{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:47:53Z","timestamp":1791805673786,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010751","name":"FONDECYT","doi-asserted-by":"publisher","award":["1151119"],"award-info":[{"award-number":["1151119"]}],"id":[{"id":"10.13039\/501100010751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["1181341"],"award-info":[{"award-number":["1181341"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VRI-Puente","award":["P1714\/2017"],"award-info":[{"award-number":["P1714\/2017"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.placenta.2018.10.003","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T22:31:37Z","timestamp":1539729097000},"page":"36-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth"],"prefix":"10.1016","volume":"72-73","author":[{"given":"Jorge","family":"Lopez-Tello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angeles","family":"Jimenez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6342-085X","authenticated-orcid":false,"given":"Emilio A.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-6143","authenticated-orcid":false,"given":"Bernardo J.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda N.","family":"Sferruzzi-Perri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2018.10.003_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejogrb.2004.03.007","article-title":"Risk factors for low birth weight: a review","volume":"116","author":"Valero De Bernab\u00e9","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.placenta.2018.10.003_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/jech.43.3.237","article-title":"The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis","volume":"43","author":"Barker","year":"1989","journal-title":"J. Epidemiol. Community Health"},{"key":"10.1016\/j.placenta.2018.10.003_bib3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.placenta.2015.03.003","article-title":"Animal models of fetal growth restriction: considerations for translational medicine","volume":"36","author":"Swanson","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1017\/S2040174416000477","article-title":"A review of fundamental principles for animal models of DOHaD research: an Australian perspective","volume":"7","author":"Dickinson","year":"2016","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.placenta.2018.10.003_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1440-1681.2008.04975.x","article-title":"Sheep models of intrauterine growth restriction: fetal adaptations and consequences","volume":"35","author":"Morrison","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphys.2016.00033","article-title":"The programming power of the placenta","volume":"7","author":"Sferruzzi-Perri","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib7","doi-asserted-by":"crossref","DOI":"10.1113\/JP274948","article-title":"Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic","author":"Morrison","year":"2018","journal-title":"J. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib8","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1113\/JP271467","article-title":"Assessment of in vivo fetal growth and placental vascular function in a novel intrauterine growth restriction model of progressive uterine artery occlusion in Guinea pigs","volume":"594","author":"Herrera","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00144","article-title":"Fetal growth restriction induces heterogeneous effects on vascular biomechanical and functional properties in Guinea pigs (Cavia porcellus)","volume":"8","author":"Ca\u00f1as","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib10","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1113\/JP273396","article-title":"N-Acetylcysteine, a glutathione precursor, reverts vascular dysfunction and endothelial epigenetic programming in intrauterine growth restricted Guinea pigs","volume":"595","author":"Herrera","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib11","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1017\/S2040174417000307","article-title":"Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal Guinea pig model","volume":"8","author":"Cumberland","year":"2017","journal-title":"J. Dev. Orig. Health Dis."},{"key":"10.1016\/j.placenta.2018.10.003_bib12","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1242\/jcs.03239","article-title":"Granzymes at a glance","volume":"119","author":"Bots","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.placenta.2018.10.003_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0143-4004(05)80255-3","article-title":"Restriction of placental and fetal growth in the Guinea-pig","volume":"14","author":"Carter","year":"1993","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169194","article-title":"Competition for materno-fetal resource partitioning in a rabbit model of undernourished pregnancy","volume":"12","author":"Lopez-Tello","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.placenta.2018.10.003_bib15","doi-asserted-by":"crossref","first-page":"R151","DOI":"10.1152\/ajpregu.00036.2014","article-title":"Impact of chronic hypoxemia on blood flow to the brain, heart, and adrenal gland in the late-gestation IUGR sheep fetus","volume":"308","author":"Poudel","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib16","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1113\/JP271057","article-title":"Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy","volume":"594","author":"Higgins","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0143-4004(84)80002-8","article-title":"Placental anatomy and diffusing capacity in Guinea pigs following long-term maternal hypoxia","volume":"5","author":"Bacon","year":"1984","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib18","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/plac.2001.0679","article-title":"Effects of maternal iron restriction on placental vascularization in the rat","volume":"22","author":"Lewis","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1203\/00006450-199009000-00007","article-title":"Placental transfer of glucose and amino acids in intrauterine growth retardation: studies with substrate analogs in the awake Guinea pig","volume":"28","author":"Jansson","year":"1990","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.placenta.2018.10.003_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/plac.2000.0602","article-title":"Maternal food restriction reduces the exchange surface area and increases the barrier thickness of the placenta in the Guinea-pig","volume":"22","author":"Roberts","year":"2001","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib21","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1210\/en.2005-1328","article-title":"Maternal insulin-like growth factors-I and -ii act via different pathways to promote fetal growth","volume":"147","author":"Sferruzzi-Perri","year":"2006","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"10.1016\/j.placenta.2018.10.003_bib22","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.placenta.2018.01.005","article-title":"Regulating needs: exploring the role of insulin-like growth factor-2 signalling in materno-fetal resource allocation","volume":"64","author":"Sferruzzi-Perri","year":"2018","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib23","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1113\/JP273330","article-title":"Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth","volume":"595","author":"Sferruzzi-Perri","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.placenta.2018.10.003_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/plac.1999.0498","article-title":"Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals","volume":"21","author":"Han","year":"2000","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1677\/joe.1.05781","article-title":"Altered expression of IGFs and IGF-binding proteins during intrauterine growth restriction in Guinea pigs","volume":"184","author":"Carter","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.placenta.2018.10.003_bib26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.reprotox.2012.01.013","article-title":"Maternal undernutrition reduces P-glycoprotein in Guinea pig placenta and developing brain in late gestation","volume":"33","author":"Soo","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.placenta.2018.10.003_bib27","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1053\/plac.2002.0945","article-title":"Histomorphology of the placenta and the placental bed of growth restricted foetuses and correlation with the Doppler velocimetries of the uterine and umbilical arteries","volume":"24","author":"Madazli","year":"2003","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2018.10.003_bib28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","article-title":"Placental apoptosis in health and disease","volume":"64","author":"Sharp","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.placenta.2018.10.003_bib29","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/molehr\/7.12.1133","article-title":"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction","volume":"7","author":"Hirst","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.placenta.2018.10.003_bib30","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0002-9378(97)70081-4","article-title":"Increased placental apoptosis in intrauterine growth restriction","volume":"177","author":"Smith","year":"1997","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2018.10.003_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front. Physiol."},{"issue":"Suppl","key":"10.1016\/j.placenta.2018.10.003_bib32","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1016\/j.placenta.2009.11.010","article-title":"Review: sex and the human placenta: mediating differential strategies of fetal growth and survival","volume":"31","author":"Clifton","year":"2010","journal-title":"Placenta"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418307161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418307161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:58:28Z","timestamp":1758909508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418307161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":32,"alternative-id":["S0143400418307161"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2018.10.003","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2018.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}