{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:32:57Z","timestamp":1785447177336,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["HI13C1934"],"award-info":[{"award-number":["HI13C1934"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.placenta.2014.09.020","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T23:29:53Z","timestamp":1419031793000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of the placental epigenetic signature of the SERPINB5 gene in maternal plasma of pregnancies complicated by small for gestational age"],"prefix":"10.1016","volume":"36","author":[{"given":"S.Y.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.W.","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2014.09.020_bib1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.siny.2004.03.005","article-title":"Paediatric consequences of fetal growth restriction","volume":"9","author":"Yanney","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1016\/j.placenta.2014.09.020_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/GCO.0b013e32835ec9b0","article-title":"Inequalities in perinatal and maternal health","volume":"25","author":"de Graaf","year":"2013","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.placenta.2014.09.020_bib4","doi-asserted-by":"crossref","first-page":"5R","DOI":"10.1203\/pdr.0b013e318045bedb","article-title":"Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease","volume":"61","author":"Godfrey","year":"2007","journal-title":"Pediatr Res"},{"key":"10.1016\/j.placenta.2014.09.020_bib5","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1067\/mob.2001.109594","article-title":"Elevation of both maternal and fetal extracellular circulating deoxyribonucleic acid concentrations in the plasma of pregnant women with preeclampsia","volume":"184","author":"Zhong","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/clinchem\/47.1.137","article-title":"Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia","volume":"47","author":"Leung","year":"2001","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2014.09.020_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/pd.596","article-title":"Cell-free fetal DNA concentration in plasma of patients with abnormal uterine artery Doppler waveform and intrauterine growth restriction-a pilot study","volume":"23","author":"Caramelli","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib8","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ajog.2004.12.023","article-title":"High levels of fetal cell-free DNA in maternal serum: a risk factor for spontaneous preterm delivery","volume":"193","author":"Farina","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib9","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1373\/49.9.1540","article-title":"Placenta increta: postpartum monitoring of plasma cell-free fetal DNA","volume":"49","author":"Jimbo","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2014.09.020_bib10","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/pd.1613","article-title":"High levels of circulatory erythroblasts and cell-free DNA prior to intrauterine fetal death","volume":"26","author":"Zhong","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/pd.647","article-title":"Increased total cell-free DNA in the serum of pregnant women carrying a fetus affected by trisomy 21","volume":"23","author":"Spencer","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.07.063","article-title":"Quantification of cell free fetal DNA in maternal plasma in normal pregnancies and in pregnancies with placental dysfunction","volume":"200","author":"Alberry","year":"2009","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib13","doi-asserted-by":"crossref","first-page":"14753","DOI":"10.1073\/pnas.0503335102","article-title":"Detection of the placental epigenetic signature of the maspin gene in maternal plasma","volume":"102","author":"Chim","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.placenta.2014.09.020_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/plac.2001.0784","article-title":"The tumour suppressor gene maspin is differentially regulated in cytotrophoblasts during human placental development","volume":"23","author":"Dokras","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2014.09.020_bib15","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1373\/clinchem.2006.076851","article-title":"Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma: theoretical and empirical considerations","volume":"52","author":"Tong","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2014.09.020_bib16","series-title":"Fetal growth disorders. Obstetrics","first-page":"626","author":"Park","year":"2007"},{"key":"10.1016\/j.placenta.2014.09.020_bib17","first-page":"722","article-title":"Hypermethylation-associated inactivation indicates a tumor suppressor role for p15lNK4B","volume":"56","author":"Herman","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.placenta.2014.09.020_bib18","doi-asserted-by":"crossref","first-page":"e78136","DOI":"10.1371\/journal.pone.0078136","article-title":"Non-invasive prenatal testing of trisomy 18 by an epigenetic marker in first trimester maternal plasma","volume":"8","author":"Lee da","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2014.09.020_bib19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.placenta.2014.09.020_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/AOG.0b013e3181c3c938","article-title":"Reliability of fetal sex determination using maternal plasma","volume":"115","author":"Scheffer","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1749-6632.2001.tb03873.x","article-title":"Quantitative analysis of fetal DNA in maternal plasma in pathological conditions associated with placental abnormalities","volume":"945","author":"Smid","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.placenta.2014.09.020_bib22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1067\/mob.2003.27","article-title":"Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restriction","volume":"188","author":"Sekizawa","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.placenta.2014.09.020_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejogrb.2012.09.006","article-title":"Cell-free fetal DNA and adverse outcome in low risk pregnancies","volume":"166","author":"Stein","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.placenta.2014.09.020_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000346806","article-title":"Maternal plasma cell-free fetal and maternal DNA at 11-13 weeks' gestation: relation to fetal and maternal characteristics and pregnancy outcomes","volume":"33","author":"Poon","year":"2013","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.placenta.2014.09.020_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-3476(67)80066-0","article-title":"A\u00a0practical classification of newborn infants by weight and gestational age","volume":"71","author":"Battaglia","year":"1967","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.placenta.2014.09.020_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1023\/A:1006260319913","article-title":"Detection of circulating tumour DNA in the blood (plasma\/serum) of cancer patients","volume":"18","author":"Anker","year":"1999","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.placenta.2014.09.020_bib27","first-page":"2721","article-title":"Apoptosis in serum of patients with solid tumours","volume":"19","author":"Holdenrieder","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1016\/j.placenta.2014.09.020_bib28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/pd.1504","article-title":"Correlation of fetal DNA levels in maternal plasma with Doppler status in pathological pregnancies","volume":"26","author":"Smid","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib29","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.placenta.2012.11.001","article-title":"Association of fetal-derived hypermethylated RASSF1A concentration in placenta-mediated pregnancy complications","volume":"34","author":"Kim","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2014.09.020_bib30","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/pd.4093","article-title":"RASSF1A in maternal plasma as a molecular marker of preeclampsia","volume":"33","author":"Papantoniou","year":"2013","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/dna.2009.0971","article-title":"Quantification of extracellular DNA using hypermethylated RASSF1A, SRY, and GLO sequences\u2013evaluation of diagnostic possibilities for predicting placental insufficiency","volume":"29","author":"Hromadnikova","year":"2010","journal-title":"DNA Cell Biol"},{"key":"10.1016\/j.placenta.2014.09.020_bib32","doi-asserted-by":"crossref","first-page":"e56787","DOI":"10.1371\/journal.pone.0056787","article-title":"Cell-free fetal DNA and cell-free total DNA levels in spontaneous abortion with fetal chromosomal aneuploidy","volume":"8","author":"Lim","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2014.09.020_bib33","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/pd.1513","article-title":"A\u00a0prospective analysis of cell-free fetal DNA concentration in maternal plasma as an indicator for adverse pregnancy outcome","volume":"26","author":"Bauer","year":"2006","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.placenta.2014.09.020_bib34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1086\/301800","article-title":"Quantitative analysis of fetal DNA in maternal plasma and serum: implications for noninvasive prenatal diagnosis","volume":"62","author":"Lo","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.placenta.2014.09.020_bib35","doi-asserted-by":"crossref","first-page":"e101500","DOI":"10.1371\/journal.pone.0101500","article-title":"Quantification of cell-free DNA in normal and complicated pregnancies: overcoming biological and technical issue","volume":"9","author":"Manokhina","year":"2014","journal-title":"PLoS One"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400414009059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400414009059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:51:39Z","timestamp":1758909099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400414009059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0143400414009059"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2014.09.020","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantification of the placental epigenetic signature of the SERPINB5 gene in maternal plasma of pregnancies complicated by small for gestational age","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2014.09.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}