{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:46:39Z","timestamp":1787503599061,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.placenta.2017.01.002","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T15:28:35Z","timestamp":1483630115000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-2250","authenticated-orcid":false,"given":"Natalie J.","family":"Hannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-0471","authenticated-orcid":false,"given":"Sally","family":"Beard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie K.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Onda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu'uhevaha J.","family":"Kaitu'u-Lino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Tuohey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manarangi","family":"De Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2017.01.002_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/nrd.2015.6","article-title":"Regulated necrosis: disease relevance and therapeutic opportunities","author":"Conrad","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7428","key":"10.1016\/j.placenta.2017.01.002_bib2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature11700","article-title":"The NAD-dependent deacetylase SIRT2 is required for programmed necrosis","volume":"492","author":"Narayan","year":"2012","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.placenta.2017.01.002_bib3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/ni.3206","article-title":"The diverse role of RIP kinases in necroptosis and inflammation","volume":"16","author":"Silke","year":"2015","journal-title":"Nat. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.placenta.2017.01.002_bib4","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2014.12.017","article-title":"IFPA Gabor than Award Lecture: recognition of placental failure is key to saving babies' lives","volume":"36","author":"Heazell","year":"2015","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.placenta.2017.01.002_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.siny.2004.03.006","article-title":"Developmental biology of the placenta and the origins of placental insufficiency","volume":"9","author":"Chaddha","year":"2004","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.placenta.2017.01.002_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ajog.2005.07.039","article-title":"Apoptosis and its role in the trophoblast","volume":"195","author":"Huppertz","year":"2006","journal-title":"Am. J. obstetrics Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2017.01.002_bib7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ajog.2005.07.035","article-title":"Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia\/intrauterine growth restriction","volume":"194","author":"Kadyrov","year":"2006","journal-title":"Am. J. obstetrics Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2017.01.002_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/10641955.2013.796969","article-title":"The role of apoptosis on trophoblast cell invasion in the placental bed of normotensive and preeclamptic pregnancies","volume":"32","author":"Naicker","year":"2013","journal-title":"Hypertens. Pregnancy"},{"issue":"12","key":"10.1016\/j.placenta.2017.01.002_bib9","first-page":"1687","article-title":"Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in\u00a0vitro. Laboratory investigation","volume":"79","author":"Huppertz","year":"1999","journal-title":"a J. Tech. methods pathology"},{"key":"10.1016\/j.placenta.2017.01.002_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0074-7696(01)05005-7","article-title":"Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle","volume":"205","author":"Huppertz","year":"2001","journal-title":"Int. Rev. Cytol."},{"issue":"6","key":"10.1016\/j.placenta.2017.01.002_bib11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF02899568","article-title":"Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies","volume":"60","author":"Arnholdt","year":"1991","journal-title":"Virchows Arch. B Cell Pathol. Incl. Mol. Pathol."},{"issue":"5","key":"10.1016\/j.placenta.2017.01.002_bib12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"Suppl:S74\u201380","key":"10.1016\/j.placenta.2017.01.002_bib13","article-title":"Review: where is the maternofetal interface?","volume":"35","author":"Chamley","year":"2014","journal-title":"Placenta"},{"issue":"11","key":"10.1016\/j.placenta.2017.01.002_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/molehr\/gal073","article-title":"An in\u00a0vitro model of human placental trophoblast deportation\/shedding","volume":"12","author":"Abumaree","year":"2006","journal-title":"Mol. Hum. Reprod."},{"issue":"1","key":"10.1016\/j.placenta.2017.01.002_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/path.2425","article-title":"A\u00a0role for interleukin-6 in spreading endothelial cell activation after phagocytosis of necrotic trophoblastic material: implications for the pathogenesis of pre-eclampsia","volume":"217","author":"Chen","year":"2009","journal-title":"J.\u00a0pathology"},{"issue":"1","key":"10.1016\/j.placenta.2017.01.002_bib16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1095\/biolreprod.110.086983","article-title":"SIRT1 is a novel regulator of key pathways of human labor","volume":"84","author":"Lappas","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2017.01.002_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","article-title":"Immunogenic cell death in cancer therapy","volume":"31","author":"Kroemer","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"42","key":"10.1016\/j.placenta.2017.01.002_bib18","doi-asserted-by":"crossref","first-page":"15072","DOI":"10.1073\/pnas.1408987111","article-title":"Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death","volume":"111","author":"Hildebrand","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.placenta.2017.01.002_bib19","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1177\/1933719114565034","article-title":"Chorioamnionitis occurring in women with preterm rupture of the fetal membranes is associated with a dynamic increase in mRNAs coding cytokines in the maternal circulation","volume":"22","author":"Stock","year":"2015","journal-title":"Reprod. Sci."},{"issue":"2","key":"10.1016\/j.placenta.2017.01.002_bib20","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/HYPERTENSIONAHA.111.182170","article-title":"Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia","volume":"59","author":"Rajakumar","year":"2012","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.placenta.2017.01.002_bib21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.placenta.2013.10.001","article-title":"Analysis of syncytial nuclear aggregates in preeclampsia shows increased sectioning artefacts and decreased inter-villous bridges compared to healthy placentas","volume":"34","author":"Calvert","year":"2013","journal-title":"Placenta"},{"issue":"12","key":"10.1016\/j.placenta.2017.01.002_bib22","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.placenta.2015.10.006","article-title":"Antiphospholipid antibodies bind syncytiotrophoblast mitochondria and alter the proteome of extruded syncytial nuclear aggregates","volume":"36","author":"Pantham","year":"2015","journal-title":"Placenta"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417300024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417300024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:54:22Z","timestamp":1758909262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400417300024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":22,"alternative-id":["S0143400417300024"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2017.01.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2017.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}