{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:44:40Z","timestamp":1778028280269,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.placenta.2009.12.025","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T05:22:33Z","timestamp":1265174553000},"page":"289-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Aldosterone and Cortisol Acutely Stimulate Na+\/H+ Exchanger Activity in the Syncytiotrophoblast of the Human Placenta: Effect of Fetal Sex"],"prefix":"10.1016","volume":"31","author":[{"given":"P.F.","family":"Speake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Glazier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.L.","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.P.","family":"Sibley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2009.12.025_bib1","first-page":"S3","article-title":"The Na+\/H+ exchanger gene family","volume":"15","author":"Burckhardt","year":"2002","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.placenta.2009.12.025_bib2","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1074\/jbc.M410041200","article-title":"Four Na+\/H+ exchanger isoforms are distributed to golgi and post-golgi compartments and are involved in organelle pH regulation","volume":"280","author":"Nakamura","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.placenta.2009.12.025_bib3","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1203\/00006450-200011000-00017","article-title":"Activity and expression of the Na+\/H+ exchanger in the microvillous plasma membrane of the syncytiotrophoblast in relation to gestation and small for gestational age birth","volume":"48","author":"Hughes","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.placenta.2009.12.025_bib4","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1210\/endo.142.8.8343","article-title":"Expression of the messenger ribonucleic acids and proteins for the Na+\/H+ exchangers and their regulatory factors in baboon and human placental syncytiotrophoblast","volume":"142","author":"Pepe","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2009.12.025_bib5","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1210\/jc.2002-020214","article-title":"Activity and protein expression of the Na+\/H+ exchanger is reduced in syncytiotrophoblast microvillous plasma membranes isolated from preterm intrauterine growth restriction pregnancies","volume":"87","author":"Johansson","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00424-005-1382-x","article-title":"Activity and expression of Na+\/H+ exchanger isoforms in the syncytiotrophoblast of the human placenta","volume":"450","author":"Speake","year":"2005","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.placenta.2009.12.025_bib7","doi-asserted-by":"crossref","first-page":"C891","DOI":"10.1152\/ajpcell.00134.2004","article-title":"Intracellular pH homeostasis in cultured human placental syncytiotrophoblast cells: recovery from acidification","volume":"288","author":"Cowley","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.placenta.2009.12.025_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0143-4004(96)80016-6","article-title":"A novel technique for studying cellular function in human placenta: gestational changes in intracellular pH regulation","volume":"17","author":"Powell","year":"1996","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2009.12.025_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0005-2736(02)00589-8","article-title":"Rapid responses to steroid hormones: from frog skin to human colon. A homage to Hans Ussing","volume":"1566","author":"Harvey","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.placenta.2009.12.025_bib10","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(88)90742-8","article-title":"Localisation of 11-\u03b2-hydroxysteroid dehydrogenase\u2013tissue specific protector of the mineralocorticoid receptor","volume":"2","author":"Edwards","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2009.12.025_bib11","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.HYP.35.5.1099","article-title":"Role of 11-\u03b2-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries","volume":"35","author":"Alzamora","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2009.12.025_bib12","doi-asserted-by":"crossref","first-page":"35807","DOI":"10.1074\/jbc.M506584200","article-title":"Rapid effects of dexamethasone on intracellular pH and Na+\/H+ exchanger activity in human bronchial epithelial cells","volume":"280","author":"Verriere","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.placenta.2009.12.025_bib13","doi-asserted-by":"crossref","first-page":"p1","DOI":"10.1159\/000081796","article-title":"Aldosterone rapidly activates Na+\/H+ exchange in M-1 cortical collecting duct cells via a PKC-MAPK pathway","volume":"99","author":"Markos","year":"2005","journal-title":"Nephron Physiol"},{"key":"10.1016\/j.placenta.2009.12.025_bib14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1126\/science.2845584","article-title":"Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated","volume":"242","author":"Funder","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.placenta.2009.12.025_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jsbmb.2003.07.006","article-title":"Profiling transcript levels for steroidogenic enzymes in fetal tissues","volume":"87","author":"Pezzi","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.placenta.2009.12.025_bib16","first-page":"4490","article-title":"Expression of type 2 11-\u03b2-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life","volume":"83","author":"Condon","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib17","first-page":"1306","article-title":"11-\u03b2 -hydroxysteroid dehydrogenase type II and mineralocorticoid receptor in human placenta","volume":"85","author":"Hirasawa","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib18","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/molehr\/7.4.357","article-title":"Expression of 11 -\u03b2-hydroxysteroid dehydrogenase isozymes and corticosteroid hormone receptors in primary cultures of human trophoblast and placental bed biopsies","volume":"7","author":"Driver","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2009.12.025_bib19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/endo.142.1.7877","article-title":"Localization and developmental regulation of 11beta-hydroxysteroid dehydrogenase-1 and -2 in the baboon syncytiotrophoblast","volume":"142","author":"Pepe","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2009.12.025_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jsgi.2005.01.029","article-title":"The effects of chorioamnionitis and betamethasone on 11-\u03b2-hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta","volume":"12","author":"Johnstone","year":"2005","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.placenta.2009.12.025_bib21","first-page":"1660","article-title":"Reduced 11-\u03b2 -hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma","volume":"87","author":"Murphy","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib22","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/j.placenta.2004.01.004","article-title":"Maternal asthma as a model for examining fetal sex-specific effects on maternal physiology and placental mechanisms that regulate human fetal growth","volume":"25","author":"Clifton","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2009.12.025_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/humrep\/14.2.536","article-title":"Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta","volume":"14","author":"Sooranna","year":"1999","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2009.12.025_bib24","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1021\/bi00578a012","article-title":"Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ","volume":"18","author":"Thomas","year":"1979","journal-title":"Biochemistry"},{"key":"10.1016\/j.placenta.2009.12.025_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1042\/bj3131007","article-title":"Cloning and production of antisera to human placental 11-\u03b2-hydroxysteroid dehydrogenase type 2","volume":"313","author":"Brown","year":"1996","journal-title":"Biochem J"},{"key":"10.1016\/j.placenta.2009.12.025_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-4827(83)90282-3","article-title":"Inhibition of glucocorticosteroid action in cultured L-929 mouse fibroblasts by RU 486, a new anti-glucocorticosteroid of high affinity for the glucocorticosteroid receptor","volume":"147","author":"Jung-Testas","year":"1983","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.placenta.2009.12.025_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1152\/ajplegacy.1976.231.1.93","article-title":"Agonist and antimineralocorticoid activities of spirolactones","volume":"231","author":"Sakauye","year":"1976","journal-title":"Am J Physiol"},{"key":"10.1016\/j.placenta.2009.12.025_bib28","doi-asserted-by":"crossref","first-page":"12586","DOI":"10.1016\/S0021-9258(17)38911-1","article-title":"Interrelationships among quinidine, amiloride and lithium as inhibitors of the renal Na+\/H+ exchanger","volume":"260","author":"Mahnensmith","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1016\/j.placenta.2009.12.025_bib29","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1172\/JCI114781","article-title":"Distribution of 11-\u03b2-hydroxysteroid dehydrogenase along the rabbit nephron","volume":"86","author":"Bonvalet","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.placenta.2009.12.025_bib30","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1210\/me.2004-0469","article-title":"Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions","volume":"19","author":"Grossmann","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.placenta.2009.12.025_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/stke.3042005pe48","article-title":"Intracellular glucocorticoid signaling: a formerly simple system turns stochastic","author":"Chrousos","year":"2005","journal-title":"Sci STKE"},{"key":"10.1016\/j.placenta.2009.12.025_bib32","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.molcel.2005.03.025","article-title":"Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes","volume":"18","author":"Lu","year":"2005","journal-title":"Mol Cell"},{"key":"10.1016\/j.placenta.2009.12.025_bib33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1083\/jcb.200409150","article-title":"G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus","volume":"169","author":"Kino","year":"2005","journal-title":"J Cell Biol"},{"key":"10.1016\/j.placenta.2009.12.025_bib34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1164\/rccm.200303-374OC","article-title":"Maternal asthma is associated with reduced female fetal growth","volume":"168","author":"Murphy","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.placenta.2009.12.025_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1124\/pr.55.2.1","article-title":"Gender differences in the membrane transport of endogenous and exogenous compounds","volume":"55","author":"Morris","year":"2003","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.placenta.2009.12.025_bib36","first-page":"521","article-title":"Association between preterm birth and increased maternal plasma cortisol concentrations","volume":"84","author":"Mazor","year":"1994","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2009.12.025_bib37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1172\/JCI106824","article-title":"Plasma aldosterone concentration at delivery and during the newborn period","volume":"51","author":"Beitins","year":"1972","journal-title":"J Clin Invest"},{"key":"10.1016\/j.placenta.2009.12.025_bib38","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1210\/jc.2005-0550","article-title":"Transgenerational effects of posttraumatic stress disorder in babies of mothers exposed to the World Trade Center attacks during pregnancy","volume":"90","author":"Yehuda","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib39","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/S0140-6736(05)66617-2","article-title":"Cardiovascular risk factors after antenatal exposure to betamethasone: 30-year follow-up of a randomised controlled trial","volume":"365","author":"Dalziel","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2009.12.025_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1196\/annals.1314.006","article-title":"Glucocorticoid programming","volume":"1032","author":"Seckl","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.placenta.2009.12.025_bib41","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1210\/jcem-35-5-678","article-title":"Steroid levels in the human fetus: cortisol and cortisone","volume":"35","author":"Murphy","year":"1972","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0303-7207(01)00633-5","article-title":"Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms","volume":"185","author":"Seckl","year":"2001","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.placenta.2009.12.025_bib43","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1677\/joe.0.1720527","article-title":"Regulation of 11-\u03b2-hydroxysteroid dehydrogenase type 2 activity in ovine placenta by fetal cortisol","volume":"172","author":"Clarke","year":"2002","journal-title":"J Endocrinol"},{"key":"10.1016\/j.placenta.2009.12.025_bib44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1530\/rep.1.00033","article-title":"Endocrine mechanisms of intrauterine programming","volume":"127","author":"Fowden","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.placenta.2009.12.025_bib45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1113\/jphysiol.1995.sp021045","article-title":"The effect of bilateral fetal adrenalectomy on fluid balance in the ovine fetus","volume":"489","author":"Benson","year":"1995","journal-title":"J Physiol"},{"key":"10.1016\/j.placenta.2009.12.025_bib46","first-page":"A66","article-title":"Dexamethasone treatment stimulates amino acid transport via System A in human term placenta","volume":"29","author":"Audette","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2009.12.025_bib47","doi-asserted-by":"crossref","first-page":"E596","DOI":"10.1152\/ajpendo.00359.2005","article-title":"Cortisol stimulates System A amino acid transport and SNAT2 expression in a human placental cell line (BeWo)","volume":"291","author":"Jones","year":"2006","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.placenta.2009.12.025_bib48","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1210\/en.2008-1100","article-title":"Altered placental function of 11-\u03b2-hydroxysteroid dehydrogenase 2 knockout mice","volume":"150","author":"Wyrwoll","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2009.12.025_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1203\/01.PDR.0000181381.82856.23","article-title":"Placental phenotypes of intrauterine growth","volume":"58","author":"Sibley","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1016\/j.placenta.2009.12.025_bib50","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1016\/S0021-9258(19)69218-5","article-title":"Neutral amino acid transport systems in Chinese hamster ovary cells","volume":"256","author":"Shotwell","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1016\/j.placenta.2009.12.025_bib51","doi-asserted-by":"crossref","first-page":"A16","DOI":"10.1016\/S0143-4004(96)90123-X","article-title":"The effect of pH on the placental microvillous membrane system A amino acid transporter","volume":"17","author":"Glazier","year":"1996","journal-title":"Placenta"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410000032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410000032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:41:40Z","timestamp":1758908500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400410000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0143400410000032"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2009.12.025","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4528956.4388054","asserted-by":"object"}]},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aldosterone and Cortisol Acutely Stimulate Na+\/H+ Exchanger Activity in the Syncytiotrophoblast of the Human Placenta: Effect of Fetal Sex","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2009.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}