{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:06:58Z","timestamp":1789697218739,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.placenta.2013.04.007","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T02:48:03Z","timestamp":1367290083000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Differentially expressed microRNAs and affected biological pathways revealed by\u00a0modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas"],"prefix":"10.1016","volume":"34","author":[{"given":"L.","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Q.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.E.","family":"Hardison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H.","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Motsinger-Reif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.A.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Piedrahita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5728","key":"10.1016\/j.placenta.2013.04.007_bib1","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Latest advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.placenta.2013.04.007_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2013.04.007_bib3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7827-7-70","article-title":"Potential markers of preeclampsia \u2013 a review","volume":"7","author":"Grill","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"10.1016\/j.placenta.2013.04.007_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","article-title":"The global impact of pre-eclampsia and eclampsia","volume":"33","author":"Duley","year":"2009","journal-title":"Semin Perinatol"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijgo.2005.11.011","article-title":"Intrauterine growth restriction","volume":"93","author":"Haram","year":"2006","journal-title":"Int J Gynaecol Obstet"},{"issue":"2","key":"10.1016\/j.placenta.2013.04.007_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.placenta.2010.11.014","article-title":"Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways","volume":"32","author":"Tsai","year":"2011","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.placenta.2013.04.007_bib7","doi-asserted-by":"crossref","first-page":"e1000479","DOI":"10.1371\/journal.pgen.1000479","article-title":"Modulated modularity clustering as an exploratory tool for functional genomic inference","volume":"5","author":"Stone","year":"2009","journal-title":"PLoS Genet"},{"issue":"Pt 1","key":"10.1016\/j.placenta.2013.04.007_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1348\/000711005X48266","article-title":"K-means clustering: a half-century synthesis","volume":"59","author":"Steinley","year":"2006","journal-title":"Br J Math Stat Psychol"},{"issue":"43","key":"10.1016\/j.placenta.2013.04.007_bib9","doi-asserted-by":"crossref","first-page":"15278","DOI":"10.1073\/pnas.0507477102","article-title":"Application of a priori established gene sets to discover biologically important differential expression in microarray data","volume":"102","author":"Bild","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mob.2000.107928","article-title":"Report of the National High Blood Pressure Education Program Working Group on high blood pressure in pregnancy","volume":"183","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2013.04.007_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1472-6750-7-76","article-title":"Characterization of EvaGreen and the implication of its physicochemical properties for qPCR applications","volume":"7","author":"Mao","year":"2007","journal-title":"BMC Biotechnol"},{"issue":"9","key":"10.1016\/j.placenta.2013.04.007_bib12","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A\u00a0new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng.495","article-title":"Geographical genomics of human leukocyte gene expression variation in southern Morocco","volume":"42","author":"Idaghdour","year":"2010","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.placenta.2013.04.007_bib14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1541-0420.2009.01292.x","article-title":"Controlling false discoveries in multidimensional directional decisions, with applications to gene expression data on ordered categories","volume":"66","author":"Guo","year":"2010","journal-title":"Biometrics"},{"issue":"3","key":"10.1016\/j.placenta.2013.04.007_bib15","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1093\/nar\/gkp942","article-title":"A\u00a0re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data","volume":"38","author":"Barbosa-Morais","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"10.1016\/j.placenta.2013.04.007_bib16","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/bioinformatics\/bth261","article-title":"Data mining in bioinformatics using Weka","volume":"20","author":"Frank","year":"2004","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.placenta.2013.04.007_bib17","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajog.2005.10.813","article-title":"Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions","volume":"194","author":"Villar","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"13","key":"10.1016\/j.placenta.2013.04.007_bib18","doi-asserted-by":"crossref","first-page":"i41","DOI":"10.1093\/bioinformatics\/btn174","article-title":"Efficient algorithms for accurate hierarchical clustering of huge datasets: tackling the entire protein space","volume":"24","author":"Loewenstein","year":"2008","journal-title":"Bioinformatics"},{"issue":"16","key":"10.1016\/j.placenta.2013.04.007_bib19","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1128\/MCB.00018-06","article-title":"Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth","volume":"26","author":"Yae","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.placenta.2013.04.007_bib20","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1095\/biolreprod.107.061747","article-title":"A\u00a0role for tissue transglutaminase in stabilization of membrane-cytoskeletal particles shed from the human placenta","volume":"77","author":"Robinson","year":"2007","journal-title":"Biol Reprod"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1083\/jcb.201112114","article-title":"Evi5 promotes collective cell migration through its Rab-GAP activity","volume":"198","author":"Laflamme","year":"2012","journal-title":"J\u00a0Cell Biol"},{"issue":"10","key":"10.1016\/j.placenta.2013.04.007_bib22","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.4049\/jimmunol.1003332","article-title":"Vitamin D and the regulation of placental inflammation","volume":"186","author":"Liu","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3892\/mmr.2020.11691","article-title":"Reduced expression of indoleamine 2,3-dioxygenase participates in pathogenesis of preeclampsia via regulatory T cells","volume":"4","author":"Liu","year":"2011","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.placenta.2013.04.007_bib24","first-page":"S207","article-title":"Vascular biology of magnesium and its transporters in hypertension","volume":"23","author":"Yogi","year":"2010","journal-title":"Magnes Res"},{"issue":"3","key":"10.1016\/j.placenta.2013.04.007_bib25","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1684\/mrh.2011.0286","article-title":"Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency","volume":"24","author":"Li","year":"2011","journal-title":"Magnes Res"},{"issue":"6","key":"10.1016\/j.placenta.2013.04.007_bib26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ajog.2009.07.031","article-title":"Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction","volume":"201","author":"Arroyo","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.placenta.2013.04.007_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am J Pathol"},{"issue":"Pt 1","key":"10.1016\/j.placenta.2013.04.007_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BST0370295","article-title":"Placental mTOR links maternal nutrient availability to fetal growth","volume":"37","author":"Roos","year":"2009","journal-title":"Biochem Soc Trans"},{"issue":"6","key":"10.1016\/j.placenta.2013.04.007_bib29","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tem.2008.03.003","article-title":"IGF signaling defects as causes of growth failure and IUGR","volume":"19","author":"Klammt","year":"2008","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.placenta.2013.04.007_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.beem.2010.08.005","article-title":"IGF1 molecular anomalies demonstrate its critical role in fetal, postnatal growth and brain development","volume":"25","author":"Netchine","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.placenta.2013.04.007_bib31","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1373\/clinchem.2007.097972","article-title":"Detection and characterization of placental microRNAs in maternal plasma","volume":"54","author":"Chim","year":"2008","journal-title":"Clin Chem"},{"issue":"7","key":"10.1016\/j.placenta.2013.04.007_bib32","doi-asserted-by":"crossref","first-page":"e41170","DOI":"10.1371\/journal.pone.0041170","article-title":"Modulation of microRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer","volume":"7","author":"Le","year":"2012","journal-title":"PloS One"},{"issue":"Suppl. 3","key":"10.1016\/j.placenta.2013.04.007_bib33","doi-asserted-by":"crossref","first-page":"S509","DOI":"10.1245\/s10434-011-1999-2","article-title":"Inverse association between miR-194 expression and tumor invasion in gastric cancer","volume":"19","author":"Song","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.placenta.2013.04.007_bib34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jmoldx.2011.11.003","article-title":"Absolute and relative quantification of placenta-specific micrornas in maternal circulation with placental insufficiency-related complications","volume":"14","author":"Hromadnikova","year":"2012","journal-title":"J\u00a0Mol Diagn"},{"issue":"5","key":"10.1016\/j.placenta.2013.04.007_bib35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1471-0528.1996.tb09767.x","article-title":"Early prediction of pre-eclampsia by measurement of kallikrein and creatinine on a random urine sample","volume":"103","author":"Millar","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"issue":"10","key":"10.1016\/j.placenta.2013.04.007_bib36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/molehr\/gan054","article-title":"Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients","volume":"14","author":"Nishizawa","year":"2008","journal-title":"Mol Hum Reprod"},{"issue":"5991","key":"10.1016\/j.placenta.2013.04.007_bib37","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1126\/science.1191880","article-title":"Btbd7 regulates epithelial cell dynamics and branching morphogenesis","volume":"329","author":"Onodera","year":"2010","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.placenta.2013.04.007_bib38","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1128\/MCB.00883-10","article-title":"\u03b2-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation","volume":"31","author":"Anthony","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.placenta.2013.04.007_bib39","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1161\/HYPERTENSIONAHA.111.176602","article-title":"Mechanisms of enhanced vascular reactivity in preeclampsia","volume":"58","author":"Mishra","year":"2011","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2013.04.007_bib40","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1095\/biolreprod.111.094797","article-title":"Placental TonEBP\/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restriction","volume":"86","author":"Arroyo","year":"2012","journal-title":"Biol Reprod"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400413001811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400413001811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:47:32Z","timestamp":1758908852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400413001811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0143400413001811"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2013.04.007","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differentially expressed microRNAs and affected biological pathways revealed by\u00a0modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2013.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}