{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:32:11Z","timestamp":1792787531173,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Erasmus+Programme of the European Union","award":["2013\u20130040"],"award-info":[{"award-number":["2013\u20130040"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"crossref"}]},{"name":"UQ-Ochsner Seed Fund for Collaborative Research"},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico (FONDECYT","doi-asserted-by":"publisher","award":["1170809"],"award-info":[{"award-number":["1170809"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"la Caixa\u201d Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cerebra Foundation for the Brain Injured Child"},{"DOI":"10.13039\/501100003030","name":"AGAUR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SGR","award":["928"],"award-info":[{"award-number":["928"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.placenta.2018.02.006","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T10:04:26Z","timestamp":1519985066000},"page":"34-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth"],"prefix":"10.1016","volume":"64","author":[{"given":"Jezid","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Paules","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumyalekshmi","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherin","family":"Scholz-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Gratacos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Crispi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4474-0046","authenticated-orcid":false,"given":"Carlos","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2018.02.006_bib1","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1016\/S2214-109X(13)70006-8","article-title":"National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010","volume":"1","author":"Lee","year":"2013","journal-title":"Lancet Glob. Heal"},{"key":"10.1016\/j.placenta.2018.02.006_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000357592","article-title":"Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol","volume":"36","author":"Figueras","year":"2014","journal-title":"Fetal Diagn. Ther."},{"key":"10.1016\/j.placenta.2018.02.006_bib3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199904223401603","article-title":"Birth weight in relation to morbidity and mortality among newborn infants","volume":"340","author":"McIntire","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.placenta.2018.02.006_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ajog.2004.01.036","article-title":"Intrauterine growth restriction increases morbidity and mortality among premature neonates","volume":"191","author":"Garite","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.02.006_bib5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ajog.2010.08.055","article-title":"Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and management","volume":"204","author":"Figueras","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.02.006_bib6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/uog.10078","article-title":"Performance of third-trimester ultrasound for prediction of small-for-gestational-age neonates and evaluation of contingency screening policies","volume":"39","author":"Souka","year":"2012","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.02.006_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.placenta.2018.02.006_bib8","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.ajog.2015.07.001","article-title":"Placental exosomes in normal and complicated pregnancy","volume":"213","author":"Mitchell","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.02.006_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079636","article-title":"Hypoxia-induced changes in the bioactivity of cytotrophoblast-derived exosomes.","volume":"8","author":"Salomon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2018.02.006_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbalip.2013.10.004","article-title":"Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies","volume":"1841","author":"Record","year":"2014","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"14","key":"10.1016\/j.placenta.2018.02.006_bib11","article-title":"Transfer of microRNAs by extracellular membrane microvesicles: a nascent crosstalk model in tumor pathogenesis, especially tumor cell-microenvironment interactions","volume":"8","author":"Zhang","year":"2015","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.placenta.2018.02.006_bib12","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2016.01.043","article-title":"Communication by extracellular vesicles: where we are and where we need to go","volume":"164","author":"Tkach","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2018.02.006_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00281-011-0250-3","article-title":"Microvesicles as mediators of intercellular communication in cancer\u2013the emerging science of cellular \u201cdebris\u201d.","volume":"33","author":"Lee","year":"2011","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.placenta.2018.02.006_bib14","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1073\/pnas.82.24.8715","article-title":"Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA","volume":"82","author":"Kam","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.placenta.2018.02.006_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1600-0897.2006.00435.x","article-title":"Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences","volume":"56","author":"Sabapatha","year":"2006","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2018.02.006_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098667","article-title":"A\u00a0gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration","volume":"9","author":"Salomon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2018.02.006_bib17","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.placenta.2016.12.020","article-title":"Influence of maternal BMI on the exosomal profile during gestation and their role on maternal systemic inflammation.","volume":"50","author":"Elfeky","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.02.006_bib18","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.placenta.2012.10.005","article-title":"Immunomodulatory molecules are released from the first trimester and term placenta via exosomes","volume":"33","author":"Kshirsagar","year":"2012","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.02.006_bib19","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/molehr\/gas013","article-title":"The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes,","volume":"18","author":"Donker","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.02.006_bib20","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1073\/pnas.0637450100","article-title":"mRNA of placental origin is readily detectable in maternal plasma","volume":"100","author":"Ng","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.placenta.2018.02.006_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.placenta.2013.11.002","article-title":"Review: placenta-specific microRNAs in exosomes - good things come in nano-packages","volume":"35","author":"Ouyang","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.02.006_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1479-5876-12-204","article-title":"Placenta-derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy.","volume":"12","author":"Sarker","year":"2014","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.placenta.2018.02.006_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068451","article-title":"Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis","volume":"8","author":"Salomon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2018.02.006_bib24","doi-asserted-by":"crossref","first-page":"E1280","DOI":"10.1210\/jc.2015-2270","article-title":"The effect of glucose on the release and bioactivity of exosomes from first trimester trophoblast cells","volume":"100","author":"Rice","year":"2015","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.placenta.2018.02.006_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.placenta.2016.12.001","article-title":"Review: fetal-maternal communication via extracellular vesicles - implications for complications of pregnancies.","volume":"54","author":"Adam","year":"2017","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.02.006_bib26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.placenta.2014.02.009","article-title":"Intercellular communication by exosomes in placenta: a possible role in cell fusion?,","volume":"35","author":"Record","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.02.006_bib27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejogrb.2006.12.015","article-title":"Customized birthweight standards for a Spanish population","volume":"136","author":"Figueras","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.placenta.2018.02.006_bib28","article-title":"Multicolor flow cytometry and nanoparticle tracking analysis of extracellular vesicles in the plasma of normal pregnant and pre-eclamptic women","volume":"213","author":"Jia","year":"2014","journal-title":"Am. J. Obstet. Gynecol"},{"key":"10.1016\/j.placenta.2018.02.006_bib29","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1038\/srep08505","article-title":"Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes","volume":"5","author":"Yamamoto","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.placenta.2018.02.006_bib30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/molehr\/gah129","article-title":"Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level","volume":"11","author":"Fr\u00e4ngsmyr","year":"2005","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.02.006_bib31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4049\/jimmunol.0803477","article-title":"Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function","volume":"183","author":"Hedlund","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.placenta.2018.02.006_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/693157","article-title":"The possible role of extravillous trophoblast-derived exosomes on the uterine spiral arterial remodeling under both normal and pathological conditions","volume":"2014","author":"Salomon","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.placenta.2018.02.006_bib33","doi-asserted-by":"crossref","first-page":"598","DOI":"10.2337\/db15-0966","article-title":"Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation","volume":"65","author":"Salomon","year":"2016","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.placenta.2018.02.006_bib34","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/bjc.1993.420","article-title":"Construction, characterisation and kinetics of a single chain antibody recognising the tumour associated antigen placental alkaline phosphatase","volume":"68","author":"Savage","year":"1993","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.placenta.2018.02.006_bib35","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/mrd.22420","article-title":"Identification of microRNAs in exosomes isolated from serum and umbilical cord blood, as well as placentomes of gestational day 90 pregnant sheep.","volume":"81","author":"Cleys","year":"2014","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.placenta.2018.02.006_bib36","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis","volume":"22","author":"Li","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.placenta.2018.02.006_bib37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ebiom.2016.04.030","article-title":"Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation","volume":"8","author":"Li","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.placenta.2018.02.006_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/scrt194","article-title":"Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in\u00a0vivo and in\u00a0vitro.","volume":"4","author":"Zhou","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.placenta.2018.02.006_bib39","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1159\/000430193","article-title":"Comparative proteomic profile of the human umbilical cord blood exosomes between normal and preeclampsia pregnancies with high-resolution mass spectrometry","volume":"36","author":"Jia","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.placenta.2018.02.006_bib40","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-2141.1998.0636a.x","article-title":"Transfer of nucleated maternal cells into fetal circulation during the second trimester of pregnancy.","volume":"100","author":"Lo","year":"1998","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.placenta.2018.02.006_bib41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1634\/stemcells.2007-0406","article-title":"Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins.","volume":"26","author":"Chen","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.placenta.2018.02.006_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1172\/JCI111938","article-title":"Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus","volume":"76","author":"DeFronzo","year":"1985","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.placenta.2018.02.006_bib43","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.bcp.2011.12.037","article-title":"The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities","volume":"83","author":"Pant","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.placenta.2018.02.006_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00203","article-title":"Emerging roles of exosomes in normal and pathological conditions: new insights for diagnosis and therapeutic applications","volume":"6","author":"De Toro","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.placenta.2018.02.006_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.placenta.2018.02.006_bib46","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s12035-014-9054-5","article-title":"Exosomes as a nanodelivery system: a key to the future of neuromedicine?","volume":"53","author":"Aryani","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.placenta.2018.02.006_bib47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0165-0378(03)00044-5","article-title":"Trophoblast deportation and the maternal inflammatory response in pre-eclampsia.","volume":"59","author":"Sargent","year":"2003","journal-title":"J.\u00a0Reprod. Immunol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418300651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418300651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:57:08Z","timestamp":1758909428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418300651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":47,"alternative-id":["S0143400418300651"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2018.02.006","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2018.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}