{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:19:40Z","timestamp":1792037980102,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":165,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Wellcome Trust International Senior Research Fellowship in Biomedical Science","award":["070191\/Z\/03\/A"],"award-info":[{"award-number":["070191\/Z\/03\/A"]}]},{"DOI":"10.13039\/501100001837","name":"Estonian Science Foundation","doi-asserted-by":"crossref","award":["ETF7471"],"award-info":[{"award-number":["ETF7471"]}],"id":[{"id":"10.13039\/501100001837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001837","name":"Estonian Science Foundation","doi-asserted-by":"crossref","award":["ETF9030"],"award-info":[{"award-number":["ETF9030"]}],"id":[{"id":"10.13039\/501100001837","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Estonian Ministry of Education and Science","award":["SF0180022s12"],"award-info":[{"award-number":["SF0180022s12"]}]},{"name":"HHMI International Scholarship","award":["#55005617"],"award-info":[{"award-number":["#55005617"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.placenta.2012.11.032","type":"journal-article","created":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T21:02:47Z","timestamp":1357160567000},"page":"141-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Increased placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent miscarriage"],"prefix":"10.1016","volume":"34","author":[{"given":"K.","family":"Rull","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tomberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"K\u00f5ks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"M\u00e4nnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"M\u00f6ls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Sirotkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"V\u00e4rv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2012.11.032_bib1","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMcp1005330","article-title":"Clinical practice. Recurrent miscarriage","volume":"363","author":"Branch","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.placenta.2012.11.032_bib2","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1093\/HUMREP\/10.6.1516","article-title":"The Euro-team early pregnancy (ETEP) protocol for recurrent miscarriage","volume":"10","author":"Berry","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2012.11.032_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/01.GIM.0000160075.96707.04","article-title":"Incidence and spectrum of chromosome abnormalities in spontaneous abortions: new insights from a 12-year study","volume":"7","author":"Menasha","year":"2005","journal-title":"Genet Med"},{"key":"10.1016\/j.placenta.2012.11.032_bib5","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/humrep\/deg309","article-title":"Embryoscopic and cytogenetic analysis of 233 missed abortions: factors involved in the pathogenesis of developmental defects of early failed pregnancies","volume":"18","author":"Philipp","year":"2003","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.fertnstert.2004.12.018","article-title":"Evidence-based investigations and treatments of recurrent pregnancy loss","volume":"83","author":"Christiansen","year":"2005","journal-title":"Fertil Steril"},{"key":"10.1016\/j.placenta.2012.11.032_bib7","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/humupd\/8.5.463","article-title":"Recurrent miscarriage: aetiology, management and prognosis","volume":"8","author":"Li","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.placenta.2012.11.032_bib8","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1093\/humrep\/del150","article-title":"Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage","volume":"21","author":"Jauniaux","year":"2006","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib9","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/humrep\/der021","article-title":"Supportive care for women with unexplained recurrent miscarriage: patients' perspectives","volume":"26","author":"Musters","year":"2011","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fgene.2012.00034","article-title":"Genetics of recurrent miscarriage: challenges, current knowledge, future directions","volume":"3","author":"Rull","year":"2012","journal-title":"Front Genet"},{"key":"10.1016\/j.placenta.2012.11.032_bib11","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1039\/c0mb00219d","article-title":"ITI-H4, as a biomarker in the serum of recurrent pregnancy loss (RPL) patients","volume":"7","author":"Kim","year":"2011","journal-title":"Mol Biosyst"},{"issue":"1","key":"10.1016\/j.placenta.2012.11.032_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajog.2011.02.051","article-title":"Pro- and antiinflammatory cytokines in threatened miscarriages","volume":"205","author":"Calleja-Agius","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2012.11.032_bib13","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1093\/humrep\/des289","article-title":"Soluble TRAIL is elevated in recurrent miscarriage and inhibits the in\u00a0vitro adhesion and migration of HTR8 trophoblastic cells","volume":"27","author":"Agostinis","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib14","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humupd\/dml016","article-title":"Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution","volume":"12","author":"Jauniaux","year":"2006","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.placenta.2012.11.032_bib15","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1073\/pnas.0508035103","article-title":"Gene expression patterns in human placenta","volume":"103","author":"Sood","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2012.11.032_bib16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1071\/RD02008","article-title":"Comparison of gene expression at the feto-maternal interface between normal and recurrent pregnancy loss patients","volume":"14","author":"Baek","year":"2002","journal-title":"Reprod Fertil Dev"},{"key":"10.1016\/j.placenta.2012.11.032_bib17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/mrd.10331","article-title":"Expression of angiogenesis- and apoptosis-related genes in chorionic villi derived from recurrent pregnancy loss patients","volume":"66","author":"Choi","year":"2003","journal-title":"Mol Reprod Dev"},{"key":"10.1016\/j.placenta.2012.11.032_bib18","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1093\/humrep\/dei261","article-title":"Expression of beta-subunit of HCG genes during normal and failed pregnancy","volume":"20","author":"Rull","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib19","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1093\/humrep\/dei167","article-title":"Updated and revised nomenclature for description of early pregnancy events","volume":"20","author":"Farquharson","year":"2005","journal-title":"Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib20","first-page":"1243","article-title":"Management of spontaneous abortion","volume":"72","author":"Griebel","year":"2005","journal-title":"Am Fam Physician"},{"issue":"Article3","key":"10.1016\/j.placenta.2012.11.032_bib21","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"10.1016\/j.placenta.2012.11.032_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1073\/pnas.98.1.31","article-title":"Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection","volume":"98","author":"Li","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2012.11.032_bib23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1601-183X.2007.00304.x","article-title":"Interpretation of knockout experiments: the congenic footprint","volume":"6","author":"Schalkwyk","year":"2007","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.placenta.2012.11.032_bib24","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbr.2007.10.020","article-title":"Gene expression profiling reveals upregulation of Tlr4 receptors in Cckb receptor deficient mice","volume":"188","author":"K\u00f5ks","year":"2008","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.placenta.2012.11.032_bib25","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2012.11.032_bib26","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.placenta.2012.11.032_bib27","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1093\/bioinformatics\/btg157","article-title":"Q-Gene: processing quantitative real-time RT-PCR data","volume":"19","author":"Simon","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2012.11.032_bib28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/er.2005-0003","article-title":"The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy","volume":"26","author":"Straszewski-Chavez","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.placenta.2012.11.032_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","article-title":"Placental apoptosis in health and disease","volume":"64","author":"Sharp","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.placenta.2012.11.032_bib30","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1477-7827-8-126","article-title":"Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients","volume":"8","author":"Meresman","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"10.1016\/j.placenta.2012.11.032_bib31","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/molehr\/gah049","article-title":"Aberrant gene expression associated with recurrent pregnancy loss","volume":"10","author":"Baek","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/molehr\/4.1.87","article-title":"Apoptosis in human chorionic villi and decidua in normal and ectopic pregnancy","volume":"4","author":"Kokawa","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.placenta.2012.11.032_bib33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","article-title":"Identification and characterization of a new member of the TNF family that induces apoptosis","volume":"3","author":"Wiley","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.placenta.2012.11.032_bib34","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.lfs.2003.07.044","article-title":"Localization and variation of TRAIL and its receptors in human placenta during gestation","volume":"74","author":"Chen","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.placenta.2012.11.032_bib35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2009.07.006","article-title":"A\u00a0placental protective role for trophoblast-derived TNF-related apoptosis-inducing ligand (TRAIL)","volume":"30","author":"Bai","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2012.11.032_bib36","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.4049\/jimmunol.162.10.6053","article-title":"TRAIL (Apo-2L) and TRAIL receptors in human placentas: implications for immune privilege","volume":"162","author":"Phillips","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.placenta.2012.11.032_bib37","first-page":"221","article-title":"Biochemical analysis of the native TRAIL death-inducing signaling complex","volume":"414","author":"Walczak","year":"2008","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.placenta.2012.11.032_bib38","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1210\/jc.2002-021905","article-title":"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptors, and the soluble receptor osteoprotegerin in human gestational membranes and amniotic fluid during pregnancy and labor at term and preterm","volume":"88","author":"Lonergan","year":"2003","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.placenta.2012.11.032_bib39","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.fertnstert.2009.04.017","volume":"92","author":"Fluhr","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.placenta.2012.11.032_bib40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-0897.2010.00844.x","article-title":"Phenotype of NK cells and cytotoxic\/apoptotic mediators expression in ectopic pregnancy","volume":"64","author":"Laskarin","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.placenta.2012.11.032_bib41","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biocel.2007.02.007","article-title":"TRAIL signalling: decisions between life and death","volume":"39","author":"Falschlehner","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.placenta.2012.11.032_bib42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejogrb.2010.03.006","article-title":"The role of calprotectin in obstetrics and gynecology","volume":"151","author":"Kostakis","year":"2010","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.placenta.2012.11.032_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajog.2004.11.055","article-title":"Calprotectin, a marker of inflammation, is elevated in the maternal but not in the fetal circulation in preeclampsia","volume":"193","author":"Braekke","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2012.11.032_bib44","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/jama.292.4.462","article-title":"Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers","volume":"292","author":"Gravett","year":"2004","journal-title":"J\u00a0Am Med Assoc"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412004675?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400412004675?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:47:13Z","timestamp":1758908833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400412004675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0143400412004675"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2012.11.032","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased placental expression and maternal serum levels of apoptosis-inducing TRAIL in recurrent miscarriage","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2012.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}