{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:15:11Z","timestamp":1789848911742,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["CU-58-001-HR"],"award-info":[{"award-number":["CU-58-001-HR"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["CU-58-001-HR"],"award-info":[{"award-number":["CU-58-001-HR"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.placenta.2019.02.004","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T07:06:33Z","timestamp":1549350393000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Proteomic identification of predictive biomarkers for malignant transformation in complete hydatidiform moles"],"prefix":"10.1016","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-9607","authenticated-orcid":false,"given":"Asama","family":"Vanichtantikul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorichaya","family":"Somparn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thammakorn","family":"Saethang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-0381","authenticated-orcid":false,"given":"Surang","family":"Triratanachat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trairak","family":"Pisitkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruangsak","family":"Lertkhachonsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2019.02.004_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.hoc.2011.10.007","article-title":"Current management of gestational trophoblastic neoplasia","volume":"26","author":"Goldstein","year":"2012","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.placenta.2019.02.004_bib2","first-page":"634","article-title":"Management of complete molar pregnancy","volume":"32","author":"Berkowitz","year":"1987","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.placenta.2019.02.004_bib3","first-page":"CD007289","article-title":"Prophylactic chemotherapy for hydatidiform mole to prevent gestational trophoblastic neoplasia","volume":"10","author":"Fu","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.placenta.2019.02.004_bib4","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/elps.201000585","article-title":"Proteomic biomarker discovery: it's more than just mass spectrometry","volume":"32","author":"Blonder","year":"2011","journal-title":"Electrophoresis"},{"key":"10.1016\/j.placenta.2019.02.004_bib5","first-page":"1160","article-title":"Proteomics for cancer biomarker discovery","volume":"48","author":"Srinivas","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1016\/j.placenta.2019.02.004_bib6","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1021\/bi0023910","article-title":"Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire","volume":"40","author":"Hoang","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.placenta.2019.02.004_bib7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12013-013-9792-4","article-title":"A proteomic analysis of placental trophoblastic cells in preeclampsia-eclampsia","volume":"69","author":"Ma","year":"2014","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.placenta.2019.02.004_bib8","first-page":"623","article-title":"Comparative proteomic analysis between benign and malignant-transformed hydatidiform mole","volume":"53","author":"Ma","year":"2008","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.placenta.2019.02.004_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.placenta.2006.10.005","article-title":"Proteome analysis of human placentae: pre-eclampsia versus normal pregnancy","volume":"28","author":"Mine","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2019.02.004_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/IGC.0b013e3182022997","article-title":"CLIC1 protein: a candidate prognostic biomarker for malignant-transformed hydatidiform moles","volume":"21","author":"Shi","year":"2011","journal-title":"Int. J. Gynecol. Canc."},{"key":"10.1016\/j.placenta.2019.02.004_bib11","first-page":"390","article-title":"Tandem mass spectrometry in physiology","volume":"22","author":"Pisitkun","year":"2007","journal-title":"Physiology (Bethesda, Md"},{"key":"10.1016\/j.placenta.2019.02.004_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/ijgc-00009577-200403000-00002","article-title":"The practicability of FIGO 2000 staging for gestational trophoblastic neoplasia","volume":"14","author":"Ngan","year":"2004","journal-title":"Int. J. Gynecol. Canc."},{"key":"10.1016\/j.placenta.2019.02.004_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.placenta.2019.02.004_bib14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/pmic.200300449","article-title":"The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins","volume":"3","author":"Pieper","year":"2003","journal-title":"Proteomics"},{"key":"10.1016\/j.placenta.2019.02.004_bib15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.placenta.2019.02.004_bib16","first-page":"5655","article-title":"Diagnosis of hydatidiform mole and persistent trophoblastic disease: diagnostic accuracy of total human chorionic gonadotropin (hCG), free hCG {alpha}- and {beta}-subunits, and their ratios","volume":"153","author":"van Trommel","year":"2005","journal-title":"Eur. J. Endocrinol.\/European Federation of Endocrine Societies"},{"key":"10.1016\/j.placenta.2019.02.004_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/172460080602100107","article-title":"Clinical utility of hyperglycosylated hCG in serum taken before hydatidiform mole evacuation to predict persistent trophoblastic disease","volume":"21","author":"Duc","year":"2006","journal-title":"Int. J. Biol. Markers"},{"key":"10.1016\/j.placenta.2019.02.004_bib18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1677\/joe.0.1710435","article-title":"Human chorionic gonadotropin (hCG) beta-core fragment is produced by degradation of hCG or free hCG beta in gestational trophoblastic tumors: a possible marker for early detection of persistent postmolar gestational trophoblastic disease","volume":"171","author":"Okamoto","year":"2001","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.placenta.2019.02.004_bib19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ygyno.2010.01.008","article-title":"Pre-evacuation hCG glycoforms in uneventful complete hydatidiform mole and persistent trophoblastic disease","volume":"117","author":"Thomas","year":"2010","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.placenta.2019.02.004_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3109\/00016349609065741","article-title":"Immunohistochemistry in the diagnosis of the gestational trophoblastic disease","volume":"75","author":"Losch","year":"1996","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.placenta.2019.02.004_bib21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.placenta.2010.01.004","article-title":"Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells","volume":"31","author":"Camolotto","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.placenta.2019.02.004_bib22","doi-asserted-by":"crossref","first-page":"5822","DOI":"10.1073\/pnas.87.15.5822","article-title":"Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole","volume":"87","author":"Leslie","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.placenta.2019.02.004_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/20742835.2010.11441161","article-title":"Pathology of gestational trophoblastic neoplasia: a review with recent insights","volume":"2","author":"Slavik","year":"2010","journal-title":"South Afr J Gynaecol Oncol"},{"key":"10.1016\/j.placenta.2019.02.004_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0092-8674(89)90970-7","article-title":"Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule","volume":"57","author":"Benchimol","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.placenta.2019.02.004_bib25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2407-5-66","article-title":"Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis","volume":"5","author":"Salahshor","year":"2005","journal-title":"BMC Canc."},{"key":"10.1016\/j.placenta.2019.02.004_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-1119(97)00485-X","article-title":"Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta","volume":"203","author":"Lawton","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.placenta.2019.02.004_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13046-018-0744-0","article-title":"GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1\/2 through the receptor ErbB2","volume":"37","author":"Li","year":"2018","journal-title":"J. Exp. Clin. Canc. Res."},{"key":"10.1016\/j.placenta.2019.02.004_bib28","doi-asserted-by":"crossref","unstructured":"Li C, Wang J, Kong J, Tang J, Wu Y, Xu E, et al. GDF15 promotes EMT and metastasis in colorectal cancer 2016; Oncotarget; 7 :860-872.","DOI":"10.18632\/oncotarget.6205"},{"key":"10.1016\/j.placenta.2019.02.004_bib29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/modpathol.2012.161","article-title":"Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma","volume":"26","author":"Kim","year":"2013","journal-title":"Mod. Pathol.: an official journal of the United States and Canadian Academy of Pathology, Inc."},{"key":"10.1016\/j.placenta.2019.02.004_bib30","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1128\/MCB.11.8.3842","article-title":"Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein","volume":"11","author":"Pogue-Geile","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.placenta.2019.02.004_bib31","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1074\/mcp.M700500-MCP200","article-title":"Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry","volume":"6","author":"Ralhan","year":"2008","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.placenta.2019.02.004_bib32","article-title":"Data\u2010independent acquisition\u2010based quantitative proteomic analysis reveals potential biomarkers of kidney cancer","volume":"11","author":"Song","year":"2017","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.placenta.2019.02.004_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/IGC.0b013e3182022997","article-title":"CLIC1 protein: a candidate prognostic biomarker for malignant-transformed hydatidiform moles","volume":"21","author":"Shi","year":"2011","journal-title":"Int. J. Gynecol. Canc."}],"updated-by":[{"DOI":"10.1016\/j.placenta.2019.06.387","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000}}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418310968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418310968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T11:37:25Z","timestamp":1694605045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418310968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":33,"alternative-id":["S0143400418310968"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2019.02.004","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.placenta.2019.06.387","asserted-by":"object"}]},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic identification of predictive biomarkers for malignant transformation in complete hydatidiform moles","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2019.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}