{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:34:33Z","timestamp":1791225273880,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.placenta.2012.11.026","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T15:12:25Z","timestamp":1357657945000},"page":"S79-S84","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"S","title":["Review: The role of autophagy in extravillous trophoblast function under hypoxia"],"prefix":"10.1016","volume":"34","author":[{"given":"S.","family":"Saito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.placenta.2012.11.026_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/35056522","article-title":"Molecular dissection of autophagy: two ubiquitin-like systems","volume":"2","author":"Ohsumi","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1\u20132","key":"10.1016\/j.placenta.2012.11.026_bib2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/B:MCBI.0000041848.57020.57","article-title":"Autophagy: many paths to the same end","volume":"263","author":"Cuervo","year":"2004","journal-title":"Mol Cell Biochem"},{"issue":"4","key":"10.1016\/j.placenta.2012.11.026_bib3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.bbrc.2003.07.023","article-title":"Autophagy: a regulated bulk degradation process inside cells","volume":"313","author":"Yoshimori","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.placenta.2012.11.026_bib5","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.placenta.2012.04.011","article-title":"Survival by self-destruction: a role for autophagy in the placenta?","volume":"33","author":"Bildirici","year":"2012","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.virol.2006.03.029","article-title":"Survival of parvovirus B19-infected cells by cellular autophagy","volume":"349","author":"Nakashima","year":"2006","journal-title":"Virology"},{"issue":"5332","key":"10.1016\/j.placenta.2012.11.026_bib7","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"Genbacev","year":"1997","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib8","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1210\/jc.2004-1513","article-title":"Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment","volume":"90","author":"Jauniaux","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"Suppl","key":"10.1016\/j.placenta.2012.11.026_bib9","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1016\/j.placenta.2009.12.021","article-title":"Review: reactive oxygen and nitrogen species and functional adaptation of the placenta","volume":"31","author":"Myatt","year":"2010","journal-title":"Placenta"},{"issue":"5885","key":"10.1016\/j.placenta.2012.11.026_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1154822","article-title":"Autophagy is essential for preimplantation development of mouse embryos","volume":"321","author":"Tsukamoto","year":"2008","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.placenta.2012.11.026_bib11","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1210\/en.2010-1456","article-title":"Autophagy regulates embryonic survival during delayed implantation","volume":"152","author":"Lee","year":"2011","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejcb.2008.09.004","article-title":"IGF-I, EGF, and sex steroids regulate autophagy in bovine mammary epithelial cells via the mTOR pathway","volume":"88","author":"Sobolewska","year":"2009","journal-title":"Eur J Cell Biol"},{"issue":"4","key":"10.1016\/j.placenta.2012.11.026_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1600-0897.2012.01115.x","article-title":"The balance of the immune system between T cells and NK cells in miscarriage","volume":"67","author":"Nakashima","year":"2012","journal-title":"Am J Reprod Immunol"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ceb.2010.01.001","article-title":"The beclin 1 interactome","volume":"22","author":"He","year":"2010","journal-title":"Curr Opin Cell Biol"},{"issue":"25","key":"10.1016\/j.placenta.2012.11.026_bib15","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1073\/pnas.2436255100","article-title":"Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor","volume":"100","author":"Yue","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.placenta.2012.11.026_bib16","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1083\/jcb.200604129","article-title":"Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways","volume":"175","author":"Gan","year":"2006","journal-title":"J\u00a0Cell Biol"},{"issue":"7148","key":"10.1016\/j.placenta.2012.11.026_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nature05925","article-title":"Ambra1 regulates autophagy and development of the nervous system","volume":"447","author":"Fimia","year":"2007","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.placenta.2012.11.026_bib18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.placenta.2011.03.005","article-title":"Autophagy in term normal human placentas","volume":"32","author":"Signorelli","year":"2011","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2012.11.026_bib19","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2008.09.001","article-title":"Autophagic and apoptotic cell death in amniotic epithelial cells","volume":"29","author":"Shen","year":"2008","journal-title":"Placenta"},{"issue":"18","key":"10.1016\/j.placenta.2012.11.026_bib20","doi-asserted-by":"crossref","first-page":"18283","DOI":"10.1074\/jbc.M413957200","article-title":"Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast","volume":"280","author":"Yamada","year":"2005","journal-title":"J\u00a0Biol Chem"},{"issue":"49","key":"10.1016\/j.placenta.2012.11.026_bib21","doi-asserted-by":"crossref","first-page":"20842","DOI":"10.1073\/pnas.0911267106","article-title":"Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response","volume":"106","author":"Saitoh","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.placenta.2012.11.026_bib22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.placenta.2010.08.011","article-title":"Trophoblast invasion: assessment of cellular models using gene expression signatures","volume":"31","author":"Bilban","year":"2010","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib23","first-page":"229","article-title":"Establishment of an immortalized human extravillous trophoblast cell line by retroviral infection of E6\/E7\/hTERT and its transcriptional profile during hypoxia and reoxygenation","volume":"23","author":"Omi","year":"2009","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.placenta.2012.11.026_bib24","unstructured":"Nakashima AYM, Fujita N, Koizumi K, Shima T, Yoshida T, Nikaido T, Okamoto A, Yoshimori T, Saito S. Impaired autophagy by soluble endoglin under physiological hypoxia in early pregnant period is involved in poor placentation in preeclampsia. Autophagy. In press."},{"issue":"5","key":"10.1016\/j.placenta.2012.11.026_bib25","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1067\/mob.2001.111935","article-title":"Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation","volume":"184","author":"Jauniaux","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2012.11.026_bib26","doi-asserted-by":"crossref","DOI":"10.1210\/en.2012-1472","article-title":"Hypoxia induces autophagy in primary human trophoblasts","author":"Chen","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.placenta.2012.11.026_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4161\/auto.5.1.7183","article-title":"Atg4B(C74A) hampers autophagosome closure: a useful protein for inhibiting autophagy","volume":"5","author":"Fujita","year":"2009","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5653\/cerm.2012.39.2.73","article-title":"Effects of hypoxia inducible factors-1alpha on autophagy and invasion of trophoblasts","volume":"39","author":"Choi","year":"2012","journal-title":"Clin Exp Reprod Med"},{"issue":"10","key":"10.1016\/j.placenta.2012.11.026_bib29","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/cdd.2008.84","article-title":"Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L","volume":"15","author":"Papandreou","year":"2008","journal-title":"Cell Death Differ"},{"issue":"10","key":"10.1016\/j.placenta.2012.11.026_bib30","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1016\/j.yexcr.2009.01.026","article-title":"mTOR mediates human trophoblast invasion through regulation of matrix-remodeling enzymes and is associated with serine phosphorylation of STAT3","volume":"315","author":"Busch","year":"2009","journal-title":"Exp Cell Res"},{"issue":"16","key":"10.1016\/j.placenta.2012.11.026_bib31","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1074\/jbc.M800102200","article-title":"Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia","volume":"283","author":"Zhang","year":"2008","journal-title":"J\u00a0Biol Chem"},{"issue":"12","key":"10.1016\/j.placenta.2012.11.026_bib32","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI6380","article-title":"Inhibition of TGF-beta 3 restores the invasive capability of extravillous trophoblasts in preeclamptic pregnancies","volume":"103","author":"Caniggia","year":"1999","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jcp.1041480207","article-title":"Mechanism of control of trophoblast invasion in situ","volume":"148","author":"Graham","year":"1991","journal-title":"J\u00a0Cell Physiol"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1095\/biolreprod.105.040337","article-title":"Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteases","volume":"73","author":"Lash","year":"2005","journal-title":"Biol Reprod"},{"issue":"6","key":"10.1016\/j.placenta.2012.11.026_bib35","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1210\/en.2009-1195","article-title":"Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast","volume":"151","author":"Wolf","year":"2010","journal-title":"Endocrinology"},{"issue":"23","key":"10.1016\/j.placenta.2012.11.026_bib36","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1158\/0008-5472.CAN-08-4401","article-title":"Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells","volume":"69","author":"Kiyono","year":"2009","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.placenta.2012.11.026_bib37","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4161\/auto.6.5.12046","article-title":"Regulation of autophagy by transforming growth factor-beta (TGF-beta) signaling","volume":"6","author":"Suzuki","year":"2010","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.placenta.2012.11.026_bib38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"issue":"7","key":"10.1016\/j.placenta.2012.11.026_bib39","doi-asserted-by":"crossref","first-page":"e40957","DOI":"10.1371\/journal.pone.0040957","article-title":"Increased autophagy in placentas of intrauterine growth-restricted pregnancies","volume":"7","author":"Hung","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.placenta.2012.11.026_bib40","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/1933719108319159","article-title":"Autophagy-related proteins, LC3 and Beclin-1, in placentas from pregnancies complicated by preeclampsia","volume":"15","author":"Oh","year":"2008","journal-title":"Reprod Sci"},{"issue":"3","key":"10.1016\/j.placenta.2012.11.026_bib41","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ajog.2006.01.067","article-title":"First-trimester trophoblast cell model gene response to hypoxia","volume":"194","author":"Koklanaris","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2012.11.026_bib42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejogrb.2005.01.017","article-title":"Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome","volume":"122","author":"Stepan","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"6","key":"10.1016\/j.placenta.2012.11.026_bib43","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.placenta.2008.03.006","article-title":"Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia","volume":"29","author":"Jeyabalan","year":"2008","journal-title":"Placenta"},{"issue":"7","key":"10.1016\/j.placenta.2012.11.026_bib44","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1210\/jc.2006-2774","article-title":"Maternal plasma concentrations of soluble endoglin in pregnancies with intrauterine growth restriction","volume":"92","author":"Stepan","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.placenta.2012.11.026_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412004614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412004614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:48:00Z","timestamp":1758908880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400412004614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":45,"alternative-id":["S0143400412004614"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2012.11.026","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Review: The role of autophagy in extravillous trophoblast function under hypoxia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2012.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}