{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:48:26Z","timestamp":1790322506421,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.placenta.2005.06.006","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T07:22:41Z","timestamp":1125040961000},"page":"691-698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["BeWo Trophoblasts are Unable to Control Replication of Toxoplasma gondii, Even in the Presence of Exogenous IFN-\u03b3"],"prefix":"10.1016","volume":"27","author":[{"given":"J.G.","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.D.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.L.S.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Mineo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.V.","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2005.06.006_bib1","series-title":"Infectious diseases of the fetus and newborn infant","first-page":"205","author":"Remington","year":"2001"},{"key":"10.1016\/j.placenta.2005.06.006_bib2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/iai.15.3.855-862.1977","article-title":"Cellular immunity to Toxoplasma and Besnoitia in hamsters: specificity and the effects of cortisol","volume":"15","author":"Lindberg","year":"1977","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-5728(91)90040-E","article-title":"Toxoplasma encephalitis of immunocompetent and nude mice: immunohistochemical characterisation of Toxoplasma antigen, infiltrates and major histocompatibility complex gene products","volume":"31","author":"Schluter","year":"1991","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0923-2494(05)80095-1","article-title":"Macrophage interactions in toxoplasmosis","volume":"144","author":"Sibley","year":"1993","journal-title":"Res Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0169-4758(88)90003-8","article-title":"Oxidative killing of intracellular parasites mediated by macrophages","volume":"4","author":"Hughes","year":"1988","journal-title":"Parasitol Today"},{"key":"10.1016\/j.placenta.2005.06.006_bib6","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1084\/jem.150.4.938","article-title":"Macrophage oxygen-dependent anti-microbial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates","volume":"150","author":"Murray","year":"1979","journal-title":"J Exp Med"},{"key":"10.1016\/j.placenta.2005.06.006_bib7","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.4049\/jimmunol.144.7.2725","article-title":"Microbiostatic effect of murine-activates macrophages for Toxoplasma gondii. Role for synthesis of nitrogen oxides from l arginine","volume":"144","author":"Adams","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib8","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.4049\/jimmunol.141.7.2407","article-title":"Release of reactives nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages","volume":"141","author":"Ding","year":"1988","journal-title":"J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib9","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1002\/eji.1830181018","article-title":"Interferon-gamma and tumor necrosis factor induce the l-arginine-dependent cytotoxic effector mechanism in murine macrophages","volume":"18","author":"Drapier","year":"1988","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/jir.1986.6.267","article-title":"Characterization of an indoleamine-2,3-dioxygenase induced by gamma-interferon in cultures human fibroblasts","volume":"6","author":"Pfefferkorn","year":"1986","journal-title":"J Interferon Res"},{"key":"10.1016\/j.placenta.2005.06.006_bib11","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/infdis\/150.6.961","article-title":"Effect of murine interferon gamma on murine toxoplasmosis","volume":"150","author":"McCabe","year":"1984","journal-title":"J Infect Dis"},{"key":"10.1016\/j.placenta.2005.06.006_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1126\/science.3128869","article-title":"Interferon-\u03b3: the major mediator of resistance against Toxoplasma gondii","volume":"240","author":"Suzuki","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.placenta.2005.06.006_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000024441","article-title":"The Th2 cytokine environment of the placenta","volume":"123","author":"Dealtry","year":"2000","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0167-5699(97)01127-4","article-title":"Th1-type immunity is incompatible with successful pregnancy","volume":"18","author":"Ragupathy","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.placenta.2005.06.006_bib15","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.placenta.2005.06.006_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0925-4439(99)00096-4","article-title":"Human placental indoleamine 2,3-dioxigenase: cellular localization and characterization of an enzyme preventing fetal infection","volume":"1500","author":"Kudo","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.placenta.2005.06.006_bib17","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4049\/jimmunol.144.2.731","article-title":"Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule","volume":"144","author":"Ellis","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib18","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0002-9378(11)91448-3","article-title":"Interferon-gamma receptors on human gestational choriocarcinoma cell lines: quantitative and functional studies","volume":"167","author":"Fulop","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2005.06.006_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/expr.1994.1054","article-title":"Attachment of Toxoplasma gondii to host cells involves major surface protein, SAG-1 (P30)","volume":"79","author":"Mineo","year":"1994","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.placenta.2005.06.006_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal Biochem"},{"key":"10.1016\/j.placenta.2005.06.006_bib21","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.placenta.2005.06.006_bib22","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s004360050609","article-title":"Calomys callosus (Rodentia: Cricetidae) trophoblast cells as host cells to Toxoplasma gondii in early pregnancy","volume":"85","author":"Ferro","year":"1999","journal-title":"Parasitol Res"},{"key":"10.1016\/j.placenta.2005.06.006_bib23","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1128\/IAI.70.12.7089-7094.2002","article-title":"Effect of Toxoplasma gondii infection kinetics on trophoblast cell population in Calomys callosus, a model of congenital toxoplasmosis","volume":"70","author":"Ferro","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib24","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1086\/377132","article-title":"Infection of placental trophoblasts by Toxoplasma gondii","volume":"188","author":"Abbasi","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.placenta.2005.06.006_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1053\/jcpa.2001.0539","article-title":"Immune regulation during pregnancy and host\u2013pathogen interactions in infectious abortion","volume":"126","author":"Entrican","year":"2002","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.placenta.2005.06.006_bib26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/82565","article-title":"Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production","volume":"26","author":"Arsenijevic","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.placenta.2005.06.006_bib27","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1098\/rstb.1997.0120","article-title":"Mechanisms of innate resistance to Toxoplasma gondii infection","volume":"352","author":"Alexander","year":"1997","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.placenta.2005.06.006_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/plac.1998.0383","article-title":"The role of reactive nitrogen\/oxygen intermediates in cytokine-induced trophoblast apoptosis","volume":"20","author":"Smith","year":"1999","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2005.06.006_bib29","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1128\/IAI.70.5.2690-2693.2002","article-title":"Gamma interferon fails to induce expression of indoleamine 2,3-dioxigenase and does not control the growth of Chlamydophila abortus in BeWo trophoblast cells","volume":"70","author":"Entrican","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib30","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/icb.1997.80","article-title":"Inhibition of Toxoplasma gondii replication in IFN-gamma-activated human intestinal epithelial cells","volume":"75","author":"Dimier","year":"1997","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.placenta.2005.06.006_bib31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/IAI.70.2.859-868.2002","article-title":"Expression of indoleamine 2,3-dioxygenase, tryptophan degradation and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous IFN-g and requirement of IRF-1","volume":"70","author":"Silva","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib32","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.1128\/IAI.69.10.6527-6531.2001","article-title":"Restriction of Toxoplasma gondii growth in human brain microvascular endothelial cells by activation of indoleamine 2,3-dioxygenase","volume":"69","author":"D\u00e4ubener","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib33","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1128\/IAI.67.5.2233-2240.1999","article-title":"Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: requirement of a functional JAK\/STAT pathway","volume":"67","author":"Cer\u00e1volo","year":"1999","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib34","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1128\/iai.64.10.4188-4196.1996","article-title":"Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells","volume":"64","author":"Nagineni","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1128\/iai.57.3.845-849.1989","article-title":"Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages","volume":"57","author":"Murray","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib36","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1128\/iai.57.10.3254-3256.1989","article-title":"Beta interferon inhibits Toxoplasma gondii growth in human monocyte-derived macrophages","volume":"57","author":"Schmitz","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.placenta.2005.06.006_bib37","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0041-1345(00)02078-9","article-title":"T cell proliferation is blocked by indoleamine 2,3-dioxygenase","volume":"33","author":"Frumento","year":"2001","journal-title":"Transplant Proc"},{"key":"10.1016\/j.placenta.2005.06.006_bib38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.167.2.708","article-title":"IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase","volume":"167","author":"Grohmann","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib39","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.4049\/jimmunol.164.7.3596","article-title":"Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation","volume":"164","author":"Hwu","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/0167-4889(89)90087-6","article-title":"Characteristics of interferon induced tryptophan metabolism in human cells in vitro","volume":"1012","author":"Werner-Felmayer","year":"1989","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.placenta.2005.06.006_bib41","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0003-9861(91)90142-6","article-title":"1-Methyl-dl-tryptophan, beta-(3-benzofuranyl)-d-l-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-d-l-alanine (the sulfur anolog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxigenase","volume":"291","author":"Cady","year":"1991","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.placenta.2005.06.006_bib42","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S1097-2765(03)00113-8","article-title":"Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites","volume":"11","author":"Jewett","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.placenta.2005.06.006_bib43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1094717","article-title":"Intracellular parasite invasion strategies","volume":"304","author":"Sibley","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.placenta.2005.06.006_bib44","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/humrep\/deh218","article-title":"Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium","volume":"19","author":"Kudo","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2005.06.006_bib45","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/humrep\/deh477","article-title":"Mechanisms regulating the expression of indoleamine 2,3-dioxygenase during decidualization of human endometrium","volume":"19","author":"Honig","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2005.06.006_bib46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jri.2003.11.003","article-title":"Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific","volume":"6","author":"Baban","year":"2004","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.placenta.2005.06.006_bib47","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/014107680109400605","article-title":"Chlamydial infection in sheep: immune control versus fetal pathology","volume":"94","author":"Entrican","year":"2001","journal-title":"J R Soc Med"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400405001840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400405001840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:36:21Z","timestamp":1758908181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400405001840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":47,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0143400405001840"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2005.06.006","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BeWo Trophoblasts are Unable to Control Replication of Toxoplasma gondii, Even in the Presence of Exogenous IFN-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2005.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}