-title":"BJOG"},{"key":"10.1016\/j.placenta.2005.04.008_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1067\/mob.2002.119777","article-title":"Maternal serum activin A, inhibin A, and follistatin in pregnancies with appropriately grown and small-for-gestational-age fetuses classified by umbilical artery Doppler ultrasound","volume":"186","author":"Bobrow","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.04.008_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1471-0528.2003.02190.x","article-title":"Maternal serum activin A levels in association with intrauterine fetal growth restriction","volume":"110","author":"Wallace","year":"2003","journal-title":"BJOG"},{"key":"10.1016\/j.placenta.2005.04.008_bib28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/plac.2002.0831","article-title":"Corticotropin-releasing factor, urocortin and endothelin-1 stimulate activin A release from cultured human placental cells","volume":"23","author":"Reis","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2005.04.008_bib29","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/sj.bjp.0702626","article-title":"Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A","volume":"127","author":"Nusing","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.placenta.2005.04.008_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0006-8993(99)01638-8","article-title":"Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic\u2013ischemic brain injury in the infant rat","volume":"835","author":"Wu","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.placenta.2005.04.008_bib31","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/77548","article-title":"Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo","volume":"6","author":"Tretter","year":"2000","journal-title":"Nat Med"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400405001335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400405001335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:35:51Z","timestamp":1758908151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400405001335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":31,"journal-issue":{"issue":"4-5","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["S0143400405001335"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2005.04.008","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Umbilical Cord Serum Activin A Levels are Increased in Pre-eclampsia with Impaired Blood Flow in the Uteroplacental and Fetal Circulation","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2005.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}