{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:40:44Z","timestamp":1770453644688,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY18H040011"],"award-info":[{"award-number":["LY18H040011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16H040010"],"award-info":[{"award-number":["LY16H040010"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY15H040012"],"award-info":[{"award-number":["LY15H040012"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671480"],"award-info":[{"award-number":["81671480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501280"],"award-info":[{"award-number":["81501280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The first open fund project of the first batch of clinical medicine of priority among priorities of Zhejiang province","award":["LKFJ023"],"award-info":[{"award-number":["LKFJ023"]}]},{"name":"Public welfare science and technology project of Wenzhou City","award":["Y20150044"],"award-info":[{"award-number":["Y20150044"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.placenta.2017.12.004","type":"journal-article","created":{"date-parts":[[2017,12,8]],"date-time":"2017-12-08T11:32:38Z","timestamp":1512732758000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Progesterone attenuates hypertension and autoantibody levels to the angiotensin II type 1 receptor in response to elevated cadmium during pregnancy"],"prefix":"10.1016","volume":"62","author":[{"given":"Qiong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongtao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duyun","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2017.12.004_bib1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2017.12.004_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of preeclampsia","volume":"357","author":"Roberts","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2017.12.004_bib3","doi-asserted-by":"crossref","first-page":"13336","DOI":"10.1038\/srep13336","article-title":"Extensive shift in placental transcriptome profile in preeclampsia and placental origin of adverse pregnancy outcomes","volume":"5","author":"S\u00f5ber","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2017.12.004_bib4","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1161\/HYPERTENSIONAHA.116.07971","article-title":"Agonistic autoantibodies to the angiotensin ii type 1 receptor enhance angiotensin ii-induced renal vascular sensitivity and reduce renal function during pregnancy","volume":"68","author":"C.M.Jr","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2017.12.004_bib5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/HJH.0000000000000521","article-title":"Angiotensin ii type 1 receptor autoantibody as a novel regulator of aldosterone independent of preeclampsia","volume":"33","author":"Yang","year":"2015","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.placenta.2017.12.004_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/CIRCRESAHA.113.300752","article-title":"Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond","volume":"113","author":"Xia","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.placenta.2017.12.004_bib7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/hr.2014.71","article-title":"A\u00a0longitudinal study of circulating angiogenic and antiangiogenic factors and at1-aa levels in preeclampsia","volume":"37","author":"Sahay","year":"2014","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.placenta.2017.12.004_bib8","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/HYPERTENSIONAHA.113.01648","article-title":"Endothelin-1, oxidative stress, and endogenous angiotensin ii mechanisms of angiotensin ii type i receptor autoantibody\u2013enhanced renal and blood pressure response during pregnancy","volume":"62","author":"Brewer","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2017.12.004_bib9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/HYPERTENSIONAHA.109.137935","article-title":"Hypertension in response to autoantibodies to the angiotensin ii type i receptor (at1-aa) in pregnant rats: role of endothelin-1","volume":"54","author":"Lamarca","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2017.12.004_bib10","series-title":"Toxicology of Cadmium and its Damage to Mammalian organs. Cadmium: from Toxicity to Essentiality","first-page":"415","author":"Th\u00e9venod","year":"2013"},{"key":"10.1016\/j.placenta.2017.12.004_bib11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10937404.2012.705107","article-title":"Potential for effects of land contamination on human health.1. The case of cadmium","volume":"15","author":"Kah","year":"2012","journal-title":"J.\u00a0Toxicol. Env. Heal B"},{"key":"10.1016\/j.placenta.2017.12.004_bib12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.taap.2012.04.002","article-title":"Prenatal cadmium exposure alters postnatal immune cell development and function","volume":"261","author":"Hanson","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.placenta.2017.12.004_bib13","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.envpol.2015.05.018","article-title":"Wild growing mushrooms for the Edible City? Cadmium and lead content in edible mushrooms harvested within the urban agglomeration of Berlin, Germany","volume":"204","author":"Schlecht","year":"2015","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.placenta.2017.12.004_bib14","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1016\/j.envpol.2009.05.048","article-title":"Food chain transfer of cadmium and lead to cattle in a lead-zinc smelter in Guizhou, China","volume":"157","author":"Cai","year":"2009","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.placenta.2017.12.004_bib15","first-page":"135","article-title":"Chronic cadmium toxicity to sperm of heavy cigarette smokers: immunomodulation by zinc","volume":"43","author":"Al","year":"2009","journal-title":"Arch. Androl."},{"key":"10.1016\/j.placenta.2017.12.004_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogen receptors regulate innate immune cells and signaling pathways","volume":"294","author":"Kovats","year":"2015","journal-title":"Cell Immunol."},{"key":"10.1016\/j.placenta.2017.12.004_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biocel.2015.08.012","article-title":"Estrogen receptor signal in regulation of b cell activation during diverse immune responses","volume":"68","author":"Asaba","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.placenta.2017.12.004_bib18","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10934529.2015.987520","article-title":"Endocrine disruptive effects of cadmium on steroidogenesis: human adrenocortical carcinoma cell line NCI-H295R as a cellular model for reproductive toxicity testing","volume":"50","author":"Knazicka","year":"2015","journal-title":"J.\u00a0Environ. Sci. Heal A"},{"key":"10.1016\/j.placenta.2017.12.004_bib19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.tjog.2013.10.015","article-title":"Metalloestrogen cadmium stimulates proliferation of stromal cells derived from the eutopic endometrium of women with endometriosis","volume":"52","author":"Silva","year":"2013","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2017.12.004_bib20","article-title":"The effect of cadmium on steroid hormones and their receptors in women with uterine myomas","volume":"62","author":"Nasiadek","year":"2011","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.placenta.2017.12.004_bib21","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1095\/biolreprod60.5.1158","article-title":"Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus","volume":"60","author":"Tibbetts","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.placenta.2017.12.004_bib22","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/art.24548","article-title":"Decrease in glomerulonephritis and th1-associated autoantibody production after progesterone treatment in nzb\/nzw mice","volume":"60","author":"Hughes","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.placenta.2017.12.004_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/08916930701464764","article-title":"Regulation of dendritic cells by female sex steroids: relevance to immunity and autoimmunity","volume":"40","author":"Hughes","year":"2007","journal-title":"Autoimmunity"},{"issue":"2014","key":"10.1016\/j.placenta.2017.12.004_bib24","first-page":"124941","article-title":"Ke and ee genotypes of icam-1 gene k469e polymorphism is associated with severe preeclampsia","volume":"5","author":"Ehsan","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.placenta.2017.12.004_bib25","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.envpol.2016.07.073","article-title":"Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia","volume":"218","author":"Zhang","year":"2016","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.placenta.2017.12.004_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7827-12-77","article-title":"Preeclampsia induced by cadmium in rats is related to abnormal local glucocorticoid synthesis in placenta","volume":"12","author":"Wang","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.placenta.2017.12.004_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molimm.2014.01.005","article-title":"Molecular cloning, expression and functional analysis of b-cell activating factor (baff) in yellow grouper, epinephelus awoara","volume":"59","author":"Xiao","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.placenta.2017.12.004_bib28","doi-asserted-by":"crossref","first-page":"37797","DOI":"10.1074\/jbc.M110.169086","article-title":"Estrogen receptors bind to and activate the hoxc4\/hoxc4 promoter to potentiate hoxc4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch dna recombination, and somatic hypermutation","volume":"285","author":"Mai","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.placenta.2017.12.004_bib29","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1161\/HYPERTENSIONAHA.109.140061","article-title":"Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity","volume":"55","author":"Siddiqui","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2017.12.004_bib30","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1161\/HYPERTENSIONAHA.109.137935","article-title":"Hypertension in response to autoantibodies to the angiotensin ii type i receptor (at1-aa) in pregnant rats: role of endothelin-1","volume":"54","author":"Lamarca","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2017.12.004_bib31","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ajh.2011.62","article-title":"Hypertension in response to at1-aa: role of reactive oxygen species in pregnancy-induced hypertension","volume":"24","author":"Parrish","year":"2011","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.placenta.2017.12.004_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogenreceptors regulate innate immune cells and signaling pathways","volume":"294","author":"Kovats","year":"2015","journal-title":"Cell Immunol."},{"key":"10.1016\/j.placenta.2017.12.004_bib33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.clim.2007.01.008","article-title":"Effects of estrogen receptor subtype-selective agonists on autoimmune disease in lupus-prone NZB\/NZW F1 mouse model","volume":"123","author":"Li","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.placenta.2017.12.004_bib34","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10934529.2015.987520","article-title":"Endocrine disruptive effects of cadmium on steroidogenesis: human adrenocortical carcinoma cell line NCI-H295R as a cellular model for reproductive toxicity testing","volume":"50","author":"Knazicka","year":"2015","journal-title":"J.\u00a0Environ. Sci. Health Part A Toxic\/hazard. Subst. Environ. Eng."},{"key":"10.1016\/j.placenta.2017.12.004_bib35","first-page":"545","article-title":"Activation of estrogen receptor alpha by the heavy metal cadmium","volume":"14","author":"Stoica","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.placenta.2017.12.004_bib36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nm902","article-title":"Cadmium mimics the in\u00a0vivo effects of estrogen in the uterus and mammary gland","volume":"9","author":"Johnson","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.placenta.2017.12.004_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08916934.2012.749244","article-title":"Regulation of Aicda expression and AID activity","volume":"46","author":"Zan","year":"2013","journal-title":"Autoimmunity"},{"key":"10.1016\/j.placenta.2017.12.004_bib38","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1007\/978-1-4939-3127-9_44","article-title":"Erratum to: regulation of activation induced deaminase (AID) by estrogen","volume":"1366","author":"Pauklin","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.placenta.2017.12.004_bib39","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1084\/jem.20080521","article-title":"Estrogen directly activates AID transcription and function","volume":"206","author":"Pauklin","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.placenta.2017.12.004_bib40","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.biocel.2015.08.012","article-title":"Estrogen receptor signal in regulation of B cell activation during diverse immune responses","volume":"68","author":"Asaba","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.placenta.2017.12.004_bib41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/17530050903074556","article-title":"Physiological and pathophysiologicalroles of placental aminopeptidase in maternal sera: possiblerelation to preeclampsia and preterm delivery","volume":"3","author":"Mizutani","year":"2009","journal-title":"Expert Opin. Med. Diagn"},{"key":"10.1016\/j.placenta.2017.12.004_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.HYP.37.1.142","article-title":"Vascular effects of progesterone: role of cellular calcium regulation","volume":"37","author":"Barbagallo","year":"2001","journal-title":"Hypertension"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417312110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417312110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:57:05Z","timestamp":1758909425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400417312110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":42,"alternative-id":["S0143400417312110"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2017.12.004","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progesterone attenuates hypertension and autoantibody levels to the angiotensin II type 1 receptor in response to elevated cadmium during pregnancy","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2017.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}