{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:51:44Z","timestamp":1771566704053,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270226"],"award-info":[{"award-number":["81270226"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571515"],"award-info":[{"award-number":["81571515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570369"],"award-info":[{"award-number":["81570369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["IRT0935"],"award-info":[{"award-number":["IRT0935"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.placenta.2016.06.008","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T15:49:10Z","timestamp":1467042550000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The effect of 17\u03b1-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heart failure"],"prefix":"10.1016","volume":"44","author":[{"given":"Chuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dajian","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9331-7653","authenticated-orcid":false,"given":"Yimin","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2016.06.008_bib1","first-page":"891","article-title":"Fetal heart failure","volume":"2","author":"Ojala","year":"2010","journal-title":"Front. Biosci."},{"issue":"7","key":"10.1016\/j.placenta.2016.06.008_bib2","first-page":"759","article-title":"Diagnosis and management of fetal heart failure","volume":"29","author":"Thakur","year":"2013","journal-title":"Can. J. Cardiol."},{"issue":"21","key":"10.1016\/j.placenta.2016.06.008_bib3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1161\/01.cir.0000437597.44550.5d","article-title":"Diagnosis and treatment of fetal cardiac disease: a scientific statement from the american heart association","volume":"129","author":"Donofrio","year":"2014","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.crd.0000102420.62200.e1","article-title":"Cardiovascular pharmacotherapeutic considerations during pregnancy and lactation","volume":"12","author":"Qasqas","year":"2004","journal-title":"Cardiol. Rev."},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib5","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/j.ijcard.2013.08.130","article-title":"Evaluation of therapeutic effect and cytokine change during transplacental Digoxin treatment for fetal heart failure associated with fetal tachycardia, a case-control study","volume":"169","author":"Zhou","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"11","key":"10.1016\/j.placenta.2016.06.008_bib6","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.3109\/14767058.2011.554924","article-title":"Transplacental digoxin therapy for fetal tachyarrhythmia with multiple evaluation systems","volume":"24","author":"Zhou","year":"2011","journal-title":"J.\u00a0Matern. Fetal Neonatal Med."},{"issue":"9","key":"10.1016\/j.placenta.2016.06.008_bib7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3109\/1061186X.2012.716847","article-title":"Pharmacotherapy in pregnancy; effect of ABC and SLC transporters on drug transport across the placenta and fetal drug exposure","volume":"20","author":"Staud","year":"2012","journal-title":"J.\u00a0Drug Target"},{"issue":"3","key":"10.1016\/j.placenta.2016.06.008_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.reprotox.2006.01.007","article-title":"P-glycoprotein in the placenta: expression, localization, regulation and function","volume":"22","author":"Ceckova-Novotna","year":"2006","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2165\/11318000-000000000-00000","article-title":"Evaluation of in\u00a0vivo P-glycoprotein phenotyping probes: a need for validation","volume":"49","author":"Ma","year":"2010","journal-title":"Clin. Pharmacokinet."},{"issue":"10","key":"10.1016\/j.placenta.2016.06.008_bib10","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1172\/JCI7963","article-title":"Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure","volume":"104","author":"Smit","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"issue":"3","key":"10.1016\/j.placenta.2016.06.008_bib11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.reprotox.2012.01.013","article-title":"Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation","volume":"33","author":"Soo","year":"2012","journal-title":"Reprod. Toxicol."},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib12","doi-asserted-by":"crossref","first-page":"e35027","DOI":"10.1371\/journal.pone.0035027","article-title":"Expression of ABC Efflux transporters in placenta from women with insulin-managed diabetes","volume":"7","author":"Anger","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.placenta.2016.06.008_bib13","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1124\/dmd.111.038166","article-title":"ATP-binding cassette transporter expression in human placenta as a function of pregnancy condition","volume":"39","author":"Mason","year":"2011","journal-title":"Drug Metab. Dispos."},{"issue":"2","key":"10.1016\/j.placenta.2016.06.008_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1124\/mi.7.2.10","article-title":"Regulation of drug transporters during infection and inflammation","volume":"7","author":"Petrovic","year":"2007","journal-title":"Mol. Interv."},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib15","doi-asserted-by":"crossref","first-page":"R963","DOI":"10.1152\/ajpregu.00173.2005","article-title":"P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages","volume":"289","author":"Mathias","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"10","key":"10.1016\/j.placenta.2016.06.008_bib16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.placenta.2015.08.007","article-title":"The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: implications in the individualized transplacental digoxin treatment for fetal heart failure","volume":"36","author":"Wang","year":"2015","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2016.06.008_bib17","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ijcard.2014.07.147","article-title":"Sodium tanshinone IIA sulfonate and sodium danshensu open the placental barrier through down-regulation of placental P-glycoprotein in mice: implications in the transplacental digoxin treatment for fetal heart failure","volume":"176","author":"Wang","year":"2014","journal-title":"Int. J. Cardiol."},{"issue":"7","key":"10.1016\/j.placenta.2016.06.008_bib18","doi-asserted-by":"crossref","first-page":"e68807","DOI":"10.1371\/journal.pone.0068807","article-title":"Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.placenta.2016.06.008_bib19","first-page":"486","article-title":"Review and further explain the new \u201cguidelines for diagnosis and treatment of intrahepatic cholestasis of pregnancy (2015)\u201d","volume":"50","author":"Qi","year":"2015","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"23","key":"10.1016\/j.placenta.2016.06.008_bib20","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.3748\/wjg.v21.i23.7134","article-title":"Review of a challenging clinical issue: intrahepatic cholestasis of pregnancy","volume":"21","author":"Ozkan","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.placenta.2016.06.008_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0028-2243(91)90222-7","article-title":"Vasoconstrictive effect of bile acids on isolated human placental chorionic veins","volume":"42","author":"Sepulveda","year":"1991","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"11","key":"10.1016\/j.placenta.2016.06.008_bib22","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.placenta.2012.08.005","article-title":"Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy","volume":"33","author":"Wikstrom Shemer","year":"2012","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.placenta.2016.06.008_bib23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.placenta.2014.06.372","article-title":"Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy","volume":"35","author":"Wei","year":"2014","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2016.06.008_bib24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/0091270007311568","article-title":"P-glycoprotein: so many ways to turn it on","volume":"48","author":"Callaghan","year":"2008","journal-title":"J.\u00a0Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.placenta.2016.06.008_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1349-7006.2003.tb01345.x","article-title":"Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal","volume":"94","author":"Tsuruo","year":"2003","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.placenta.2016.06.008_bib26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1665-2681(19)32126-X","article-title":"Cholestasis: human disease and experimental animal models","volume":"2","author":"Rodriguez-Garay","year":"2003","journal-title":"Ann. Hepatol."},{"issue":"12","key":"10.1016\/j.placenta.2016.06.008_bib27","first-page":"927","article-title":"Expression of FXR mRNA, PPAR alpha mRNA and bile acid metabolism related genes in intrahepatic cholestasis of pregnant rats","volume":"18","author":"Shi","year":"2010","journal-title":"Chin. J. Hepatol."},{"issue":"2","key":"10.1016\/j.placenta.2016.06.008_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/jog.12206","article-title":"Expression of neuropeptide Y and pro-opiomelanocortin in hypothalamic arcuate nucleus in 17alpha-ethinyl estradiol-induced intrahepatic cholestasis pregnant rat offspring","volume":"40","author":"Shi","year":"2014","journal-title":"J.\u00a0Obstet. Gynaecol. Res."},{"issue":"5","key":"10.1016\/j.placenta.2016.06.008_bib29","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.placenta.2015.02.005","article-title":"Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta\u2013a study on maternal cholestasis model","volume":"36","author":"Wu","year":"2015","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.placenta.2016.06.008_bib30","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/pds.1241","article-title":"National patterns of medication use during pregnancy","volume":"15","author":"Lee","year":"2006","journal-title":"Pharmacoepidemiol Drug Saf."},{"issue":"2","key":"10.1016\/j.placenta.2016.06.008_bib31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/03602532.2015.1007012","article-title":"MDR1 will play a key role in pharmacokinetic changes under hypoxia at high altitude and its potential regulatory networks","volume":"47","author":"Li","year":"2015","journal-title":"Drug Metab. Rev."},{"issue":"12","key":"10.1016\/j.placenta.2016.06.008_bib32","first-page":"3387","article-title":"Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene","volume":"62","author":"Comerford","year":"2002","journal-title":"Cancer Res."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416301278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416301278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:54:17Z","timestamp":1758909257000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400416301278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":32,"alternative-id":["S0143400416301278"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2016.06.008","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of 17\u03b1-ethynylestradiol induced intrahepatic cholestasis of pregnancy on placental P-glycoprotein in mice: Implications in the individualized transplacental digoxin treatment for fetal heart failure","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2016.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}