{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:44:36Z","timestamp":1782139476704,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.placenta.2011.07.082","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T17:51:02Z","timestamp":1312653062000},"page":"757-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genistein upregulates placental corticotropin-releasing hormone expression in lipopolysaccharide-sensitized mice"],"prefix":"10.1016","volume":"32","author":[{"given":"H.","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.Y.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2011.07.082_bib1","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1530\/eje.1.02247","article-title":"Corticotropin-releasing hormone physiology","volume":"155","author":"Majzoub","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.placenta.2011.07.082_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S1043-2760(98)00146-5","article-title":"Corticotropin-releasing hormone in human pregnancy and parturition","volume":"10","author":"McLean","year":"1999","journal-title":"Trends Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.placenta.2011.07.082_bib3","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1210\/jcem.83.5.4804","article-title":"Maternal corticotropin-releasing hormone is increased with impending preterm birth","volume":"83","author":"Korebrits","year":"1998","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.placenta.2011.07.082_bib4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.ajog.2004.06.070","article-title":"Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigation","volume":"191","author":"Wadhwa","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"14","key":"10.1016\/j.placenta.2011.07.082_bib5","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1073\/pnas.85.14.5244","article-title":"Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta","volume":"85","author":"Robinson","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.placenta.2011.07.082_bib6","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1210\/jcem.87.8.8745","article-title":"Estrogen represses whereas the estrogen-antagonist ICI 182780 stimulates placental CRH gene expression","volume":"87","author":"Ni","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.placenta.2011.07.082_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1677\/joe.0.0520299","article-title":"Steroid and phyto-oestrogen binding to sheep uterine receptors in\u00a0vitro","volume":"52","author":"Shutt","year":"1972","journal-title":"J\u00a0Endocrinol"},{"issue":"10","key":"10.1016\/j.placenta.2011.07.082_bib8","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"issue":"8881","key":"10.1016\/j.placenta.2011.07.082_bib9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0140-6736(93)92188-Y","article-title":"Plasma concentrations of phyto-oestrogens in Japanese men","volume":"342","author":"Adlercreutz","year":"1993","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.placenta.2011.07.082_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00042192-200109000-00015","article-title":"Dietary inclusion of whole soy foods results in significant reductions in clinical risk factors for osteoporosis and cardiovascular disease in normal postmenopausal women","volume":"8","author":"Scheiber","year":"2001","journal-title":"Menopause"},{"issue":"17","key":"10.1016\/j.placenta.2011.07.082_bib11","first-page":"3833","article-title":"Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in\u00a0vitro and in\u00a0vivo","volume":"58","author":"Hsieh","year":"1998","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.placenta.2011.07.082_bib12","first-page":"2474","article-title":"Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice","volume":"62","author":"Ju","year":"2002","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.placenta.2011.07.082_bib13","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1093\/carcin\/bgn161","article-title":"Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in\u00a0vivo","volume":"29","author":"Ju","year":"2008","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.placenta.2011.07.082_bib14","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/mnfr.200600258","article-title":"Disruption of the developing female reproductive system by phytoestrogens: genistein as an example","volume":"51","author":"Jefferson","year":"2007","journal-title":"Mol Nutr Food Res"},{"issue":"2","key":"10.1016\/j.placenta.2011.07.082_bib15","first-page":"399","article-title":"Glucuronides are the main isoflavone metabolites in women","volume":"133","author":"Zhang","year":"2003","journal-title":"J\u00a0Nutr"},{"issue":"6","key":"10.1016\/j.placenta.2011.07.082_bib16","first-page":"825","article-title":"Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women","volume":"124","author":"Xu","year":"1994","journal-title":"J\u00a0Nutr"},{"issue":"7","key":"10.1016\/j.placenta.2011.07.082_bib17","first-page":"1665","article-title":"Genistein inhibits growth of estrogen-independent human breast cancer cells in culture but not in athymic mice","volume":"130","author":"Santell","year":"2000","journal-title":"J\u00a0Nutr"},{"issue":"1","key":"10.1016\/j.placenta.2011.07.082_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1210\/en.2007-0372","article-title":"Estradiol regulates corticotropin-releasing hormone gene (crh) expression in a rapid and phasic manner that parallels estrogen receptor-alpha and -beta recruitment to a 3\u2019,5\u2019-cyclic adenosine 5\u2019-monophosphate regulatory region of the proximal crh promoter","volume":"149","author":"Lalmansingh","year":"2008","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.placenta.2011.07.082_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00404-005-0728-0","article-title":"Regulation of progesterone production in human term trophoblasts in\u00a0vitro by CRH, ACTH and cortisol (prednisolone)","volume":"272","author":"Jeschke","year":"2005","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.placenta.2011.07.082_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1080\/09513590802485020","article-title":"Effects of phytoestrogens genistein and daidzein on progesterone and estrogen (estradiol) production of human term trophoblast cells in\u00a0vitro","volume":"25","author":"Richter","year":"2009","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"10.1016\/j.placenta.2011.07.082_bib21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejogrb.2009.08.014","article-title":"Evaluation of the tocolytic effect of morphine in a mouse model of lipopolysaccharide-induced preterm delivery: the role of nitric oxide","volume":"147","author":"Javadi-Paydar","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"10.1016\/j.placenta.2011.07.082_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1933719109358456","article-title":"Tocolytic effect of delta9-tetrahydrocannabinol in mice model of lipopolysaccharide\u2013induced preterm delivery: role of nitric oxide","volume":"17","author":"Asghari-Roodsari","year":"2010","journal-title":"Reprod Sci"},{"issue":"2","key":"10.1016\/j.placenta.2011.07.082_bib23","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/S0002-9378(96)70460-X","article-title":"Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: a model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery","volume":"174","author":"Kaga","year":"1996","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.placenta.2011.07.082_bib24","first-page":"3168","article-title":"Phytoestrogen concentrations in serum from Japanese men and women over forty years of age","volume":"132","author":"Morton","year":"2002","journal-title":"J\u00a0Nutr"},{"issue":"4","key":"10.1016\/j.placenta.2011.07.082_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.placenta.2011.07.082_bib26","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1095\/biolreprod.105.041277","article-title":"Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses","volume":"73","author":"Jefferson","year":"2005","journal-title":"Biol Reprod"},{"issue":"8","key":"10.1016\/j.placenta.2011.07.082_bib27","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1289\/ehp.0800158","article-title":"Chronic dietary exposure to a low-dose mixture of genistein and vinclozolin modifies the reproductive axis, testis transcriptome, and fertility","volume":"117","author":"Eustache","year":"2009","journal-title":"Environ Health Perspect"},{"issue":"1\u20133","key":"10.1016\/j.placenta.2011.07.082_bib28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ygcen.2007.01.046","article-title":"Regulation of vertebrate corticotropin-releasing factor genes","volume":"153","author":"Yao","year":"2007","journal-title":"Gen Comp Endocrinol"},{"issue":"3","key":"10.1016\/j.placenta.2011.07.082_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000322590","article-title":"Lipopolysaccharide increases plasma levels of corticotropin-releasing hormone in rats","volume":"93","author":"Goebel","year":"2011","journal-title":"Neuroendocrinology"},{"issue":"5","key":"10.1016\/j.placenta.2011.07.082_bib30","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/1933719108315300","article-title":"Corticotrophin-releasing hormone in lipopolysaccharide-stimulated term fetal membranes and amniotic fluid from term and preterm birth in African Americans and Caucasians","volume":"15","author":"Menon","year":"2008","journal-title":"Reprod Sci"},{"key":"10.1016\/j.placenta.2011.07.082_bib31","first-page":"54","article-title":"Corticotrophin-releasing hormone and CRH-binding protein - Differences between patients at risk for preterm birth and hypertension","volume":"897","author":"Hobel","year":"1999","journal-title":"Neuropeptides: Struct Funct Biol Behav"},{"issue":"2","key":"10.1016\/j.placenta.2011.07.082_bib32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2010-1740","article-title":"Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis","volume":"96","author":"Torricelli","year":"2011","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.placenta.2011.07.082_bib33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1051\/rnd:2005055","article-title":"The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells","volume":"45","author":"Edmunds","year":"2005","journal-title":"Reprod Nutr Dev"},{"issue":"1","key":"10.1016\/j.placenta.2011.07.082_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.taap.2004.08.009","article-title":"In vitro effects of diethylstilbestrol, genistein, 4-tert-butylphenol, and 4-tert-octylphenol on steroidogenic activity of isolated immature rat ovarian follicles","volume":"204","author":"Myllymaki","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4\u20135","key":"10.1016\/j.placenta.2011.07.082_bib35","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsbmb.2006.06.021","article-title":"Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells","volume":"101","author":"Rice","year":"2006","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.placenta.2011.07.082_bib36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1477-7827-7-43","article-title":"Reduced expression of CRH receptor type 1 in upper segment human myometrium during labour","volume":"7","author":"Cong","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"issue":"11","key":"10.1016\/j.placenta.2011.07.082_bib37","first-page":"4107","article-title":"Corticotropin-releasing hormone receptor subtype 1 is significantly up-regulated at the time of labor in the human myometrium","volume":"83","author":"Stevens","year":"1998","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.placenta.2011.07.082_bib38","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0002-9378(98)70219-4","article-title":"Maternal corticotropin-releasing hormone levels in the early third trimester predict length of gestation in human pregnancy","volume":"179","author":"Wadhwa","year":"1998","journal-title":"Am J Obstet Gynecol"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400411003407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400411003407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:45:23Z","timestamp":1758908723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400411003407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0143400411003407"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2011.07.082","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genistein upregulates placental corticotropin-releasing hormone expression in lipopolysaccharide-sensitized mice","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2011.07.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}