{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:41:55Z","timestamp":1773211315740,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["81100437"],"award-info":[{"award-number":["81100437"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The University of Auckland, New Zealand","award":["3708810"],"award-info":[{"award-number":["3708810"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.placenta.2016.07.007","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T07:18:06Z","timestamp":1469690286000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Trophoblastic debris extruded from hydatidiform molar placentae activates endothelial cells: Possible relevance to the pathogenesis of preeclampsia"],"prefix":"10.1016","volume":"45","author":[{"given":"Min","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxiang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaokuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9461","key":"10.1016\/j.placenta.2016.07.007_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3109\/10641950802629626","article-title":"Obesity and the hypertensive disorders of pregnancy","volume":"28","author":"Callaway","year":"2009","journal-title":"Hypertens. Pregnancy"},{"issue":"2","key":"10.1016\/j.placenta.2016.07.007_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: an excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2016.07.007_bib4","series-title":"Pathologisch-Anatomische Untersuchungen Uber Puerperal-Eklampsie","author":"Schmorl","year":"1893"},{"issue":"2","key":"10.1016\/j.placenta.2016.07.007_bib5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1471-0528.1964.tb04263.x","article-title":"Clinical observations on some aspects of hydatidiform moles","volume":"71","author":"Chun","year":"1964","journal-title":"J.\u00a0Obstet. Gynecol. Br. Comm."},{"issue":"5","key":"10.1016\/j.placenta.2016.07.007_bib6","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0029-7844(95)00268-V","article-title":"The changing clinical presentation of complete molar pregnancy","volume":"86","author":"Soto-Wright","year":"1995","journal-title":"Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2016.07.007_bib7","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1080\/01443610600987092","article-title":"Partial molar pregnancy with severe pre-eclampsia at 19 weeks' gestation","volume":"26","author":"Prasannan-Nair","year":"2006","journal-title":"J.\u00a0Obstet. Gynaecol."},{"issue":"5\u20136","key":"10.1016\/j.placenta.2016.07.007_bib8","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1053\/plac.1999.0390","article-title":"Partial moles: from postnatal to prenatal diagnosis","volume":"20","author":"Jauniaux","year":"1999","journal-title":"Placenta"},{"issue":"2 Pt 2","key":"10.1016\/j.placenta.2016.07.007_bib9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/AOG.0b013e3181998877","article-title":"Insights into angiogenic imbalances during pregnancy","volume":"114","author":"Espinoza","year":"2009","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2016.07.007_bib10","series-title":"Gestational Trophoblastic Diseases (Chapter11) in Williams Obstetrics","author":"Cunningham","year":"2010"},{"issue":"3","key":"10.1016\/j.placenta.2016.07.007_bib11","doi-asserted-by":"crossref","first-page":"a023028","DOI":"10.1101\/cshperspect.a023028","article-title":"Placental extracellular vesicles and feto-maternal communication","volume":"5","author":"Tong","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-0528.1961.tb02778.x","article-title":"Embolism to the lungs by trophoblast","volume":"68","author":"Attwood","year":"1961","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"issue":"7","key":"10.1016\/j.placenta.2016.07.007_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1053\/plac.1999.0422","article-title":"Trophoblast deportation in human pregnancy\u2013its relevance for pre-eclampsia","volume":"20","author":"Johansen","year":"1999","journal-title":"Placenta"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2016.07.007_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/plac.2002.0903","article-title":"Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation","volume":"24","author":"Huppertz","year":"2003","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.HYP.0000196731.56062.7c","article-title":"Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation","volume":"47","author":"Chen","year":"2006","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.placenta.2016.07.007_bib17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.placenta.2014.06.370","article-title":"High mobility group box 1 protein (HMGB-1): a pathogenic role in preeclampsia?","volume":"35","author":"Pradervand","year":"2014","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib18","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.bbrc.2013.07.098","article-title":"HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway","volume":"438","author":"Luo","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.placenta.2016.07.007_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2016.06.001","article-title":"Increased expression of high mobility group box 1 (HMGB1) in the cytoplasm of placental syncytiotrophoblast from preeclamptic placentae","volume":"85","author":"Chen","year":"2016","journal-title":"Cytokine"},{"issue":"21\u201322","key":"10.1016\/j.placenta.2016.07.007_bib20","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.cca.2011.06.042","article-title":"Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia","volume":"412","author":"Molvarec","year":"2011","journal-title":"Clin. Chimica Acta Int. J. Clin. Chem."},{"issue":"11","key":"10.1016\/j.placenta.2016.07.007_bib21","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/molehr\/gal073","article-title":"An in\u00a0vitro model of human placental trophoblast deportation\/shedding","volume":"12","author":"Abumaree","year":"2006","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib22","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.placenta.2009.11.005","article-title":"Spreading endothelial cell dysfunction in response to necrotic trophoblasts. Soluble factors released from endothelial cells that have phagocytosed necrotic shed trophoblasts reduce the proliferation of additional endothelial cells","volume":"31","author":"Chen","year":"2010","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/path.2425","article-title":"A\u00a0role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia","volume":"217","author":"Chen","year":"2009","journal-title":"J.\u00a0Pathol."},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/01.HYP.0000196731.56062.7c","article-title":"Phagocytosis of necrotic but not apoptotic trophoblasts induces endothelial cell activation","volume":"47","author":"Chen","year":"2006","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.placenta.2016.07.007_bib25","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B","article-title":"COX-2 is expressed in human pulmonary, colonic, and mammary tumors","volume":"89","author":"Soslow","year":"2000","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.placenta.2016.07.007_bib26","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/uog.7621","article-title":"Maternal plasma soluble endoglin at 11-13 weeks' gestation in pre-eclampsia","volume":"35","author":"Foidart","year":"2010","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"11","key":"10.1016\/j.placenta.2016.07.007_bib27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/14767050902994754","article-title":"A\u00a0prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia","volume":"22","author":"Kusanovic","year":"2009","journal-title":"J.\u00a0Matern. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.placenta.2009.11.005","article-title":"IL-6, TNF [alpha] and TGF [beta] promote nonapoptotic trophoblast deportation and subsequently causes endothelial cell activation","volume":"31","author":"Chen","year":"2010","journal-title":"Placenta"},{"issue":"2\u20133","key":"10.1016\/j.placenta.2016.07.007_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/plac.2002.0903","article-title":"Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation","volume":"24","author":"Huppertz","year":"2003","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib30","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/74697","article-title":"HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine","volume":"6","author":"Asea","year":"2000","journal-title":"Nat. Med."},{"issue":"6","key":"10.1016\/j.placenta.2016.07.007_bib31","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.4049\/jimmunol.174.6.3306","article-title":"Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells","volume":"174","author":"Wang","year":"2005","journal-title":"J.\u00a0Immunol."},{"issue":"3","key":"10.1016\/j.placenta.2016.07.007_bib32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1189\/jlb.0607356","article-title":"Sensing danger\u2013Hsp72 and HMGB1 as candidate signals","volume":"83","author":"Williams","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.placenta.2016.07.007_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0897.2010.00975.x","article-title":"High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia","volume":"66","author":"Wang","year":"2011","journal-title":"Am. J. Reprod. Immunol."},{"issue":"3","key":"10.1016\/j.placenta.2016.07.007_bib34","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1365-2567.2007.02662.x","article-title":"The novel inflammatory cytokine high mobility group box protein 1 (HMGB1) is expressed by human term placenta","volume":"122","author":"Holmlund","year":"2007","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.placenta.2016.07.007_bib35","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.fsi.2014.11.017","article-title":"Non-lethal heat shock induces HSP70 and HMGB1 protein production sequentially to protect Artemia franciscana against Vibrio campbellii","volume":"42","author":"Norouzitallab","year":"2015","journal-title":"Fish. Shellfish Immunol."},{"issue":"5425","key":"10.1016\/j.placenta.2016.07.007_bib36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.placenta.2016.07.007_bib37","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"1","key":"10.1016\/j.placenta.2016.07.007_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ajog.2005.12.049","article-title":"Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia","volume":"195","author":"Robinson","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2016.07.007_bib39","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1002\/1097-0142(19941015)74:8<2361::AID-CNCR2820740822>3.0.CO;2-G","article-title":"Vascular patterns of gestational trophoblastic tumors by color Doppler ultrasound","volume":"74","author":"Hsieh","year":"1994","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/j.placenta.2016.07.007_bib40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.earlhumdev.2013.02.008","article-title":"Placental expression of VEGF is increased in pregnancies with hydatidiform mole: possible association with developing very early onset preeclampsia","volume":"89","author":"Zhao","year":"2013","journal-title":"Early Hum. Dev."},{"issue":"5","key":"10.1016\/j.placenta.2016.07.007_bib41","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.placenta.2011.02.006","article-title":"Does oxygen concentration affect shedding of trophoblastic debris or production of inflammatory mediators from first trimester human placenta?","volume":"32","author":"Chen","year":"2011","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.placenta.2016.07.007_bib42","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/humrep\/dew004","article-title":"Proteomic characterization of macro-, micro- and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication","volume":"31","author":"Tong","year":"2016","journal-title":"Hum. Reprod."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416303897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416303897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:53:33Z","timestamp":1758909213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400416303897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":42,"alternative-id":["S0143400416303897"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2016.07.007","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trophoblastic debris extruded from hydatidiform molar placentae activates endothelial cells: Possible relevance to the pathogenesis of preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2016.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}