{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:58:44Z","timestamp":1788998324082,"version":"build-2803163510"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T00:00:00Z","timestamp":1556755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009228","name":"Region \u00d6rebro l\u00e4n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.placenta.2019.05.001","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T01:59:03Z","timestamp":1556762343000},"page":"46-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["Placental expression of microRNAs in infants born small for gestational age"],"prefix":"10.1016","volume":"81","author":[{"given":"H.","family":"\u00d6stling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Helenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5292-4913","authenticated-orcid":false,"given":"M.","family":"Lodefalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.placenta.2019.05.001_bib1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1824-7288-37-41","article-title":"Intrauterine growth retardation--small events, big consequences","volume":"37","author":"Saleem","year":"2011","journal-title":"Ital. J. Pediatr."},{"issue":"6","key":"10.1016\/j.placenta.2019.05.001_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.ajog.2009.10.889","article-title":"Defining normal and abnormal fetal growth: promises and challenges","volume":"202","author":"Zhang","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"8","key":"10.1016\/j.placenta.2019.05.001_bib3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.jgyn.2013.09.012","article-title":"Definitions: small for gestational age and intrauterine growth retardation","volume":"42","author":"Ego","year":"2013","journal-title":"J. Gynecol. Obstet. Biol. Reprod."},{"issue":"Suppl 3","key":"10.1016\/j.placenta.2019.05.001_bib4","first-page":"15","article-title":"New definition of small for gestational age based on fetal growth potential","volume":"65","author":"Gardosi","year":"2006","journal-title":"Horm. Res."},{"issue":"4 Suppl","key":"10.1016\/j.placenta.2019.05.001_bib5","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1016\/j.ajog.2015.07.046","article-title":"Placental transcriptome in development and pathology: expression, function, and methods of analysis","volume":"213","author":"Cox","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.placenta.2019.05.001_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.placenta.2019.05.001_bib7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4161\/epi.5.7.12762","article-title":"Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta","volume":"5","author":"Maccani","year":"2010","journal-title":"Epigenetics"},{"issue":"7","key":"10.1016\/j.placenta.2019.05.001_bib8","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/ajt.13185","article-title":"Dysregulated MicroRNA expression and chronic lung allograft rejection in recipients with antibodies to donor HLA","volume":"15","author":"Xu","year":"2015","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.placenta.2019.05.001_bib9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fcvm.2017.00060","article-title":"MicroRNAs: new players in the pathobiology of preeclampsia","volume":"4","author":"Bounds","year":"2017","journal-title":"Frontiers in cardiovascular medicine"},{"issue":"5","key":"10.1016\/j.placenta.2019.05.001_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1095\/biolreprod.113.107805","article-title":"Human placental microRNAs and preeclampsia","volume":"88","author":"Chen","year":"2013","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.placenta.2019.05.001_bib11","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.placenta.2013.04.007","article-title":"Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas","volume":"34","author":"Guo","year":"2013","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2019.05.001_bib12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/pd.4045","article-title":"Characterization of placenta-specific microRNAs in fetal growth restriction pregnancy","volume":"33","author":"Higashijima","year":"2013","journal-title":"Prenat. Diagn."},{"issue":"6","key":"10.1016\/j.placenta.2019.05.001_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/dna.2014.2687","article-title":"Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications","volume":"34","author":"Hromadnikova","year":"2015","journal-title":"DNA Cell Biol."},{"issue":"6","key":"10.1016\/j.placenta.2019.05.001_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021210","article-title":"miR-16 and miR-21 expression in the placenta is associated with fetal growth","volume":"6","author":"Maccani","year":"2011","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.placenta.2019.05.001_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176493","article-title":"Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid transport","volume":"12","author":"Thamotharan","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2019.05.001_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.placenta.2017.11.005","article-title":"Dysregulated placental microRNAs in early and late onset preeclampsia","volume":"61","author":"Lykoudi","year":"2018","journal-title":"Placenta"},{"issue":"7","key":"10.1016\/j.placenta.2019.05.001_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.placenta.2013.04.009","article-title":"Increased levels of microRNA-424 are associated with the pathogenesis of fetal growth restriction","volume":"34","author":"Huang","year":"2013","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib18","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1055\/s-0033-1361832","article-title":"Altered Expression of miR-518b and miR-519a in the placenta is associated with low fetal birth weight","volume":"31","author":"Wang","year":"2014","journal-title":"Am. J. Perinatol."},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138383","article-title":"Cardiovascular and cerebrovascular disease associated microRNAs are dysregulated in placental tissues affected with gestational hypertension, preeclampsia and intrauterine growth restriction","volume":"10","author":"Hromadnikova","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.placenta.2010.07.001","article-title":"The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction","volume":"31","author":"Mouillet","year":"2010","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.placenta.2019.05.001_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058737","article-title":"miR-141 contributes to fetal growth restriction by regulating PLAG1 expression","volume":"8","author":"Tang","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.placenta.2019.05.001_bib22","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.3892\/mmr.2017.7462","article-title":"MicroRNA expression profiles and networks in placentas complicated with selective intrauterine growth restriction","volume":"16","author":"Wen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.placenta.2019.05.001_bib23","first-page":"1","article-title":"Outcomes of maternal weight gain","volume":"168","author":"Viswanathan","year":"2008","journal-title":"Evid. Rep. Technol. Assess."},{"issue":"7","key":"10.1016\/j.placenta.2019.05.001_bib24","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1651-2227.2002.tb03322.x","article-title":"Swedish population-based longitudinal reference values from birth to 18 years of age for height, weight and head circumference","volume":"91","author":"Wikland","year":"2002","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.placenta.2019.05.001_bib25","series-title":"Weight Gain during Pregnancy: Reexamining the Guidelines","author":"Rasmussen","year":"2009"},{"issue":"6 Pt 1","key":"10.1016\/j.placenta.2019.05.001_bib26","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1542\/peds.111.6.1253","article-title":"International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001","volume":"111","author":"Lee","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.placenta.2019.05.001_bib27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2431-8-8","article-title":"Continuous growth reference from 24th week of gestation to 24 months by gender","volume":"8","author":"Niklasson","year":"2008","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.placenta.2019.05.001_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbior.2014.09.013","article-title":"MicroRNA and cancer--a brief overview","volume":"57","author":"Acunzo","year":"2015","journal-title":"Adv Biol Regul"},{"issue":"4 Suppl","key":"10.1016\/j.placenta.2019.05.001_bib29","first-page":"S6","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.placenta.2019.05.001_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2012.11.001","article-title":"Pregnancy-associated miRNA-clusters","volume":"97","author":"Morales-Prieto","year":"2013","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.placenta.2019.05.001_bib31","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3892\/mmr.2016.5268","article-title":"Placental microRNA expression in pregnancies complicated by superimposed preeclampsia on chronic hypertension","volume":"14","author":"Vashukova","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.placenta.2019.05.001_bib32","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/HYPERTENSIONAHA.113.02647","article-title":"Variations of microRNAs in human placentas and plasma from preeclamptic pregnancy","volume":"63","author":"Xu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.placenta.2019.05.001_bib33","doi-asserted-by":"crossref","first-page":"19910","DOI":"10.1038\/srep19910","article-title":"The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-beta signaling","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib34","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.numecd.2018.03.013","article-title":"Transient postnatal over nutrition induces long-term alterations in cardiac NLRP3-inflammasome pathway","volume":"28","author":"Siddeek","year":"2018","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"issue":"1","key":"10.1016\/j.placenta.2019.05.001_bib35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3349\/ymj.2017.58.1.234","article-title":"miR-379 inhibits cell proliferation, invasion, and migration of vascular smooth muscle cells by targeting insulin-like factor-1","volume":"58","author":"Li","year":"2017","journal-title":"Yonsei Med. J."},{"issue":"1","key":"10.1016\/j.placenta.2019.05.001_bib36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1469-7580.2008.01035.x","article-title":"Insulin and the IGF system in the human placenta of normal and diabetic pregnancies","volume":"215","author":"Hiden","year":"2009","journal-title":"J. Anat."},{"issue":"11","key":"10.1016\/j.placenta.2019.05.001_bib37","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0029-1231026","article-title":"Changes in GH\/IGF-1 axis in intrauterine growth retardation: consequences of fetal programming?","volume":"41","author":"Setia","year":"2009","journal-title":"Horm. Metab. Res."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.001_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0954422412000145","article-title":"Peripheral signalling involved in energy homeostasis control","volume":"25","author":"Lancha","year":"2012","journal-title":"Nutr. Res. Rev."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.001_bib39","first-page":"540","article-title":"Circulating miR-379 as a potential novel biomarker for diagnosis of acute myocardial infarction","volume":"22","author":"Yi","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"19","key":"10.1016\/j.placenta.2019.05.001_bib40","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.15252\/embj.201387038","article-title":"The miR-379\/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation","volume":"33","author":"Labialle","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.placenta.2019.05.001_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1745-6150-8-10","article-title":"Genome-wide analysis reveals downregulation of miR-379\/miR-656 cluster in human cancers","volume":"8","author":"Laddha","year":"2013","journal-title":"Biol. Direct"},{"issue":"23","key":"10.1016\/j.placenta.2019.05.001_bib42","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.1002\/1873-3468.12458","article-title":"MicroRNA-105 targets SOX9 and inhibits human glioma cell progression","volume":"590","author":"Liu","year":"2016","journal-title":"FEBS Lett."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.001_bib43","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.acthis.2016.02.001","article-title":"MicroRNA-193b inhibits the proliferation, migration and invasion of gastric cancer cells via targeting cyclin D1","volume":"118","author":"Wang","year":"2016","journal-title":"Acta Histochem."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.001_bib44","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jss.2016.03.021","article-title":"MiR-330-5p regulates tyrosinase and PDIA3 expression and suppresses cell proliferation and invasion in cutaneous malignant melanoma","volume":"203","author":"Su","year":"2016","journal-title":"J. Surg. Res."},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib45","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1007\/s13277-015-3382-6","article-title":"miR-335 inhibits the proliferation and invasion of clear cell renal cell carcinoma cells through direct suppression of BCL-W","volume":"36","author":"Wang","year":"2015","journal-title":"Tumour Biol"},{"key":"10.1016\/j.placenta.2019.05.001_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.lfs.2017.03.010","article-title":"miR-519 suppresses nasopharyngeal carcinoma cell proliferation by targeting oncogene URG4\/URGCP","volume":"175","author":"Yu","year":"2017","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.001_bib47","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","article-title":"Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis","volume":"25","author":"Zhou","year":"2014","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.placenta.2019.05.001_bib48","first-page":"2030","article-title":"MiR-205 silences MED1 in hypoxic primary human trophoblasts","volume":"24","author":"Mouillet","year":"2010","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.001_bib49","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.3892\/mmr.2015.4018","article-title":"Upregulation of microRNA335 and microRNA584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase","volume":"12","author":"Jiang","year":"2015","journal-title":"Mol. Med. Rep."},{"issue":"8","key":"10.1016\/j.placenta.2019.05.001_bib50","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1515\/CCLM.2009.228","article-title":"Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia","volume":"47","author":"Hu","year":"2009","journal-title":"Clin. Chem. Lab. Med."},{"issue":"9","key":"10.1016\/j.placenta.2019.05.001_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091878","article-title":"Inflammatory diseases and growth: effects on the GH-IGF Axis and on growth plate","volume":"18","author":"Cirillo","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.placenta.2019.05.001_bib52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2164-13-115","article-title":"Transcriptome landscape of the human placenta","volume":"13","author":"Kim","year":"2012","journal-title":"BMC Genomics"},{"issue":"5","key":"10.1016\/j.placenta.2019.05.001_bib53","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10142-017-0555-y","article-title":"Transcriptome profile of the human placenta","volume":"17","author":"Majewska","year":"2017","journal-title":"Funct. Integr. Genom."},{"issue":"2015","key":"10.1016\/j.placenta.2019.05.001_bib54","first-page":"951","article-title":"RNA sequencing and analysis","volume":"11","author":"Kukurba","year":"2015","journal-title":"Cold Spring Harb. Protoc."},{"issue":"20","key":"10.1016\/j.placenta.2019.05.001_bib55","doi-asserted-by":"crossref","first-page":"7361","DOI":"10.1073\/pnas.1405528111","article-title":"Noninvasive in vivo monitoring of tissue-specific global gene expression in humans","volume":"111","author":"Koh","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.placenta.2019.05.001_bib56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpeds.2017.12.059","article-title":"Consensus based definition of growth restriction in the newborn","volume":"196","author":"Beune","year":"2018","journal-title":"J. Pediatr."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418307069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400418307069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:58:36Z","timestamp":1758909516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400418307069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":56,"alternative-id":["S0143400418307069"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2019.05.001","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental expression of microRNAs in infants born small for gestational age","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2019.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}