{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:08:30Z","timestamp":1791612510630,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"NIH","award":["HL075297"],"award-info":[{"award-number":["HL075297"]}]},{"name":"CTSA grant","award":["UL1RR025767"],"award-info":[{"award-number":["UL1RR025767"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.placenta.2012.07.002","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:39:02Z","timestamp":1343263142000},"page":"816-823","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":217,"title":["MIR-210 modulates mitochondrial respiration in placenta with preeclampsia"],"prefix":"10.1016","volume":"33","author":[{"given":"S.","family":"Muralimanoharan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Maloyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Myatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Myatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.placenta.2012.07.002_bib1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/14034940500217037","article-title":"The World Health Report 2005: \u201cmake every mother and child count\u201d \u2013 including Africans","volume":"33","author":"Hogberg","year":"2005","journal-title":"Scand J Public Health"},{"issue":"1","key":"10.1016\/j.placenta.2012.07.002_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1385\/ENDO:19:1:103","article-title":"Role of placenta in preeclampsia","volume":"19","author":"Myatt","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.placenta.2012.07.002_bib3","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.2741\/2246","article-title":"Trophoblast biology, responses to hypoxia and placental dysfunction in preeclampsia","volume":"12","author":"Rampersad","year":"2007","journal-title":"Front Biosci"},{"issue":"24","key":"10.1016\/j.placenta.2012.07.002_bib4","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1101\/gad.853700a","article-title":"Placental cell fates are regulated in\u00a0vivo by HIF-mediated hypoxia responses","volume":"14","author":"Adelman","year":"2000","journal-title":"Genes Dev"},{"issue":"5332","key":"10.1016\/j.placenta.2012.07.002_bib5","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"Genbacev","year":"1997","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1095\/biolreprod63.2.559","article-title":"Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta","volume":"63","author":"Rajakumar","year":"2000","journal-title":"Biol Reprod"},{"issue":"Suppl. A","key":"10.1016\/j.placenta.2012.07.002_bib7","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1053\/plac.2002.0815","article-title":"Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies \u2013 a review","volume":"23","author":"Caniggia","year":"2002","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.placenta.2012.07.002_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2004.02.011","article-title":"Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae","volume":"25","author":"Rajakumar","year":"2004","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2012.07.002_bib9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.placenta.2010.08.008","article-title":"Regulation of hypoxia inducible factors (HIF) in hypoxia and normoxia during placental development","volume":"31","author":"Patel","year":"2010","journal-title":"Placenta"},{"issue":"Suppl","key":"10.1016\/j.placenta.2012.07.002_bib10","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.placenta.2009.12.021","article-title":"Review: reactive oxygen and nitrogen species and functional adaptation of the placenta","volume":"31","author":"Myatt","year":"2010","journal-title":"Placenta"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2012.07.002_bib11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/plac.2000.0608","article-title":"Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia","volume":"22","author":"Wang","year":"2001","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.dnarep.2005.03.002","article-title":"Role of mitochondrial DNA in toxic responses to oxidative stress","volume":"5","author":"Van Houten","year":"2006","journal-title":"DNA Repair (Amst)"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/00016348909009902","article-title":"Pre-eclampsia \u2013 a mitochondrial disease?","volume":"68","author":"Torbergsen","year":"1989","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.placenta.2012.07.002_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrm2868","article-title":"MicroRNA control of signal transduction","volume":"11","author":"Inui","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib16","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.ajog.2010.09.004","article-title":"Placental microRNA expression in pregnancies complicated by preeclampsia","volume":"204","author":"Enquobahrie","year":"2011","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/HYPERTENSIONAHA.111.180232","article-title":"Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by Mir-210 and Mir-518c that are Aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia","volume":"59","author":"Ishibashi","year":"2012","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajpath.2011.04.035","article-title":"miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies","volume":"179","author":"Lee","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.placenta.2012.07.002_bib19","article-title":"MiR-210: an important player in the pathogenesis of preeclampsia?","author":"Liu","year":"2011","journal-title":"J\u00a0Cell Mol Med"},{"issue":"3","key":"10.1016\/j.placenta.2012.07.002_bib20","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2007.01.008","article-title":"Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia","volume":"196","author":"Pineles","year":"2007","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.placenta.2012.07.002_bib21","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2008.12.045","article-title":"Differential expression profile of microRNAs in human placentas from preeclamptic pregnancies vs normal pregnancies","volume":"200","author":"Zhu","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1582-4934.2011.01291.x","article-title":"Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease","volume":"16","author":"Zhang","year":"2012","journal-title":"J\u00a0Cell Mol Med"},{"issue":"6","key":"10.1016\/j.placenta.2012.07.002_bib23","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molcel.2009.09.006","article-title":"Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation","volume":"35","author":"Huang","year":"2009","journal-title":"Mol Cell"},{"issue":"30","key":"10.1016\/j.placenta.2012.07.002_bib24","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1038\/onc.2010.193","article-title":"Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression","volume":"29","author":"Chen","year":"2010","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.placenta.2012.07.002_bib25","doi-asserted-by":"crossref","first-page":"e10345","DOI":"10.1371\/journal.pone.0010345","article-title":"MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU","volume":"5","author":"Favaro","year":"2010","journal-title":"Plos One"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.placenta.2008.11.019","article-title":"Effect of increasing maternal body mass index on oxidative and nitrative stress in the human placenta","volume":"30","author":"Roberts","year":"2009","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0143-4004(89)90039-8","article-title":"Ultrastructural changes and immunocytochemical analysis of human placental trophoblast during short-term culture","volume":"10","author":"Bax","year":"1989","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.placenta.2012.07.002_bib28","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1177\/002215549704501012","article-title":"Differential localization of superoxide dismutase isoforms in placental villous tissue of normotensive, pre-eclamptic, and intrauterine growth-restricted pregnancies","volume":"45","author":"Myatt","year":"1997","journal-title":"J\u00a0Histochem Cytochem"},{"issue":"10","key":"10.1016\/j.placenta.2012.07.002_bib29","doi-asserted-by":"crossref","first-page":"e13288","DOI":"10.1371\/journal.pone.0013288","article-title":"Abnormalities in oxygen sensing define early and late onset preeclampsia as distinct pathologies","volume":"5","author":"Rolfo","year":"2010","journal-title":"Plos One"},{"issue":"7","key":"10.1016\/j.placenta.2012.07.002_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S1357-4310(98)01293-3","article-title":"Pre-eclampsia: a disorder of placental mitochondria?","volume":"4","author":"Widschwendter","year":"1998","journal-title":"Mol Med Today"},{"issue":"3","key":"10.1016\/j.placenta.2012.07.002_bib31","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jemt.1070270303","article-title":"Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria","volume":"27","author":"Bereiter-Hahn","year":"1994","journal-title":"Microsc Res Tech"},{"issue":"8","key":"10.1016\/j.placenta.2012.07.002_bib32","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.cdd.4401260","article-title":"Dynamics of mitochondrial morphology in healthy cells and during apoptosis","volume":"10","author":"Karbowski","year":"2003","journal-title":"Cell Death Differ"},{"issue":"5A","key":"10.1016\/j.placenta.2012.07.002_bib33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1582-4934.2008.00398.x","article-title":"Hypoxia response and microRNAs: no longer two separate worlds","volume":"12","author":"Ivan","year":"2008","journal-title":"J\u00a0Cell Mol Med"},{"issue":"5","key":"10.1016\/j.placenta.2012.07.002_bib34","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1128\/MCB.01395-06","article-title":"A\u00a0microRNA signature of hypoxia","volume":"27","author":"Kulshreshtha","year":"2007","journal-title":"Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/path.2860","article-title":"Overexpression of miR-210, a downstream target of HIF1alpha, causes centrosome amplification in renal carcinoma cells","volume":"224","author":"Nakada","year":"2011","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.placenta.2012.07.002_bib36","article-title":"miR-210: the master hypoxamir","author":"Chan","year":"2011","journal-title":"Microcirculation"},{"issue":"2","key":"10.1016\/j.placenta.2012.07.002_bib37","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/iub.427","article-title":"miR-210: more than a silent player in hypoxia","volume":"63","author":"Devlin","year":"2011","journal-title":"Iubmb Life"},{"issue":"4","key":"10.1016\/j.placenta.2012.07.002_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cmet.2009.08.015","article-title":"MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1\/2","volume":"10","author":"Chan","year":"2009","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.placenta.2012.07.002_bib39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/cdd.2010.119","article-title":"miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity","volume":"18","author":"Puissegur","year":"2011","journal-title":"Cell Death Differ"},{"issue":"21","key":"10.1016\/j.placenta.2012.07.002_bib40","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1038\/emboj.2011.379","article-title":"The mitochondrial contact site complex, a determinant of mitochondrial architecture","volume":"30","author":"Harner","year":"2011","journal-title":"EMBO J"},{"issue":"5","key":"10.1016\/j.placenta.2012.07.002_bib41","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.ejhg.5200793","article-title":"Succinate dehydrogenase and human diseases: new insights into a well-known enzyme","volume":"10","author":"Rustin","year":"2002","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1016\/j.placenta.2012.07.002_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbadis.2010.02.001","article-title":"Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts","volume":"1802","author":"Moran","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.placenta.2012.07.002_bib43","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.freeradbiomed.2010.01.015","article-title":"Mitochondrial reserve capacity in endothelial cells: the impact of nitric oxide and reactive oxygen species","volume":"48","author":"Dranka","year":"2010","journal-title":"Free Radic Biol Med"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412002615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412002615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:46:22Z","timestamp":1758908782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400412002615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0143400412002615"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2012.07.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MIR-210 modulates mitochondrial respiration in placenta with preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2012.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}