{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:53:04Z","timestamp":1784033584815,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.placenta.2017.12.014","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T12:54:23Z","timestamp":1513342463000},"page":"9-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies"],"prefix":"10.1016","volume":"62","author":[{"given":"Allessandra","family":"Tramontana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonore","family":"Pablik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Stangl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beda","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Dieplinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Hafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib1","first-page":"391","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy, Best practice & research","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Clin. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.semperi.2011.09.011","article-title":"Maternal mortality from preeclampsia\/eclampsia","volume":"36","author":"Ghulmiyyah","year":"2012","journal-title":"Semin. Perinatol."},{"issue":"7","key":"10.1016\/j.placenta.2017.12.014_bib3","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/pd.4403","article-title":"Low-dose aspirin for prevention of adverse outcomes related to abnormal placentation","volume":"34","author":"Bujold","year":"2014","journal-title":"Prenat. Diagn."},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib4","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","article-title":"Placental origins of preeclampsia: challenging the current hypothesis","volume":"51","author":"Huppertz","year":"2008","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","article-title":"Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia","volume":"69","author":"Kaufmann","year":"2003","journal-title":"Biol. Reprod."},{"issue":"9","key":"10.1016\/j.placenta.2017.12.014_bib6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.placenta.2010.06.011","article-title":"First trimester placental and myometrial blood perfusion measured by 3D power Doppler in normal and unfavourable outcome pregnancies","volume":"31","author":"Hafner","year":"2010","journal-title":"Placenta"},{"issue":"10","key":"10.1016\/j.placenta.2017.12.014_bib7","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.placenta.2013.06.303","article-title":"Measurement of placental bed vascularization in the first trimester, using 3D-power-Doppler, for the detection of pregnancies at-risk for fetal and maternal complications","volume":"34","author":"Hafner","year":"2013","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.06.006","article-title":"First-trimester 3-dimensional power Doppler of the uteroplacental circulation space: a potential screening method for preeclampsia","volume":"203","author":"Dar","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.placenta.2011.01.010","article-title":"Placental volume and vascular flow assessed by 3D power Doppler and adverse pregnancy outcomes","volume":"32","author":"Odibo","year":"2011","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.placenta.2017.12.014_bib10","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/uog.6212","article-title":"Maternal serum inhibin-A and activin-A levels in the first trimester of pregnancies developing pre-eclampsia","volume":"32","author":"Spencer","year":"2008","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2017.12.014_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/uog.6275","article-title":"First-trimester maternal serum tumor necrosis factor receptor-1 and pre-eclampsia","volume":"33","author":"Leal","year":"2009","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.placenta.2017.12.014_bib12","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1002\/pd.2375","article-title":"Maternal serum placental protein 13 at 11-13 weeks of gestation in preeclampsia","volume":"29","author":"Akolekar","year":"2009","journal-title":"Prenat. Diagn."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/pd.2433","article-title":"Maternal plasma soluble fms-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia","volume":"30","author":"Akolekar","year":"2010","journal-title":"Prenat. Diagn."},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/uog.7621","article-title":"Maternal plasma soluble endoglin at 11-13 weeks' gestation in pre-eclampsia","volume":"35","author":"Foidart","year":"2010","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/uog.6280","article-title":"First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia","volume":"33","author":"Poon","year":"2009","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib16","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/uog.6244","article-title":"Maternal serum placental growth factor at 11\u00a0+ 0 to 13\u00a0+ 6 weeks of gestation in the prediction of pre-eclampsia","volume":"32","author":"Akolekar","year":"2008","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/pd.2440","article-title":"Hypertensive disorders in pregnancy: combined screening by uterine artery Doppler, blood pressure and serum PAPP-A at 11-13 weeks","volume":"30","author":"Poon","year":"2010","journal-title":"Prenat. Diagn."},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000341264","article-title":"Competing risks model in early screening for preeclampsia by biophysical and biochemical markers","volume":"33","author":"Akolekar","year":"2013","journal-title":"Fetal Diagn. Ther."},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib19","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000341712","article-title":"Combined screening for preeclampsia and small for gestational age at 11-13 weeks","volume":"33","author":"Poon","year":"2013","journal-title":"Fetal Diagn. Ther."},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib20","first-page":"103","article-title":"Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation","volume":"214","author":"O'Gorman","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2017.12.014_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cca.2015.04.010","article-title":"Afamin\u2013A pleiotropic glycoprotein involved in various disease states","volume":"446","author":"Dieplinger","year":"2015","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCGENETICS.113.000654","article-title":"Plasma concentrations of afamin are associated with the prevalence and development of metabolic syndrome","volume":"7","author":"Kronenberg","year":"2014","journal-title":"Circulation. Cardiovasc. Genet."},{"key":"10.1016\/j.placenta.2017.12.014_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1477-7827-12-88","article-title":"Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome","volume":"12","author":"Seeber","year":"2014","journal-title":"Reprod. Biol. Endocrinol. : RB&E"},{"key":"10.1016\/j.placenta.2017.12.014_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cca.2014.03.036","article-title":"The vitamin E-binding protein afamin increases in maternal serum during pregnancy","volume":"434","author":"Hubalek","year":"2014","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"issue":"2","key":"10.1016\/j.placenta.2017.12.014_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.atherosclerosis.2004.01.038","article-title":"Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy?","volume":"175","author":"Rodie","year":"2004","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.placenta.2017.12.014_bib26","doi-asserted-by":"crossref","DOI":"10.1081\/PRG-100104165","article-title":"The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)","volume":"20","author":"Brown","year":"2001","journal-title":"Hypertens. Pregnancy"},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib27","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-2007-999626","article-title":"Accuracy of ultrasonic fetal weight estimation and detection of small for gestational age fetuses","volume":"6","author":"Palo","year":"1989","journal-title":"Am. J. Perinatol."},{"issue":"2","key":"10.1016\/j.placenta.2017.12.014_bib28","first-page":"402","article-title":"Prediction and early detection of preterm labor","volume":"101","author":"Iams","year":"2003","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib29","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2337\/dc09-1848","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy","volume":"33","author":"Metzger","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.placenta.2017.12.014_bib30","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cca.2013.08.016","article-title":"Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma","volume":"425","author":"Dieplinger","year":"2013","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1053\/plac.2001.0684","article-title":"Three-dimensional ultrasound measurement of the placental volume in early pregnancy: method and correlation with biochemical placenta parameters","volume":"22","author":"Metzenbauer","year":"2001","journal-title":"Placenta"},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1046\/j.0960-7692.2001.00594.x","article-title":"Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler at 11-14 weeks of gestation","volume":"18","author":"Martin","year":"2001","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2017.12.014_bib33","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/uog.13257","article-title":"Longitudinal changes in uterine artery Doppler and blood pressure and risk of pre-eclampsia","volume":"43","author":"Khalil","year":"2014","journal-title":"Ultrasound Obstet. Gynecol. : Official J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000356171","article-title":"Prediction of preeclampsia by uterine artery Doppler at 20-24 weeks' gestation","volume":"34","author":"Gallo","year":"2013","journal-title":"Fetal Diagn. Ther."},{"issue":"12","key":"10.1016\/j.placenta.2017.12.014_bib35","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/pd.4692","article-title":"First trimester placental volume and vascular indices in pregnancies complicated by preeclampsia","volume":"35","author":"Plasencia","year":"2015","journal-title":"Prenat. Diagn."},{"issue":"2","key":"10.1016\/j.placenta.2017.12.014_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens. Pregnancy"},{"issue":"10","key":"10.1016\/j.placenta.2017.12.014_bib37","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"Khong","year":"1986","journal-title":"Br. J. Obstet. Gynaecol."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/aje\/155.3.203","article-title":"Impact of preeclampsia and gestational hypertension on birth weight by gestational age","volume":"155","author":"Xiong","year":"2002","journal-title":"Am. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.placenta.2017.12.014_bib39","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/HYPERTENSIONAHA.108.117358","article-title":"Early and late preeclampsia: two different maternal hemodynamic states in the latent phase of the disease","volume":"52","author":"Valensise","year":"2008","journal-title":"Hypertension"},{"issue":"6 Pt 1","key":"10.1016\/j.placenta.2017.12.014_bib40","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.HYP.23.6.717","article-title":"Glucose intolerance as a predictor of hypertension in pregnancy","volume":"23","author":"Solomon","year":"1994","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib41","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1161\/01.HYP.0000205122.47333.7f","article-title":"Preeclampsia in lean normotensive normotolerant pregnant women can be predicted by simple insulin sensitivity indexes","volume":"47","author":"Parretti","year":"2006","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib42","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/HYPERTENSIONAHA.109.130765","article-title":"Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother","volume":"53","author":"Lykke","year":"2009","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001425","article-title":"Preeclampsia as a risk factor for diabetes: a population-based cohort study","volume":"10","author":"Feig","year":"2013","journal-title":"PLoS Med."},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ajog.2015.06.022","article-title":"Timing of treatment initiation for mild gestational diabetes mellitus and perinatal outcomes","volume":"213","author":"Palatnik","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2017.12.014_bib45","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2337\/dc11-1790","article-title":"The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes","volume":"35","author":"Catalano","year":"2012","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.placenta.2017.12.014_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD010211.pub2","article-title":"Interconception care for women with a history of gestational diabetes for improving maternal and infant outcomes","author":"Tieu","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"3","key":"10.1016\/j.placenta.2017.12.014_bib47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/AOG.0000000000000420","article-title":"A\u00a0web-based lifestyle intervention for women with recent gestational diabetes mellitus: a randomized controlled trial","volume":"124","author":"Nicklas","year":"2014","journal-title":"Obstet. Gynecol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417312365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400417312365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:56:48Z","timestamp":1758909408000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400417312365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":47,"alternative-id":["S0143400417312365"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2017.12.014","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of first trimester serum afamin levels and three-dimensional placental bed vascularization as a possible screening method to detect women at-risk for adverse pregnancy complications like pre-eclampsia and gestational diabetes mellitus in low-risk pregnancies","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2017.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}