{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:30:44Z","timestamp":1793377844170,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.placenta.2010.04.014","type":"journal-article","created":{"date-parts":[[2010,6,12]],"date-time":"2010-06-12T04:34:27Z","timestamp":1276317267000},"page":"S21-S29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"special_numbering":"S1","title":["Microarray Profiling Reveals That Placental Transcriptomes of Early-onset HELLP Syndrome and Preeclampsia Are Similar"],"prefix":"10.1016","volume":"32","author":[{"given":"T.","family":"V\u00e1rkonyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"F\u00fcle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.L.","family":"Tarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kar\u00e1szi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sch\u00f6nl\u00e9ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hupuczi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Mihalik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kovalszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"J.","family":"Rig\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Meiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Papp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.G.","family":"Than","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2010.04.014_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0002-9378(16)32330-4","article-title":"Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy","volume":"142","author":"Weinstein","year":"1982","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0002-9378(96)70056-X","article-title":"Heterogeneous causes constituting the single syndrome of preeclampsia: a hypothesis and its implications","volume":"175","author":"Ness","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib3","first-page":"8","article-title":"Prenatal medicine: the child is the father of the man","volume":"1","author":"Romero","year":"1996","journal-title":"Prenat Neonatal Med"},{"key":"10.1016\/j.placenta.2010.04.014_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1053\/plac.2002.0819","article-title":"Recent insights into the pathogenesis of pre-eclampsia","volume":"23","author":"Roberts","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.placenta.2010.04.014_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2010.04.014_bib7","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.placenta.2010.04.014_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.med.59.110106.214058","article-title":"Preeclampsia and angiogenic imbalance","volume":"59","author":"Maynard","year":"2008","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.placenta.2010.04.014_bib9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-2007-999675","article-title":"Clinical significance of liver dysfunction in pregnancy-induced hypertension","volume":"5","author":"Romero","year":"1988","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.placenta.2010.04.014_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1055\/s-2007-999540","article-title":"Clinical significance, prevalence, and natural history of thrombocytopenia in pregnancy-induced hypertension","volume":"6","author":"Romero","year":"1989","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.placenta.2010.04.014_bib11","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.clp.2004.06.008","article-title":"Diagnosis and management of hemolysis, elevated liver enzymes, and low platelets syndrome","volume":"31","author":"Barton","year":"2004","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.placenta.2010.04.014_bib12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/01.ogx.0000146948.19308.c5","article-title":"HELLP syndrome: the state of the art","volume":"59","author":"Baxter","year":"2004","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.placenta.2010.04.014_bib13","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1067\/S0002-9378(03)00576-3","article-title":"The frequency and severity of placental findings in women with preeclampsia are gestational age dependent","volume":"189","author":"Moldenhauer","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/014436105400041396","article-title":"Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity","volume":"25","author":"Sebire","year":"2005","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib15","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.ajog.2005.11.018","article-title":"Elevated maternal levels of the long pentraxin-3 (PTX3) in preeclampsia and intrauterine growth restriction","volume":"194","author":"Cetin","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.placenta.2008.09.003","article-title":"Protein nitration in placenta \u2013 functional significance","volume":"29","author":"Webster","year":"2008","journal-title":"Placenta"},{"issue":"Suppl. A","key":"10.1016\/j.placenta.2010.04.014_bib17","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.placenta.2008.11.003","article-title":"Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.placenta.2009.04.011","article-title":"Utero-placental haemodynamics in the pathogenesis of pre-eclampsia","volume":"30","author":"Hutchinson","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.placenta.2006.05.010","article-title":"Microarray analysis of differentially expressed fetal genes in placental tissue derived from early and late onset severe pre-eclampsia","volume":"28","author":"Nishizawa","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/jmf.16.5.287.293","article-title":"A clinicohistopathologic comparison between HELLP syndrome and severe preeclampsia","volume":"16","author":"Smulian","year":"2004","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.placenta.2010.04.014_bib22","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00428-008-0658-x","article-title":"Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome","volume":"453","author":"Than","year":"2008","journal-title":"Virchows Arch"},{"key":"10.1016\/j.placenta.2010.04.014_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrg1749","article-title":"Microarray data analysis: from disarray to consolidation and consensus","volume":"7","author":"Allison","year":"2006","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.placenta.2010.04.014_bib24","first-page":"1865","article-title":"Fetal growth rate and its variations 1988\/89","volume":"132","author":"Papp","year":"1991","journal-title":"Orv Hetil"},{"key":"10.1016\/j.placenta.2010.04.014_bib25","first-page":"159","article-title":"ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002","volume":"99","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib26","first-page":"449","article-title":"Practice guideline for examination of the placenta: developed by the Placental Pathology Practice Guideline Development Task Force of the College of American Pathologists","volume":"121","author":"Langston","year":"1997","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.placenta.2010.04.014_bib27","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/jcp.2003.014217","article-title":"Best practice no 178. Examination of the human placenta","volume":"57","author":"Hargitai","year":"2004","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.placenta.2010.04.014_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10024-003-8083-2","article-title":"Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns","volume":"7","author":"Redline","year":"2004","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.placenta.2010.04.014_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2010.04.014_bib30","first-page":"111","article-title":"Statistical issues in cDNA microarray data analysis","volume":"224","author":"Smyth","year":"2003","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.placenta.2010.04.014_bib31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.placenta.2010.04.014_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bioinformatics\/btl567","article-title":"Using GOstats to test gene lists for GO term association","volume":"23","author":"Falcon","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2010.04.014_bib33","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res"},{"key":"10.1016\/j.placenta.2010.04.014_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/bioinformatics\/btn577","article-title":"A novel signaling pathway impact analysis","volume":"25","author":"Tarca","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2010.04.014_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1471-2164-7-59","article-title":"Large scale real-time PCR validation on gene expression measurements from two commercial long-oligonucleotide microarrays","volume":"7","author":"Wang","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.placenta.2010.04.014_bib36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/14767050600852718","article-title":"Tissue microarray: an effective high-throughput method to study the placenta for clinical and research purposes","volume":"19","author":"Richani","year":"2006","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.placenta.2010.04.014_bib37","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.placenta.2004.07.003","article-title":"The correlation between sampling site and gene expression in the term human placenta","volume":"26","author":"Wyatt","year":"2005","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib38","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.2353\/ajpath.2007.070528","article-title":"Oxidative stress, gene expression, and protein changes induced in the human placenta during labor","volume":"171","author":"Cindrova-Davies","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.placenta.2010.04.014_bib39","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/molehr\/8.7.674","article-title":"Microarray analysis of differentially expressed genes in placental tissue of pre-eclampsia: up-regulation of obesity-related genes","volume":"8","author":"Reimer","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2010.04.014_bib40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.0001-6349.2005.00814.x","article-title":"Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia\u2014an array study on case-specific human preeclamptic placental tissue","volume":"84","author":"Heikkila","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.placenta.2010.04.014_bib41","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2005-0078","article-title":"Molecular evidence of placental hypoxia in preeclampsia","volume":"90","author":"Soleymanlou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2010.04.014_bib42","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.HYP.0000257797.49289.71","article-title":"Dysregulation of the circulating and tissue-based renin\u2013angiotensin system in preeclampsia","volume":"49","author":"Herse","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2010.04.014_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.04.020","article-title":"Differential placental gene expression in preeclampsia","volume":"199","author":"Enquobahrie","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.04.014_bib44","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.placenta.2008.02.007","article-title":"Seven placental transcripts characterize HELLP-syndrome","volume":"29","author":"Buimer","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.placenta.2008.09.015","article-title":"Altered global gene expression in first trimester placentas of women destined to develop preeclampsia","volume":"30","author":"Founds","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib46","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.placenta.2009.01.012","article-title":"Differential placental gene expression in severe preeclampsia","volume":"30","author":"Sitras","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/en.2008-0990","article-title":"Severe preeclampsia-related changes in gene expression at the maternal\u2013fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2","volume":"150","author":"Winn","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.placenta.2010.04.014_bib48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0301-2115(03)00185-4","article-title":"Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG)","volume":"110","author":"Islami","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.placenta.2010.04.014_bib49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cyto.2007.08.010","article-title":"Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome","volume":"40","author":"Tranquilli","year":"2007","journal-title":"Cytokines"},{"key":"10.1016\/j.placenta.2010.04.014_bib50","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1006\/bbrc.2000.2925","article-title":"Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22","volume":"273","author":"Thiesen","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.placenta.2010.04.014_bib51","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mam.2007.04.002","article-title":"Serum markers for predicting pre-eclampsia","volume":"28","author":"Baumann","year":"2007","journal-title":"Mol Aspects Med"},{"issue":"Suppl. A","key":"10.1016\/j.placenta.2010.04.014_bib52","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/j.placenta.2007.10.008","article-title":"Prediction of preeclampsia \u2013 a workshop report","volume":"29","author":"Than","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.04.014_bib53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7827-7-70","article-title":"Potential markers of preeclampsia\u2014a review","volume":"7","author":"Grill","year":"2009","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410001736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410001736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:43:52Z","timestamp":1758908632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400410001736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":53,"alternative-id":["S0143400410001736"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2010.04.014","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microarray Profiling Reveals That Placental Transcriptomes of Early-onset HELLP Syndrome and Preeclampsia Are Similar","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2010.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}