{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:40:08Z","timestamp":1790800808557,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.placenta.2013.01.004","type":"journal-article","created":{"date-parts":[[2013,2,9]],"date-time":"2013-02-09T15:02:11Z","timestamp":1360422131000},"page":"291-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Heme oxygenase-1 in placental development and pathology"],"prefix":"10.1016","volume":"34","author":[{"given":"K.","family":"Levytska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kingdom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Baczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Drewlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0033-0620(74)90028-0","article-title":"Maternal cardiovascular adjustments to pregnancy","volume":"16","author":"Metcalfe","year":"1974","journal-title":"Prog Cardiovasc Dis"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijcard.2003.10.028","article-title":"Pregnancy and the cardiovascular system","volume":"98","author":"Abbas","year":"2005","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.112.194159","article-title":"Maternal cardiovascular impairment in pregnancies complicated by severe fetal growth restriction","volume":"60","author":"Melchiorre","year":"2012","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.placenta.2009.02.009","article-title":"Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/AOG.0b013e31820ca040","article-title":"Placental infarction and thrombophilia","volume":"117","author":"Franco","year":"2011","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.placenta.2012.02.014","article-title":"Hydrogen sulfide producing enzymes in pregnancy and preeclampsia","volume":"33","author":"Holwerda","year":"2012","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1161\/HYPERTENSIONAHA.111.187559","article-title":"Endothelial nitric oxide synthase deficiency reduces uterine blood flow, spiral artery elongation, and placental oxygenation in pregnant mice","volume":"60","author":"Kulandavelu","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1067\/mob.2000.109047","article-title":"End-tidal carbon monoxide measurements in women with pregnancy-induced hypertension and preeclampsia","volume":"183","author":"Baum","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib10","first-page":"67","article-title":"American college of obstetricians and gynecologists","volume":"77","author":"ACOG practice bulletin","year":"2002","journal-title":"Int J Gynaecol Obstet"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J\u00a0Clin Invest"},{"issue":"7","key":"10.1016\/j.placenta.2013.01.004_bib12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib13","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/CIRCULATIONAHA.111.034793","article-title":"Pilot study of extracorporeal removal of soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"124","author":"Thadhani","year":"2011","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib14","doi-asserted-by":"crossref","first-page":"R1495","DOI":"10.1152\/ajpregu.00325.2011","article-title":"Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats","volume":"301","author":"George","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"13","key":"10.1016\/j.placenta.2013.01.004_bib15","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1161\/CIRCULATIONAHA.106.660134","article-title":"Negative regulation of soluble Flt-1 and soluble endoglin release by heme oxygenase-1","volume":"115","author":"Cudmore","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.11.010","article-title":"Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta","volume":"206","author":"Cudmore","year":"2012","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2045-9912-2-4","article-title":"Exploring the potential of low doses carbon monoxide as therapy in pregnancy complications","volume":"2","author":"El-Mousleh","year":"2012","journal-title":"Med Gas Res"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/path.2946","article-title":"Haem oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide","volume":"225","author":"Zenclussen","year":"2011","journal-title":"J\u00a0Pathol"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/HYPERTENSIONAHA.111.172627","article-title":"Peroxisome proliferator-activated receptor-gamma as a potential therapeutic target in the treatment of preeclampsia","volume":"58","author":"McCarthy","year":"2011","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0021-9258(17)42488-4","article-title":"Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible","volume":"261","author":"Maines","year":"1986","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/oxfordjournals.jbchem.a124028","article-title":"Functional analysis of cDNAs for two types of human heme oxygenase and evidence for their separate regulation","volume":"113","author":"Shibahara","year":"1993","journal-title":"J\u00a0Biochem"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1432-1033.1988.tb13811.x","article-title":"Human heme oxygenase cDNA and induction of its mRNA by hemin","volume":"171","author":"Yoshida","year":"1988","journal-title":"Eur J Biochem"},{"issue":"23","key":"10.1016\/j.placenta.2013.01.004_bib23","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1016\/S0021-9258(18)63477-5","article-title":"Microsomal heme oxygenase. Characterization of the enzyme","volume":"244","author":"Tenhunen","year":"1969","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S1367-5931(99)00079-4","article-title":"The mechanism of heme oxygenase","volume":"4","author":"Montellano","year":"2000","journal-title":"Curr Opin Chem Biol"},{"issue":"24","key":"10.1016\/j.placenta.2013.01.004_bib25","doi-asserted-by":"crossref","first-page":"16712","DOI":"10.1016\/S0021-9258(19)89449-8","article-title":"Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation","volume":"269","author":"Neuzil","year":"1994","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF03401783","article-title":"Induction of placental heme oxygenase-1 is protective against TNFalpha-induced cytotoxicity and promotes vessel relaxation","volume":"6","author":"Ahmed","year":"2000","journal-title":"Mol Med"},{"issue":"7","key":"10.1016\/j.placenta.2013.01.004_bib27","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1084\/jem.192.7.1015","article-title":"Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis","volume":"192","author":"Brouard","year":"2000","journal-title":"J\u00a0Exp Med"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1165\/rcmb.4816","article-title":"Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colony-stimulating factor in macrophages","volume":"27","author":"Sarady","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5109","key":"10.1016\/j.placenta.2013.01.004_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.8484109","article-title":"Carbon monoxide and dilation of blood vessels","volume":"260","author":"Coceani","year":"1993","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.92.5.1475","article-title":"Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP","volume":"92","author":"Morita","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib31","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI927","article-title":"Hemeoxygenase-1 inhibits human myometrial contractility via carbon monoxide and is upregulated by progesterone during pregnancy","volume":"101","author":"Acevedo","year":"1998","journal-title":"J\u00a0Clin Invest"},{"issue":"8\u20139","key":"10.1016\/j.placenta.2013.01.004_bib32","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1053\/plac.2002.0845","article-title":"Carbon monoxide decreases perfusion pressure in isolated human placenta","volume":"23","author":"Bainbridge","year":"2002","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1172\/JCI4165","article-title":"Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency","volume":"103","author":"Yachie","year":"1999","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/molehr\/gah024","article-title":"The size of a microsatellite polymorphism of the haem oxygenase 1 gene is associated with idiopathic recurrent miscarriage","volume":"10","author":"Denschlag","year":"2004","journal-title":"Mol Hum Reprod"},{"issue":"1\u20132","key":"10.1016\/j.placenta.2013.01.004_bib35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/gtmb.2010.0103","article-title":"Association of heme oxygenase-1 gene polymorphisms with essential hypertension and blood pressure in the Chinese Han population","volume":"15","author":"Lin","year":"2011","journal-title":"Genet Test Mol Biomarkers"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib36","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1097\/00004872-200308000-00013","article-title":"Association of a promoter variant of the haeme oxygenase-1 gene with hypertension in women","volume":"21","author":"Ono","year":"2003","journal-title":"J\u00a0Hypertens"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12192-011-0309-z","article-title":"Short (GT) ( n ) repeats in heme oxygenase-1 gene promoter are associated with lower risk of coronary heart disease in subjects with high levels of oxidative stress","volume":"17","author":"Chen","year":"2012","journal-title":"Cell Stress Chaperones"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib38","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1203\/01.PDR.0000072516.83498.07","article-title":"Gestational pattern of heme oxygenase expression in the rat","volume":"54","author":"Kreiser","year":"2003","journal-title":"Pediatr Res"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.placenta.2003.10.012","article-title":"Marked developmental changes in heme oxygenase-1 (HO-1) expression in the mouse placenta: correlation between HO-1 expression and placental development","volume":"25","author":"Watanabe","year":"2004","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib40","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1095\/biolreprod.107.064899","article-title":"Regulation of maternal and fetal hemodynamics by heme oxygenase in mice","volume":"78","author":"Zhao","year":"2008","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1096\/fasebj.14.1.208","article-title":"Hemeoxygenase expression in human placenta and placental bed implies a role in regulation of trophoblast invasion and placental function","volume":"14","author":"Lyall","year":"2000","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib42","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/15353702-0322805-28","article-title":"Heme oxygenase expression in selected regions of term human placenta","volume":"228","author":"McLaughlin","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib43","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1210\/jcem.85.6.6705","article-title":"Expression of the heme oxygenase-carbon monoxide signalling system in human placenta","volume":"85","author":"McLean","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib44","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1006\/bbrc.2000.3551","article-title":"Expression and localization of heme oxygenase in human placental villi","volume":"276","author":"Yoshiki","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.jp.7211062","article-title":"End tidal carbon monoxide levels are lower in women with gestational hypertension and pre-eclampsia","volume":"24","author":"Kreiser","year":"2004","journal-title":"J\u00a0Perinatol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1034\/j.1600-0897.2003.00047.x","article-title":"Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies","volume":"50","author":"Zenclussen","year":"2003","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib47","doi-asserted-by":"crossref","first-page":"H160","DOI":"10.1152\/ajpheart.00738.2002","article-title":"Relationship between tissue damage and heme oxygenase expression in chorionic villi of term human placenta","volume":"284","author":"Lash","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"7","key":"10.1016\/j.placenta.2013.01.004_bib48","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1096\/fj.00-0376com","article-title":"Heme oxygenase expression in human placenta and placental bed: reduced expression of placenta endothelial HO-2 in preeclampsia and fetal growth restriction","volume":"15","author":"Barber","year":"2001","journal-title":"FASEB J"},{"issue":"12","key":"10.1016\/j.placenta.2013.01.004_bib49","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000024411.22110.AA","article-title":"Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia","volume":"90","author":"Hung","year":"2002","journal-title":"Circ Res"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib50","doi-asserted-by":"crossref","first-page":"H2055","DOI":"10.1152\/ajpheart.01084.2001","article-title":"Heme oxygenase activity in placenta: direct dependence on oxygen availability","volume":"282","author":"Appleton","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib51","doi-asserted-by":"crossref","first-page":"C92","DOI":"10.1152\/ajpcell.2000.278.1.C92","article-title":"Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts","volume":"278","author":"Panchenko","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"issue":"18","key":"10.1016\/j.placenta.2013.01.004_bib52","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.275.18.13613","article-title":"Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols","volume":"275","author":"Motterlini","year":"2000","journal-title":"J\u00a0Biol Chem"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib53","doi-asserted-by":"crossref","first-page":"L806","DOI":"10.1152\/ajplung.2000.278.4.L806","article-title":"Expression of heme oxygenase-1 in the lung in chronic hypoxia","volume":"278","author":"Carraway","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib54","doi-asserted-by":"crossref","first-page":"H853","DOI":"10.1152\/ajpheart.00655.2002","article-title":"Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells","volume":"284","author":"Appleton","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib55","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/10641950802132811","article-title":"Heme oxygenase expression in human placental villous tissue in response to exposure to in\u00a0vitro ischemia-reperfusion injury","volume":"28","author":"McCaig","year":"2009","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.placenta.2013.01.004_bib56","doi-asserted-by":"crossref","first-page":"486053","DOI":"10.1155\/2012\/486053","article-title":"Heme oxygenase-1 attenuates hypoxia-induced sFlt-1 and oxidative stress in placental villi through its metabolic products CO and bilirubin","volume":"2012","author":"George","year":"2012","journal-title":"Int J Hypertens"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib57","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/HYPERTENSIONAHA.111.169755","article-title":"Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension","volume":"57","author":"George","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2013.01.004_bib58","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-1-60761-869-0_25","article-title":"Pregnancy: tolerance and suppression of immune responses","volume":"677","author":"Leber","year":"2011","journal-title":"Methods Mol Biol"},{"issue":"10","key":"10.1016\/j.placenta.2013.01.004_bib59","doi-asserted-by":"crossref","first-page":"e46755","DOI":"10.1371\/journal.pone.0046755","article-title":"Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression","volume":"7","author":"Gonzalez","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.placenta.2013.01.004_bib60","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol Today"},{"issue":"9","key":"10.1016\/j.placenta.2013.01.004_bib61","doi-asserted-by":"crossref","first-page":"e25046","DOI":"10.1371\/journal.pone.0025046","article-title":"Protective role of heme oxygenase-1 in Listeria monocytogenes-induced abortion","volume":"6","author":"Tachibana","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib62","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.4049\/jimmunol.175.8.4875","article-title":"Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface","volume":"175","author":"Sollwedel","year":"2005","journal-title":"J\u00a0Immunol"},{"issue":"9","key":"10.1016\/j.placenta.2013.01.004_bib63","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1600-0463.2011.02774.x","article-title":"Placental trophoblasts shifted Th1\/Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface","volume":"119","author":"Liu","year":"2011","journal-title":"APMIS"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib64","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.0001-6349.2005.00714.x","article-title":"Placental imbalance of Th1- and Th2-type cytokines in preeclampsia","volume":"84","author":"Dong","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib65","doi-asserted-by":"crossref","first-page":"R713","DOI":"10.1152\/ajpregu.00712.2009","article-title":"Interleukin-10 reduces inflammation, endothelial dysfunction, and blood pressure in hypertensive pregnant rats","volume":"298","author":"Tinsley","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib66","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice","volume":"8","author":"Lee","year":"2002","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib67","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2567.2004.01869.x","article-title":"Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset","volume":"112","author":"Somerset","year":"2004","journal-title":"Immunology"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases","volume":"10","author":"Sasaki","year":"2004","journal-title":"Mol Hum Reprod"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib69","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0002-9440(10)62302-4","article-title":"Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model","volume":"166","author":"Zenclussen","year":"2005","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib70","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1046\/j.1365-3083.2002.01091.x","article-title":"Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion","volume":"55","author":"Zenclussen","year":"2002","journal-title":"Scand J Immunol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib71","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/eji.200535428","article-title":"Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface","volume":"36","author":"Zenclussen","year":"2006","journal-title":"Eur J Immunol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.intimp.2004.09.011","article-title":"Heme oxygenase as a therapeutic target in immunological pregnancy complications","volume":"5","author":"Zenclussen","year":"2005","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib73","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jri.2005.10.001","article-title":"Over-expression of heme oxygenase-1 by adenoviral gene transfer improves pregnancy outcome in a murine model of abortion","volume":"69","author":"Zenclussen","year":"2006","journal-title":"J\u00a0Reprod Immunol"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib74","doi-asserted-by":"crossref","first-page":"e42301","DOI":"10.1371\/journal.pone.0042301","article-title":"Blockage of heme oxygenase-1 abrogates the protective effect of regulatory T cells on murine pregnancy and promotes the maturation of dendritic cells","volume":"7","author":"Schumacher","year":"2012","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.placenta.2013.01.004_bib75","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.94.20.10925","article-title":"Reduced stress defense in heme oxygenase 1-deficient cells","volume":"94","author":"Poss","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"10.1016\/j.placenta.2013.01.004_bib76","doi-asserted-by":"crossref","first-page":"10919","DOI":"10.1073\/pnas.94.20.10919","article-title":"Heme oxygenase 1 is required for mammalian iron reutilization","volume":"94","author":"Poss","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.placenta.2013.01.004_bib77","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63365-2","article-title":"Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse","volume":"165","author":"Kapturczak","year":"2004","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.placenta.2013.01.004_bib78","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.placenta.2009.07.012","article-title":"Effect of heme oxygenase-1 deficiency on placental development","volume":"30","author":"Zhao","year":"2009","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.placenta.2013.01.004_bib79","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1651-2227.2012.02729.x","article-title":"A\u00a0deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects","volume":"101","author":"Wong","year":"2012","journal-title":"Acta Paediatr"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib80","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1095\/biolreprod.111.093039","article-title":"Maternal heme oxygenase 1 regulates placental vasculature development via angiogenic factors in mice","volume":"85","author":"Zhao","year":"2011","journal-title":"Biol Reprod"},{"issue":"50","key":"10.1016\/j.placenta.2013.01.004_bib81","doi-asserted-by":"crossref","first-page":"42863","DOI":"10.1074\/jbc.M111.286880","article-title":"Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia","volume":"286","author":"Kweider","year":"2011","journal-title":"J\u00a0Biol Chem"},{"issue":"28","key":"10.1016\/j.placenta.2013.01.004_bib82","doi-asserted-by":"crossref","first-page":"20621","DOI":"10.1074\/jbc.M607954200","article-title":"Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress","volume":"282","author":"Lin","year":"2007","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.placenta.2013.01.004_bib83","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/en.2008-0456","article-title":"Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma","volume":"150","author":"Bilban","year":"2009","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.placenta.2013.01.004_bib84","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.placenta.2011.01.018","article-title":"Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A","volume":"32","author":"Fitzgerald","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2013.01.004_bib85","first-page":"383","article-title":"Reduced uterine perfusion pressure (RUPP) model for studying cardiovascular-renal dysfunction in response to placental ischemia","volume":"122","author":"Granger","year":"2006","journal-title":"Methods Mol Med"},{"issue":"10","key":"10.1016\/j.placenta.2013.01.004_bib86","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/ajh.2008.239","article-title":"Role of reactive oxygen species in hypertension produced by reduced uterine perfusion in pregnant rats","volume":"21","author":"Sedeek","year":"2008","journal-title":"Am J Hypertens"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib87","doi-asserted-by":"crossref","first-page":"R620","DOI":"10.1152\/ajpregu.00617.2011","article-title":"Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure","volume":"302","author":"George","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"10.1016\/j.placenta.2013.01.004_bib88","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/ATVBAHA.107.142638","article-title":"Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors","volume":"27","author":"Kronke","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib89","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/jcp.22726","article-title":"Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARalpha-heme oxygenase-1 signaling pathway","volume":"227","author":"Cheng","year":"2011","journal-title":"J\u00a0Cell Physiol"},{"issue":"5","key":"10.1016\/j.placenta.2013.01.004_bib90","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1161\/HYPERTENSIONAHA.111.179440","article-title":"Evidence implicating peroxisome proliferator-activated receptor-gamma in the pathogenesis of preeclampsia","volume":"58","author":"McCarthy","year":"2011","journal-title":"Hypertension"},{"issue":"Suppl. A","key":"10.1016\/j.placenta.2013.01.004_bib91","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.placenta.2006.12.006","article-title":"Involvement of PPARgamma in human trophoblast invasion","volume":"28","author":"Fournier","year":"2007","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2013.01.004_bib92","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jri.2011.05.003","article-title":"PPARgamma and human trophoblast differentiation","volume":"90","author":"Fournier","year":"2011","journal-title":"J\u00a0Reprod Immunol"},{"issue":"11","key":"10.1016\/j.placenta.2013.01.004_bib93","doi-asserted-by":"crossref","first-page":"e8055","DOI":"10.1371\/journal.pone.0008055","article-title":"PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation","volume":"4","author":"Parast","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.placenta.2013.01.004_bib94","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/jcb.24110","article-title":"Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARgamma\/RXRalpha in placentogenesis","volume":"113","author":"Ruebner","year":"2012","journal-title":"J\u00a0Cell Biochem"},{"issue":"Suppl. 3","key":"10.1016\/j.placenta.2013.01.004_bib95","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1016\/S0049-3848(11)70020-2","article-title":"New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications","volume":"127","author":"Ahmed","year":"2011","journal-title":"Thromb Res"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400413000325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400413000325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:48:06Z","timestamp":1758908886000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400413000325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":95,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0143400413000325"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2013.01.004","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heme oxygenase-1 in placental development and pathology","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2013.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}