{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:56:11Z","timestamp":1790978171891,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Hellenic Society of Obstetrics and Gynecology"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.placenta.2010.10.017","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T04:32:30Z","timestamp":1291437150000},"page":"51-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction"],"prefix":"10.1016","volume":"32","author":[{"given":"O.","family":"Koukoura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sifakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zaravinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Apostolidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hajiioannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Widschwendter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.A.","family":"Spandidos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2010.10.017_bib1","first-page":"2","article-title":"Intrauterine growth retardation","volume":"11","author":"Hokken-Koelega","year":"2001","journal-title":"Int Growth Onitor"},{"key":"10.1016\/j.placenta.2010.10.017_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/GRF.0b013e31804c96a9","article-title":"Intrauterine growth restriction: how to manage and when to deliver","volume":"50","author":"Mari","year":"2007","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.placenta.2010.10.017_bib3","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1542\/peds.111.6.1253","article-title":"International small for gestational age Advisory Board:International small for gestational age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001","volume":"111","author":"Lee","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.placenta.2010.10.017_bib4","first-page":"235","article-title":"The insulin-like growth factor system and fetal growth restriction","volume":"6","author":"Randhawa","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"key":"10.1016\/j.placenta.2010.10.017_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2164-10-144","article-title":"Expression profile and transcription factor binding site exploration of imprinted genes in human and mouse","volume":"10","author":"Steinhoff","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.placenta.2010.10.017_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0959-437X(05)80054-1","article-title":"Parental imprinting of autosomal mammalian genes","volume":"4","author":"Efstratiadis","year":"1994","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.placenta.2010.10.017_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0168-9525(91)90040-W","article-title":"Genomic imprinting in mammalian development: a parental tug-of-war","volume":"7","author":"Moore","year":"1991","journal-title":"Trends Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib8","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.1074\/jbc.M208437200","article-title":"Imprint control element-mediated secondary methylation imprints at the Igf2\/H19 locus","volume":"278","author":"Srivastava","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.placenta.2010.10.017_bib9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/365764a0","article-title":"Tumour-suppressor activity of H19 RNA","volume":"365","author":"Hao","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2010.10.017_bib10","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1242\/dev.036061","article-title":"H19 acts as a trans regulator of the imprinted gene network controlling growth in mice","volume":"136","author":"Gabory","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.placenta.2010.10.017_bib11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/35013106","article-title":"CTCF mediates methylation-sensitive enhancer blocking activity at the H19\/Igf2 locus","volume":"405","author":"Hark","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2010.10.017_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jmg.2007.053017","article-title":"The genetic aetiology of Silver-Russell syndrome","volume":"45","author":"Abu-Amero","year":"2008","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.placenta.2003.10.016","article-title":"Large variability of trophoblast gene expression within and between human normal term placentae","volume":"25","author":"Pidoux","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.10.017_bib14","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/jmv.21534","article-title":"Prevalence of human papilloma virus and human herpes virus types 1-7 in human nasal polyposis","volume":"81","author":"Zaravinos","year":"2009","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.placenta.2010.10.017_bib15","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/hmg\/ddg034","article-title":"Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site","volume":"12","author":"Ulaner","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib16","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1093\/nar\/gki987","article-title":"Analysis of repetitive element DNA methylation by MethyLight","volume":"33","author":"Weisenberger","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.placenta.2010.10.017_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/ng1941","article-title":"Epigenetic stem cell signature in cancer","volume":"39","author":"Widschwendter","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib18","series-title":"Online Mendelian Inheritance in Man, 180860, Silver-Russell syndrome; SRS","author":"OMIM","year":"2010"},{"key":"10.1016\/j.placenta.2010.10.017_bib19","first-page":"837","article-title":"The spectrum of Silver-Russell syndrome: a clinical and molecular genetic study and new diagnostic criteria","volume":"36","author":"Price","year":"1999","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng0492-40","article-title":"Monoallelic expression of the human H19 gene","volume":"1","author":"Zhang","year":"1992","journal-title":"Nat Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0795-318","article-title":"Establishment of functional imprinting of the H19 gene in human developing placentae","volume":"10","author":"Jinno","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.placenta.2009.05.004","article-title":"Placental glycogen stores are increased in mice with H19 null mutations but not in those with insulin or IGF type 1 receptor mutations","volume":"30","author":"Esquiliano","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.10.017_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.placenta.2009.02.011","article-title":"The H19 gene imprinting in normal pregnancy and pre-eclampsia","volume":"30","author":"Yu","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.10.017_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ydbio.2008.04.025","article-title":"Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae","volume":"320","author":"Guo","year":"2008","journal-title":"Dev Biol"},{"issue":"Suppl 3","key":"10.1016\/j.placenta.2010.10.017_bib25","first-page":"50","article-title":"Imprinted genes, placental development and fetal growth","volume":"65","author":"Fowden","year":"2006","journal-title":"Horm Res"},{"key":"10.1016\/j.placenta.2010.10.017_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0925-4439(01)00109-0","article-title":"Alterations in promoter usage and expression levels of insulin-like growth factor-II and H19 genes in cervical carcinoma exhibiting biallelic expression of IGF-II","volume":"1586","author":"Kim","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.placenta.2010.10.017_bib27","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/carcin\/21.4.683","article-title":"Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53","volume":"21","author":"Cai","year":"2000","journal-title":"Carcinogenesis (Lond.)"},{"key":"10.1016\/j.placenta.2010.10.017_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1158\/1541-7786.MCR-05-0138","article-title":"Frequent IGF2\/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer","volume":"4","author":"Murphy","year":"2006","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.placenta.2010.10.017_bib29","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4161\/epi.9019","article-title":"Differential expression of imprinted genes in normal and IUGR human placentas","volume":"4","author":"Diplas","year":"2009","journal-title":"Epigenetics"},{"key":"10.1016\/j.placenta.2010.10.017_bib30","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/ng1468","article-title":"Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation","volume":"36","author":"Lewis","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib31","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1128\/MCB.18.6.3466","article-title":"Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster","volume":"18","author":"Caspary","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.placenta.2010.10.017_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.placenta.2009.12.003","article-title":"Decreased placental methylation at the H19\/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia","volume":"31","author":"Bourque","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2010.10.017_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1471-2407-10-317","article-title":"Promoter methylation of CDKN2A and lack of p16 expression characterize patients with hepatocellular carcinoma","volume":"10","author":"Csepregi","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.placenta.2010.10.017_bib34","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1086\/504729","article-title":"Intra- and interindividual epigenetic variation in human germ cells","volume":"79","author":"Flanagan","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1471-2105-9-365","article-title":"Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions","volume":"9","author":"Houseman","year":"2008","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.placenta.2010.10.017_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/432053a","article-title":"Resourceful imprinting","volume":"432","author":"Constancia","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2010.10.017_bib37","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/hmg\/ddg167","article-title":"Familial aggregation of abnormal methylation of parental alleles at the IGF2\/H19 and IGF2R differentially methylated regions","volume":"12","author":"Sandovici","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib38","doi-asserted-by":"crossref","first-page":"e1001033","DOI":"10.1371\/journal.pgen.1001033","article-title":"Inter- and intra-individual variation in allele-specific DNA methylation and gene expression in children conceived using assisted reproductive technology","volume":"6","author":"Turan","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.placenta.2010.10.017_bib39","doi-asserted-by":"crossref","first-page":"e7389","DOI":"10.1371\/journal.pone.0007389","article-title":"Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes","volume":"4","author":"Yuen","year":"2009","journal-title":"PLoS One"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410004194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400410004194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:44:05Z","timestamp":1758908645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400410004194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0143400410004194"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2010.10.017","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypomethylation along with increased H19 expression in placentas from pregnancies complicated with fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2010.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}