{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:46:31Z","timestamp":1790361991117,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.placenta.2008.08.018","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T04:51:23Z","timestamp":1222923083000},"page":"942-949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["The Effect of Labour and Placental Separation on the Shedding of Syncytiotrophoblast Microparticles, Cell-free DNA and mRNA in Normal Pregnancy and Pre-eclampsia"],"prefix":"10.1016","volume":"29","author":[{"given":"A.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.Y.","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rusterholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Holzgreve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.G.","family":"Redman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.L.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2008.08.018_bib1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.placenta.2008.08.018_bib2","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/humrep\/15.7.1640","article-title":"Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia","volume":"15","author":"Muttukrishna","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2008.08.018_bib3","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1056\/NEJMoa055352","article-title":"Soluble endoglin and other circulating antiangiogenic factors in preeclampsia","volume":"355","author":"Levine","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.placenta.2008.08.018_bib4","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/plac.2000.0560","article-title":"Placental debris, Oxidative stress and pre-eclampsia","volume":"21","author":"Redman","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1053\/plac.1999.0422","article-title":"Trophoblast deportation in human pregnancy-its relevance for pre-eclampsia","volume":"20","author":"Johansen","year":"1999","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1471-0528.1998.tb10178.x","article-title":"Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies","volume":"105","author":"Knight","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.placenta.2004.11.007","article-title":"Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction","volume":"27","author":"Goswami","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.placenta.2004.10.017","article-title":"Fetal cells and cell free fetal nucleic acids in maternal blood: new tools to study abnormal placentation?","volume":"26","author":"Hahn","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jri.2005.05.003","article-title":"Syncytiotrophoblast micro-particles do not induce apoptosis in peripheral lymphocytes, but differ in their activity depending on the mode of preparation","volume":"68","author":"Gupta","year":"2005","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.placenta.2008.08.018_bib10","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.4049\/jimmunol.178.9.5949","article-title":"Systemic inflammatory priming in normal pregnancy and pre-eclampsia: the role of circulating syncytiotrophoblast microparticles","volume":"178","author":"Germain","year":"2007","journal-title":"J. Immunol"},{"key":"10.1016\/j.placenta.2008.08.018_bib11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1471-0528.1993.tb15114.x","article-title":"The effect of placental syncytiotrophoblast microvillous membranes from normal and pre-eclamptic women on the growth of endothelial cells in vitro","volume":"100","author":"Smarason","year":"1993","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1471-0528.1997.tb11052.x","article-title":"Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function","volume":"104","author":"Cockell","year":"1997","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.placenta.2004.04.004","article-title":"A comparative study of the effect of three different syncytiotrophoblast micro-particles preparations on endothelial cells","volume":"26","author":"Gupta","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ajog.2003.08.027","article-title":"Labor induces a maternal inflammatory response syndrome","volume":"190","author":"Molloy","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","article-title":"Oxidative stress, gene expression, and protein changes induced in the human placenta during labor","volume":"171","author":"Cindrova-Davies","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.placenta.2008.08.018_bib16","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0002-9378(88)90100-7","article-title":"Qualitative assessment of maternal uterine and fetal umbilical artery blood flow and resistance in laboring patients by Doppler velocimetry","volume":"158","author":"Brar","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000067884","article-title":"Fetal blood saturation during the 1st and 2nd stage of labor and its relation to the neonatal outcome","volume":"54","author":"Leszczy\u0144ska-Gorzelak","year":"2002","journal-title":"Gynecol Obstet Invest"},{"key":"10.1016\/j.placenta.2008.08.018_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0143-4004(97)90015-1","article-title":"Increased xanthine oxidase during labour-implications for oxidative stress","volume":"18","author":"Many","year":"1997","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000024411.22110.AA","article-title":"Hypoxia-reoxygenation a potent inducer of apoptotic changes in the human placenta and possible etiological factor in pre-eclampsia","volume":"90","author":"Hung","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.placenta.2008.08.018_bib20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1067\/mob.2002.119176","article-title":"Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation","volume":"186","author":"Ishihara","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajog.2005.07.039","article-title":"Apoptosis and its role in the trophoblast","volume":"195","author":"Huppertz","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.placenta.2008.08.018_bib22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ajog.2004.02.037","article-title":"Delayed postpartum preeclampsia: an experience of 151 cases","volume":"20190","author":"Matthys","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib23","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1067\/mob.2001.109594","article-title":"Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia","volume":"184","author":"Zhong","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib24","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1373\/clinchem.2005.051235","article-title":"Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma","volume":"51","author":"Zimmermann","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2008.08.018_bib25","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1373\/clinchem.2005.053959","article-title":"Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early- and late-onset preeclampsia","volume":"51","author":"Zhong","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2008.08.018_bib26","first-page":"A51","article-title":"Irregular placental haemodynamics in the pathophysiology of pre-eclampsia","volume":"26","author":"Crocker","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2008.08.018_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0002-9378(75)90490-1","article-title":"Intervillous space during uterine contractions in human subjects: an ultrasonic study","volume":"123","author":"Bleker","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib28","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1093\/humrep\/15.7.1624","article-title":"Increased fetal erythroblasts in women who subsequently develop pre-eclampsia","volume":"15","author":"Al-Mufti","year":"2000","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2008.08.018_bib29","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/molehr\/8.9.864","article-title":"Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts","volume":"8","author":"Zhong","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2008.08.018_bib30","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/clinchem\/48.4.650","article-title":"Hemolysis elevated liver enzymes and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum","volume":"48","author":"Swinkels","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2008.08.018_bib31","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2353\/ajpath.2006.060161","article-title":"Trophoblastic oxidative stress and the release of cell-free feto-placental DNA","volume":"169","author":"Tjoa","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.placenta.2008.08.018_bib32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/pd.757","article-title":"Free fetal DNA concentration in maternal plasma during normal labour at term","volume":"23","author":"Ingargiola","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2008.08.018_bib33","first-page":"991","article-title":"Fluctuation of maternal and fetal free extracellular circulatory DNA in maternal plasma","volume":"96","author":"Zhong","year":"2000","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2008.08.018_bib34","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1373\/clinchem.2004.040196","article-title":"Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro","volume":"50","author":"Gupta","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2008.08.018_bib35","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2362.2004.01355.x","article-title":"Cellular microparticles: new players in the field of vascular disease?","volume":"34","author":"Diamant","year":"2004","journal-title":"Eur J Clinical Invest"},{"key":"10.1016\/j.placenta.2008.08.018_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1074\/jbc.274.33.23111","article-title":"Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in JNK1 signalling pathway","volume":"274","author":"Mesri","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.placenta.2008.08.018_bib37","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1055\/s-0037-1615913","article-title":"Mechanisms of cellular activation by platelet microparticles","volume":"82","author":"Barry","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.placenta.2008.08.018_bib38","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1055\/s-0037-1613378","article-title":"Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction","volume":"89","author":"Bretelle","year":"2003","journal-title":"Thromb Haemost"},{"issue":"3","key":"10.1016\/j.placenta.2008.08.018_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/01443619750113348","article-title":"Late postnatal pre-eclampsia","volume":"17","author":"Lilley","year":"1997","journal-title":"J Obstet Gynaecol"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400408002634?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400408002634?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:39:41Z","timestamp":1758908381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400408002634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0143400408002634"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2008.08.018","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Labour and Placental Separation on the Shedding of Syncytiotrophoblast Microparticles, Cell-free DNA and mRNA in Normal Pregnancy and Pre-eclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2008.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}