{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:13:15Z","timestamp":1791166395137,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.placenta.2010.06.018","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T04:24:29Z","timestamp":1295670269000},"page":"S17-S20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"special_numbering":"S1","title":["Cell-free Nucleic Acids as Potential Markers for Preeclampsia"],"prefix":"10.1016","volume":"32","author":[{"given":"S.","family":"Hahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rusterholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"H\u00f6sli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Lapaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9461","key":"10.1016\/j.placenta.2010.06.018_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.placenta.2010.06.018_bib2","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1067\/mob.2000.107357","article-title":"Association between level of delivery hospital and neonatal outcomes among South Carolina Medicaid recipients","volume":"183","author":"Sanderson","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"9076","key":"10.1016\/j.placenta.2010.06.018_bib3","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","article-title":"Presence of fetal DNA in maternal plasma and serum","volume":"350","author":"Lo","year":"1997","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajmg.c.30115","article-title":"Prenatal diagnosis using cell-free nucleic acids in maternal body fluids: a decade of progress","volume":"145C","author":"Maron","year":"2007","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1471-0528.2008.02010.x","article-title":"Noninvasive prenatal detection of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis: a review of the current state of the art","volume":"116","author":"Lo","year":"2009","journal-title":"BJOG"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/humupd\/dmn047","article-title":"The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis","volume":"15","author":"Wright","year":"2009","journal-title":"Hum Reprod Update"},{"issue":"12","key":"10.1016\/j.placenta.2010.06.018_bib7","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/pd.1284","article-title":"Reduction in diagnostic and therapeutic interventions by non-invasive determination of fetal sex in early pregnancy","volume":"25","author":"Hyett","year":"2005","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2010.06.018_bib8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1196\/annals.1318.019","article-title":"A clinical service in the UK to predict fetal Rh (Rhesus) D blood group using free fetal DNA in maternal plasma","volume":"1022","author":"Finning","year":"2004","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/pd.2172","article-title":"Noninvasive prenatal diagnosis of fetal blood group phenotypes: current practice and future prospects","volume":"29","author":"Daniels","year":"2009","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2006.02.004","article-title":"Georg Schmorl on trophoblasts in the maternal circulation","volume":"28","author":"Lapaire","year":"2007","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.placenta.2010.06.018_bib11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1471-0528.1991.tb15334.x","article-title":"Trophoblast deportation in pre-eclamptic pregnancy","volume":"98","author":"Chua","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"issue":"5 Pt 1","key":"10.1016\/j.placenta.2010.06.018_bib12","first-page":"669","article-title":"Disturbed feto-maternal cell traffic in preeclampsia","volume":"91","author":"Holzgreve","year":"1998","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/clinchem\/45.2.184","article-title":"Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia","volume":"45","author":"Lo","year":"1999","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.placenta.2010.06.018_bib14","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1067\/mob.2001.109594","article-title":"Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia","volume":"184","author":"Zhong","year":"2001","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.placenta.2010.06.018_bib15","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/pd.965","article-title":"beta-globin DNA in maternal plasma as a molecular marker of pre-eclampsia","volume":"24","author":"Sekizawa","year":"2004","journal-title":"Prenat Diagn"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/clinchem\/47.1.137","article-title":"Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia","volume":"47","author":"Leung","year":"2001","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1081\/PRG-120002911","article-title":"The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia","volume":"21","author":"Zhong","year":"2002","journal-title":"Hypertens Pregnancy"},{"issue":"3","key":"10.1016\/j.placenta.2010.06.018_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ajog.2003.12.019","article-title":"Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia","volume":"190","author":"Levine","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199707103370201","article-title":"Trial of calcium to prevent preeclampsia","volume":"337","author":"Levine","year":"1997","journal-title":"N Engl J Med"},{"issue":"472","key":"10.1016\/j.placenta.2010.06.018_bib20","first-page":"e1","article-title":"First-trimester maternal plasma cell-free fetal DNA and preeclampsia","volume":"201(5)","author":"Sifakis","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.placenta.2010.06.018_bib21","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1373\/clinchem.2005.051235","article-title":"Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma","volume":"51","author":"Zimmermann","year":"2005","journal-title":"Clin Chem"},{"issue":"4","key":"10.1016\/j.placenta.2010.06.018_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/jmg.2003.015784","article-title":"Detection of cell free placental DNA in maternal plasma: direct evidence from three cases of confined placental mosaicism","volume":"41","author":"Masuzaki","year":"2004","journal-title":"J Med Genet"},{"issue":"3","key":"10.1016\/j.placenta.2010.06.018_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/humrep\/deh117","article-title":"Circulating cell-free fetal DNA in maternal serum appears to originate from cyto- and syncytio-trophoblastic cells. Case report","volume":"19","author":"Flori","year":"2004","journal-title":"Hum Reprod"},{"issue":"5","key":"10.1016\/j.placenta.2010.06.018_bib24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/pd.1700","article-title":"Free fetal DNA in maternal plasma in anembryonic pregnancies: confirmation that the origin is the trophoblast","volume":"27","author":"Alberry","year":"2007","journal-title":"Prenat Diagn"},{"issue":"12","key":"10.1016\/j.placenta.2010.06.018_bib25","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000024411.22110.AA","article-title":"Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia","volume":"90","author":"Hung","year":"2002","journal-title":"Circ Res"},{"issue":"7","key":"10.1016\/j.placenta.2010.06.018_bib26","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1210\/jc.2005-0078","article-title":"Molecular evidence of placental hypoxia in preeclampsia","volume":"90","author":"Soleymanlou","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2010.06.018_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/plac.2002.0903","article-title":"Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation","volume":"24","author":"Huppertz","year":"2003","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2010.06.018_bib28","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1471-0528.1998.tb10178.x","article-title":"Shedding of syncytiotrophoblast microvilli into the maternal circulation in pre-eclamptic pregnancies","volume":"105","author":"Knight","year":"1998","journal-title":"Br J Obstet Gynaecol"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2353\/ajpath.2006.060161","article-title":"Trophoblastic oxidative stress and the release of cell-free feto-placental DNA","volume":"169","author":"Tjoa","year":"2006","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/302205","article-title":"Rapid clearance of fetal DNA from maternal plasma","volume":"64","author":"Lo","year":"1999","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.placenta.2010.06.018_bib31","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1093\/clinchem\/48.12.2141","article-title":"Fetal DNA clearance from maternal plasma is impaired in preeclampsia","volume":"48","author":"Lau","year":"2002","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.placenta.2010.06.018_bib32","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1084\/jem.147.3.684","article-title":"Kinetics and mechanisms for removal of circulating single-stranded DNA in mice","volume":"147","author":"Emlen","year":"1978","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1373\/clinchem.2009.132951","article-title":"Detection of increased amounts of cell-free fetal DNA with short PCR amplicons","volume":"56","author":"Sikora","year":"2010","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.placenta.2010.06.018_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/AOG.0b013e3181c3c938","article-title":"Reliability of fetal sex determination using maternal plasma","volume":"115","author":"Scheffer","year":"2010","journal-title":"Obstet Gynecol"},{"issue":"41","key":"10.1016\/j.placenta.2010.06.018_bib35","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.0503335102","article-title":"Detection of the placental epigenetic signature of the maspin gene in maternal plasma","volume":"102","author":"Chim","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.placenta.2010.06.018_bib36","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1373\/clinchem.2006.074997","article-title":"Hypermethylated RASSF1A in maternal plasma: a universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis","volume":"52","author":"Chan","year":"2006","journal-title":"Clin Chem"},{"issue":"13","key":"10.1016\/j.placenta.2010.06.018_bib37","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/pd.1897","article-title":"Quantitative aberrations of hypermethylated RASSF1A gene sequences in maternal plasma in pre-eclampsia","volume":"27","author":"Tsui","year":"2007","journal-title":"Prenat Diagn"},{"issue":"9","key":"10.1016\/j.placenta.2010.06.018_bib38","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/pd.973","article-title":"Total cell-free DNA (beta-globin gene) distribution in maternal plasma at the second trimester: a new prospective for preeclampsia screening","volume":"24","author":"Farina","year":"2004","journal-title":"Prenat Diagn"},{"issue":"4","key":"10.1016\/j.placenta.2010.06.018_bib39","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/clinchem\/48.4.650","article-title":"Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum","volume":"48","author":"Swinkels","year":"2002","journal-title":"Clin Chem"},{"issue":"10","key":"10.1016\/j.placenta.2010.06.018_bib40","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/clinchem\/48.10.1647","article-title":"Stability of endogenous and added RNA in blood specimens, serum, and plasma","volume":"48","author":"Tsui","year":"2002","journal-title":"Clin Chem"},{"issue":"8","key":"10.1016\/j.placenta.2010.06.018_bib41","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1093\/clinchem\/47.8.1488","article-title":"Extracellular tyrosinase mRNA within apoptotic bodies is protected from degradation in human serum","volume":"47","author":"Hasselmann","year":"2001","journal-title":"Clin Chem"},{"issue":"11","key":"10.1016\/j.placenta.2010.06.018_bib42","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1373\/clinchem.2004.040196","article-title":"Detection of fetal DNA and RNA in placenta-derived syncytiotrophoblast microparticles generated in vitro","volume":"50","author":"Gupta","year":"2004","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.placenta.2010.06.018_bib43","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.placenta.2010.06.018_bib44","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1373\/49.5.727","article-title":"The concentration of circulating corticotropin-releasing hormone mRNA in maternal plasma is increased in preeclampsia","volume":"49","author":"Ng","year":"2003","journal-title":"Clin Chem"},{"issue":"9","key":"10.1016\/j.placenta.2010.06.018_bib45","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1373\/clinchem.2005.053959","article-title":"Parallel assessment of circulatory fetal DNA and corticotropin-releasing hormone mRNA in early- and late-onset preeclampsia","volume":"51","author":"Zhong","year":"2005","journal-title":"Clin Chem"},{"issue":"8","key":"10.1016\/j.placenta.2010.06.018_bib46","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/pd.1780","article-title":"Cell-free mRNA concentrations of CRH, PLAC1, and selectin-P are increased in the plasma of pregnant women with preeclampsia","volume":"27","author":"Purwosunu","year":"2007","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2010.06.018_bib47","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1515\/CCLM.2010.160","article-title":"Evaluation of a panel of circulating DNA, RNA and protein potential markers for pathologies of pregnancy","volume":"48","author":"Galbiati","year":"2010","journal-title":"Clin Chem Lab Med"},{"issue":"12","key":"10.1016\/j.placenta.2010.06.018_bib48","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/pd.1562","article-title":"Quantitative distribution of a panel of circulating mRNA in preeclampsia versus controls","volume":"26","author":"Farina","year":"2006","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000224111","article-title":"mRNA of placental origin in maternal serum of women with normal and preeclamptic pregnancies","volume":"25","author":"Schmidt","year":"2009","journal-title":"Fetal Diagn Ther"},{"issue":"7","key":"10.1016\/j.placenta.2010.06.018_bib50","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/00016340903008953","article-title":"Are tests for predicting pre-eclampsia good enough to make screening viable? A review of reviews and critical appraisal","volume":"88","author":"Cnossen","year":"2009","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.placenta.2010.06.018_bib51","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7827-7-70","article-title":"Potential markers of preeclampsia\u2013a review","volume":"7","author":"Grill","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"issue":"2","key":"10.1016\/j.placenta.2010.06.018_bib52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.siny.2007.12.011","article-title":"Post-genomics studies and their application to non-invasive prenatal diagnosis","volume":"13","author":"Avent","year":"2008","journal-title":"Semin Fetal Neonatal Med"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410002481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410002481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:43:45Z","timestamp":1758908625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400410002481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":52,"alternative-id":["S0143400410002481"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2010.06.018","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-free Nucleic Acids as Potential Markers for Preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2010.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}