{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:43:41Z","timestamp":1786995821378,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.placenta.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T09:33:49Z","timestamp":1557653629000},"page":"17-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Downregulation of receptor tyrosine kinase-like orphan receptor 1 in preeclampsia placenta inhibits human trophoblast cell proliferation, migration, and invasion by PI3K\/AKT\/mTOR pathway accommodation"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1558-7564","authenticated-orcid":false,"given":"Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jine","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-0557","authenticated-orcid":false,"given":"Yuanhua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.placenta.2019.05.002_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.placenta.2019.05.002_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/PRG-120021060","article-title":"Subclassification of preeclampsia","volume":"22","author":"von Dadelszen","year":"2003","journal-title":"Hypertens. Pregnancy"},{"issue":"9879","key":"10.1016\/j.placenta.2019.05.002_bib3","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0140-6736(13)60686-8","article-title":"Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study","volume":"381","author":"Souza","year":"2013","journal-title":"Lancet (London, England)"},{"issue":"5","key":"10.1016\/j.placenta.2019.05.002_bib4","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1096\/fj.201701008R","article-title":"Angiogenic factor imbalance precedes complement deposition in placentae of the BPH\/5 model of preeclampsia","volume":"32","author":"Sones","year":"2018","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.placenta.2019.05.002_bib5","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","article-title":"Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface","volume":"114","author":"Red-Horse","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"3","key":"10.1016\/j.placenta.2019.05.002_bib6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \"Great Obstetrical Syndromes\" are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"36","key":"10.1016\/j.placenta.2019.05.002_bib7","doi-asserted-by":"crossref","first-page":"26181","DOI":"10.1016\/S0021-9258(18)35733-8","article-title":"A novel family of cell surface receptors with tyrosine kinase-like domain","volume":"267","author":"Masiakowski","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.002_bib8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1006\/geno.1997.4653","article-title":"Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis","volume":"41","author":"Reddy","year":"1997","journal-title":"Genomics"},{"issue":"11","key":"10.1016\/j.placenta.2019.05.002_bib9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tcb.2008.08.006","article-title":"Ror receptor tyrosine kinases: orphans no more","volume":"18","author":"Green","year":"2008","journal-title":"Trends Cell Biol."},{"issue":"7","key":"10.1016\/j.placenta.2019.05.002_bib10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.2003.00662.x","article-title":"The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a\/JNK signalling pathway","volume":"8","author":"Oishi","year":"2003","journal-title":"Genes Cells : Devoted Mol. Cell. Mech."},{"issue":"12","key":"10.1016\/j.placenta.2019.05.002_bib11","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1158\/1078-0432.CCR-16-2083","article-title":"Analysis of ROR1 protein expression in human cancer and normal tissues","volume":"23","author":"Balakrishnan","year":"2017","journal-title":"Clin. Cancer Res.: Offic. J. Am. Assoc. Canc. Res."},{"issue":"5","key":"10.1016\/j.placenta.2019.05.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127092","article-title":"Silencing of receptor tyrosine kinase ROR1 inhibits tumor-cell proliferation via PI3K\/AKT\/mTOR signaling pathway in lung adenocarcinoma","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.placenta.2019.05.002_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/bjh.13228","article-title":"The PI3K\/AKT\/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies","volume":"169","author":"Daneshmanesh","year":"2015","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.placenta.2019.05.002_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2443.1999.00234.x","article-title":"Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system","volume":"4","author":"Oishi","year":"1999","journal-title":"Genes Cells : Devoted Mol. Cell. Mech."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.002_bib15","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.celrep.2014.06.027","article-title":"Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling","volume":"8","author":"Cha","year":"2014","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.placenta.2019.05.002_bib16","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1111\/j.1582-4934.2010.01191.x","article-title":"The relationship between early embryo development and tumourigenesis","volume":"14","author":"Ma","year":"2010","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.002_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s004270100140","article-title":"Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development","volume":"211","author":"Al-Shawi","year":"2001","journal-title":"Dev. Gene. Evol."},{"issue":"5","key":"10.1016\/j.placenta.2019.05.002_bib18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00439-006-0259-1","article-title":"Genetics of preeclampsia: paradigm shifts","volume":"120","author":"Oudejans","year":"2007","journal-title":"Hum. Genet."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.002_bib19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1067\/S0002-9378(03)00576-3","article-title":"The frequency and severity of placental findings in women with preeclampsia are gestational age dependent","volume":"189","author":"Moldenhauer","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.placenta.2019.05.002_bib20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/HYPERTENSIONAHA.111.00250","article-title":"Redefining preeclampsia using placenta-derived biomarkers","volume":"61","author":"Staff","year":"2013","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.placenta.2019.05.002_bib21","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1471-0528.2009.02453.x","article-title":"Different profiles of circulating angiogenic factors and adipocytokines between early- and late-onset pre-eclampsia","volume":"117","author":"Masuyama","year":"2010","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.002_bib22","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/AOG.0000000000000472","article-title":"Maternal morbidity associated with early-onset and late-onset preeclampsia","volume":"124","author":"Lisonkova","year":"2014","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.placenta.2019.05.002_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/uog.5184","article-title":"Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction","volume":"31","author":"Crispi","year":"2008","journal-title":"Ultrasound Obstet. Gynecol.: Offic. J. Int. Soc. Ultrasound Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.placenta.2019.05.002_bib24","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","article-title":"Placental origins of preeclampsia: challenging the current hypothesis","volume":"51","author":"Huppertz","year":"2008","journal-title":"Hypertension"},{"issue":"9461","key":"10.1016\/j.placenta.2019.05.002_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet (London, England)"},{"issue":"12","key":"10.1016\/j.placenta.2019.05.002_bib26","article-title":"Molecular cross-talk at the feto-maternal interface","volume":"5","author":"Lash","year":"2015","journal-title":"Cold Spring Harbor Perspect. Med."},{"issue":"2","key":"10.1016\/j.placenta.2019.05.002_bib27","doi-asserted-by":"crossref","first-page":"R81","DOI":"10.1530\/JOE-17-0185","article-title":"Treating the dysfunctional placenta","volume":"234","author":"Sibley","year":"2017","journal-title":"J. Endocrinol."},{"issue":"15","key":"10.1016\/j.placenta.2019.05.002_bib28","doi-asserted-by":"crossref","first-page":"20193","DOI":"10.18632\/oncotarget.7935","article-title":"Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1 alpha via the PI3K\/AKT\/mTOR pathway","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.placenta.2019.05.002_bib29","doi-asserted-by":"crossref","first-page":"27071","DOI":"10.1038\/srep27071","article-title":"Stellettin B induces G1 arrest, apoptosis and autophagy in human non-small cell lung cancer A549 cells via blocking PI3K\/Akt\/mTOR pathway","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.placenta.2019.05.002_bib30","article-title":"ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.placenta.2019.05.002_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029353","article-title":"Inhibition of Akt activity and calcium channel function coordinately drive cell-cell fusion in the BeWO choriocarcinoma placental cell line","volume":"7","author":"Vatish","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.placenta.2019.05.002_bib32","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.biopha.2018.02.134","article-title":"Overexpression of long non-coding RNA H19 promotes invasion and autophagy via the PI3K\/AKT\/mTOR pathways in trophoblast cells","volume":"101","author":"Xu","year":"2018","journal-title":"Biomed. Pharmacother. = Biomedecine & pharmacotherapie"},{"issue":"1","key":"10.1016\/j.placenta.2019.05.002_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-016-0759-3","article-title":"Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight","volume":"15","author":"Dimasuay","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.placenta.2019.05.002_bib34","doi-asserted-by":"crossref","first-page":"5947859","DOI":"10.1155\/2017\/5947859","article-title":"Akt\/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy","volume":"2017","author":"Villalobos-Labra","year":"2017","journal-title":"J. Diabetes Res."}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340041930102X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014340041930102X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:59:01Z","timestamp":1758909541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014340041930102X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"alternative-id":["S014340041930102X"],"URL":"https:\/\/doi.org\/10.1016\/j.placenta.2019.05.002","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of receptor tyrosine kinase-like orphan receptor 1 in preeclampsia placenta inhibits human trophoblast cell proliferation, migration, and invasion by PI3K\/AKT\/mTOR pathway accommodation","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.placenta.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}