{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:41:18Z","timestamp":1786995678865,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.placenta.2018.01.001","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T12:54:06Z","timestamp":1515156846000},"page":"S29-S35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"S1","title":["Virtual reality imaging techniques in the study of embryonic and early placental health"],"prefix":"10.1016","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3008-2567","authenticated-orcid":false,"given":"Melek","family":"Rousian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-0361","authenticated-orcid":false,"given":"Maria P.H.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie G.M.G.J.","family":"Mulders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3147-0887","authenticated-orcid":false,"given":"Anton H.J.","family":"Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gine P.M.","family":"Steegers-Theunissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.P.","family":"Steegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2018.01.001_bib1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humupd\/dmt041","article-title":"The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism","volume":"19","author":"Steegers-Theunissen","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.placenta.2018.01.001_bib2","doi-asserted-by":"crossref","first-page":"g14","DOI":"10.1136\/bmj.g14","article-title":"First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study","volume":"348","author":"Jaddoe","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.placenta.2018.01.001_bib3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1530\/REP-09-0092","article-title":"Regulation of vascular growth and function in the human placenta","volume":"138","author":"Burton","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.placenta.2018.01.001_bib4","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0140-6736(58)91905-6","article-title":"Investigation of abdominal masses by pulsed ultrasound","volume":"1","author":"Donald","year":"1958","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2018.01.001_bib5","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/uog.2794","article-title":"Three-dimensional ultrasound volume calculations of human embryos and young fetuses: a study on the volumetry of compound structures and its reproducibility","volume":"27","author":"Blaas","year":"2006","journal-title":"Ultrasound Obstet. Gynecol."},{"issue":"26","key":"10.1016\/j.placenta.2018.01.001_bib6","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/uog.2635","article-title":"A\u00a0virtual reality rendition of a fetal meningomyelocele at 32 weeks of gestation","author":"Groenenberg","year":"2005","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib7","first-page":"136","article-title":"V-scope: design and implementation of an immersive and desktop virtual reality volume visualization system","volume":"142","author":"Koning","year":"2009","journal-title":"Stud. Health Technol. Inf."},{"key":"10.1016\/j.placenta.2018.01.001_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jcu.22207","article-title":"Design and validation of a 3D virtual reality desktop system for sonographic length and volume measurements in early pregnancy evaluation","volume":"43","author":"Baken","year":"2015","journal-title":"J.\u00a0Clin. Ultrasound"},{"key":"10.1016\/j.placenta.2018.01.001_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1471-0528.2008.02006.x","article-title":"Early pregnancy volume measurements: validation of ultrasound techniques and new perspectives","volume":"116","author":"Rousian","year":"2009","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib10","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/uog.5390","article-title":"Reliability of three-dimensional sonographic measurements in early pregnancy using virtual reality","volume":"32","author":"Verwoerd-Dikkeboom","year":"2008","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib11","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/humrep\/deq061","article-title":"Innovative virtual reality measurements for embryonic growth and development","volume":"25","author":"Verwoerd-Dikkeboom","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib12","first-page":"1","article-title":"First-trimester hand measurements in euploid and aneuploidy human fetuses using virtual reality","volume":"32","author":"Baken","year":"2014","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.placenta.2018.01.001_bib13","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1177\/1933719112468950","article-title":"Human embryonic growth and development of the cerebellum using 3-dimensional ultrasound and virtual reality","volume":"20","author":"Rousian","year":"2013","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2018.01.001_bib14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.earlhumdev.2010.11.002","article-title":"First trimester umbilical and vitelline duct measurements using virtual reality","volume":"87","author":"Rousian","year":"2011","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.placenta.2018.01.001_bib15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/uog.9074","article-title":"A\u00a0review of fetal volumetry: the need for standardization and definitions in measurements methodology","volume":"38","author":"Ioannou","year":"2011","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib16","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1093\/humrep\/deq175","article-title":"An innovative virtual reality technique for automated human embryonic volume measurements","volume":"25","author":"Rousian","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib17","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/humrep\/dew043","article-title":"Growth trajectories of the human embryonic head and periconceptional maternal conditions","volume":"31","author":"Koning","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib18","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/humrep\/det035","article-title":"First trimester brain ventricle fluid and embryonic volumes measured by three-dimensional ultrasound with the use of I-Space virtual reality","volume":"28","author":"Rousian","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1953076","article-title":"First-trimester crown-rump length and embryonic volume of fetuses with structural congenital abnormalities measured in virtual reality: an observational study","author":"Baken","year":"2017","journal-title":"Int. J. Biomed. Res."},{"key":"10.1016\/j.placenta.2018.01.001_bib20","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/uog.12365","article-title":"First-trimester crown-rump length and embryonic volume of aneuploidy fetuses measured in virtual reality","volume":"41","author":"Baken","year":"2013","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib21","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.fertnstert.2008.07.1721","article-title":"Embryonic delay in growth and development related to confined placenta triomy 16 mosaicism, diagnosed by I-Space virtual reality","volume":"90","author":"Verwoerd Dikkeboom","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2018.01.001_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000289817","article-title":"Developmental stages in human embryos: revised and new measurements","volume":"292","author":"O'Rahilly","year":"2010","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.placenta.2018.01.001_bib23","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1093\/humrep\/den023","article-title":"Embryonic staging using a 3D virtual reality system","volume":"23","author":"Verwoerd-Dikkeboom","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1093\/molehr\/4.9.857","article-title":"Protein and enzyme pattern in fluid cavities of the first trimester gestational sac: relevance to the absorptive role of the secondary yolk sac","volume":"4","author":"Gulbis","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib25","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/jcu.1870070608","article-title":"Ultrasound visualization of the human yolk sac","volume":"7","author":"Mantoni","year":"1979","journal-title":"J.\u00a0Clin. Ultrasound"},{"key":"10.1016\/j.placenta.2018.01.001_bib26","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/uog.9033","article-title":"Gestational sac fluid volume measurements in virtual reality","volume":"38","author":"Rousian","year":"2011","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib27","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.fertnstert.2004.02.119","article-title":"Abnormal development of the vasculosyncytial membrane in early pregnancy failure","volume":"82","author":"Lisman","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2018.01.001_bib28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.placenta.2008.12.014","article-title":"Vasculogenesis and angiogenesis in the first trimester human placenta: an innovative 3D study using an immersive virtual reality system","volume":"30","author":"Van Oppenraaij","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.01.001_bib29","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.placenta.2012.05.007","article-title":"The effect of smoking on early chorionic villous vascularisation","volume":"33","author":"Van Oppenraaij","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.01.001_bib30","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.ultrasmedbio.2014.02.022","article-title":"Early pregnancy placental bed and fetal vascular volume measurements using 3-D virtual reality","volume":"40","author":"Reus","year":"2014","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.placenta.2018.01.001_bib31","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1093\/humrep\/deu273","article-title":"First trimester trophoblast and placental bed vascular volume measurement in IVF of IVF\/ICSI pregnancies","volume":"29","author":"Rifouna","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib32","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/1471-0528.12592","article-title":"An optimal periconception maternal folate status for embryonic size: the Rotterdam predict study","volume":"121","author":"van Uitert","year":"2014","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.6411","article-title":"A\u00a0multivariate Bayesian model for embryonic growth","volume":"34","author":"Willemsen","year":"2015","journal-title":"Stat. Med."},{"key":"10.1016\/j.placenta.2018.01.001_bib34","article-title":"Maternal lifestyle impairs embryonic growth: the Rotterdam periconception cohort","author":"van Dijk","year":"2017","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2018.01.001_bib35","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1093\/humrep\/det375","article-title":"Periconception maternal characteristics and embryonic growth trajectories: the Rotterdam predict study","volume":"28","author":"van Uitert","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib36","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/humrep\/det115","article-title":"Human embryonic growth trajectories and associations with fetal growth and birthweight","volume":"28","author":"Van Uitert","year":"2013","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib37","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/humrep\/dew060","article-title":"The periconception maternal cardiovascular risk profile influences human embryonic growth trajectories in IVF\/ICSI pregnancies","volume":"31","author":"Wijnands","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib38","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/humrep\/deu271","article-title":"The influence of IVF\/ICSI treatment on human embryonic growth trajectories","volume":"29","author":"Eindhoven","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib39","first-page":"523","article-title":"Periconceptional maternal one-carbon biomarkers are associated with embryonic development according to the Carnegie stages","volume":"32","author":"Parisi","year":"2017","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.01.001_bib40","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.fertnstert.2016.11.030","article-title":"Periconceptional maternal biomarkers of one-carbon metabolism and embryonic growth trajectories: the Rotterdam Periconceptional Cohort (Predict Study)","volume":"107","author":"Parisi","year":"2017","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.placenta.2018.01.001_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/uog.17408","article-title":"Periconceptional maternal \u2018high fish and olive oil, low meat\u2019 dietary pattern is associated with increased embryonic growth: the Rotterdam Periconceptional Cohort (Predit Study)","author":"Parisi","year":"2017","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.01.001_bib42","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3109\/17453674.2011.623566","article-title":"Visualization of postoperative anterior cruciate ligament reconstruction bone tunnels: reliability of standard radiographs, CT scans, and 3D virtual reality images","volume":"82","author":"Meuffels","year":"2011","journal-title":"Acta Orthop."},{"key":"10.1016\/j.placenta.2018.01.001_bib43","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1177\/1933719113519172","article-title":"First trimester detection of surface abnormalities: a comparison of 2- and 3-dimensional ultrasound and 3-dimensional virtual reality ultrasound","volume":"21","author":"Baken","year":"2014","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.placenta.2018.01.001_bib44","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/OGX.0000000000000000","article-title":"Diagnostic techniques and criteria for first-trimester conjoined twin documentation: a review of the literature illustrated by three recent cases","volume":"11","author":"Baken","year":"2013","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.placenta.2018.01.001_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/MCD.0000000000000029","article-title":"First-trimester diagnosis of thrombocytopenia-absent radius syndrome using virtual reality","volume":"23","author":"Baken","year":"2014","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.placenta.2018.01.001_bib46","first-page":"A7373","article-title":"Embryonic health and preconception care: importance for current and future generations","volume":"158","author":"Steegers","year":"2014","journal-title":"Ned. Tijdschr. Geneeskd."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418300018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418300018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:57:34Z","timestamp":1758909454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418300018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":46,"alternative-id":["S0143400418300018"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2018.01.001","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Virtual reality imaging techniques in the study of embryonic and early placental health","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2018.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 IFPA and Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}