{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:27:31Z","timestamp":1772800051662,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"European Union's Horizon 2020' research"},{"name":"Marie Sk\u0142odowska-Curie grant","award":["690876"],"award-info":[{"award-number":["690876"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.placenta.2016.11.001","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T15:32:23Z","timestamp":1478100743000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-3868","authenticated-orcid":false,"given":"Mladena","family":"Lalic-Popovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana","family":"Paunkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zorica","family":"Grujic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Golocorbin-Kon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velibor","family":"Vasovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani","family":"Al-Salami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momir","family":"Mikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.placenta.2016.11.001_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.mpaic.2007.07.011","article-title":"Preventing aspiration and regurgitation","volume":"8","author":"Benington","year":"2007","journal-title":"Anaesth. Intensive Care Med."},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2044.1983.tb13927.x","article-title":"Ranitidine as an antacid before elective Caesarean section","volume":"38","author":"McAuley","year":"1983","journal-title":"Anaesthesia"},{"issue":"6","key":"10.1016\/j.placenta.2016.11.001_bib3","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2165\/00003495-198937060-00003","article-title":"Ranitidine. An updated review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases","volume":"37","author":"Grant","year":"1989","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.placenta.2016.11.001_bib4","first-page":"130","article-title":"Ranitidine in the treatment of reflux oesophagitis in pregnancy","volume":"16","author":"Armentano","year":"1989","journal-title":"Clin. Exp. obstetrics Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2016.11.001_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.reprotox.2004.09.002","article-title":"Pregnancy outcome after exposure to ranitidine and other H2-blockers. A collaborative study of the European Network of Teratology Information Services","volume":"19","author":"Garbis","year":"2005","journal-title":"Reprod. Toxicol."},{"issue":"1","key":"10.1016\/j.placenta.2016.11.001_bib6","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1542\/peds.2011-0796","article-title":"Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns","volume":"129","author":"Terrin","year":"2012","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.placenta.2016.11.001_bib7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/MOG.0b013e3283025c57","article-title":"The nonerosive reflux disease-gastroesophageal reflux disease controversy","volume":"24","author":"Winter","year":"2008","journal-title":"Curr. Opin. gastroenterol."},{"issue":"4","key":"10.1016\/j.placenta.2016.11.001_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00535-009-0019-9","article-title":"Cytokine responses of intraepithelial lymphocytes are regulated by histamine H(2) receptor","volume":"44","author":"Takagaki","year":"2009","journal-title":"J.\u00a0gastroenterol."},{"issue":"1","key":"10.1016\/j.placenta.2016.11.001_bib9","first-page":"44","article-title":"Effect of gestational diabetes and maternal hypertension on gross morphology of placenta","volume":"17","author":"Ashfaq","year":"2005","journal-title":"J.\u00a0Ayub Med. Coll. Abbottabad: JAMC"},{"key":"10.1016\/j.placenta.2016.11.001_bib10","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.2337\/dc07-s203","article-title":"The human placenta in gestational diabetes mellitus. The insulin and cytokine network","volume":"2","author":"Desoye","year":"2007","journal-title":"Diab. care"},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/0976-9668.136182","article-title":"Study of structural changes in placenta in pregnancy-induced hypertension","volume":"5","author":"Salmani","year":"2014","journal-title":"J.\u00a0Nat. Sci. Biol. Med."},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2165\/00003088-199528020-00006","article-title":"Models for placental transfer studies of drugs","volume":"28","author":"Bourget","year":"1995","journal-title":"Clin. Pharmacokinet."},{"issue":"8","key":"10.1016\/j.placenta.2016.11.001_bib13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","article-title":"Drug transfer and metabolism by the human placenta","volume":"43","author":"Syme","year":"2004","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.placenta.2016.11.001_bib14","first-page":"389","article-title":"Pharmacokinetics in pregnancy and placental drug transfer","volume":"11","author":"Reynolds","year":"1989","journal-title":"Oxf. Rev. reprod. Biol."},{"key":"10.1016\/j.placenta.2016.11.001_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1471-2393-13-188","article-title":"Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women","volume":"13","author":"Lalic-Popovic","year":"2013","journal-title":"BMC pregnancy childbirth"},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/1753-0407.12288","article-title":"Decreased placental and transcellular permeation of cefuroxime in pregnant women with diabetes","volume":"8","author":"Lalic-Popovic","year":"2016","journal-title":"J.\u00a0diabetes"},{"key":"10.1016\/j.placenta.2016.11.001_bib17","series-title":"The Good Clinical Practice National Guidelines on Diagnostic and Treatment of Arterial Hypertension","first-page":"29","author":"Ministry of Health of Republic Serbia","year":"2011"},{"key":"10.1016\/j.placenta.2016.11.001_bib18","series-title":"The Good Clinical Practice National Guidelines on Diabetes Mellitus","first-page":"69","author":"Ministry of Health of Republic Serbia","year":"2012"},{"issue":"7","key":"10.1016\/j.placenta.2016.11.001_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF02466469","article-title":"Rapid determination of ranitidine in human plasma by high-performance liquid chromatography","volume":"47","author":"Campanero","year":"1998","journal-title":"Chromatographia"},{"issue":"3","key":"10.1016\/j.placenta.2016.11.001_bib20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2125.1986.tb05191.x","article-title":"Pharmacokinetics of ranitidine in critically ill patients","volume":"21","author":"Ilett","year":"1986","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"4","key":"10.1016\/j.placenta.2016.11.001_bib21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/clpt.1981.201","article-title":"Ranitidine kinetics and dynamics. II. Intravenous dose studies and comparison with cimetidine","volume":"30","author":"Lebert","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"issue":"8","key":"10.1016\/j.placenta.2016.11.001_bib22","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/jps.20392","article-title":"Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride","volume":"94","author":"Kortejarvi","year":"2005","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"6","key":"10.1016\/j.placenta.2016.11.001_bib23","doi-asserted-by":"crossref","first-page":"F430","DOI":"10.1136\/adc.2006.099846","article-title":"Use of umbilical cord blood gas analysis in the assessment of the newborn","volume":"92","author":"Armstrong","year":"2007","journal-title":"Archives Dis. Child. Fetal neonatal Ed."},{"issue":"8","key":"10.1016\/j.placenta.2016.11.001_bib24","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1002\/jps.20392","article-title":"Biowaiver monographs for immediate release solid oral dosage forms: ranitidine hydrochloride","volume":"94","author":"Kortejarvi","year":"2005","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib25","doi-asserted-by":"crossref","first-page":"C263","DOI":"10.1152\/ajpcell.00333.2003","article-title":"L-Carnitine transport in human placental brush-border membranes is mediated by the sodium-dependent organic cation transporter OCTN2","volume":"287","author":"Lahjouji","year":"2004","journal-title":"Am. J. physiology Cell physiology"},{"issue":"12","key":"10.1016\/j.placenta.2016.11.001_bib26","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1023\/A:1018965929419","article-title":"Mechanism of intestinal absorption of ranitidine and ondansetron: transport across Caco-2 cell monolayers","volume":"10","author":"Gan","year":"1993","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib27","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1124\/jpet.102.038521","article-title":"Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers","volume":"303","author":"Lee","year":"2002","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.placenta.2016.11.001_bib28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1021\/js980474k","article-title":"Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers","volume":"88","author":"Lee","year":"1999","journal-title":"J.\u00a0Pharm. Sci."},{"issue":"3","key":"10.1016\/j.placenta.2016.11.001_bib29","doi-asserted-by":"crossref","first-page":"R677","DOI":"10.1152\/ajpregu.2000.278.3.R677","article-title":"Denudations as paracellular routes for alphafetoprotein and creatinine across the human syncytiotrophoblast","volume":"278","author":"Brownbill","year":"2000","journal-title":"Am. J. physiology Regul. Integr. Comp. physiol."},{"key":"10.1016\/j.placenta.2016.11.001_bib30","series-title":"Placental Molecules in Hemodynamics, Transport and Cellular Regulation","author":"Toshio","year":"1997"},{"issue":"5 Spec No","key":"10.1016\/j.placenta.2016.11.001_bib31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/adc.68.5_Spec_No.602","article-title":"Ranitidine pharmacokinetics in newborn infants","volume":"68","author":"Fontana","year":"1993","journal-title":"Archives Dis. Child."},{"issue":"2","key":"10.1016\/j.placenta.2016.11.001_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-3476(85)80156-6","article-title":"Pharmacokinetic determination of ranitidine pharmacodynamics in pediatric ulcer disease","volume":"107","author":"Blumer","year":"1985","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.placenta.2016.11.001_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2014.00065","article-title":"Physiologic and pharmacokinetic changes in pregnancy","volume":"5","author":"Costantine","year":"2014","journal-title":"Front. Pharmacol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416305926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400416305926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:55:17Z","timestamp":1758909317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400416305926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":33,"alternative-id":["S0143400416305926"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2016.11.001","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Effect of Diabetes and Hypertension on the Placental Permeation of the Hydrophilic Drug, Ranitidine","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2016.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}