{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:09:45Z","timestamp":1785269385992,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.placenta.2018.04.008","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T02:02:30Z","timestamp":1523844150000},"page":"8-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies"],"prefix":"10.1016","volume":"66","author":[{"given":"Tsegaselassie","family":"Workalemahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Enquobahrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bizu","family":"Gelaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixto E.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasil","family":"Tekola-Ayele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjum","family":"Hajat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cande V.","family":"Ananth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/01.AOG.0000239439.04364.9a","article-title":"Placental abruption","volume":"108","author":"Oyelese","year":"2006","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/tropej\/49.4.231","article-title":"The profile and complications of women with placental abruption and intrauterine death","volume":"49","author":"Leunen","year":"2003","journal-title":"J. Trop. Pediatr."},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/01443610050111940","article-title":"Risk factors for and perinatal mortality of abruptio placentae in patients hospitalised for early onset severe pre-eclampsia-a case controlled study","volume":"20","author":"Odendaal","year":"2000","journal-title":"J. Obstet. Gynaecol."},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/ppe.12089","article-title":"Placental abruption as a significant risk factor for long-term cardiovascular mortality in a follow-up period of more than a decade","volume":"28","author":"Pariente","year":"2014","journal-title":"Paediatr. Perinat. Epidemiol."},{"issue":"5","key":"10.1016\/j.placenta.2018.04.008_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125246","article-title":"An international contrast of rates of placental abruption: an age-period-cohort analysis","volume":"10","author":"Ananth","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib6","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/01.AOG.0000207560.41604.19","article-title":"Placental abruption in term and preterm gestations: evidence for heterogeneity in clinical pathways","volume":"107","author":"Ananth","year":"2006","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib7","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1210\/jc.2003-030141","article-title":"Effects of thrombin, hypoxia, and steroids on interleukin-8 expression in decidualized human endometrial stromal cells: implications for long-term progestin-only contraceptive-induced bleeding","volume":"89","author":"Lockwood","year":"2004","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajog.2007.05.047","article-title":"Chronic hypertension and risk of placental abruption: is the association modified by ischemic placental disease?","volume":"197","author":"Ananth","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"9","key":"10.1016\/j.placenta.2018.04.008_bib9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/oxfordjournals.aje.a009022","article-title":"Maternal cigarette smoking as a risk factor for placental abruption, placenta previa, and uterine bleeding in pregnancy","volume":"144","author":"Ananth","year":"1996","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/aje\/kwm073","article-title":"Influence of maternal smoking on placental abruption in successive pregnancies: a population-based prospective cohort study in Sweden","volume":"166","author":"Ananth","year":"2007","journal-title":"Am. J. Epidemiol."},{"issue":"9","key":"10.1016\/j.placenta.2018.04.008_bib11","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/oxfordjournals.aje.a116181","article-title":"Risk factors for abruptio placentae","volume":"134","author":"Williams","year":"1991","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.placenta.2018.04.008_bib12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/00001648-199111000-00012","article-title":"Chronic hypertension, cigarette smoking, and abruptio placentae","author":"Williams","year":"1991","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib13","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1186\/s40064-016-2946-2","article-title":"Placental abruption possibly due to parvovirus B19 infection","volume":"5","author":"Kawabe","year":"2016","journal-title":"SpringerPlus"},{"issue":"5","key":"10.1016\/j.placenta.2018.04.008_bib14","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1471-0528.2008.02064.x","article-title":"Occurrence of placental abruption in relatives","volume":"116","author":"Rasmussen","year":"2009","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1399-0004.2004.00294.x","article-title":"Risk of placental abruption in first-degree relatives of index patients","volume":"66","author":"Toivonen","year":"2004","journal-title":"Clin. Genet."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.AOG.0000173986.32528.ca","article-title":"The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus","volume":"106","author":"Dizon-Townson","year":"2005","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00001703-199804000-00010","article-title":"Inherited thrombophilia and pregnancy","volume":"10","author":"Girling","year":"1998","journal-title":"Curr. Opin. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2018.04.008_bib18","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.placenta.2004.02.006","article-title":"M385T polymorphism in the factor V gene, but not Leiden mutation, is associated with placental abruption in Finnish women","volume":"25","author":"Jaaskelainen","year":"2004","journal-title":"Placenta"},{"issue":"12","key":"10.1016\/j.placenta.2018.04.008_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116346","article-title":"Placental genome and maternal-placental genetic interactions: a genome-wide and candidate gene association study of placental abruption","volume":"9","author":"Denis","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib20","first-page":"305","article-title":"A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption","volume":"3","author":"Moore","year":"2012","journal-title":"International Journal of Molelecular Epidemiolgy and Genetics"},{"issue":"12","key":"10.1016\/j.placenta.2018.04.008_bib21","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.placenta.2015.10.005","article-title":"Circadian clock-related genetic risk scores and risk of placental abruption","volume":"36","author":"Qiu","year":"2015","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib22","first-page":"128","article-title":"Genome-wide and candidate gene association studies of placental abruption","volume":"4","author":"Workalemahu","year":"2013","journal-title":"International Journal of Molelecular Epidemiolgy and Genetics"},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/EDE.0b013e3181635694","article-title":"Genetic risk factors for placental abruption: a HuGE review and meta-analysis","volume":"19","author":"Zdoukopoulos","year":"2008","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib24","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1186\/1471-2105-9-540","article-title":"Shape-IT: new rapid and accurate algorithm for haplotype inference","volume":"9","author":"Delaneau","year":"2008","journal-title":"BMC Bioinf."},{"issue":"6","key":"10.1016\/j.placenta.2018.04.008_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"Howie","year":"2009","journal-title":"PLoS Genet."},{"issue":"7","key":"10.1016\/j.placenta.2018.04.008_bib26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrg2796","article-title":"Genotype imputation for genome-wide association studies","volume":"11","author":"Marchini","year":"2010","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib27","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2156-11-108","article-title":"Clustering by genetic ancestry using genome-wide SNP data","volume":"11","author":"Solovieff","year":"2010","journal-title":"BMC Genet."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1541-0420.2010.01520.x","article-title":"Control of population stratification by correlation-selected principal components","volume":"67","author":"Lee","year":"2011","journal-title":"Biometrics"},{"issue":"5","key":"10.1016\/j.placenta.2018.04.008_bib29","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/nprot.2014.071","article-title":"Quality control and conduct of genome-wide association meta-analyses","volume":"9","author":"Winkler","year":"2014","journal-title":"Nat. Protoc."},{"issue":"17","key":"10.1016\/j.placenta.2018.04.008_bib30","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Contr. Clin. Trials"},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-11-288","article-title":"GWAMA: software for genome-wide association meta-analysis","volume":"11","author":"M\u00e4gi","year":"2010","journal-title":"BMC Bioinf."},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.placenta.2018.04.008_bib34","first-page":"110023","article-title":"FUMA: functional mapping and annotation of genetic associations","author":"Watanabe","year":"2017","journal-title":"BioRxiv"},{"issue":"6220","key":"10.1016\/j.placenta.2018.04.008_bib35","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.placenta.2018.04.008_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib37","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib38","first-page":"215","article-title":"ChromHMM: automating chromatin-state discovery and characterization","volume":"9","author":"Ernst","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"7414","key":"10.1016\/j.placenta.2018.04.008_bib39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.diabres.2006.12.002","article-title":"Impact of the sulfonylurea receptor 1 (SUR1) exon 16-3c\/t polymorphism on acute hyperglycaemia in type 2 diabetic patients","volume":"77","author":"Dworacka","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"3","key":"10.1016\/j.placenta.2018.04.008_bib41","doi-asserted-by":"crossref","first-page":"C506","DOI":"10.1152\/ajpcell.00429.2010","article-title":"Syntaxin 1A regulates surface expression of \u03b2-cell ATP-sensitive potassium channels","volume":"300","author":"Chen","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1477-7827-9-35","article-title":"Expression of ATP-sensitive potassium channels in human pregnant myometrium","volume":"9","author":"Xu","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.placenta.2018.04.008_bib43","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/908152","article-title":"KCNJ11: genetic polymorphisms and risk of diabetes mellitus","volume":"2015","author":"Haghvirdizadeh","year":"2015","journal-title":"J. Diabetes Res."},{"issue":"4","key":"10.1016\/j.placenta.2018.04.008_bib44","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/humupd\/dmt013","article-title":"Genetic variants and the risk of gestational diabetes mellitus: a systematic review","volume":"19","author":"Zhang","year":"2013","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.placenta.2018.04.008_bib45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3892\/br.2017.921","article-title":"Identification of genetic variants in pharmacogenetic genes associated with type 2 diabetes in a Mexican-Mestizo population","volume":"7","author":"Rodr\u00edguez-Rivera","year":"2017","journal-title":"Biomed. Rep."},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11892-015-0709-z","article-title":"Genetics of gestational diabetes mellitus and maternal metabolism","volume":"16","author":"Lowe","year":"2016","journal-title":"Curr. Diabetes Rep."},{"issue":"1\u20132","key":"10.1016\/j.placenta.2018.04.008_bib47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/19336918.2015.1083668","article-title":"ADAM12 and PAPP-A: candidate regulators of trophoblast invasion and first trimester markers of healthy trophoblasts","volume":"10","author":"Christians","year":"2016","journal-title":"Cell Adhes. Migrat."},{"issue":"9","key":"10.1016\/j.placenta.2018.04.008_bib48","doi-asserted-by":"crossref","first-page":"23035","DOI":"10.3390\/ijms160923035","article-title":"Early pregnancy biomarkers in pre-eclampsia: a systematic review and meta-analysis","volume":"16","author":"Wu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.placenta.2018.04.008_bib49","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1471-0528.1992.tb13848.x","article-title":"Placental bed biopsies in placental abruption","volume":"99","author":"Dommisse","year":"1992","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"issue":"8","key":"10.1016\/j.placenta.2018.04.008_bib50","first-page":"505","article-title":"Objective prioritization of positional candidate genes at a quantitative trait locus for pre-eclampsia on 2q22","volume":"12","author":"Moses","year":"2006","journal-title":"MHR: Basic Sci. Reprod. Med."},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib51","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0002-9378(97)70205-9","article-title":"Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction","volume":"177","author":"Dizon-Townson","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.04.008_bib52","series-title":"dbPTB: a Database for Preterm Birth, Database 2012","author":"Uzun","year":"2012"},{"issue":"12","key":"10.1016\/j.placenta.2018.04.008_bib53","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.placenta.2012.09.016","article-title":"PESNPdb: a comprehensive database of SNPs studied in association with pre-eclampsia","volume":"33","author":"Tuteja","year":"2012","journal-title":"Placenta"},{"issue":"D1","key":"10.1016\/j.placenta.2018.04.008_bib54","doi-asserted-by":"crossref","first-page":"D1308","DOI":"10.1093\/nar\/gkr798","article-title":"SNPedia: a wiki supporting personal genome annotation, interpretation and analysis","volume":"40","author":"Cariaso","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.placenta.2018.04.008_bib55","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ajog.2015.09.069","article-title":"Severe placental abruption: clinical definition and associations with maternal complications","volume":"214","author":"Ananth","year":"2016","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418301644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418301644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:56:58Z","timestamp":1758909418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418301644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":55,"alternative-id":["S0143400418301644"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2018.04.008","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2018.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}