{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:41:58Z","timestamp":1790775718558,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.placenta.2015.08.002","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T12:52:06Z","timestamp":1439211126000},"page":"1087-1094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Role of Slit2\/Robo1 in trophoblast invasion and vascular remodeling during ectopic tubal pregnancy"],"prefix":"10.1016","volume":"36","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-lin","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-bin","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheung-kwan","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth Ka","family":"Ho Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2015.08.002_bib1","first-page":"810","article-title":"Aberrant alteration of vascular endothelial growth factor- family signaling in human tubal ectopic pregnancy: what is known and unknown?","volume":"6","author":"Shao","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.placenta.2015.08.002_bib2","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1096\/fj.12-210310","article-title":"Uterine natural killer cells initiate spiral artery remodeling in human pregnancy","volume":"26","author":"Robson","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.placenta.2015.08.002_bib3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/path.1801","article-title":"The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in\u00a0vitro","volume":"206","author":"Crocker","year":"2005","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.placenta.2015.08.002_bib4","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1096\/fj.12-203679","article-title":"The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy","volume":"26","author":"Bulmer","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.placenta.2015.08.002_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00004347-198706000-00005","article-title":"Placentation in the fallopian tube","volume":"6","author":"Randall","year":"1987","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.placenta.2015.08.002_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature12416","article-title":"Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection","volume":"501","author":"Zhou","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.placenta.2015.08.002_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/cr.2011.17","article-title":"Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis","volume":"21","author":"Zhou","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.placenta.2015.08.002_bib8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/labinvest.2014.70","article-title":"Slit2 promotes tumor growth and invasion in chemically induced skin carcinogenesis","volume":"94","author":"Qi","year":"2014","journal-title":"Lab. Invest."},{"key":"10.1016\/j.placenta.2015.08.002_bib9","first-page":"1181","article-title":"Perspectives of SLIT\/ROBO signaling in placental angiogenesis","volume":"25","author":"Liao","year":"2010","journal-title":"Histol. Histopathol."},{"issue":"111","key":"10.1016\/j.placenta.2015.08.002_bib10","first-page":"1","article-title":"Human placental expression of SLIT\/ROBO signaling cues: effects of preeclampsia and hypoxia","volume":"86","author":"Liao","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2015.08.002_bib11","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.2353\/ajpath.2009.080995","article-title":"Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy","volume":"174","author":"Smith","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.placenta.2015.08.002_bib12","doi-asserted-by":"crossref","first-page":"411 e1","DOI":"10.1016\/j.ajog.2010.12.027","article-title":"Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast","volume":"204","author":"Wehrum","year":"2014","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2015.08.002_bib13","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/aps.2011.106","article-title":"Over-expression of Slit2 induces vessel formation and changes blood vessel permeability in mouse brain","volume":"32","author":"Han","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.placenta.2015.08.002_bib14","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1093\/humrep\/det246","article-title":"Enhanced beta-catenin expression and inflammation are associated with human ectopic tubal pregnancy","volume":"28","author":"Li","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2015.08.002_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijcard.2014.06.044","article-title":"Excess ROS induced by AAPH causes myocardial hypertrophy in the developing chick embryo","volume":"176","author":"Li","year":"2014","journal-title":"Int. J Cardiol."},{"key":"10.1016\/j.placenta.2015.08.002_bib16","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00428-013-1427-z","article-title":"Differential expression of E-cadherin, beta-catenin, and Lewis x between invasive hydatidiform moles and post-molar choriocarcinomas","volume":"462","author":"Candelier","year":"2013","journal-title":"Virchows Arch."},{"key":"10.1016\/j.placenta.2015.08.002_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cm.21165","article-title":"Cell fusion mediates dramatic alterations in the actin cytoskeleton, focal adhesions, and E-cadherin in trophoblastic cells","volume":"71","author":"Ishikawa","year":"2014","journal-title":"Cytoskelet. Hob."},{"key":"10.1016\/j.placenta.2015.08.002_bib18","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta\u2013epithelial\u2013mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2015.08.002_bib19","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/humrep\/det363","article-title":"Reply: the inflammatory regulation of tubal beta-catenin expression in human ectopic pregnancy: is it too early to propose a cause-and-effect relationship?","volume":"28","author":"Li","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2015.08.002_bib20","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/humrep\/dei489","article-title":"Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy","volume":"21","author":"Shih","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2015.08.002_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00418-002-0396-0","article-title":"Invasive depth of extravillous trophoblast correlates with cellular phenotype: a comparison of intra-and extrauterine implantation sites","volume":"117","author":"Kemp","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.placenta.2015.08.002_bib22","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/molehr\/6.10.943","article-title":"Localization of E-cadherin in villous, extravillous and vascular trophoblasts during intrauterine, ectopic and molar pregnancy","volume":"6","author":"Floridon","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2015.08.002_bib23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.1058766","article-title":"Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration","volume":"292","author":"Kramer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.placenta.2015.08.002_bib24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/toxsci\/kfj138","article-title":"Suppressive effect of 2, 3, 7,8- tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation","volume":"91","author":"Ishimura","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.placenta.2015.08.002_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jri.2011.05.001","article-title":"Immunological regulation of trophoblast invasion","volume":"90","author":"Hammer","year":"2011","journal-title":"J.\u00a0Reprod. Immunol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400415300291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400415300291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:52:40Z","timestamp":1758909160000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400415300291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0143400415300291"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2015.08.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Slit2\/Robo1 in trophoblast invasion and vascular remodeling during ectopic tubal pregnancy","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2015.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}