{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:29:50Z","timestamp":1791386990034,"version":"4.3.3"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["07F003"],"award-info":[{"award-number":["07F003"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["24390382"],"award-info":[{"award-number":["24390382"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.placenta.2014.10.015","type":"journal-article","created":{"date-parts":[[2014,11,7]],"date-time":"2014-11-07T03:39:37Z","timestamp":1415331577000},"page":"27-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Porphyromonas gingivalis lipopolysaccharide inhibits trophoblast invasion in the presence of nicotine"],"prefix":"10.1016","volume":"36","author":[{"given":"S.","family":"Komine-Aizawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hirohata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.placenta.2014.10.015_bib1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1600-051X.2006.00929.x","article-title":"Type 2 diabetes and risk for periodontal disease: a role for dental health awareness","volume":"33","author":"Jansson","year":"2006","journal-title":"J\u00a0Clin Periodontol"},{"issue":"5","key":"10.1016\/j.placenta.2014.10.015_bib2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1001\/archinte.166.5.554","article-title":"Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the coronary event and periodontal disease (CORODONT) study","volume":"166","author":"Spahr","year":"2006","journal-title":"Arch Intern Med"},{"issue":"4","key":"10.1016\/j.placenta.2014.10.015_bib3","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/CMR.13.4.547","article-title":"Systemic diseases caused by oral infection","volume":"13","author":"Li","year":"2000","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1902\/annals.1998.3.1.233","article-title":"Potential pathogenic mechanisms of periodontitis associated pregnancy complications","volume":"3","author":"Offenbacher","year":"1998","journal-title":"Ann Periodontol"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1447-0756.2012.01957.x","article-title":"Association of maternal periodontal health with adverse pregnancy outcome","volume":"39","author":"Kumar","year":"2013","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1442-200X.2011.03502.x","article-title":"Maternal periodontitis as a risk factor for prematurity","volume":"54","author":"Piscoya","year":"2012","journal-title":"Pediatr Int"},{"issue":"11","key":"10.1016\/j.placenta.2014.10.015_bib7","first-page":"1388","article-title":"Periodontitis as a risk factor for preeclampsia","volume":"83","author":"Moura da Silva","year":"2012","journal-title":"J\u00a0Periodontol"},{"issue":"9","key":"10.1016\/j.placenta.2014.10.015_bib8","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/IAI.71.9.5156-5162.2003","article-title":"Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice","volume":"71","author":"Lin","year":"2003","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.placenta.2014.10.015_bib9","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1128\/IAI.71.9.5163-5168.2003","article-title":"Porphyromonas gingivalis infection in pregnant mice is associated with placental dissemination, an increase in the placental Th1\/Th2 cytokine ratio, and fetal growth restriction","volume":"71","author":"Lin","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajog.2007.07.040","article-title":"Maternal infection and risk of preeclampsia: systematic review and metaanalysis","volume":"198","author":"Conde-Agudelo","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.placenta.2014.10.015_bib11","first-page":"871","article-title":"Periodontal disease is not associated with preeclampsia in Canadian pregnant women","volume":"83","author":"Taghzouti","year":"2012","journal-title":"J\u00a0Periodontol"},{"issue":"4","key":"10.1016\/j.placenta.2014.10.015_bib12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/14767058.2012.733776","article-title":"Lack of association between maternal periodontal status and adverse pregnancy outcomes: a multicentric epidemiologic study","volume":"26","author":"Abati","year":"2013","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"9","key":"10.1016\/j.placenta.2014.10.015_bib13","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1128\/IAI.72.9.5041-5051.2004","article-title":"Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4","volume":"72","author":"Darveau","year":"2004","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.placenta.2014.10.015_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2249.2009.03920.x","article-title":"Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide","volume":"156","author":"Barksby","year":"2009","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"10.1016\/j.placenta.2014.10.015_bib15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.bbrc.2009.08.062","article-title":"Toll-like receptors and innate immunity","volume":"388","author":"Kumar","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"10.1016\/j.placenta.2014.10.015_bib16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.placenta.2004.08.010","article-title":"Toll-like receptors and their role in the trophoblast","volume":"26","author":"Abrahams","year":"2005","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2014.10.015_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.placenta.2008.11.017","article-title":"Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens","volume":"30","author":"Arce","year":"2009","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/humrep\/der362","article-title":"Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunction","volume":"27","author":"Anton","year":"2012","journal-title":"Hum Reprod"},{"issue":"2","key":"10.1016\/j.placenta.2014.10.015_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1600-0897.2004.00247.x","article-title":"Regulation and signal transduction of toll-like receptors in human chorioncarcinoma cell lines","volume":"53","author":"Klaffenbach","year":"2005","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jri.2006.05.005","article-title":"LPS induces secretion of chemokines by human syncytiotrophoblast cells in a MAPK-dependent manner","volume":"73","author":"Lucchi","year":"2007","journal-title":"J\u00a0Reprod Immunol"},{"issue":"237","key":"10.1016\/j.placenta.2014.10.015_bib21","doi-asserted-by":"crossref","first-page":"237ra65","DOI":"10.1126\/scitranslmed.3008599","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"Aagaard","year":"2014","journal-title":"Sci Transl Med"},{"issue":"6","key":"10.1016\/j.placenta.2014.10.015_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/0022034509338032","article-title":"Localization of P.\u00a0gingivalis in preterm delivery placenta","volume":"88","author":"Katz","year":"2009","journal-title":"J\u00a0Dent Res"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib23","first-page":"57","article-title":"The effect of smoking and caffeine on the fetus and placenta in pregnancy","volume":"30","author":"Balat","year":"2003","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.placenta.2014.10.015_bib24","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0143-4004(03)00033-X","article-title":"Caffeine enhances the expression of the angiotensin II type 2 receptor mRNA in BeWo cell culture and in the rat placenta","volume":"24","author":"Tanuma","year":"2003","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2014.10.015_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jnutbio.2003.12.007","article-title":"Caffeine suppresses the expression of the Bcl-2 mRNA in BeWo cell culture and rat placenta","volume":"15","author":"Nomura","year":"2004","journal-title":"J\u00a0Nutr Biochem"},{"issue":"6","key":"10.1016\/j.placenta.2014.10.015_bib26","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0890-6238(00)00107-6","article-title":"Concordant in situ and in\u00a0vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle","volume":"14","author":"Genbacev","year":"2000","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.placenta.2014.10.015_bib27","article-title":"Associations of lifetime active and passive smoking with spontaneous abortion, stillbirth and tubal ectopic pregnancy: a cross-sectional analysis of historical data from the Women's Health Initiative","author":"Hyland","year":"2014","journal-title":"Tob Control"},{"issue":"5\u20136","key":"10.1016\/j.placenta.2014.10.015_bib28","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.placenta.2006.06.001","article-title":"Effect of low oxygen concentrations on trophoblast-like cell line invasion","volume":"28","author":"Lash","year":"2007","journal-title":"Placenta"},{"issue":"2","key":"10.1016\/j.placenta.2014.10.015_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1447-0756.2008.00963.x","article-title":"Toll-like receptors and pregnancy: trophoblast as modulators of the immune response","volume":"35","author":"Koga","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"2","key":"10.1016\/j.placenta.2014.10.015_bib30","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxlet.2013.10.032","article-title":"Exposure to ethanol and nicotine induces stress responses in human placental BeWo cells","volume":"224","author":"Repo","year":"2014","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.placenta.2014.10.015_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-051X.2011.01784.x","article-title":"Periodontal health status and bacteraemia from daily oral activities: systematic review\/meta-analysis","volume":"39","author":"Tomas","year":"2012","journal-title":"J\u00a0Clin Periodontol"},{"key":"10.1016\/j.placenta.2014.10.015_bib32","doi-asserted-by":"crossref","first-page":"c7017","DOI":"10.1136\/bmj.c7017","article-title":"Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis","volume":"341","author":"Polyzos","year":"2010","journal-title":"BMJ"},{"issue":"7","key":"10.1016\/j.placenta.2014.10.015_bib33","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1471-0528.1991.tb13450.x","article-title":"Placental bed spiral arteries in the hypertensive disorders of pregnancy","volume":"98","author":"Pijnenborg","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"issue":"10","key":"10.1016\/j.placenta.2014.10.015_bib34","doi-asserted-by":"crossref","first-page":"e47055","DOI":"10.1371\/journal.pone.0047055","article-title":"A\u00a0role for Nrf2 in redox signalling of the invasive extravillous trophoblast in severe early onset IUGR associated with preeclampsia","volume":"7","author":"Kweider","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.placenta.2014.10.015_bib35","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/path.1927","article-title":"Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion","volume":"208","author":"Ball","year":"2006","journal-title":"J\u00a0Pathol"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2014.10.015_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.placenta.2005.03.003","article-title":"Human cytomegalovirus-induced inhibition of cytotrophoblast invasion in a first trimester extravillous cytotrophoblast cell line","volume":"27","author":"LaMarca","year":"2006","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2014.10.015_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bpobgyn.2007.01.005","article-title":"Periodontal disease and pregnancy outcomes: exposure, risk and intervention","volume":"21","author":"Clothier","year":"2007","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"9","key":"10.1016\/j.placenta.2014.10.015_bib38","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1600-051X.2011.01755.x","article-title":"Evidence grade associating periodontitis to preterm birth and\/or low birth weight: I. A systematic review of prospective cohort studies","volume":"38","author":"Chambrone","year":"2011","journal-title":"J\u00a0Clin Periodontol"},{"issue":"2","key":"10.1016\/j.placenta.2014.10.015_bib39","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/GRF.0b013e31804c9f05","article-title":"Should we treat periodontal disease during gestation to improve pregnancy outcomes?","volume":"50","author":"Ferguson","year":"2007","journal-title":"Clin Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1447-0756.2007.00474.x","article-title":"Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes","volume":"33","author":"Yoneda","year":"2007","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"8","key":"10.1016\/j.placenta.2014.10.015_bib41","doi-asserted-by":"crossref","first-page":"e71387","DOI":"10.1371\/journal.pone.0071387","article-title":"Relationship between periodontitis and pre-eclampsia: a meta-analysis","volume":"8","author":"Sgolastra","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.placenta.2014.10.015_bib42","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/j.1462-5822.2009.01344.x","article-title":"Porphyromonas gingivalis invades human trophoblasts and inhibits proliferation by inducing G1 arrest and apoptosis","volume":"11","author":"Inaba","year":"2009","journal-title":"Cell Microbiol"},{"issue":"8","key":"10.1016\/j.placenta.2014.10.015_bib43","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1128\/IAI.00258-12","article-title":"Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts","volume":"80","author":"Inaba","year":"2012","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.placenta.2014.10.015_bib44","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1472-6831-14-38","article-title":"Low birth weight, preterm birth or small-for-gestational-age are not associated with dental caries in young Japanese children","volume":"14","author":"Tanaka","year":"2014","journal-title":"BMC Oral Health"},{"issue":"11","key":"10.1016\/j.placenta.2014.10.015_bib45","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.earlhumdev.2007.07.016","article-title":"Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit","volume":"83","author":"Jauniaux","year":"2007","journal-title":"Early Hum Dev"},{"issue":"5","key":"10.1016\/j.placenta.2014.10.015_bib46","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/HYPERTENSIONAHA.109.147082","article-title":"Tobacco use during pregnancy and preeclampsia risk: effects of cigarette smoking and snuff","volume":"55","author":"Wikstrom","year":"2010","journal-title":"Hypertension"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400414008273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400414008273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:50:27Z","timestamp":1758909027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400414008273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0143400414008273"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2014.10.015","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porphyromonas gingivalis lipopolysaccharide inhibits trophoblast invasion in the presence of nicotine","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2014.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}